Oncology Summaries

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Autosegmentation tool
Grigsby, Perry ; Ma, Daniel ; Rao, Yuan
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Tumor detection by targeting and monitoring integrin expression using synergistic effects of molecular beacons and peptides
Achilefu, Samuel
T-005371

— Background: Integrins are multi-subunit transmembrane proteins involved in a wide range of cellular processes including the induction of new blood vessel formation and tumor metastasis. The growth of new blood vessels, termed angiogenesis, is associated with an altered integrin expression profile wh…

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

LINAC design for radiosurgery with precise 4pi delivery and fast, integrated CT imaging
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Technology Description This technology is a patented LINAC (linear accelerator) radiation therapy system designed to enable non-coplanar cone beams to be delivered from all angles by using a ring gantry instead of a robotic moving couch. This simple approach enables easier treatment planning and q…

Biomarker to predict cancer response to chemotherapy
Diamond, Marc ; Shao, Jieya
T-015631

— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

Tumor-targeted fusion protein platform for enhanced cancer immunotherapy
Pachynski, Russell
T-015906

— Disease indication – cancer, particularly lung, breast, colon, and prostate cancer or melanoma (cancers where chemerin is down-regulated at the tumor site) Drug format – engineered fusion protein Drug class – first in class Research stage and Preliminary data Target &ndash…

scFv-TR3: TRAIL trimers targeted to mesothelin
Hawkins, William ; Spitzer, Dirk
T-016481

— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activity
Hawkins, William ; Spitzer, Dirk
T-011885

— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
Wang, Xiaowei
T-012911

— Oropharyngeal squamous cell carcinoma (OSCC) rates have increased significantly in recent years, and because of the different underlying causes of the disease no single treatment regime seems to be advantageous over another. Currently, the prognosis of OSCC is based on clinical features of the OSCC…

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Mutant PDGF-B as a VEGFR inhibitor
Imoukhuede, Princess
T-018996

— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

TREM2 blockade as an adjuvant for checkpoint inhibitors
Colonna, Marco
T-019371

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapy
Wang, Xiaowei
T-014021

— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Zika Oncolytic Virus to Treat Glioblastoma and Other Solid Tumors
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— Disease indication: Glioblastoma, Lung Cancer, Breast Cancer and other Cancers with Cancer Stem Cells Drug format: Oncolytic Virus Drug class: First-in class Research stage and Preliminary data: 1st Generation – Zika Virus (ZIKV) 2nd Generation – Attenuated ZIKV (E218A) Figur…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

Chimeric antigen receptor dendritic cells
DeSelm, Carl
T-019199

— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

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