Summaries by Inventor Klechevsky, Eynav

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

Mechanically Optimized Synthetic Dendritic Cells for the Expansion of Antigen-Specific T Cells
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Published Date: 12/19/2024 Value Proposition: New method for expanding T cells against individualized tumor-specific mutational antigens. Technology Description Researchers at Washington University in St. Louis have developed a device that enables high-throughput production of patient specific …