Summaries by Inventor Hirbe, Angela

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Development of a Preclinical NF1-MPNST Platform Suitable for Precision Oncology Drug Discovery and Evaluation
Hirbe, Angela ; Li, Shunqiang

— This technology contains a set of patient derived xenograft cell lines. These cell lines represent the heterogeneity of human malignant peripheral nerve sheath tumors (MPNSTs) that can be used to test novel agents to move forward into clinical trials.


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