Summaries by Inventor Feldman, Mario

System to Engineer Vesicle Enzymatic Cargo from Gut Bacteria
Feldman, Mario ; Sartorio, Mariana
T-020642

— T-020642 System to Engineer Vesicle Enzymatic Cargo from Gut Bacteria Technology Description Researchers at Washington University in St. Louis have developed a novel bacterial delivery system that may be used to deliver enzymes to the gut via outer membrane vesicles (OMVs). This system identi…

UPAB1 plasmid lacking pAB5
Di Venanzio, Gisela ; Feldman, Mario
T-019205

— An UPAB1 derivative, UPAB1p-, that spontaneously loss pAB5 was identified by detection of restored Hcp secretion and isolated via an ELISA. Compared to wildype UPAB1, UPAB1p- displayed comparable growth in vitro in both rich medium and urine from healthy donors, indicating that less pAB5 did not in…

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…