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Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detectionRao, Bin ; Song, Liang ; Maslov, Konstantin ; Wang, Lihong
T-010922
— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…
Gaussian Process AudiogramSong, Xinyu ; Weinberger, Kilian ; Gardner, Jacob ; Ledbetter, Noah ; Barbour, Dennis
T-015053
— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…
Parallel single step prediction algorithm for conductivity-tensor estimationNehorai, Arye ; La Rosa Araya, Patricio ; Gilboa, Elad
T-011907
— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…
Parallel single step prediction algorithm for conductivity-tensor estimationNehorai, Arye ; La Rosa Araya, Patricio ; Gilboa, Elad
— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…
Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed OptimizationGilboa, Elad
T-012524
— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDARÂ. PDAR is able to solve both t…
Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)Wang, Qing ; Wang, Yong ; Song, Sheng-Kwei "Victor"
T-009943
— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…
Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique CompositionsThimsen, Elijah ; McDonald, Rafael ; Biswas, Pratim
T-006824
— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …
Radiation Oncology Dashboards (LATTICE)Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen ; Danieley, Jonathan ; LaBrash, Jason
T-014089
— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.
Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric SitesMitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi ; Corbo, Joseph ; Havranek, James
T-015523
— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…
Autosegmentation toolRao, Yuan ; Ma, Daniel ; Grigsby, Perry
T-010736
— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…
Managing Diabetes status in diabetic patientsRavi, V. Nathan
T-005389
— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…
Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteriesRamadesigan, Venkatasailanathan ; Suthar, Bharatkumar ; Lawder, Matthew ; Northrop, Paul ; De, Sumitava ; Subramanian, Venkat
T-013089
— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…
Disulfide trapped antigenic peptide in an MHC molecule.Fremont, Daved ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven ; Connolly, Janet ; Hansen, Ted
T-004551 Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Becker, Matthew ; Wooley, Karen
T-004487
— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.
Conformationally-flexible benzamide analogs as sigma-2 selective ligandsWelch, Michael ; Tu, Zhude "Will" ; Rowland, Douglas ; Mach, Robert
T-004063
— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …
Modulation of Lymphocyte ActivityWatanabe, Norihiko ; Yang, Jianfei ; Murphy, Theresa ; Murphy, Kenneth
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
Tri-heterocyclic ring compounds as alpha-synuclein ligandsYu, Lihai ; Mach, Robert ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-011942
— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…
Copy number Aberration Driven Endocrine Response (CADER) gene signatureLuo, Jingqin ; Ellis, Matthew
T-011920
— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…
Urinary Biomarker of Uropathogen ColonizationParker, Kaveri ; Hung, Chia ; Henderson, Jeffrey P.
T-011741
— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …
Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtiiGoodson, Carrie ; Goodenough, Ursula
T-011504
— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…
