Gill, John | Washington University Office of Technology Management

High Affinity Mannose Receptor Ligand

by | Oct 22, 2019 | Stahl, Philip

— Technology Description: The mannose receptor is uniquely found on macrophages and not on monocytes, making the mannose receptor a target for macrophage activation. Researchers at Washington University have developed polypeptide backbones to target the mannose receptor on macrophages. This technology…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)

by | Oct 22, 2019 | Guruswami, Sundaram, Sharma, Vijay, Sivapackiam, Jothilingam

— Background

Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Nanomaterials for Imaging and Treatment of Amyloidosis

by | Oct 22, 2019 | Bieschke, Jan, Guruswami, Sundaram, Liu, Yongjian, Sharma, Vijay

— Background

8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase

by | Jun 7, 2018 | Shaikh, Nurmohammad, Tarr, Phillip

— Primary Inventor: Phillip I. Tarr, MD

Target: GelE(mAb 8A3)

Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…