by | Jan 25, 2022 | Bowman, Gregory
— Technology Description
Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…
by | Sep 2, 2021 | Schreiber, Robert
— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice.
F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…
by | Mar 17, 2021 | Djuranovic, Sergej
— Technology Description
Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…
by | Jan 7, 2021 | Hogrebe, Nathaniel, Millman, Jeffrey, Velazco-Cruz, Leonardo, Veronese Paniagua, Daniel, Wernes, Kristina
— Technology Description:
Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…
by | Nov 23, 2020 | Mitra, Robi, Moudgil, Arnav, Qi, Zongtai, Wilkinson, Michael Nathaniel
— Technology Description
Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…