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SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variantsEllebedy, Ali
T-019707
— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …
Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infectionRobinson, John ; Crowley, Jan ; Henderson, Jeffrey P.
T-019079
— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …
A novel modulator of tumor angiogenesis and anti-tumor immunityKrchma, Karen ; Kabir, Ashraf Ul ; Choi, Kyunghee
T-019294
— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…
Hydrogels for localized radiotherapyde la Puente Garcia, Maria del Pilar ; Azab, Feda ; Azab, Abdel Kareem
T-013626
— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…
Hamster Hybridoma producing Monoclonal Antibody against Murine IFNAR-1Sheehan, Kathleen ; Schreiber, Robert
T-004451
— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway. Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization. Publication:
d42m1 & F279 tumor cell linesSchreiber, Robert
T-011286
— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…
Deterministic two-photon controlled-phase logic gateZhou, Yao ; Chen, Zihao ; Shen, Jung-Tsung
T-018542
— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…
Predictive biomarker for CAR T-associated neurotoxicityDiPersio, John ; Ghobadi, Armin ; Ances, Beau ; Butt, Omar
T-019528
— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…
Exosome-based therapy for tendon injuries and other soft tissue repairShen, Hua
T-018565
— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…
Sustainable rare earth element extraction from coal ashZhu, Yaguang ; Jun, Young-Shin
T-019257
— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…
ELISpot assay to immune phenotype patientsRemy, Kenneth ; Turnbull, Isaiah ; Mazer, Monty ; Hotchkiss, Richard
T-019522
— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…
TREM2 blockade as an adjuvant for checkpoint inhibitorsColonna, Marco
T-019371
— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…
Stimulating Innate Immune Cells for Cancer Therapy or Vaccine AdjuvantsBarrow, Alexander ; Colonna, Marco
T-016924
— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…
SARS-CoV-2 neutralizing antibody effective against all variantsVanBlargan, Laura ; Fremont, Daved ; Adams, Lucas ; Diamond, Michael
T-019791
— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
Software to predict low back pain from brain imagingLeuthardt, Eric ; Ray, Wilson ; Lamichhane, Bidhan ; Jayasekera, Dinal ; Hawasli, Ammar
T-019322
— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…
Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imagingMutch, Matthew ; Uddin, Shihab ; Leng, Xiandong ; Chapman Jr., William "Will Jr" ; Zhu, Quing
T-019449
— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…
Peptides responsible for Type 1 diabetesWan, Xiaoxiao ; Lichti, Cheryl ; Unanue, Emil
T-018626
— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …
Photothermal disinfection of N95 respiratorsSingamaneni, Srikanth ; Jun, Young-Shin
T-019477
— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…
Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assetsZhou, Liang ; Chakrabartty, Shantanu
T-015908
— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …
Simple, universal DNA motifs for modulating protein productionDjuranovic, Sergej
T-016819
— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…
