Summaries by Inventor Cooper, Matthew

Gene-Edited iNKT Cell Expressing Chimeric Antigen Receptor for the Treatment of Cancer
Cooper, Matthew ; DiPersio, John
T-018642

— Value Proposition: Engineered iNKT cells with potential as a “universal” source of immune effector cells to treat cancer. Technology Description Researchers at Washington University in St. Louis have developed a new composition of matter that uses gene-edited invariant natural kill…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…