Advanced Search
Select the Categories and/or Inventors to begin filtering. To narrow search results, use the search bar for additional keywords.
Search returned 630 results
Energy efficient, scalable neuromorphic computing with Growth Transform Neural NetworkGangopadhyay, Ahana ; Chakrabartty, Shantanu
T-019112
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…
Robust, scalable phase control system for non-invasive neuromodulation devicesZlotnik, Anatoly ; Li, Jr-Shin
T-016206
— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …
Water filtration platform technologies using crumpled graphene oxide nanocompositesJiang, Yi ; Wang, WeiNing ; Fortner, John ; Biswas, Pratim
T-014428
— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…
A Highly Efficient Brine ElectrolyzerSankarasubramanian, Shrihari ; Gayen, Pralay ; Ramani, Vijay
T-019234
— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …
Lightweight, wearable cap for bedside functional optical neuroimagingEggebrecht, Adam ; Ferradal, Silvina ; Bergonzi, Karla ; Culver, Joseph
T-013611
— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …
Efficient multi-dimensional 4D MRI and PET/MR motion correctionEldeniz, Cihat ; An, Hongyu
T-016414
— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…
MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluationBaldelomar, Edwin ; Bennett, Kevin
T-019017
— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…
Method of increasing chemotherapy sensitivity in leukemia using BET inhibitorWilkinson, Michael Nathaniel ; Moudgil, Arnav ; Mitra, Robi
T-019486
— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …
Fusion protein for treating multiple strains of Venezuelan equine encephalitis virusKim, Arthur ; Ma, Hongming ; Thackray, Larissa ; Fremont, Daved ; Kafai, Natasha ; Basore, Katherine ; Diamond, Michael
T-019414
— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …
PI3K inhibitors to treat Cytokine Release SyndromeDiPersio, John ; Carter, Alun ; Amatya, Parmeshwar ; Cooper, Matthew
T-019429
— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…
Plasmids to express tagged genes in yeastRoy, Basab ; White, Michael A ; Granas, David ; Stormo, Gary
T-019559
— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…
Plasmid to test regulation 5′ untranslated sequences in yeastWhite, Michael A ; Granas, David ; Roy, Basab ; Stormo, Gary
T-019560
— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…
CD226 (DNAM1) knockout miceGilfillan, Susan ; Colonna, Marco
T-019563
— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…
CHIKV-3’Cre – recombinant Chikungunya virus expressing CreLenschow, Deborah
T-019567
— This is a recombinant clone of the Chikungunya LR2006 virus expressing Cre recombinase inserted downstream of a subgenomic promoter. In vitro transcription and transfection of RNA derived from this plasmid into cells will result in the generation of Chikungunya virus that expresses Cre recombinase i…
IL-34-deficient reporter mice (IL34 LacZ/LacZ)Colonna, Marco
T-019588
— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations. Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…
Ebola VP30 proteinsAmarasinghe, Gaya
T-019593
— Ebola viral protein 30 (eVP30) plays a critical role in transcription initiation for viral RNA synthesis. These materials could be used to test for Ebola virus infection. Publication: Xu, W., Luthra, P., Wu, C., Batra, J., Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2017). Ebola virus VP…
Broad spectrum chemokine receptor imaging agentLiu, Yongjian
T-019607
— 64Cu-DOTA-vMIP-II is a broad spectrum PET imaging agent that provides a non-invasive measurement of up to 10 chemokine receptors involved in the inflammatory processes of various diseases. This agent is based on the peptide vMIP-II (viral macrophage inflammatory protein-II), a viral CC chemokine enc…
ACE2 expressing cellsKumar, Sandeep ; Peterson, Timothy
T-019619
— These cells are K562 cells that express ACE2 (the receptor for SARS-CoV-2) from the endogenous locus and not a transgene.
CEPT1 floxed miceLodhi, Irfan ; Semenkovich, Clay
T-019637
— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…
Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug developmentVeronese Paniagua, Daniel ; Wernes, Kristina ; Velazco-Cruz, Leonardo ; Hogrebe, Nathaniel ; Millman, Jeffrey
T-019409
— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…
