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Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingSivapackiam, Jothilingam ; Piwnica-Worms, David ; Sharma, Vijay
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Novel PET/SPECT Radiopharmaceutical for Improving Biomedical ImagingSivapackiam, Jothilingam ; Piwnica-Worms, David ; Sharma, Vijay
T-010438
— Technology Description Researchers at Washington University in St. Louis have developed a novel positron emission tomography (PET) radiopharmaceutical for myocardial perfusion imaging. Myocardial perfusion scintigraphy is widely employed in the evaluation of patients with heart disease. Several ag…
Highly Accurate Model used to Predict Alzheimer’s Disease StatusAli, Muhammad ; Cruchaga, Carlos
T-020673
— Technology Description Researchers at Washington University in St. Louis have developed models that can very accurately predict brain amyloidosis—Alzheimer’s disease status. Alzheimer’s disease (AD) is characterized by the accumulation of Amyloid-β (Aβ42) and hyperphos…
Software used to Detect Neural Oscillations in the Time-Frequency SpaceCho, Hohyun ; Brunner, Peter
T-020025
— Technology Description Researchers at Washington University in St. Louis have developed a software method that demonstrates high precision and specificity in detecting neural oscillations in time and frequency domains. Current methods to look at identifying peaks over 1/f noise within the power s…
Novel Bile Acids as Biomarkers for Early Detection of Niemann-Pick Type C DiseaseJiang, Xuntian ; Ory, Daniel
T-014292
— Technology Description Researchers at Washington University in St. Louis have developed a set of novel bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick type C (NPC) disease. Current testing for this disease takes an average of three months, is invasive (a skin…
Optimizing Patient Treatment through Electrical Stimulation for Targeted Deep Brain StimulationWillie, Jon ; Leuthardt, Eric ; Adamek, Markus ; Brunner, Peter
T-020028
— Technology Description Researchers at Washington University in St. Louis have developed a deep brain stimulation approach that can identify optimal stimulation parameters intraoperatively, which significantly reduces the amount of time spent on adapting stimulation parameters, thus reducing costs,…
Measuring Spontaneous Plasticity Pulses in Patients with Brain InjuriesNewbold, Dillan ; Dosenbach, Nico
T-019480
— Technology Description Researchers at Washington University in St. Louis have developed an analysis stream to detect and measure spontaneous plasticity pulses in patients with brain injuries. In stark contrast to existing methodologies (resting-state functional MRI and resting state functional co…
Oxonol Dyes with Near Infrared Fluorescence for Improving BioimagingFuentes, Isaac ; Berezin, Mikhail ; Birman, Vladimir
T-020648
— Value proposition: Fluorescent oxonol dyes that can be used to enhance bioimaging for the treatment of cancer. Technology Description Researchers at Washington University in St. Louis have developed a new class of fluorescent oxonol dyes that exhibit absorption and emission in the near infrared…
Novel Composition Designed to Treat Nematode InfectionsMitreva, Makedonka ; Janetka, James
T-019949
— Novel Composition Designed to Treat Nematode Infections Value proposition: Small molecule treatments designed to target the adult worm to treat nematode infections in animals. Technology Description Researchers at Washington University in St. Louis have developed novel small molecule treatment…
System and method for non-invasive brain stimulation for cognitive enhancementWheelock, Jacob ; Singh, Matthew ; Braver, Todd ; Ching, ShiNung
T-020194
— T-020194 System and method for non-invasive brain stimulation for cognitive enhancement Technology Description Researchers at Washington University in St. Louis have developed a system that enables near- real-time control of human brain activity using non-invasive transcranial electrical curr…
Endoscopic Mucosal Graft Stabilizer Used to Treat UrethroplastyMurphy, Gregory ; McGinnis, Riley ; Wong, Daniel
T-020503
— T-020503 Endoscopic Mucosal Graft Stabilizer Used to Treat Urethroplasty Technology Description Researchers at Washington University in St. Louis have developed a sheath device designed to hold a segment of mucosal graft in the correct position to be applied over a stricture repair site. The she…
Antibodies that can Identify C. Acnes InfectionsIlagan, Maxenia ; Aleem, Alexander ; McCoy IV, William
T-020481
— Value Proposition: This invention uses antibodies to detect Cutibacterium acnes (C. acnes) infections. Technology Description Researchers at Washington University in St. Louis have developed antibodies that can identify Cutibacterium acnes (C. acnes), which opportunistically causes infection rang…
New Strategy for Treatment of Neurodegenerative Diseases with AxonopathySummers, Daniel ; Mao, Xianrong ; Milbrandt, Jeffrey ; Geisler, Stefanie ; DiAntonio, Aaron
T-017543
— Value Proposition: This invention uses a novel gene therapy that blocks the axon degeneration typical of neurodegenerative diseases. Technology Description Researchers at Washington University in St. Louis have developed a new strategy for treatment of neurodegenerative diseases with axonopathy…
Compounds for Targeting Mixed Lineage Kinase Domain-Like Protein Expressions in the BrainJiang, Hao ; Huang, Tianyu ; Tu, Zhude "Will"
T-020592
— Value Proposition: This new composition of matter uses a series of new compounds to trace mixed lineage kinase domain like proteins (MLKL) and treat neurological diseases. Technology Description Researchers at Washington University in St. Louis have developed a series of new compounds that can …
New Process for Diagnosing Abnormal Heart Rhythms AutomaticallyMay, Adam
T-019674
— Technology Description Researchers at Washington University in St. Louis have developed a new method for automatically differentiating accelerated heart rhythms caused by wide complex tachycardia (WCTs) into fast, or irregularly fast heart rhythms caused by ventricular tachycardia (VT) and suprave…
System to Engineer Vesicle Enzymatic Cargo from Gut BacteriaSartorio, Mariana ; Feldman, Mario
T-020642
— T-020642 System to Engineer Vesicle Enzymatic Cargo from Gut Bacteria Technology Description Researchers at Washington University in St. Louis have developed a novel bacterial delivery system that may be used to deliver enzymes to the gut via outer membrane vesicles (OMVs). This system identi…
VLDLR-based Decoy Receptors to Prevent Alphavirus InfectionsFremont, Daved ; Raju, Saravanan ; Adams, Lucas ; Diamond, Michael
T-020745
— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…
Software that Generates Radiology Reports using Deep LearningRahbar, Kasra ; Kansagra, Akash
T-018976
— T-018976 Software that Generates Radiology Reports using Deep Learning Technology Description Researchers at Washington University in St. Louis have developed a computational software method designed to assist radiologists with generating and correcting patient reports more effectively. Radiolo…
Absolute Perfusion Reserve (T-020127)Bugenhagen, Scott
T-020127
— Ask Experimental de-risking strategy Regulatory advice Background: Fractional flow reserve (FFR) is the current gold standard for grading coronary artery stenoses; however, more recent studies have demonstrated no significant improvement in primary patient outcomes when using FFR…
Deep Tissue Diagnostics with Disposable Fiber-Optic DeviceYang, Shuo ; Ling, Jingwei ; Hu, Song
T-020656
— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…