Small molecules targeting KCNQ in ventricular arrhythmia

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness)

Drug format – Small molecule

Drug class – Lead compounds are repurposed drugs

Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

Rational drug design using Boltzmann docking

— Technology Description

Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…

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