Vectors Summaries

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

In vivo editing via targeted adenoviral vectors
Curiel, David

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

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