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Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)Fremont, Daved ; Diamond, Michael ; Ellebedy, Ali
T-019438
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …
Human monoclonal antibodies against SARS-CoV-2 nucleocapsid proteinEllebedy, Ali
T-019492
— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab
High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar InterfaceSankarasubramanian, Shrihari ; Ramani, Vijay ; Wang, Zhongyang
T-019124
— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …
Liquid biopsy assay for personalized prostate cancer treatmentPachynski, Russell ; Maher, Christopher ; Chaudhuri, Aadel
T-019287
— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…
Chimpanzee adenovirus-based vaccine for COVID-19Dmitriev, Igor ; Hassan, Ahmed ; Diamond, Michael ; Curiel, David
T-019478
— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…
PET tracers for detection of early stage Alzheimer’s diseaseSivapackiam, Jothilingam ; Guruswami, Sundaram ; Sharma, Vijay
T-013525
— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…
Novel Method and Device to Produce Fluorine-18 PET TracersZhou, Dong
T-019276
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Novel Method and Device to Produce Fluorine-18 PET TracersChu, Wenhua ; Zhou, Dong
T-015970
— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …
Intestinal biomarker predicts response to treatment for inflammatory bowel diseaseVanDussen, Kelli ; Stappenbeck, Thaddeus
T-019186
— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…
Precise, dynamic control of macromolecule adhesion to glass slides and other surfacesTurney, Steve ; Bridgman, Paul
T-005874
— Technology Description This technology is a patented method for producing microarrays or directing cell growth on a surface by precisely and dynamically manipulating the adhesion of macromolecules. While many techniques exist for adhering proteins, nucleic acids, and other macromolecules to solid …
Method to characterize gut microbiomeRaman, Arjun ; Gordon, Jeffrey
T-018977
— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…
Method to evaluate function of members of a gut microbiotaPatnode, Michael ; Gordon, Jeffrey
T-018760
— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…
Sigma-1 targeted PET tracersWang, Wei ; Mach, Robert ; Tu, Zhude "Will"
T-010394
— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…
Methods to accurately measure diastolic function from echocardiogramShmuylovich, Leonid ; Chung, Charles ; Kovacs, Sandor
T-005426
— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…
Novel Acute Myocardial Injury Biomarker ProfileBach, Richard ; Boyle, Walter
T-015345
— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…
Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trialsIbanez, Laura ; Dube, Umber ; Cruchaga, Carlos
T-019198
— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …
Method to create designer stem cells for safer, more effective therapeuticsGuilak, Farshid
T-018758
— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…
Real-time air and water quality monitoring with AI-based data analysis and low cost sensorsLi, Jiayu ; Biswas, Pratim
T-018523
— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…
Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalinationWu, Xuanhao ; Singamaneni, Srikanth ; Jiang, Qisheng ; Jun, Young-Shin
T-019047
— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…
AAVLenti-WFS1 (adeno-associated virus expressing WFS1, lentivirus expressing WFS1)Urano, Fumihiko
T-018716
— Adeno-associated virus expressing WFS1, lentivirus expressing WFS1
