Vaccines Summaries
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064
— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…
Target and Method to Treat Alphavirus InfectionsBasore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583
— Published date: 1/14/2026 Value Proposition: Fusion protein that can be used to prevent and treat arthritogenic alphavirus infections. Technology Description Researchers at Washington University in St. Louis have identified MXRA8 (matrix remodeling associated protein 8) protein as a key recepto…
Novel Antiviral Treatment for Yellow Fever VirusChong, Zhenlu ; Diamond, Michael ; Fremont, Daved ; Hui, Sean
T-021452
— Published date: 1/14/2026 Value Proposition: First antiviral treatment that uses soluble receptors to treat yellow fever. Technology Description Researchers at Washington University in St. Louis have developed new soluble receptor decoy Fc-fusion protein inhibitors for the treatment of yellow f…
Uropathogen VaccinesDodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120
— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…
Chimpanzee adenovirus-based vaccine for COVID-19Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
Recombinant VSV vector for COVID-19 vaccine or drug screeningRothlauf, Paul ; Whelan, Sean
T-019338
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…
Soluble Decoy Receptors for Treating Tick-Borne Encephalitis VirusDiamond, Michael ; Fremont, Daved ; Hui, Sean ; Li, Pengfei
T-021652
— Published date: 1/14/2026 Value Proposition: Entry receptors that bind directly to TBEV, promoting virus attachment to treat TBEV and other viruses. Technology Description Researchers at Washington University in St. Louis have developed LRP8 soluble decoy receptors (minimal domains-Fc fusion …
Pan-Receptor Decoy Protein to Treat Encephalitic AlphavirusesDiamond, Michael ; Palakurty, Sathvik ; Raju, Saravanan ; Sariol, Alan
T-021655
— Published date: 1/14/2026 Value Proposition: Soluble engineered decoy receptor protein that on its own can be used to treat multiple alphavirus types. Technology Description Researchers at Washington University in St. Louis have developed a composition of matter that consists of a mutagenized…
Prefusion Glycoprotein for the Prevention of Bourbon Virus and other ThogotovirusesBoon, Adrianus "Jacco" ; Dai, Yanan ; Fremont, Daved ; Harastani, Houda
T-021548
— Published date: 1/6/2025 Value Proposition: Stabilization of glycoprotein of Bourbon Virus (BRBV) and related thogotoviruses as a key target for vaccine and antiviral development. Technology Description Researchers at Washington University in St. Louis have determined the pre-fusion structure…
Vaccine to prevent catheter-associated urinary tract infectionCaparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965
— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…
Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer ImmunotherapyCuriel, David
T-011681
— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…
Monoclonal Antibodies Against Zika Virus and Purified Zika E ProteinDiamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168
— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…
geOMV: Bacterial vaccine development platform using glycoengineered microbesFeldman, Mario
T-015094
— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…
Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritisFinkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294
— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…
Chimpanzee adenovirus-based vaccine for COVID-19Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
Recombinant VSV vector for COVID-19 vaccine or drug screeningRothlauf, Paul ; Whelan, Sean
T-019338
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…
