Summaries by Inventor Wencewicz, Timothy
Blake, Kevin ; Dantas, Gautam ; Wencewicz, Timothy ; Williford, Emily ; Xue, Yao-Peng
T-021043
— Published Date: 1/4/2025 Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics. Technology Description Researchers at Washington University in St. Louis have developed an enzymatic…
Novel Combination Therapy that Improves Resistance to Tetracycline AntibioticsBlake, Kevin ; Dantas, Gautam ; DeAngelo, Caitlin ; Wencewicz, Timothy ; Williford, Emily
T-020451
— Published Date: 1/4/2025 Value Proposition: New composition of matter that combines tetracycline class compounds with destructase inhibitors to overcome resistance to tetracycline antibiotics. Technology Description Researchers at Washington University in St. Louis have developed an enzymatic…
Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discoveryReck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508
— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…
Clifednamide compoundsQi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321
— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…
Small molecule inhibitors to prevent tetracycline resistanceDantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593
— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…
