by | Sep 21, 2020 | Djuranovic, Sergej
— This is the pcDNA-5 plasmid library with 6500 barcoded constructs containing eGFP followed by 650 combinations of 3’UTRs with miRNA, Pumilio, Smaug and AU-rich. This library can be used to optimize gene expression and to study gene regulation by different micro RNAs and RNA-binding proteins.
…
by | Sep 3, 2020 | Hu, Yifei, Van Dyke-Blodgett, Joshua
— Background:
Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…
by | Aug 26, 2020 | Cao, Yu-Qing, Cloud, Megan, Hu, Rong, Zhang, Jintao, Zhang, Zhiyu
— Technology Description
Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…
by | Aug 24, 2020 | Dougherty, Joseph, Kopp, Nathan
— Dr. Dougherty developed a collection of mouse lines with deletions of Gft2i and Gtfird1 in various combinations. The genes are related to Williams Beuren locus.
Publications:
by | Aug 24, 2020 | Emfinger, Christopher, Nichols, Colin
— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor.
Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets