Modeling-Simulation Tools Summaries

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Highly Accurate Model used to Predict Alzheimer’s Disease Status
Ali, Muhammad ; Cruchaga, Carlos
T-020673

— Technology Description Researchers at Washington University in St. Louis have developed models that can very accurately predict brain amyloidosis—Alzheimer’s disease status. Alzheimer’s disease (AD) is characterized by the accumulation of Amyloid-β (Aβ42) and hyperphos…

Rational drug design using Boltzmann docking
Bowman, Gregory
T-016234

— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…

Computer-Implemented Method for Measuring Strains
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Published date: 1/7/2025 Value Proposition: Accurate, efficient 2D strain mapping with robust detection of strain localization. Technology Description Researchers at Washington University in St. Louis have developed a novel method using 2D Direct Deformation Estimation (2D-DDE) and SIMPLE (St…

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…