PET/SPECT Agents for Applications in Biomedical Imaging

Tech ID: T-010438


Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global interest in radiopharmaceuticals containing gallium-68 is growing because this PET radionuclide can be produced from non-cyclotron sources. An additional benefit is that the overall exposure to radiation is lower because Ga-68 has a shorter half life than 99mTc.

Technology Summary

Washington University investigators have developed a Ga-68 based radiopharmaceutical for PET myocardial perfusion imaging. This novel agent can also be labeled with Ga-67 for SPECT myocardial perfusion imaging. Both Ga-labeled agents have the ability to “paint” the heart within five minutes of injection. Data from the lab demonstrates that in comparison to other tracers, the Ga-labeled agents have an enhanced uptake into the heart, decreased liver retention, and increased clearance from non-cardiac and adjoining tissues. These characteristics of the agents increase the imaging sensitivity and decrease the background signal from other organs.


Granted – US 9,579,408




Gill, John

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