Drug Delivery Summaries
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910
— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…
In vivo editing via targeted adenoviral vectorsCuriel, David
T-016332
— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…
Protein-Based Drugs that Target Condensate-Dependent DiseasesDai, Yifan ; Pappu, Rohit
T-021094
— Published date: 1/6/2025 Value Proposition: Directed evolution of synthetic intrinsically disordered proteins for condensate editing. Technology Description Researchers at Washington University in St. Louis have developed a directed evolution method and selection strategies to enable the evolut…
Prefusion Glycoprotein for the Prevention of Bourbon Virus and other ThogotovirusesBoon, Adrianus "Jacco" ; Dai, Yanan ; Fremont, Daved ; Harastani, Houda
T-021548
— Published date: 1/6/2025 Value Proposition: Stabilization of glycoprotein of Bourbon Virus (BRBV) and related thogotoviruses as a key target for vaccine and antiviral development. Technology Description Researchers at Washington University in St. Louis have determined the pre-fusion structure…
Antisense Oligonucleotides (ASOs) to Treat Neurodegeneration in ALS and FTDDjuranovic, Sergej ; Pirzada, Mujeeb
T-021032
— Published Date: 5/14/2025 Value proposition: Novel ASOs that increase key protein production to limit neurodegeneration caused by ALS and frontotemporal dementia (FTD). Technology Description TDP-43 pathology is present in ~97% of ALS, ~50% of FTD, and frequently observed in other neurodegenerat…
Genetically Engineered Yeast Strain for the Treatment of Gastrointestinal Tumors with Immune Checkpoint Inhibitor TherapyDantas, Gautam ; Gorushi, Olivia ; Helmink, Beth ; Kwak, Suryang ; Prusa, Jerome ; Wallace, Miranda
T-020850
— Published date: 1/9/2025 Value Proposition: Genetically engineered yeast used to treat gastrointestinal tumors through the delivery of immune checkpoint inhibitor (ICI) proteins. Technology Description Researchers at Washington University in St. Louis have developed a genetically engineered …
Antagonizing the Endothelin B Receptor to Improve Aging-Dependent Neuronal Regenerative DeclineCavalli, Valeria ; Feng, Rui
T-020705
— Published Date: 12/21/24 Value proposition: A cost-effective, drug-based therapy targeting the endothelin B receptor (ETBR) to promote peripheral nerve regeneration, offering improved recovery and compatibility with existing treatments. Technology Description Researchers at Washington University…
Mechanically Optimized Synthetic Dendritic Cells for the Expansion of Antigen-Specific T CellsKlechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391
— Published Date: 12/19/2024 Value Proposition: New method for expanding T cells against individualized tumor-specific mutational antigens. Technology Description Researchers at Washington University in St. Louis have developed a device that enables high-throughput production of patient specific …
Small Molecule Gastrin-releasing peptide receptor (GRPR) antagonists used for Anti-Itch TreatmentDolle, Roland "Ron" ; Zhou, Mingzhou
T-020002
— Value Proposition: Small molecule Gastrin-releasing peptide receptor (GRPR) antagonists used to treat chronic itch. Technology Description Researchers at Washington University in St. Louis have discovered a group of small molecule Gastrin-releasing peptide receptor (GRPR) antagonists to treat c…
Candidate Probiotic Strains for Improving Infant Health T-020134 & T-019665Barratt, Michael ; Chang, Hao-Wei ; Gordon, Jeffrey ; Hibberd, Matthew ; Wang, Yi ; Webber, Daniel
T-020134
— Value Proposition: Human microbe strains with robust colonization efficacy and potent in vivo harvesting of beneficial metabolites involved in infant health. Technology Description Researchers from the laboratory of Dr. Jeffrey Gordon at Washington University in St. Louis have discovered str…
Oxygen-releasing hydrogel for rapid wound healingGuan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931
— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …
CCR2-targeted cancer nanoimmunotherapyLim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463
— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…
Targeted liposome drug delivery system to improve multiple myeloma treatmentAzab, Abdel Kareem ; Federico, Cinzia
T-019089
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…
Rapid PEG-based drug delivery implant for local treatment of cervical cancerAzab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …
Exosome-based therapy for tendon injuries and other soft tissue repairShen, Hua
T-018565
— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…
PEGylated-GIRLRG Peptide for Radiopharmaceutical DeliveryHallahan, Dennis
T-014562
— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…
Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic PlaqueRossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679
— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…
Ultrasound “painting” for precise, targeted drug delivery to the brainChen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953
— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…
Cell-based tumor targeting for delivering therapeutic and imaging agentsAzab, Abdel Kareem ; Muz, Barbara
T-018893
— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…
