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Combination therapy for malignant peripheral nerve sheath tumorsBorcherding, Dana ; Amin, Neha ; Hirbe, Angela
T-020000
— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…
Single cell massively parallel reporter assaysZhao, Siqi ; Cohen, Barak
T-019923
— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…
Single cell massively parallel reporter assaysZhao, Siqi ; Cohen, Barak
T-019923
— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…
Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water DiffusionWang, Qing ; Guzman, Gloria ; Benzinger, Tammie ; Wang, Yong
T-016652
— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…
Tumor Detection Using Digitally Enhanced and Stimulated Thermal ImagingO'Brien, Christine ; Shmuylovich, Leonid ; Mondal, Suman ; Meng, Hongyu ; Achilefu, Samuel
T-018541
— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…
Technique to reduce juxta-anastomotic stenosis development in AV fistulaeShenoy, Surendra
T-010339
— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…
Novel benzo crown-ethers to create synthetic ion channelsCarrasquel Ursulaez, Willy ; Chanda, Baron
T-019832
— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…
Drug target and biomarker for multiple sclerosisWilliams, Jessica ; Klein, Robyn
T-017623
— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…
Novel benzo crown-ethers to create synthetic ion channelsCarrasquel Ursulaez, Willy ; Chanda, Baron
T-019832
— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…
NRF2 inhibitors as cancer therapeuticsMedcalf, Matthew ; Lapak, Kyle ; Dolle, Roland "Ron" ; Bowman, Brittany ; Major, Michael Ben
T-019534
— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…
Stent System for the Treatment of Aorto-Iliac Occlusive DiseaseWirtz, Alexander ; Zayed, Mohamed
T-018558
— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …
Oxygen-releasing hydrogel for rapid wound healingGuan, Ya ; Guan, Jianjun ; Niu, Hong
T-019931
— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …
Optimized MHC-independent T cell receptors as a CAR-T alternativeChang, Ju Fang ; Singh, Nathan
T-019636
— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …
Anti-fungal treatment and companion diagnostic for Crohn’s DiseaseJain, Umang ; Stappenbeck, Thaddeus
T-019293
— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…
Effective test for active tuberculosis infectionCoullon, Heloise ; Chandra, Pallavi ; Philips, Jennifer
T-019244
— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…
Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseasesSecca da Silva, Cristiane ; Colonna, Marco
T-019316
— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…
High-speed perovskite LED fabrication by inkjet printingZhao, Junyi ; Wang, Chuan
T-019910
— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…
Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue InjuryGelman, Andrew ; Puyo, Carlos
T-015918
— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…
Neuroactive steroid anesthetic compoundsJiang, Xin ; Covey, Douglas
T-004034
— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…
ME1 Deficiency Primes for FerroptosisLange, Sara ; Kremer, Jeff ; Van Tine, Brian
T-016416
— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…
