Summaries by Inventor Brett, Thomas

A TREM2 Variant Protein Library for Mapping Interactions with Ligands
Alexander-Brett, Jennifer ; Brett, Thomas ; Greven, Jessica ; Wydra, Joshua
T-021344

— Published date: 9/18/2025 Value Proposition: Variant protein library that can map ligand binding. Technology Description Researchers at Washington University in St. Louis have developed a TREM2 variant protein library that can be used to map interactions with ligands to guide development of the…

Potentiator that Enhances Mucociliary Transport to Treat Cystic Fibrosis and other Mucus Obstructive Diseases
Alexander-Brett, Jennifer ; Berry, Kayla ; Brett, Thomas ; Miller, Mark ; Nichols, Colin ; Sala-Rabanal, Monica ; Yurtsever, Zeynep
T-021341

— Published date: 6/3/2026 Value Proposition: Using CLCA1 VWA to specifically potentiate TMEM16A to enhance mucociliary transport in cystic fibrosis and other mucus obstructive diseases. Technology Description Researchers at Washington University in St. Louis have developed a potentiator, CLCA1 …