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Therapy to treat and prevent respiratory disease in pre-term and at-risk neonatesTodd, Elizabeth (Betsy) ; Morley, Sharon "Celeste"
T-017434
— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…
High-performance, nanoengineered two-phase cooling system for high powered electronicsShan, Li ; Ma, Binjian ; Agonafer, Damena
T-018032
— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …
Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseasesLubman, Olga ; Lu, Yun Hsuan ; Fremont, Daved
T-017443
— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…
Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disordersOnken, Michael ; Blumer, Kendall
T-017344
— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…
Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disordersYue, Xuyi ; Kotzbauer, Paul ; Dhavale, Dhruva ; Tu, Zhude "Will"
T-018038
— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…
Breath-based testing for malariaTrehan, Indi ; Schaber, Chad ; John, Audrey Odom "Audrey Odom"
T-016183
— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…
Nanothermometers for cellular-level temperature monitoring in ablation therapy or researchGustafson, Tiffany ; Berezin, Mikhail
T-012606
— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…
Ultrasound “painting” for precise, targeted drug delivery to the brainYang, Yaoheng "Mack" ; Williamson, Jeffrey ; Chen, Hong
T-018953
— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…
Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planningFu, Yabo ; Yang, Deshan
T-018708
— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…
Hydrogel substrate system with easy, robust protein functionalization for cell cultureSarker, Bapi ; Pathak, Amit
T-018649
— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…
Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancersGrigsby, Perry
T-012905
— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…
Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devicesRamani, Vijay ; Parrondo, Javier ; Wang, Zhongyang
T-018608
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…
Target and method to treat alphavirus infectionsThackray, Larissa ; Zhang, Rong ; Kim, Arthur ; Nelson, Christopher ; Fremont, Daved ; Basore, Katherine ; Diamond, Michael
T-017583
— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…
Cytokine therapy for juvenile dermatomyositis and other autoimmune diseasesThrom, Allison ; Alinger, Joshua ; French, Anthony
T-018911
— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…
Rotoscope – A Self-Cleaning EndoscopeSomers, Thane ; Yarbrough, Chester ; Margolis, Daniel ; Genin, Guy ; Leuthardt, Eric
T-016245
— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…
Plasma oxysterols as biomarkers for Niemann-Pick C diseaseOry, Daniel
T-007594
— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.
Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritisZhao, Guoyan ; Virgin, Herbert ; Finkbeiner, Stacy ; Wang, David
T-009294
— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…
Treatments for Wolfram syndromeMahadevan, Jana ; Clark, Amy ; Urano, Fumihiko
T-015862
— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…
Selective RANK ligand to treat osteoporosisNelson, Christopher ; Warren, Julia ; Fremont, Daved ; Teitelbaum, Steven
T-014404
— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…
Therapeutic food supplements that promote healthy gut microbiome to treat malnutritionVenkatesh, Siddarth ; Chang, Hao-Wei ; Gehrig, Jeanette ; Barratt, Michael ; Gordon, Jeffrey
T-018889
— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…