Tracers-Probes-Reporters Summaries
Berezin, Mikhail ; Gustafson, Tiffany
T-012606
— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…
Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingPiwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingPiwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Simple, universal DNA motifs for modulating protein productionDjuranovic, Sergej
T-016819
— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…
S1P1-targeted PET tracersLiu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
Novel Method and Device to Produce Fluorine-18 PET TracersChu, Wenhua ; Zhou, Dong
T-015970
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Sigma-1 targeted PET tracersMach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394
— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…
S1P1-targeted PET tracersLiu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151
— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…
SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activityAchilefu, Samuel ; Black, Kvar
T-014635
— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…
Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive functionJin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517
— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…
PET tracer to diagnose kidney diseaseBaldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
PET tracer to diagnose kidney diseaseBaldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
Molecular imaging of COVID binding receptorAbou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485
— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …
MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluationBaldelomar, Edwin ; Bennett, Kevin
T-019017
— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…
Compositions for targeting pathologic cells and tissuesAchilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230
— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …
Novel Method and Device to Produce Fluorine-18 PET TracersZhou, Dong
T-019276
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
