— This is a CRISPR/Cas9 germline mutation in the KCNJ8 gene, equivalent to a human Cantu Syndrome mutation. The mouse is therefore a genetic model of human Cantu Syndrome. This mouse model can be used for pre-clinical testing of targeted therapy for Cantu Syndrome.
Publication: Cardiovascular consequ…
— Technology Description
Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…
— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome
Drug format – small molecule (FR900359, a bioavailable inhibitor of…
— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases
Drug format – neurosteroid
Drug class – drug repurposing (25-hydroxycholesterol)
Research stage and Preliminary data:
In vitro – The inventors demonstrated…
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Creating...
