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Method to Determine the Amount of DNA Contamination in an RNA ExtractionCruchaga, Carlos
T-021415
— Published date: 9/18/2025 Value Proposition: Process that can be used to quantify the amount of DNA contamination in an RNA isolation tube. Technology Description Researchers at Washington University in St. Louis have developed a method to determine the amount of DNA contamination in an RNA extr…
A TREM2 Variant Protein Library for Mapping Interactions with LigandsWydra, Joshua ; Alexander-Brett, Jennifer ; Greven, Jessica ; Brett, Thomas
T-021344
— Published date: 9/18/2025 Value Proposition: Variant protein library that can map ligand binding. Technology Description Researchers at Washington University in St. Louis have developed a TREM2 variant protein library that can be used to map interactions with ligands to guide development of the…
Genotype-Based Severity Scoring System in Wolfram SyndromeTang, Abby ; Oiknine, Liam ; Urano, Fumihiko
T-021494
— Published Date: 8/5/2025 Value Proposition: Disease severity scoring system that can predict the progression of Wolfram syndrome. Technology Description Researchers at Washington University in St. Louis have developed a genotype-based severity scoring system to predict the onset of cardinal sym…
Engineered RANK Protein for Treatment of OsteoporosisWarren, Julia ; Nelson, Christopher ; Fremont, Daved ; Teitelbaum, Steven
T-014404
— Published date: 9/18/2025 Value Proposition: Single chain RANK ligand that can selectively inhibit pathological bone loss. Technology Description Researchers at Washington University in St. Louis have developed a genetically engineered mutant RANKL protein that prevents bone loss by selective…
Trackable Pedicle Screws for Improving Spinal Fusion SurgeryHacker, Carl ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob ; Brunner, Peter ; Genin, Guy ; Leuthardt, Eric
T-019941
— Published date: 9/18/2025 Value Proposition: Non-obstructing trackable pedicle screw system that streamlines the rod-shaping process for surgeons. Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle…
AI-Empowered MR-guided Radiotherapy for the Treatment of CancerHollingsworth, Scott ; Kim, Taeho
T-021391
— Published date: 9/12/2025 Value Proposition: Innovative real-time prediction method that uses deep learning to track tumors. Technology Description Researchers at Washington University in St. Louis have developed a pioneering method that leverages prior 3D cine MRI and simulation CT scans to p…
Wearable Finger Goniometer for Hand PhysiotherapyPet, Mitchell
T-021195
— Published date: 9/12/2025 Value Proposition: Wireless device that offers a range of motion biofeedback to patients undergoing hand therapy. Technology Description Researchers at Washington University in St. Louis have developed a device designed to provide continuous, real-time kinematic biofee…
Ultrasound Computational Method for Prenatal ScreeningYang, Patrick ; Kamilov, Ulugbek ; Odibo, Anthony ; Scott, Adrienne ; Sheehan, Emily ; Hu, Yuyang ; Oyen, Michelle
T-020951
— Published Date: 8/8/2025 Value Proposition: Computational method that uses placental ultrasound images to detect prenatal and placental conditions early. Technology Description Researchers at Washington University in St. Louis have developed a computational method that predicts fetal conditions …
Novel Method to Remove Electrical Stimulation Artifacts in Neural SignalsWillie, Jon ; Xie, Tao ; Demarest, Phillip ; Leuthardt, Eric ; Brunner, Peter
T-020905
— Published Date: 6/18/2025 Value Proposition: Software tool that uses a novel denoising method to remove electrical stimulation artifacts from electrophysiology data while preserving physiological signals. Technology Description Researchers at Washington University in St. Louis have developed …
Steerable Thermoablation Probe for Improved Access to Brain LesionsLeuthardt, Eric
T-015768
— Published Date: 6/18/2025 Value Proposition: Non-sweeping, steerable guide for laser probes used in thermo-ablative systems to improve treatment of brain tumors. Technology Description Researchers at Washington University in St. Louis have developed a steerable device that can be integrated i…
Ventricular Support Device that Reduces Left Ventricle WorkloadRoberts, Sophia ; Rucker, Devaughn ; Cashin, John ; Zayed, Mohamed
T-020787
— Published Date: 6/12/2025 Value Proposition: Endovascular ventricular device that improves blood flow at lower rotational speed. Technology Description Researchers at Washington University in St. Louis have developed a toroidal endovascular ventricular support device (TEVAD) that is design…
NuPanc – A Sustainable Cure for Chronic DiabetesMillman, Jeffrey ; Zayed, Mohamed
T-016290
— Published Date: 6/12/2025 Value Proposition: Novel vascular graft device that delivers whole pancreatic islets to enhance glycemic control and chronic management of diabetes, without the need for immunosuppression. Technology Description Researchers at Washington University in St. Louis have de…
Hypervesiculating Gut Microbes for the Treatment of Chronic Gut ConditionsPardue, Evan ; Sartorio, Mariana ; Jana, Biswanath ; Feldman, Mario
T-020706
— Published Date: 6/3/2025 Value Proposition: System that employs gut microbe strains engineered with therapeutic enzymes to treat chronic gut conditions. Technology Description Researchers at Washington University in St. Louis have developed a hypervesiculating Bacteroides theatiotaomicron (Bt) …
Anti-FCRL5 Chimeric Antigen Receptor (CAR) Targeting Multiple MyelomaRitchey, Julie ; DiPersio, John ; Ghobadi, Armin ; O'Neal, Julie
T-020082
— Published Date: 5/13/2025 Value Proposition: An innovative therapy leveraging unique chimeric antigen receptors (CAR) to specifically target Fc receptor-like 5 (FCRL5), enabling the precise elimination of FCRL5-expressing cells to treat multiple myeloma and other cancers. Technology Description …
Antisense Oligo to Enhance Neuronal Survival in Huntington’s DiseaseOh, Youngmi ; Yoo, Andrew
T-020121
— Published Date: 5/14/2025 Value Proposition: Novel antisense oligonucleotide (ASO) directly targeting a microRNA-mediated mechanism responsible for autophagy reduction and neurodegeneration in Huntington’s disease (HD) improving patient outcomes in pre-HD subjects. Technology Description R…
Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor ResponseVerma, Priyanka ; Zhao, Peinan ; Lomonosova, Elena ; Mullen, Mary "Maggie"
T-020659
— Published Date: 5/14/2025 Value Proposition: Robust and reliable biomarker to accurately predict patient response to PARP inhibitors and platinum chemotherapy for high grade serous ovarian cancer. Technology Description Researchers at Washington University in St. Louis have developed an automat…
CAR Macrophages for Targeted Degradation of Pathogenic SubstancesLee, Jin-Moo ; Diwan, Abhinav ; DeSelm, Carl
T-020543
— Published Date: 5/14/2025 Value proposition: Self-sustaining chimeric macrophages as a novel approach to target amyloid plaques resulting in improved efficacy and survival in patients. Technology Description Researchers from Washington University in St. Louis have engineered macrophages to expre…
Effector CAR T-Cells for Treatment of Alzheimer’s DiseaseBoskovic, Pavle ; Kipnis, Jonathan
T-020995
— Published Date: 5/14/2025 Value proposition: Using CAR T-cells to treat Alzheimer’s disease and other neurodegenerative diseases through Ab-specific activation. Technology Description While CD4+ (helper or effector) T-cells play complex roles in the pathophysiology of Alzheimer’s …
Antisense Oligonucleotides (ASOs) to Treat Neurodegeneration in ALS and FTDPirzada, Mujeeb ; Djuranovic, Sergej
T-021032
— Published Date: 5/14/2025 Value proposition: Novel ASOs that increase key protein production to limit neurodegeneration caused by ALS and frontotemporal dementia (FTD). Technology Description TDP-43 pathology is present in ~97% of ALS, ~50% of FTD, and frequently observed in other neurodegenerat…
Novel Neurosteroids for Treating Pain DisordersCovey, Douglas
T-021245
— Published Date: 5/15/2025 Value proposition: Novel analgesic compounds that block CaV3.2 currents in nociceptive dorsal root ganglion neurons in order preemptively treat pain in subjects, unlike other products that are continuously administered post onset of pain. Technology Description Resear…
