Summaries by Inventor Diamond, Michael
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745
— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…
Engineered Oncolytic Zika Virus Therapy for GlioblastomaChheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429
— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…
SARS-CoV-2 neutralizing antibody effective against all variantsAdams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791
— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
Fusion protein for treating multiple strains of Venezuelan equine encephalitis virusBasore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …
Mayaro virus monoclonal antibodies and hybridomasDiamond, Michael ; Earnest, James
T-019543
— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values
Irg1 conditional knockout mouseDiamond, Michael
T-019215
— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…
LDLRAD3 KO miceDiamond, Michael ; Thackray, Larissa
T-019372
— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…
Mouse monoclonal antibodies against SARS-CoV-2 spike proteinDiamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…
Venezuelan equine encephalitis virus (VEEV) E2 DNA plasmidDiamond, Michael ; Kim, Arthur
T-019082
— VEEV E2 DNA plasmid
Irg1 point mutant miceDiamond, Michael ; Nair, Sharmila
T-018684
— Description: CRISPR-Cas9 gene edited mice with point mutation in Irg1 (ACOD1). Note: Please contact for additional information.
Chikungunya Monoclonal AntibodiesDiamond, Michael ; Fremont, Daved
T-010020
— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus Publication:
anti-Powassan virus antibodies and hybridoma cell linesDiamond, Michael ; VanBlargan, Laura
T-018559
— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections
Mouse embryonic fibroblasts from IRF 3/5/7 knock out animalsDiamond, Michael
T-018546
— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background. Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
Eastern Equine Encephalitis virus (EEEV) antibodiesDiamond, Michael
T-018711
— Eastern Equine Encephalitis virus (EEEV) antibodies
Antibodies to Western Equine Encephalitis Virus (WEEV)Austin, Stephen ; Diamond, Michael ; VanBlargan, Laura
T-019128
— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.
Target and method to treat alphavirus infectionsBasore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583
— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…
Anti-prM Monoclonal Antibody against all four Dengue Virus SerotypesDiamond, Michael
T-015814
— Target: Dengue Virus Notes: PrM-12 and -22
Venezuelan Equine Encephalitis Virus (VEEV) AntibodiesDiamond, Michael
T-015386
— Primary Inventor: Michael S. Diamond, MD Target: Venezuelan Equine Encephalitis Virus
Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E ProteinsBrien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila
T-009276
— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…
Monoclonal Antibodies Against Zika Virus and Purified Zika E ProteinDiamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168
— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…
Transmembrane Protein Targeted to Treat Obesity and Associated Metabolic DiseasesBrestoff Parker, Jonathan ; Diamond, Michael ; Jia, Wentong
T-020807
— Value Proposition: This invention targets MXRA8 protein as a therapy for obesity and other metabolic diseases. Technology Description Researchers at Washington University in St. Louis have developed an MXRA8 targeted therapeutic to treat obesity and associated metabolic diseases. MXRA8 is the re…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …
Chimpanzee adenovirus-based vaccine for COVID-19Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
Knockout Mouse lacking Expression of the Batf3 GeneDiamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136
— Notes: Batf3-/- knockout mouse with a 129SvEv background.
New Approach for the Treatment of Brain CancersChheda, Milan ; Curiel, David ; Diamond, Michael ; Li, Yuping
T-021004
— Published Date: 12/20/2024 Value Proposition: Treats brain tumors by combining a hematopoietic growth protein and cancer therapeutics to increase survival rates. Technology Description Researchers at Washington University in St. Louis have developed a new way to treat brain cancers by combining…
Recombinant Chikungunya Virus Soluble E2 ProteinBarrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734
