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Anti-fungal treatment and companion diagnostic for Crohn’s DiseaseJain, Umang ; Stappenbeck, Thaddeus
T-019293
— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…
Effective test for active tuberculosis infectionCoullon, Heloise ; Chandra, Pallavi ; Philips, Jennifer
T-019244
— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…
Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseasesSecca da Silva, Cristiane ; Colonna, Marco
T-019316
— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…
Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseasesSecca da Silva, Cristiane ; Colonna, Marco
T-019316
— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…
High-speed perovskite LED fabrication by inkjet printingZhao, Junyi ; Wang, Chuan
T-019910
— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…
Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue InjuryGelman, Andrew ; Puyo, Carlos
T-015918
— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…
Neuroactive steroid anesthetic compoundsJiang, Xin ; Covey, Douglas
T-004034
— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…
Alphavirus-Resistant FishZhang, Rong ; Diamond, Michael
T-018625
— Background: Aquaculture is the most resource-efficient method to produce protein, improve nutrition, and food security and is vital for supporting seafood production. The Food and Agriculture Organization of the United Nations estimates over 50% of all global seafood for human consumption is produce…
ME1 Deficiency Primes for FerroptosisLange, Sara ; Kremer, Jeff ; Van Tine, Brian
T-016416
— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…
JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantationDiPersio, John ; Persaud, Stephen "Steve"
T-019132
— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…
ME1 Deficiency Primes for FerroptosisLange, Sara ; Kremer, Jeff ; Van Tine, Brian
T-016416
— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…
NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myelomaAlhallak, Kinan ; Azab, Abdel Kareem
T-018892
— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…
MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trialsZhao, Yue ; Yablonskiy, Dmitriy
T-015754
— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …
CCR2-targeted cancer nanoimmunotherapyZhang, Xiaohui ; Lim, Kian-Huat ; Liu, Yongjian
T-019463
— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…
Wireless, dissolvable electrical stimulation device for nerve or bone regenerationMacEwan, Matthew ; Ray, Wilson
T-017504
— Technology Description An interdisciplinary team of inventors has developed an implantable, bioabsorbable device to accelerate nerve or bone repair by delivering programmable electrical stimulation over the course of days or weeks following surgery. Direct electrical stimulation during surgery for…
Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computingLi, Jr-Shin
T-017456
— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …
Small molecules targeting KCNQ in ventricular arrhythmiaNo items found
T-013554
— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…
Small molecules targeting KCNQ in ventricular arrhythmiaCui, Jianmin
T-013554
— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…
Real-time interference compensation in MRI guided radiotherapyVilla, Umberto ; Kim, Taeho ; Curcuru, Austen ; Gach, H. Michael
T-019745
— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…
Therapeutic targeting of LDL in ALSNielsen, Susan ; Racette, Brad ; Kreple, Collin ; Miller, Timothy
T-020021
— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…