Office of Technology Management/Tech Transfer

WASHU INNOVATION CATALOG

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase

by | Jun 7, 2018 | Shaikh, Nurmohammad, Tarr, Phillip

— Primary Inventor: Phillip I. Tarr, MD

Target: GelE(mAb 8A3)

Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

PEGylated-GIRLRG Peptide for Radiopharmaceutical Delivery

by | Mar 10, 2018 | Hallahan, Dennis

— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…

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