Summaries by Inventor Curiel, David

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

In vivo editing via targeted adenoviral vectors
Curiel, David

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…


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