Blood Summaries

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…