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Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseasesMitra, Robi ; Milbrandt, Jeffrey ; Lalli, Matthew ; Buchser, William
T-019442
— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
Atrial fibrillation treatment with patient-specific model to design ablation lesionsSchuessler, Richard ; Damiano, Ralph
T-005819
— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…
Computer vision training system for robust artificial intelligence image classificationWu, Tong ; Tong, Liang ; Vorobeychik, Yevgeniy
T-019303
— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…
Error correcting codes for robust, secure deep neural networksRaviv, Netanel
T-019252
— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…
Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materialsDai, Bin ; Bowen, Christopher ; Zhang, Fuzhong
T-018602
— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…
Rapid Strep Throat Diagnostic Using Host Gene Expression AnalysisYu, Jinsheng ; Storch, Gregory
T-019526
— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…
Rapid Strep Throat Diagnostic Using Host Gene Expression AnalysisYu, Jinsheng ; Storch, Gregory
T-019526
— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…
Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoringWhite, Brian ; Lanc, Irena ; Fulton, Robert ; Tomasson, Michael
T-016907
— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …
Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometryBose, Arpita ; Rengasamy, Karthikeyan ; Binkley, Michael ; Meacham, John
T-018839
— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…
MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditionsYe, Zezhong ; Song, Sheng-Kwei "Victor"
T-016528
— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein – Colonna labCella, Marina ; Colonna, Marco
T-019509
— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).
VSV-SARS2-mutants to characterize antibody panelsLiu, Zhuoming ; Whelan, Sean
T-019501
— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…
Leishmania major mutant lacking IPCS geneBeverley, Stephen
T-019504
— The creators used homologous gene recombination to delete the gene encoding inositol phosphoryl ceramide synthase (IPCS) from the genome of the protozoan parasite Leshmania major.
Leishmania major mutant lacking TOR3 geneBeverley, Stephen
T-019505
— The creators used classical homologous recombination to remove both copies of the Leishmania major target of rapamycin (TOR3). This mutant was used to study TOR3’s suitability as a potential drug candidate. Da Silva, L. M., & Beverley, S. M. (2010). Expansion of the target of rapamycin (T…
Wolfram syndrome conditional knock-out miceUrano, Fumihiko
T-019506
— Genetically engineered mice and frozen sperm with two loxP sites flanking the mouse Wfs1 gene. These mice can be used to study the mechanisms of neurodegeneration in Wolfram syndrome.
Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019510
— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.
Transcription factor EB (TFEB) materialsDiwan, Abhinav
T-019513
— Materials that have been used to study transcription factor EB (TFEB), a lysosomal biogenesis factor:
Plasmid library for miRNA, Pumilio, Smaug and AU-rich elementsDjuranovic, Sergej
T-019514
— This is the pcDNA-5 plasmid library with 6500 barcoded constructs containing eGFP followed by 650 combinations of 3’UTRs with miRNA, Pumilio, Smaug and AU-rich. This library can be used to optimize gene expression and to study gene regulation by different micro RNAs and RNA-binding proteins. …
Leishmania guyanensis with mCherry and luciferaseBeverley, Stephen
T-019515
— Leishmania guyanensis strain M4147 (+/- LRV) engineered to express two markers, mCherry and firefly luciferase. The constructs are stably integrated into the ribosomal RNA SSU locus. Parasites with these markers can be followed by fluorescence or bioluminescence approaches which is faster and requir…
VSV-BSL2 reporter of SARS CoV infectionBloyet, Louis-Marie ; Whelan, Sean
T-019518
— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.
