Advanced Search
Select the Categories and/or Inventors to begin filtering. To narrow search results, use the search bar for additional keywords.
Search returned 649 results
Breath-based testing for malariaTrehan, Indi ; Schaber, Chad ; John, Audrey Odom "Audrey Odom"
T-016183
— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…
Ultrasound “painting” for precise, targeted drug delivery to the brainYang, Yaoheng "Mack" ; Williamson, Jeffrey ; Chen, Hong
T-018953
— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…
Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planningFu, Yabo ; Yang, Deshan
T-018708
— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…
Hydrogel substrate system with easy, robust protein functionalization for cell cultureSarker, Bapi ; Pathak, Amit
T-018649
— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…
Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancersGrigsby, Perry
T-012905
— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…
Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devicesRamani, Vijay ; Parrondo, Javier ; Wang, Zhongyang
T-018608
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…
Target and method to treat alphavirus infectionsNelson, Christopher ; Thackray, Larissa ; Zhang, Rong ; Kim, Arthur ; Fremont, Daved ; Basore, Katherine ; Diamond, Michael
T-017583
— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…
Cytokine therapy for juvenile dermatomyositis and other autoimmune diseasesThrom, Allison ; Alinger, Joshua ; French, Anthony
T-018911
— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…
Rotoscope – A Self-Cleaning EndoscopeYarbrough, Chester ; Margolis, Daniel ; Somers, Thane ; Genin, Guy ; Leuthardt, Eric
T-016245
— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…
Plasma oxysterols as biomarkers for Niemann-Pick C diseaseOry, Daniel
T-007594
— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.
Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritisVirgin, Herbert ; Zhao, Guoyan ; Finkbeiner, Stacy ; Wang, David
T-009294
— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…
Treatments for Wolfram syndromeMahadevan, Jana ; Clark, Amy ; Urano, Fumihiko
T-015862
— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…
Selective RANK ligand to treat osteoporosisNelson, Christopher ; Warren, Julia ; Fremont, Daved ; Teitelbaum, Steven
T-014404
— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…
Therapeutic food supplements that promote healthy gut microbiome to treat malnutritionGehrig, Jeanette ; Venkatesh, Siddarth ; Chang, Hao-Wei ; Barratt, Michael ; Gordon, Jeffrey
T-018889
— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…
Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fieldsRamaswamy, Kannan ; Mui, Stacy ; Hayes, Sophia
T-008875
— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…
Mobile PET imaging systemMathews, Aswin ; Wen, Jie ; Li, Ke ; Tai, Yuan-Chuan
T-014964
— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…
Multiparametric Cardiac Strain Analysis of Myocardial ViabilityPasque, Michael ; Cupps, Brian ; Kar, Julia
T-014564
— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…
Washington University Satisfaction and Function SurveyBarrack, Robert ; Nunley, Ryan
T-015700
— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…
Spray Pyrolysis for the Production of Li+ Ion Battery CathodesLengyel, Miklos ; Elhassid, Dror ; Atlas, Gal ; Axelbaum, Richard
T-013647
— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…
Software to assemble HLA alleles using short paired reads from exome sequencing dataPfeifer, John ; Liu, Chang
T-013332
— Technology Description: In collaboration with the scientists at Broad Institute, WU scientists have developed a new software with a new algorithm that enables HLA high resolution typing from exome sequencing data. It will provide a significantly better tool to guide the bone marrow transplantation a…