Summaries by Inventor Fremont, Daved
Boon, Adrianus "Jacco" ; Dai, Yanan ; Fremont, Daved ; Harastani, Houda
T-021548
— Published date: 1/6/2025 Value Proposition: Stabilization of glycoprotein of Bourbon Virus (BRBV) and related thogotoviruses as a key target for vaccine and antiviral development. Technology Description Researchers at Washington University in St. Louis have determined the pre-fusion structure…
Bacterial and Mammalian Expression Vectors for Production of SARS-CoV ProteinsDai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413
— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…
Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseasesFremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443
— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…
Recombinant Chikungunya Virus Soluble E2 ProteinBarrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 Soluble Decoy Receptors for Treating Tick-Borne Encephalitis Virus
Diamond, Michael ; Fremont, Daved ; Hui, Sean ; Li, Pengfei
T-021652
— Published date: 1/14/2026 Value Proposition: Entry receptors that bind directly to TBEV, promoting virus attachment to treat TBEV and other viruses. Technology Description Researchers at Washington University in St. Louis have developed LRP8 soluble decoy receptors (minimal domains-Fc fusion …
Engineered RANK Protein for Treatment of OsteoporosisFremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404
— Published date: 9/18/2025 Value Proposition: Single chain RANK ligand that can selectively inhibit pathological bone loss. Technology Description Researchers at Washington University in St. Louis have developed a genetically engineered mutant RANKL protein that prevents bone loss by selective…
Mouse monoclonal antibodies against SARS-CoV-2 spike proteinDiamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…
Chikungunya Monoclonal AntibodiesDiamond, Michael ; Fremont, Daved
T-010020
— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus Publication:
Target and Method to Treat Alphavirus InfectionsBasore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583
— Published date: 1/14/2026 Value Proposition: Fusion protein that can be used to prevent and treat arthritogenic alphavirus infections. Technology Description Researchers at Washington University in St. Louis have identified MXRA8 (matrix remodeling associated protein 8) protein as a key recept…
Novel Antiviral Treatment for Yellow Fever VirusChong, Zhenlu ; Diamond, Michael ; Fremont, Daved ; Hui, Sean
T-021452
— Published date: 1/14/2026 Value Proposition: First antiviral treatment that uses soluble receptors to treat yellow fever. Technology Description Researchers at Washington University in St. Louis have developed new soluble receptor decoy Fc-fusion protein inhibitors for treatment of yellow fever…
VLDLR-based Decoy Receptors to Prevent Alphavirus InfectionsAdams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745
— Published date: 1/14/2026 Value Proposition: Method and composition to potently neutralize EEEV infection. Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory acti…
SARS-CoV-2 neutralizing antibody effective against all variantsAdams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791
— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…
Fusion protein for treating multiple strains of Venezuelan equine encephalitis virusBasore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414
— Published date: 1/14/2026 Value Proposition: Decoy receptor therapeutic that can treat multiple VEEV subtypes by blocking VEEV entry and infection. Technology Description Researchers at Washington University in St. Louis have developed a decoy Ldlrad3-D1-Fc protein for prevention of treatment o…
Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438
— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …
Targeting B Cells for Antibody-Mediated Graft RejectionEdelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682
— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …
Monoclonal Antibodies Against Zika Virus and Purified Zika E ProteinDiamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168
— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…
Disulfide trapped antigenic peptide in an MHC molecule.Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681
— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells
