Diabetes, Metabolism, Endocrinology Summaries
Connor, Michelle ; Leuthardt, Eric ; Osbun, Joshua ; Siripoksup, Piyarat ; Zayed, Mohamed
T-021406
— Published date: 2/6/2026 Value Proposition: Device designed to stimulate neural structures to increase weight loss in people affected by obesity. Technology Description Researchers at Washington University in St. Louis are developing an endovascular stimulation device that can be implanted i…
NuPanc – A Sustainable Cure for Chronic DiabetesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Published Date: 6/12/2025 Value Proposition: Novel vascular graft device that delivers whole pancreatic islets to enhance glycemic control and chronic management of diabetes, without the need for immunosuppression. Technology Description Researchers at Washington University in St. Louis have de…
Treatments for Wolfram syndromeClark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862
— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…
Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal EnzymesDoray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569
— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…
Managing Diabetes status in diabetic patientsRavi, V. Nathan
T-005389
— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…
Transmembrane Protein Targeted to Treat Obesity and Associated Metabolic DiseasesBrestoff Parker, Jonathan ; Diamond, Michael ; Jia, Wentong
T-020807
— Published date: 1/14/2026 Value Proposition: Novel target for therapeutic treatment of obesity and related metabolic diseases. Technology Description Researchers at Washington University in St. Louis have developed a therapeutic targeting MXRA8 to treat obesity and associated metabolic disea…
Oxygen-releasing hydrogel for rapid wound healingGuan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931
— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …
Therapeutic targeting of LDL in ALSKreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021
— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…
Method to generate functionally mature, stem-cell derived, beta cellsMillman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…
miRNA mimics to treat metabolic diseaseGong, Yong-feng ; Hou, Jianghui
T-017930
— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…
Device for diabetes cell replacement therapyMillman, Jeffrey ; Song, Jiwon
T-016681
— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…
High-throughput blood biomarker test for peripheral atherosclerosisSemenkovich, Clay ; Zayed, Mohamed
T-017421
— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…
Peptides responsible for Type 1 diabetesLichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626
— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …
Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug developmentHogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409
— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…
