Advanced Search
Select the Categories and/or Inventors to begin filtering. To narrow search results, use the search bar for additional keywords.
Search returned 630 results
Six2-GFP reporter iPSC line (subject to GE – GFP license)Humphreys, Benjamin
T-017760
— Researchers used CRISPR/Cas9-mediated gene targeting to knock in a GFP-P2A cassette into the ATG of the Six2 gene in human BJFF.6 induced pluripotent stem cells. The cells exhibit GFP expression in Six2+ cells when induced to differentiate towards the renal lineage. Six2 expression marks a progenito…
Mutant Zebrafish with chemically induced point mutationsSolnica-Krezel, Lilianna
T-017763
— Mutant zebrafish animals harboring chemically induced point mutations in the genome. Animals: spon1b fh440, kiss1 stl82, kiss1rb fh438, pon2 fh450
Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical ApplicationsYang, Deshan
T-017324
— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …
Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapyWang, Xiaowei
T-014021
— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…
Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3Wang, Xiaoli ; Lybarger, Lonnie ; Hansen, Ted
T-016628
— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…
St. Louis isolate of Bourbon virus (BRBV-STL)Boon, Adrianus "Jacco"
T-018815
— This strain of the Bourbon virus was isolated from the serum of an infected St. Louis-area patient. The isolated virus was used to demonstrate in vitro and in a mouse model that the antiviral drug favipiravir has prophylactic and therapeutic efficacy against the Bourbon virus, indicating it as a goo…
Mouse anti-MR1 hybridomas, clone 4E3 and 6D1Wang, Xiaoli ; Hansen, Ted
T-017622
— mAb 4E3 was derived by immunization of β2m-deficient BALB/c mice with a keyhole limpet hemocyanin-conjugated peptide corresponding to mMR1 residues 130–153 (L A M D Y V A H I T K Q A W E A N L H E L Q Y Q). Hybridomas were produced by standard methods and screened by anti-peptide ELISA. …
Armenian Hamster Anti-Mouse Properdin Monoclonal Antibody (clone H4)Bertram, Paula ; Hourcade, Dennis
T-014378
— Target: Full length mouse properdin Application(s): Western blot and immunofluorescenceTwo functional properties of one of the two hamster antibodies have been examined, the H4 subclone of the 3D12 clone. In experiments the H4 antibody was used to identify mouse properdin present in histological sections, to block mouse properdin function in vitro, and to ameliorate complement alterna…
Fibroblast-Derived Cell Line Producing Wnt3a, R-spondin 3, & NogginMiyoshi, Hiroyuki ; Stappenbeck, Thaddeus
T-014239
— Tangible Tool: Growth factor over-expressing cell line. Notes: Produces conditioned media to grow various mammalian tissue stem cells.These supportive L-WRN cells can produce conditioned media containing Wnt3a, R-spondin, and Noggin for the the support of gastrointestinal stem cells. This system can be used to make stem cell enriched epithelial spheroids from the mouse gastrointestine. Publication: In vitro expansion and genetic…
New PARP-1 Inhibitors for Imaging PARP-1 Expression in VivoXu, Jinbin ; Rogers, Buck ; Chu, Wenhua ; Zhou, Dong
T-018730
— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…
SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditionsMoran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher ; MacEwan, Matthew ; Moore, Amy ; Kamath, Ashwin ; Cloonan, Paige ; Leuthardt, Eric
T-017895
— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …
Mouse and Human Anti-MR1 HybridomaFremont, Daved ; Gilfillan, Susan ; Myers, Nancy ; Colonna, Marco ; Cella, Marina ; Hansen, Ted
T-013681
— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells
Tumor-targeted fusion protein platform for enhanced cancer immunotherapyPachynski, Russell
T-015906
— Disease indication – cancer, particularly lung, breast, colon, and prostate cancer or melanoma (cancers where chemerin is down-regulated at the tumor site) Drug format – engineered fusion protein Drug class – first in class Research stage and Preliminary data Target &ndash…
Cryopreserved sperm from Bnip3-KO mice, Nix KO mice, and Nix floxed allele miceDorn, Gerald
T-018843
— Bnip3-KO mice: These were generated by replacing exons 2 and 3 with a neomycin resistance cassette. Recombinations were identified via southern blot. Publication: Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice Nix KO m…
Plasmids for pDD56, pDD57, pDD87, pDD103, pDD108, pDD112, pDD120, pDD131, pDD132, and pDD143Moon, Tae Seok
T-018853
— o pDD56: a shuttle vector between Escherichia coli and Rhodococcus opacus PD630 that contains arabinose inducible EYFP on pAL5000/pMB1 backbone with kanamycin resistance. o pDD57: a shuttle vector between Escherichia coli and Rhodococcus opacus PD630 that contains a constitutively expressed GFP+ on…
HoxB5 cDTR miceKarpova, Darja ; DiPersio, John
T-018897
— Transgenic HoxB5 conditional DTR (cDTR) mice have been generated using CRISPR mediated targeting of the HoxB5 gene (exon2) in fertilized wildtype C57Bl/6 eggs that were then microinjected into pseudopregnant wildtype female mice. The construct targeted under the controls of the endogenous HoxB5 prom…
cryaa-R49C knock-in miceAndley, Usha
T-018903
— Knock-in mice with a mutation in alpha-crystallin (cryaa-R49C) that causes cataracts. A knock-in plasmid was generated by cloning the 5′ and 3′ arms of the mouse RAcrystallin gene, followed by mutation and homologous recombination in mouse embryonic stem cells, which were implanted into …
pTrc-eYFP ConstructPakrasi, Himadri
T-018769
— This self-replicating plasmid is a derivative of pPMQAK1-BBa_P1010 and contains an expression-enhanced YFP gene under the control of an inducible Trc promoter. This plasmid was used to demonstrate that transgenic DNA could be introduced to Synechococcus UTEX 2973 cyanobacteria cells using conjugatio…
TR3: a stabilized TRAIL timer for use as an anticancer therapeuticHotchkiss, Richard ; Hawkins, William ; Spitzer, Dirk
T-007646
— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…
Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activityHawkins, William ; Spitzer, Dirk
T-011885
— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…
