Life Sciences Research Platforms Summaries

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

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