Summaries by Inventor Diamond, Michael

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

Mayaro virus monoclonal antibodies and hybridomas
Diamond, Michael ; Earnest, James

— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values

Irg1 conditional knockout mouse
Diamond, Michael

— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…

Diamond, Michael ; Thackray, Larissa

— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Venezuelan equine encephalitis virus (VEEV) E2 DNA plasmid
Diamond, Michael ; Kim, Arthur

— VEEV E2 DNA plasmid

Irg1 point mutant mice
Diamond, Michael ; Nair, Sharmila

— Description: CRISPR-Cas9 gene edited mice with point mutation in Irg1 (ACOD1). Note: Please contact for additional information.

Chikungunya Monoclonal Antibodies
Diamond, Michael ; Fremont, Daved

— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus Publication:

anti-Powassan virus antibodies and hybridoma cell lines
Diamond, Michael ; VanBlargan, Laura

— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

Mouse embryonic fibroblasts from IRF 3/5/7 knock out animals
Diamond, Michael

— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background. Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Eastern Equine Encephalitis virus (EEEV) antibodies
Diamond, Michael

— Eastern Equine Encephalitis virus (EEEV) antibodies

Antibodies to Western Equine Encephalitis Virus (WEEV)
Austin, Stephen ; Diamond, Michael ; VanBlargan, Laura

— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.

Target and method to treat alphavirus infections
Diamond, Michael ; Kim, Arthur ; Thackray, Larissa ; Zhang, Rong

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Zika Oncolytic Virus to Treat Glioblastoma and Other Solid Tumors
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew

— Disease indication: Glioblastoma, Lung Cancer, Breast Cancer and other Cancers with Cancer Stem Cells Drug format: Oncolytic Virus Drug class: First-in class Research stage and Preliminary data: 1st Generation – Zika Virus (ZIKV) 2nd Generation – Attenuated ZIKV (E218A) Figur…

Alphavirus-Resistant Fish
Diamond, Michael ; Zhang, Rong

— Background: Aquaculture is the most resource-efficient method to produce protein, improve nutrition, and food security and is vital for supporting seafood production. The Food and Agriculture Organization of the United Nations estimates over 50% of all global seafood for human consumption is produce…

Anti-prM Monoclonal Antibody against all four Dengue Virus Serotypes
Diamond, Michael

— Target: Dengue Virus Notes: PrM-12 and -22

Venezuelan Equine Encephalitis Virus (VEEV) Antibodies
Diamond, Michael

— Primary Inventor: Michael S. Diamond, MD Target: Venezuelan Equine Encephalitis Virus

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj


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