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Irg1 conditional knockout mouseDiamond, Michael
T-019215
— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…
Compound to treat alcohol use disorderMennerick, Steven ; Covey, Douglas
T-019232
— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…
geOMV: Bacterial vaccine development platform using glycoengineered microbesFeldman, Mario
T-015094
— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…
Recombinant VSV vector for COVID-19 vaccine or drug screeningNo items found
T-019338
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…
Recombinant VSV vector for COVID-19 vaccine or drug screeningRothlauf, Paul ; Whelan, Sean
T-019338
— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…
PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birthTuuli, Methodius ; Zhao, Peinan ; Macones, George ; Stout, Molly ; Hu, Peng ; Qu, Yuan "Ed"
T-018998
— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…
LDLRAD3 KO miceThackray, Larissa ; Diamond, Michael
T-019372
— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…
Bacterial and Mammalian Expression Vectors for Production of SARS-CoV ProteinsHarvey, Ian ; Nelson, Christopher ; Zhao, Haiyan ; Dai, Yanan ; Fremont, Daved
T-019413
— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…
Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and deathPeterson, Linda ; Ory, Daniel ; Schaffer, Jean
T-014627
— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…
Method to generate functionally mature, stem-cell derived, beta cellsVelazco-Cruz, Leonardo ; Millman, Jeffrey
T-019270
— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…
miRNA mimics to treat metabolic diseaseGong, Yong-feng ; Hou, Jianghui
T-017930
— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…
PET tracer to diagnose kidney diseaseReichert, David ; Beeman, Scott ; Baldelomar, Edwin ; Bennett, Kevin
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
PET tracer to diagnose kidney diseaseReichert, David ; Beeman, Scott ; Baldelomar, Edwin ; Bennett, Kevin
T-018902
— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…
Human monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019492
— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab
Rapid PEG-based drug delivery implant for local treatment of cervical cancerSchwarz, Julie ; Sun, Jennifer ; Federico, Cinzia ; Azab, Abdel Kareem
T-019396
— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …
Mouse monoclonal antibodies against SARS-CoV-2 spike proteinZhao, Haiyan ; VanBlargan, Laura ; Fremont, Daved ; Diamond, Michael
T-019470
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…
Human monoclonal antibodies against SARS-CoV-2 spike proteinSchmitz, Aaron ; Turner, Jackson ; Mudd, Philip ; McIntire, Katherine ; Ellebedy, Ali
T-019454
— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)Fremont, Daved ; Diamond, Michael ; Ellebedy, Ali
T-019438
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …
Human monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019492
— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab
Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2Hassan, Ahmed ; Diamond, Michael
T-019482
— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…