Summaries by Inventor Ornitz, David

Achondroplasia (ACH) Mouse Model
Ornitz, David

— Target: Mouse model with the mutation for ACH knocked in.Description: Inventors created a transgenic mouse model of achondroplasia by targeting the expression of activated FGFR3 to growth plate cartilage in mice using regulatory elements from the collagen II gene. As with humans carrying the achondroplasia mutation, the resulting transgenic mice were dwa…


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