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An Intradermal Method for the Treatment of Hair Loss and AlopeciaYang, Pu ; Luo, Jialie ; Feng, Jing ; Hu, Hongzhen
T-017716
— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…
Early, specific, blood-based diagnostic for septic arthritisLuhmann, Scott
T-018905
— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…
Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancerPetti, Allegra ; Rettig, Michael ; Ley, Timothy ; DiPersio, John ; Christopher, Matthew
T-018954
— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…
String Theory: Neurovascular Catheter System with 2-in-1 Variable RigidityLowe, Halle ; Osbun, Joshua ; Zayed, Mohamed ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Chandrasekaran, Vinay ; Leuthardt, Eric
T-019184
— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…
Barbed mesh for fast, suture-less surgical wound closureFelder, John
T-018828
— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…
Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expressionQi, Zongtai ; Wilkinson, Michael Nathaniel ; Moudgil, Arnav ; Mitra, Robi
T-018609
— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…
Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseasesMitra, Robi ; Milbrandt, Jeffrey ; Lalli, Matthew ; Buchser, William
T-019442
— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…
Atrial fibrillation treatment with patient-specific model to design ablation lesionsSchuessler, Richard ; Damiano, Ralph
T-005819
— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…
Computer vision training system for robust artificial intelligence image classificationWu, Tong ; Tong, Liang ; Vorobeychik, Yevgeniy
T-019303
— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…
Error correcting codes for robust, secure deep neural networksRaviv, Netanel
T-019252
— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…
Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materialsDai, Bin ; Bowen, Christopher ; Zhang, Fuzhong
T-018602
— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…
Rapid Strep Throat Diagnostic Using Host Gene Expression AnalysisYu, Jinsheng ; Storch, Gregory
T-019526
— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…
Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoringLanc, Irena ; White, Brian ; Fulton, Robert ; Tomasson, Michael
T-016907
— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …
Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometryBose, Arpita ; Rengasamy, Karthikeyan ; Binkley, Michael ; Meacham, John
T-018839
— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…
MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditionsYe, Zezhong ; Song, Sheng-Kwei "Victor"
T-016528
— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein – Colonna labCella, Marina ; Colonna, Marco
T-019509
— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).
Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019510
— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.
VSV-SARS2-mutants to characterize antibody panelsLiu, Zhuoming ; Whelan, Sean
T-019501
— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…
Leishmania major mutant lacking IPCS geneBeverley, Stephen
T-019504
— The creators used homologous gene recombination to delete the gene encoding inositol phosphoryl ceramide synthase (IPCS) from the genome of the protozoan parasite Leshmania major.
Leishmania major mutant lacking TOR3 geneBeverley, Stephen
T-019505
— The creators used classical homologous recombination to remove both copies of the Leishmania major target of rapamycin (TOR3). This mutant was used to study TOR3’s suitability as a potential drug candidate. Da Silva, L. M., & Beverley, S. M. (2010). Expansion of the target of rapamycin (T…
