Blood Summaries
Cashin, John ; Roberts, Sophia ; Rucker, Devaughn ; Zayed, Mohamed
T-020787
— Published Date: 6/12/2025 Value Proposition: Endovascular ventricular device that improves blood flow at lower rotational speed. Technology Description Researchers at Washington University in St. Louis have developed a toroidal endovascular ventricular support device (TEVAD) that is design…
Anti-FCRL5 Chimeric Antigen Receptor (CAR) Targeting Multiple MyelomaDiPersio, John ; Ghobadi, Armin ; O'Neal, Julie ; Ritchey, Julie
T-020082
— Published Date: 5/13/2025 Value Proposition: An innovative therapy leveraging unique chimeric antigen receptors (CAR) to specifically target Fc receptor-like 5 (FCRL5), enabling the precise elimination of FCRL5-expressing cells to treat multiple myeloma and other cancers. Technology Description …
New Process for Treating Multiple MyelomaSilva-Fisher, Jessica
T-020751
— Value Proposition: Long non-coding RNA as biomarker and therapeutic target for treating diagnosed multiple myeloma patients. Technology Description Researchers at Washington University in St. Louis have developed a long non-coding RNA as a diagnostic marker and clinical target for multiple my…
Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem CellsLuff, Stephanie ; Sturgeon, Christopher
T-018886
— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …
Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancerChristopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954
— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…
Prognostic for Lymphoproliferative DisordersQavi, Abraham ; Swat, Wojciech
T-019271
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…
NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myelomaAlhallak, Kinan ; Azab, Abdel Kareem
T-018892
— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…
Targeted liposome drug delivery system to improve multiple myeloma treatmentAzab, Abdel Kareem ; Federico, Cinzia
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
