Summaries

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Polyclonal antibody for straining human Cytokeratin 13 (HuCK13)
Ladenson, Jack
T-004395

— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …

Phospholipase A2 Epsilon
Gross, Richard ; Jenkins, Christopher
T-004045

— This features an enzymatic function for a protein so that Washington University can obtain composition of matter rights and use rights for screening for inhibitors. This can be used for weight loss, diabetes, treatment of obesity and associated lipotoxicity, body sculpting, heart disease, stroke a…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Immunohistochemical diagnosis of human renal chromophobe carcinoma
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack
T-011164

— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…

LINAC design for radiosurgery with precise 4pi delivery and fast, integrated CT imaging
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Technology Description This technology is a patented LINAC (linear accelerator) radiation therapy system designed to enable non-coplanar cone beams to be delivered from all angles by using a ring gantry instead of a robotic moving couch. This simple approach enables easier treatment planning and q…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
Wang, Xiaowei
T-012911

— Oropharyngeal squamous cell carcinoma (OSCC) rates have increased significantly in recent years, and because of the different underlying causes of the disease no single treatment regime seems to be advantageous over another. Currently, the prognosis of OSCC is based on clinical features of the OSCC…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Nanothermometers for cellular-level temperature monitoring in ablation therapy or research
Berezin, Mikhail ; Gustafson, Tiffany
T-012606

— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Breath-based testing for malaria
John, Audrey Odom "Audrey Odom" ; Schaber, Chad ; Trehan, Indi
T-016183

— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variants
Ellebedy, Ali
T-019707

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …

Target and small molecule drugs to selectively neutralize bacteria in urinary tract infections
Henderson, Jeffrey P.
T-018628

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs). Currently, UTI…

Manipulating Tricellular Junction Permeability in Blood Brain Barrier to Treat Brain Tumors
Gong, Yong-feng ; Hou, Jianghui
T-017092

— Background: Brain tumors are the most lethal disease known to mankind with approximately 170,000 annual diagnoses and 13,000 deaths attributed to brain cancer. Glioblastoma, the most common and aggressive, has a median survival of approximately 18 months. Chemotherapeutic agents have been approved b…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

VSV-BSL2 reporter of SARS CoV infection
Bloyet, Louis-Marie ; Whelan, Sean
T-019518

— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Huang, Li-Hao ; Randolph, Gwendalyn ; Zinselmeyer, Bernd
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019510

— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein – Colonna lab
Cella, Marina ; Colonna, Marco
T-019509

— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

New diagnostic test method for infectious diseases
Storch, Gregory
T-013735

— Background: Viral infections are common causes of fever without an apparent source (FWS) in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leuko…

Precise, dynamic control of macromolecule adhesion to glass slides and other surfaces
Bridgman, Paul ; Turney, Steve
T-005874

— Technology Description This technology is a patented method for producing microarrays or directing cell growth on a surface by precisely and dynamically manipulating the adhesion of macromolecules. While many techniques exist for adhering proteins, nucleic acids, and other macromolecules to solid …

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique Compositions
Biswas, Pratim ; McDonald, Rafael ; Thimsen, Elijah
T-006824

— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

Dementia Screening test: the AD8
Galvin, James ; Morris, John ; Roe, Catherine
T-007516

— The AD8 is an 8 question interview tool which distinguishes individuals with very mild dementia from those without dementia, regardless of etiology. The AD8 is based on intraindividual decline and has been demonstrated to be a valid and reliable screening tool for dementia.

Armenian Hamster Anti-Mouse Properdin Monoclonal Antibody (clone H4)
Bertram, Paula ; Hourcade, Dennis
T-014378

— Target: Full length mouse properdin Application(s): Western blot and immunofluorescenceTwo functional properties of one of the two hamster antibodies have been examined, the H4 subclone of the 3D12 clone. In experiments the H4 antibody was used to identify mouse properdin present in histological sections, to block mouse properdin function in vitro, and to ameliorate complement alterna…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

Enantiomeric16-ketosteroids and Related Tetracyclic & Tricyclic Analogues with Neuronal Actions
Covey, Douglas
T-011272

— Neurosteroids are of great interest because of their ability to alter brain function. Compounds of the type disclosed here have potential to be new drugs useful for causing anesthesia and treating depression, anxiety, sleep disorders, seizures.

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

Treatment for Centrally Mediated Itching
Chen, Zhoufeng ; Sun, Yan Gang
T-006757

— Background: Severe itch (or pruritus) is associated with multiple diseases such as liver disease, non-Hodgkin’s lymphoma, psoriasis, and common eczema and is also a side effect of many treatments including analgesics (like morphine) and renal dialysis. Chronic pruritus is a top reason for derm…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Method to create designer stem cells for safer, more effective therapeutics
Guilak, Farshid
T-018758

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infections
Iqbal, Zahid
T-019400

— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

Technique to reduce juxta-anastomotic stenosis development in AV fistulae
Shenoy, Surendra
T-010339

— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

Intraocular Artificial Lenses
Ravi, V. Nathan
T-006771

— The present hydrogel technology can be used as a lens replacement material for the permanent treatment of cataracts and presbyopia as well as a vitreous substitute. This co-polymeric hydrogel system can be reversibly converted between a hydrogel in the oxidized state and a solution in the reduced st…

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Tumor detection by targeting and monitoring integrin expression using synergistic effects of molecular beacons and peptides
Achilefu, Samuel
T-005371

— Background: Integrins are multi-subunit transmembrane proteins involved in a wide range of cellular processes including the induction of new blood vessel formation and tumor metastasis. The growth of new blood vessels, termed angiogenesis, is associated with an altered integrin expression profile wh…

Methods to Treat Vasodilatory Septic Shock
Boyle, Walter
T-007528

— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …

Biomarker to predict cancer response to chemotherapy
Diamond, Marc ; Shao, Jieya
T-015631

— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Managing Diabetes status in diabetic patients
Ravi, V. Nathan
T-005389

— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Armenian hamster anti-mouse TCR Vb 8.3 IgG3 monoclonal antibody (clone 1B3.3)
Allen, Paul
T-000304

— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3. Application: Flow cytometryThis antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice. Publication: TCR transgenic mice in which …

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and death
Ory, Daniel ; Peterson, Linda ; Schaffer, Jean
T-014627

— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

8IGHT WAYS to Stay Healthy and Prevent Disease
Colditz, Graham
T-013927

— One important aspect for individuals to maintain health and prevent disease is through an educational understanding of making healthy choices while avoiding unhealthy choices. Clinicians at Washington University in St. Louis have created an evidence-based guide to disease prevention and healthy liv…

FES Recovery of Neurologic Function and Regeneration
McDonald, John W.
T-003694

— Washington University inventors have found that FES enhances spontaneous neurological recovery. This can be used in the development of FES systems for regeneration of recovery of function.

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

High-yield, heat tolerant tomatoes
Frick, Elizabeth ; Strader, Lucia
T-018506

— Technology Description Researchers in Prof. Lucia Strader’s laboratory have cultivated genetically-stable, high-yield tomato plants that are tolerant to high temperature growing conditions (40oC). These plants were identified using a screen for mutants. Excitingly, two mutants (IR-12 an IR-1…

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological Tissue
An, Woo Jin ; Wang, Lihong
T-010123

— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

Coupled Visualization and Ablation of Specific Cells and Tissues in Zebrafish
Mumm, Jeffrey ; Schroeter, Eric
T-003399

— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

Scanning Apparatus for Reflection-Mode Photoacoustic Tomography
Maslov, Konstantin ; Wang, Lihong
T-007645

— The greatest limitation on clinical use of existing photo-acoustic imaging technologies is the slow scanning speed caused by mechanical scanning, the bulky design of the scanning apparatus, and the necessity to immerse the body part into a ultrasonic coupling liquid. The present invention overcomes…

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal Inoculation
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064

— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Tetrahedron Beam Computed Tomography with Multi-pixel X-ray Source
Zhang, Tiezhi
T-015342

— About 70 million computed tomography (CT) scans are performed in the United State alone each year. Traditional helical scanners use a single point x-ray source that rotates around the patient, acquiring images in sequential slices, which results in high quality images. But these helical scanners a…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Tumor-targeted fusion protein platform for enhanced cancer immunotherapy
Pachynski, Russell
T-015906

— Disease indication – cancer, particularly lung, breast, colon, and prostate cancer or melanoma (cancers where chemerin is down-regulated at the tumor site) Drug format – engineered fusion protein Drug class – first in class Research stage and Preliminary data Target &ndash…

Antibody to SPRR3
Ladenson, Jack ; Young, Pampee
T-004462

— Analyte: Small proline rich protein 3 (gene SPRR3) Antibody codes: 3E9.1 (4587), 4G3.1 (4563), and 2F10.2 (4604) Publications:

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Red-Shifted Chromophore Substitution for Optogenetic Applications
Corbo, Joseph ; Enright, Jennifer ; Toomey, Matthew
T-014377

— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …

scFv-TR3: TRAIL trimers targeted to mesothelin
Hawkins, William ; Spitzer, Dirk
T-016481

— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Differentiation protocol for RA-dependent hematopoietic progenitor cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— Technology Description Researchers in Chris Sturgeon’s lab at Washington University have developed a protocol for definitive differentiation of hematopoietic progenitor cells that can be used to develop replacement blood products. This protocol involves a sequential, time-sensitive manipulat…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activity
Hawkins, William ; Spitzer, Dirk
T-011885

— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Optical Coherence Computed Tomography
Li, Li ; Wang, Lihong
T-008832

— Optical coherence tomography (OCT) utilizes optical light to obtain an image of opaque or translucent objects, ie tissue. Because scattered light contributes to the bluring found in other optical imaging techniques, OCT filters out all the scattered light. An image is formed using only the back refl…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

PEGylated-GIRLRG Peptide for Radiopharmaceutical Delivery
Hallahan, Dennis
T-014562

— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Exosome-based therapy for tendon injuries and other soft tissue repair
Shen, Hua
T-018565

— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Drugs to supplement microglial metabolism during treatment of Alzheimer’s disease
Colonna, Marco ; Ulland, Tyler
T-017401

— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Data security for IoT and mobile devices using Bit2RNG random number generator with no additional hardware
Yan, Wei ; Zhang, Xuan "Silvia"
T-019418

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a robust true random number generator (RNG) designed to be used as a low-resource security system for mobile and internet-of-things (IoT) devices. This technology, called “Bit2RNG&rdqu…

Antibodies to transferrin receptor
Ladenson, Jack ; Porter, Sharon
T-000757

— Analyte: Transferrin Receptor (CD71) Antibody codes: 2B7.4 (4065) and 2F6.3 (4077) Publications:

Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue Injury
Gelman, Andrew ; Puyo, Carlos
T-015918

— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Albring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Error correcting codes for robust, secure deep neural networks
Raviv, Netanel
T-019252

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Single nanoparticle detection and sizing by mode-splitting in an ultra-high-Q microresonator
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— With the rapid progress in nanotechnology, a variety of nanoparticles of different materials and sizes have been synthesized and engineered as key components in various applications ranging from solar cell technologies to biomolecular detection1-3. Meanwhile, nanoparticles generated continuously by …

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

TREM2 blockade as an adjuvant for checkpoint inhibitors
Colonna, Marco
T-019371

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Eye test to diagnose preclinical Alzheimer’s disease
Apte, Rajendra ; Van Stavern, Gregory
T-018518

— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…

Therapeutic Approach for Huntington’s Disease (HD)
Kim, Albert ; Yano, Hiroko
T-016079

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Subtyping of schizophrenia based on genome and pathology
Cloninger, C. Robert ; Svrakic, Dragan ; Zwir, Jorge "Igor"
T-015118

— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…

Simple, universal DNA motifs for modulating protein production
Djuranovic, Sergej
T-016819

— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Energy efficient, scalable neuromorphic computing with Growth Transform Neural Network
Chakrabartty, Shantanu ; Gangopadhyay, Ahana
T-019112

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Song, Sheng-Kwei "Victor" ; Wang, Qing ; Wang, Yong
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

Plasma oxysterols as biomarkers for Niemann-Pick C disease
Ory, Daniel
T-007594

— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

IP-10 as a blood biomarker of respiratory failure
Mudd, Philip
T-019671

— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 Neonatal Eating Outcome (NEO) Assessment
Pineda, Roberta
T-014917

— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for Children
Jeffe, Donna ; Lieu, Judith ; Umansky, Amy
T-010222

— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pr…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Blockchain-based algorithms for secure, collaborative risk assessment and decision making
Jain, Raj ; Salman, Tara
T-018710

— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Single Nanoparticle Detection by Mode Splitting in Active Microresonators using Heterodyne Technique
He, Lina ; Ozdemir, Sahin ; Yang, Lan
T-010140

— Dr. Lan Yang, Professor at Washington University in St. Louis, is a pioneer in the field of micro- and nano photonics. She recently developed a uniquely sensitive and versatile particle detector using whispering gallery mode (WGM) optical microresonators. Realtime detection and accurate sizing of la…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Vaccines and antibodies against malaria and other parasitic diseases in humans and animals
Jimah, John ; Tolia, Niraj
T-016150

— Technology Description Researchers in Prof. Niraj Tolia’s laboratory have exploited structure-based vaccine design to develop immunogenic compositions and neutralizing antibodies that could protect against malaria and a range of other parasitic diseases that affect humans, livestock and comp…

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean
T-019338

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Neuroactive steroid anesthetic compounds
Covey, Douglas ; Jiang, Xin
T-004034

— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

A biomarker to monitor CNS efficacy of 2-hydroxypropyl-β-cyclodextrin (HPBCD)
Ory, Daniel
T-012136

— Background: Niemann-Pick type C1 (NPC1) disease is a rare neurological disorder characterized by cholesterol and lipid accumulation in the central nervous system. Individuals with the abnormal buildup of cholesterol and other lipids in the brain often suffer from cognitive and movement difficulties,…

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Rational drug design using Boltzmann docking
Bowman, Gregory
T-016234

— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…

Autosegmentation tool
Grigsby, Perry ; Ma, Daniel ; Rao, Yuan
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Target and method to treat alphavirus infections
Diamond, Michael ; Kim, Arthur ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Novel Method and Device to Produce Fluorine-18 PET Tracers
Chu, Wenhua ; Zhou, Dong
T-015970

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Low-cost, flexible paper substrate for sensitive trace chemical and biological detection using SERS (surface enhanced Raman scattering)
Kharasch, Evan ; Lee, Chang Hee ; Morrissey, Jeremiah ; Singamaneni, Srikanth
T-010600

— Technology Description Researchers in Prof. Srikanth Singamaneni’s laboratory have developed a patented, low-cost, flexible substrate designed to improve sample collection and enhance analyte detection with surface enhanced Raman scattering (SERS) or localized surface plasmon resonance (LSPR…

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Fast, low-cost analysis tool to extend the dynamic range of single-step immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— Technology Description A team of researchers at Washington University in St. Louis has developed Area Under the Curvature (AUCU), a data analysis method to improve the accuracy of homogeneous immunoassays (e.g., turbidimetric and nephelometric) while reducing costs and turn-around-times. AUCU can …

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Novel Method and Device to Produce Fluorine-18 PET Tracers
Zhou, Dong
T-019276

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in Macrophages
Apte, Rajendra
T-011268

— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapy
Wang, Xiaowei
T-014021

— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Chimeric antigen receptor dendritic cells
DeSelm, Carl
T-019199

— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trials
Yablonskiy, Dmitriy ; Zhao, Yue
T-015754

— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

Artificial Materials with Enhanced Nonlinearity
Ironside, Daniel ; Shen, Jung-Tsung
T-011141

— Background: Advances in nonlinear materials give rise to a multitude of optical phenomena that have important applications as switches and modulators in telecommunications and optical computing industry. The degree of optical nonlinearity in a material depends upon the strength of the optical field…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPR
Chen, Zhoufeng ; Liu, Xianyu
T-011473

— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Intestinal biomarker predicts response to treatment for inflammatory bowel disease
Stappenbeck, Thaddeus ; VanDussen, Kelli
T-019186

— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtii
Goodenough, Ursula ; Goodson, Carrie
T-011504

— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Drug target and biomarker for multiple sclerosis
Klein, Robyn ; Williams, Jessica
T-017623

— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…

Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
Anastasaki, Corina ; Gutmann, David
T-015422

— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Zika Oncolytic Virus to Treat Glioblastoma and Other Solid Tumors
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— Disease indication: Glioblastoma, Lung Cancer, Breast Cancer and other Cancers with Cancer Stem Cells Drug format: Oncolytic Virus Drug class: First-in class Research stage and Preliminary data: 1st Generation – Zika Virus (ZIKV) 2nd Generation – Attenuated ZIKV (E218A) Figur…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn's disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Improved MRI resolution with Diffusion Dictionary Imaging (DDI)
Wang, Qing ; Wang, Yong
T-019608

— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Chaotic Optomechanical Resonators
Ozdemir, Sahin ; Yang, Lan
T-016229

— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

Blood-based prognostic marker for respiratory distress from influenza and other viral infections
Mudd, Philip
T-019387

— Technology Description A team of researchers at Washington University has discovered an easily-measured, blood-based marker that could provide an early indicator to identify patients who will develop very severe disease following a viral infection. This immune cell marker for acute respiratory dis…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mutant PDGF-B as a VEGFR inhibitor
Imoukhuede, Princess
T-018996

— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Washington University Satisfaction and Function Survey
Barrack, Robert ; Nunley, Ryan
T-015700

— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Real-time 3D MRI
Kim, Taeho ; Park, Chunjoo
T-019011

— Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used in diagnostic MRI and MRI-guided radiotherapy (MRgRT). MRgRT combines medical imaging with radiation therapy to provide visualization of the tumor…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Novel bile acids as biomarkers for Niemann-Pick type C disease
Jiang, Xuntian ; Ory, Daniel
T-014292

— Technology Description Researchers at Washington University have developed and validated a set of bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick disease type C (NPC), a genetic lysosomal storage disorder resulting from a defect in lipid transport. Previous ef…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Photon tunneling
An, Woo Jin ; Wang, Lihong
T-012515

— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

LINAC design for radiosurgery with precise 4pi delivery and fast, integrated CT imaging
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Technology Description This technology is a patented LINAC (linear accelerator) radiation therapy system designed to enable non-coplanar cone beams to be delivered from all angles by using a ring gantry instead of a robotic moving couch. This simple approach enables easier treatment planning and q…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
Wang, Xiaowei
T-012911

— Oropharyngeal squamous cell carcinoma (OSCC) rates have increased significantly in recent years, and because of the different underlying causes of the disease no single treatment regime seems to be advantageous over another. Currently, the prognosis of OSCC is based on clinical features of the OSCC…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Nanothermometers for cellular-level temperature monitoring in ablation therapy or research
Berezin, Mikhail ; Gustafson, Tiffany
T-012606

— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Breath-based testing for malaria
John, Audrey Odom "Audrey Odom" ; Schaber, Chad ; Trehan, Indi
T-016183

— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variants
Ellebedy, Ali
T-019707

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …

Target and small molecule drugs to selectively neutralize bacteria in urinary tract infections
Henderson, Jeffrey P.
T-018628

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs). Currently, UTI…

Manipulating Tricellular Junction Permeability in Blood Brain Barrier to Treat Brain Tumors
Gong, Yong-feng ; Hou, Jianghui
T-017092

— Background: Brain tumors are the most lethal disease known to mankind with approximately 170,000 annual diagnoses and 13,000 deaths attributed to brain cancer. Glioblastoma, the most common and aggressive, has a median survival of approximately 18 months. Chemotherapeutic agents have been approved b…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

New diagnostic test method for infectious diseases
Storch, Gregory
T-013735

— Background: Viral infections are common causes of fever without an apparent source (FWS) in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leuko…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Method to create designer stem cells for safer, more effective therapeutics
Guilak, Farshid
T-018758

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infections
Iqbal, Zahid
T-019400

— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

Technique to reduce juxta-anastomotic stenosis development in AV fistulae
Shenoy, Surendra
T-010339

— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Tumor detection by targeting and monitoring integrin expression using synergistic effects of molecular beacons and peptides
Achilefu, Samuel
T-005371

— Background: Integrins are multi-subunit transmembrane proteins involved in a wide range of cellular processes including the induction of new blood vessel formation and tumor metastasis. The growth of new blood vessels, termed angiogenesis, is associated with an altered integrin expression profile wh…

Methods to Treat Vasodilatory Septic Shock
Boyle, Walter
T-007528

— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …

Biomarker to predict cancer response to chemotherapy
Diamond, Marc ; Shao, Jieya
T-015631

— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Managing Diabetes status in diabetic patients
Ravi, V. Nathan
T-005389

— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and death
Ory, Daniel ; Peterson, Linda ; Schaffer, Jean
T-014627

— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

High-yield, heat tolerant tomatoes
Frick, Elizabeth ; Strader, Lucia
T-018506

— Technology Description Researchers in Prof. Lucia Strader’s laboratory have cultivated genetically-stable, high-yield tomato plants that are tolerant to high temperature growing conditions (40oC). These plants were identified using a screen for mutants. Excitingly, two mutants (IR-12 an IR-1…

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological Tissue
An, Woo Jin ; Wang, Lihong
T-010123

— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal Inoculation
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064

— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Tetrahedron Beam Computed Tomography with Multi-pixel X-ray Source
Zhang, Tiezhi
T-015342

— About 70 million computed tomography (CT) scans are performed in the United State alone each year. Traditional helical scanners use a single point x-ray source that rotates around the patient, acquiring images in sequential slices, which results in high quality images. But these helical scanners a…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Tumor-targeted fusion protein platform for enhanced cancer immunotherapy
Pachynski, Russell
T-015906

— Disease indication – cancer, particularly lung, breast, colon, and prostate cancer or melanoma (cancers where chemerin is down-regulated at the tumor site) Drug format – engineered fusion protein Drug class – first in class Research stage and Preliminary data Target &ndash…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Red-Shifted Chromophore Substitution for Optogenetic Applications
Corbo, Joseph ; Enright, Jennifer ; Toomey, Matthew
T-014377

— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …

scFv-TR3: TRAIL trimers targeted to mesothelin
Hawkins, William ; Spitzer, Dirk
T-016481

— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Differentiation protocol for RA-dependent hematopoietic progenitor cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— Technology Description Researchers in Chris Sturgeon’s lab at Washington University have developed a protocol for definitive differentiation of hematopoietic progenitor cells that can be used to develop replacement blood products. This protocol involves a sequential, time-sensitive manipulat…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activity
Hawkins, William ; Spitzer, Dirk
T-011885

— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Optical Coherence Computed Tomography
Li, Li ; Wang, Lihong
T-008832

— Optical coherence tomography (OCT) utilizes optical light to obtain an image of opaque or translucent objects, ie tissue. Because scattered light contributes to the bluring found in other optical imaging techniques, OCT filters out all the scattered light. An image is formed using only the back refl…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

PEGylated-GIRLRG Peptide for Radiopharmaceutical Delivery
Hallahan, Dennis
T-014562

— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Exosome-based therapy for tendon injuries and other soft tissue repair
Shen, Hua
T-018565

— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Drugs to supplement microglial metabolism during treatment of Alzheimer’s disease
Colonna, Marco ; Ulland, Tyler
T-017401

— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Data security for IoT and mobile devices using Bit2RNG random number generator with no additional hardware
Yan, Wei ; Zhang, Xuan "Silvia"
T-019418

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a robust true random number generator (RNG) designed to be used as a low-resource security system for mobile and internet-of-things (IoT) devices. This technology, called “Bit2RNG&rdqu…

Antibodies to transferrin receptor
Ladenson, Jack ; Porter, Sharon
T-000757

— Analyte: Transferrin Receptor (CD71) Antibody codes: 2B7.4 (4065) and 2F6.3 (4077) Publications:

Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue Injury
Gelman, Andrew ; Puyo, Carlos
T-015918

— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Albring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Error correcting codes for robust, secure deep neural networks
Raviv, Netanel
T-019252

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

TREM2 blockade as an adjuvant for checkpoint inhibitors
Colonna, Marco
T-019371

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Eye test to diagnose preclinical Alzheimer’s disease
Apte, Rajendra ; Van Stavern, Gregory
T-018518

— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…

Therapeutic Approach for Huntington’s Disease (HD)
Kim, Albert ; Yano, Hiroko
T-016079

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Subtyping of schizophrenia based on genome and pathology
Cloninger, C. Robert ; Svrakic, Dragan ; Zwir, Jorge "Igor"
T-015118

— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…

Simple, universal DNA motifs for modulating protein production
Djuranovic, Sergej
T-016819

— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Energy efficient, scalable neuromorphic computing with Growth Transform Neural Network
Chakrabartty, Shantanu ; Gangopadhyay, Ahana
T-019112

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Song, Sheng-Kwei "Victor" ; Wang, Qing ; Wang, Yong
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

Plasma oxysterols as biomarkers for Niemann-Pick C disease
Ory, Daniel
T-007594

— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

IP-10 as a blood biomarker of respiratory failure
Mudd, Philip
T-019671

— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 Neonatal Eating Outcome (NEO) Assessment
Pineda, Roberta
T-014917

— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pr…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Blockchain-based algorithms for secure, collaborative risk assessment and decision making
Jain, Raj ; Salman, Tara
T-018710

— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Vaccines and antibodies against malaria and other parasitic diseases in humans and animals
Jimah, John ; Tolia, Niraj
T-016150

— Technology Description Researchers in Prof. Niraj Tolia’s laboratory have exploited structure-based vaccine design to develop immunogenic compositions and neutralizing antibodies that could protect against malaria and a range of other parasitic diseases that affect humans, livestock and comp…

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean
T-019338

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

A biomarker to monitor CNS efficacy of 2-hydroxypropyl-β-cyclodextrin (HPBCD)
Ory, Daniel
T-012136

— Background: Niemann-Pick type C1 (NPC1) disease is a rare neurological disorder characterized by cholesterol and lipid accumulation in the central nervous system. Individuals with the abnormal buildup of cholesterol and other lipids in the brain often suffer from cognitive and movement difficulties,…

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Rational drug design using Boltzmann docking
Bowman, Gregory
T-016234

— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…

Target and method to treat alphavirus infections
Diamond, Michael ; Kim, Arthur ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Novel Method and Device to Produce Fluorine-18 PET Tracers
Chu, Wenhua ; Zhou, Dong
T-015970

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Fast, low-cost analysis tool to extend the dynamic range of single-step immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— Technology Description A team of researchers at Washington University in St. Louis has developed Area Under the Curvature (AUCU), a data analysis method to improve the accuracy of homogeneous immunoassays (e.g., turbidimetric and nephelometric) while reducing costs and turn-around-times. AUCU can …

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Novel Method and Device to Produce Fluorine-18 PET Tracers
Zhou, Dong
T-019276

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in Macrophages
Apte, Rajendra
T-011268

— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapy
Wang, Xiaowei
T-014021

— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Chimeric antigen receptor dendritic cells
DeSelm, Carl
T-019199

— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trials
Yablonskiy, Dmitriy ; Zhao, Yue
T-015754

— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Intestinal biomarker predicts response to treatment for inflammatory bowel disease
Stappenbeck, Thaddeus ; VanDussen, Kelli
T-019186

— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtii
Goodenough, Ursula ; Goodson, Carrie
T-011504

— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Drug target and biomarker for multiple sclerosis
Klein, Robyn ; Williams, Jessica
T-017623

— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…

Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
Anastasaki, Corina ; Gutmann, David
T-015422

— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Zika Oncolytic Virus to Treat Glioblastoma and Other Solid Tumors
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— Disease indication: Glioblastoma, Lung Cancer, Breast Cancer and other Cancers with Cancer Stem Cells Drug format: Oncolytic Virus Drug class: First-in class Research stage and Preliminary data: 1st Generation – Zika Virus (ZIKV) 2nd Generation – Attenuated ZIKV (E218A) Figur…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn's disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Improved MRI resolution with Diffusion Dictionary Imaging (DDI)
Wang, Qing ; Wang, Yong
T-019608

— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Chaotic Optomechanical Resonators
Ozdemir, Sahin ; Yang, Lan
T-016229

— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

Blood-based prognostic marker for respiratory distress from influenza and other viral infections
Mudd, Philip
T-019387

— Technology Description A team of researchers at Washington University has discovered an easily-measured, blood-based marker that could provide an early indicator to identify patients who will develop very severe disease following a viral infection. This immune cell marker for acute respiratory dis…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mutant PDGF-B as a VEGFR inhibitor
Imoukhuede, Princess
T-018996

— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Real-time 3D MRI
Kim, Taeho ; Park, Chunjoo
T-019011

— Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used in diagnostic MRI and MRI-guided radiotherapy (MRgRT). MRgRT combines medical imaging with radiation therapy to provide visualization of the tumor…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Novel bile acids as biomarkers for Niemann-Pick type C disease
Jiang, Xuntian ; Ory, Daniel
T-014292

— Technology Description Researchers at Washington University have developed and validated a set of bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick disease type C (NPC), a genetic lysosomal storage disorder resulting from a defect in lipid transport. Previous ef…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Photon tunneling
An, Woo Jin ; Wang, Lihong
T-012515

— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

LINAC design for radiosurgery with precise 4pi delivery and fast, integrated CT imaging
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Technology Description This technology is a patented LINAC (linear accelerator) radiation therapy system designed to enable non-coplanar cone beams to be delivered from all angles by using a ring gantry instead of a robotic moving couch. This simple approach enables easier treatment planning and q…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Nanothermometers for cellular-level temperature monitoring in ablation therapy or research
Berezin, Mikhail ; Gustafson, Tiffany
T-012606

— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variants
Ellebedy, Ali
T-019707

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …

Target and small molecule drugs to selectively neutralize bacteria in urinary tract infections
Henderson, Jeffrey P.
T-018628

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs). Currently, UTI…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Method to create designer stem cells for safer, more effective therapeutics
Guilak, Farshid
T-018758

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infections
Iqbal, Zahid
T-019400

— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

Technique to reduce juxta-anastomotic stenosis development in AV fistulae
Shenoy, Surendra
T-010339

— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Methods to Treat Vasodilatory Septic Shock
Boyle, Walter
T-007528

— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological Tissue
An, Woo Jin ; Wang, Lihong
T-010123

— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Differentiation protocol for RA-dependent hematopoietic progenitor cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— Technology Description Researchers in Chris Sturgeon’s lab at Washington University have developed a protocol for definitive differentiation of hematopoietic progenitor cells that can be used to develop replacement blood products. This protocol involves a sequential, time-sensitive manipulat…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

Exosome-based therapy for tendon injuries and other soft tissue repair
Shen, Hua
T-018565

— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Drugs to supplement microglial metabolism during treatment of Alzheimer’s disease
Colonna, Marco ; Ulland, Tyler
T-017401

— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Data security for IoT and mobile devices using Bit2RNG random number generator with no additional hardware
Yan, Wei ; Zhang, Xuan "Silvia"
T-019418

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a robust true random number generator (RNG) designed to be used as a low-resource security system for mobile and internet-of-things (IoT) devices. This technology, called “Bit2RNG&rdqu…

Antibodies to transferrin receptor
Ladenson, Jack ; Porter, Sharon
T-000757

— Analyte: Transferrin Receptor (CD71) Antibody codes: 2B7.4 (4065) and 2F6.3 (4077) Publications:

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Error correcting codes for robust, secure deep neural networks
Raviv, Netanel
T-019252

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

TREM2 blockade as an adjuvant for checkpoint inhibitors
Colonna, Marco
T-019371

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Eye test to diagnose preclinical Alzheimer’s disease
Apte, Rajendra ; Van Stavern, Gregory
T-018518

— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…

Therapeutic Approach for Huntington’s Disease (HD)
Kim, Albert ; Yano, Hiroko
T-016079

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Energy efficient, scalable neuromorphic computing with Growth Transform Neural Network
Chakrabartty, Shantanu ; Gangopadhyay, Ahana
T-019112

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

Plasma oxysterols as biomarkers for Niemann-Pick C disease
Ory, Daniel
T-007594

— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

IP-10 as a blood biomarker of respiratory failure
Mudd, Philip
T-019671

— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pr…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Blockchain-based algorithms for secure, collaborative risk assessment and decision making
Jain, Raj ; Salman, Tara
T-018710

— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Vaccines and antibodies against malaria and other parasitic diseases in humans and animals
Jimah, John ; Tolia, Niraj
T-016150

— Technology Description Researchers in Prof. Niraj Tolia’s laboratory have exploited structure-based vaccine design to develop immunogenic compositions and neutralizing antibodies that could protect against malaria and a range of other parasitic diseases that affect humans, livestock and comp…

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean
T-019338

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Target and method to treat alphavirus infections
Diamond, Michael ; Kim, Arthur ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Novel Method and Device to Produce Fluorine-18 PET Tracers
Chu, Wenhua ; Zhou, Dong
T-015970

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Fast, low-cost analysis tool to extend the dynamic range of single-step immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— Technology Description A team of researchers at Washington University in St. Louis has developed Area Under the Curvature (AUCU), a data analysis method to improve the accuracy of homogeneous immunoassays (e.g., turbidimetric and nephelometric) while reducing costs and turn-around-times. AUCU can …

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Novel Method and Device to Produce Fluorine-18 PET Tracers
Zhou, Dong
T-019276

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapy
Wang, Xiaowei
T-014021

— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Chimeric antigen receptor dendritic cells
DeSelm, Carl
T-019199

— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trials
Yablonskiy, Dmitriy ; Zhao, Yue
T-015754

— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Intestinal biomarker predicts response to treatment for inflammatory bowel disease
Stappenbeck, Thaddeus ; VanDussen, Kelli
T-019186

— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Drug target and biomarker for multiple sclerosis
Klein, Robyn ; Williams, Jessica
T-017623

— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…

Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
Anastasaki, Corina ; Gutmann, David
T-015422

— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Zika Oncolytic Virus to Treat Glioblastoma and Other Solid Tumors
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— Disease indication: Glioblastoma, Lung Cancer, Breast Cancer and other Cancers with Cancer Stem Cells Drug format: Oncolytic Virus Drug class: First-in class Research stage and Preliminary data: 1st Generation – Zika Virus (ZIKV) 2nd Generation – Attenuated ZIKV (E218A) Figur…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn's disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Improved MRI resolution with Diffusion Dictionary Imaging (DDI)
Wang, Qing ; Wang, Yong
T-019608

— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…

Chaotic Optomechanical Resonators
Ozdemir, Sahin ; Yang, Lan
T-016229

— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

Blood-based prognostic marker for respiratory distress from influenza and other viral infections
Mudd, Philip
T-019387

— Technology Description A team of researchers at Washington University has discovered an easily-measured, blood-based marker that could provide an early indicator to identify patients who will develop very severe disease following a viral infection. This immune cell marker for acute respiratory dis…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mutant PDGF-B as a VEGFR inhibitor
Imoukhuede, Princess
T-018996

— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

Real-time 3D MRI
Kim, Taeho ; Park, Chunjoo
T-019011

— Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used in diagnostic MRI and MRI-guided radiotherapy (MRgRT). MRgRT combines medical imaging with radiation therapy to provide visualization of the tumor…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

LINAC design for radiosurgery with precise 4pi delivery and fast, integrated CT imaging
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Technology Description This technology is a patented LINAC (linear accelerator) radiation therapy system designed to enable non-coplanar cone beams to be delivered from all angles by using a ring gantry instead of a robotic moving couch. This simple approach enables easier treatment planning and q…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variants
Ellebedy, Ali
T-019707

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …

Target and small molecule drugs to selectively neutralize bacteria in urinary tract infections
Henderson, Jeffrey P.
T-018628

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs). Currently, UTI…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Method to create designer stem cells for safer, more effective therapeutics
Guilak, Farshid
T-018758

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infections
Iqbal, Zahid
T-019400

— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

Technique to reduce juxta-anastomotic stenosis development in AV fistulae
Shenoy, Surendra
T-010339

— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Differentiation protocol for RA-dependent hematopoietic progenitor cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— Technology Description Researchers in Chris Sturgeon’s lab at Washington University have developed a protocol for definitive differentiation of hematopoietic progenitor cells that can be used to develop replacement blood products. This protocol involves a sequential, time-sensitive manipulat…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed a