Summaries by Inventor Feldman, Mario

Hypervesiculating Gut Microbes for the Treatment of Chronic Gut Conditions
Feldman, Mario ; Jana, Biswanath ; Pardue, Evan ; Sartorio, Mariana
T-020706

— Published Date: 6/3/2025 Value Proposition: System that employs gut microbe strains engineered with therapeutic enzymes to treat chronic gut conditions. Technology Description Researchers at Washington University in St. Louis have developed a hypervesiculating Bacteroides theatiotaomicron (Bt) …

UPAB1 plasmid lacking pAB5
Di Venanzio, Gisela ; Feldman, Mario
T-019205

— An UPAB1 derivative, UPAB1p-, that spontaneously loss pAB5 was identified by detection of restored Hcp secretion and isolated via an ELISA. Compared to wildype UPAB1, UPAB1p- displayed comparable growth in vitro in both rich medium and urine from healthy donors, indicating that less pAB5 did not in…

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…