Search returned 727 results
Tumor treatment for patients with neurofibromatosis type 1 (NF1)Gutmann, David ; Weber, Jason
T-007548
— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…
Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in MacrophagesApte, Rajendra
T-011268
— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…
MRI-based multiparametric cardiac strain analysis of myocardial viabilityCupps, Brian ; Pasque, Michael
T-006692
— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…
Novel kinase inhibitor drugs to treat respiratory disease or breast cancerPatel, Anand ; Romero, Arthur ; Patel, Dhara ; Brett, Thomas ; Alevy, Yael ; Holtzman, Michael
T-011991
— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…
Biodegradable beads for capturing phosphorus from water and releasing it as fertilizerKim, Doyoon ; Jun, Young-Shin
T-017987
— Engineers in Prof. Young-Shin Jun’s laboratory at Washington University in St. Louis have developed a scalable, effective, environmentally-friendly system for removing phosphorus from water using biodegradable alginate beads that can then be recycled as a slow release fertilizer in soil. This …
Stable, non-toxic lead-free perovskite materials for high efficiency solar cells and other semiconductor applicationsThind, Arashdeep Singh ; Kavadiya, Shalinee ; Biswas, Pratim ; Mishra, Rohan
T-018532
— Engineers at Washington University in St. Louis have discovered a new class of stable, benign perovskite semiconductor materials with performance properties optimized for solar cell and photocatalysis applications. Traditional lead-halide perovskites show remarkable power conversion efficiency in ph…
In vivo PopQC – Simple quality control system to enhance industrial-scale microbial production of chemicals, biofuels and pharmaceuticalsXiao, Yi ; Zhang, Fuzhong
T-014647
— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…
Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditionsTadepalli, Sirimuvva ; Morrissey, Jeremiah ; Kharasch, Evan ; Singamaneni, Srikanth
T-014923
— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…
Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injuryLaterza, Omar ; Lockwood, Christina ; Modur, Vijay ; Ladenson, Jack ; Crimmins, Dan ; Gaut, Joseph
T-013292
— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…
Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapyChou, Chun ; Egawa, Takeshi
T-016284
— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…
3D tissue culture device that mimics cancer metastasis for in vitro drug discoveryNasrollahi, Samila ; Pathak, Amit
T-016671
— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…
MR-HIFU acoustic coupling device to improve performance and reduce side effectsXie, Kevin ; Kothapalli, Veera "Satya" ; Altman, Michael ; Chen, Hong
T-017089
— Technology Description Engineers in Prof. Hong Chen’s laboratory have developed a multifunctional, MR-compatible device designed to improve the performance of Magnetic Resonance High Intensity Focused Ultrasound (MR-HIFU) by increasing the efficiency of the ultrasound transmission, cooling t…
NMDA receptor modulator for neuroprotection after a strokeZorumski, Charles ; Taylor, Amanda ; Sun, Min-Yu ; Mennerick, Steven
T-016328
— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…
Accurate, efficient 2D strain mapping with robust detection of strain localizationThomopoulos, Stavros ; Pless, Robert ; Genin, Guy ; Boyle, John
T-014090
— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…
Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer ImmunotherapyCuriel, David
T-011681
— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…
High-yield, heat tolerant tomatoesFrick, Elizabeth ; Strader, Lucia
T-018506
— Technology Description Researchers in Prof. Lucia Strader’s laboratory have cultivated genetically-stable, high-yield tomato plants that are tolerant to high temperature growing conditions (40oC). These plants were identified using a screen for mutants. Excitingly, two mutants (IR-12 an IR-1…
Applicator device for reducing artifacts in MR-guided gynecological brachytherapyGrigsby, Perry ; Zoberi, Jacqueline
T-011297
— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…
Therapy to treat and prevent respiratory disease in pre-term and at-risk neonatesTodd, Elizabeth (Betsy) ; Morley, Sharon "Celeste"
T-017434
— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…
High-performance, nanoengineered two-phase cooling system for high powered electronicsShan, Li ; Ma, Binjian ; Agonafer, Damena
T-018032
— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …
Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseasesLubman, Olga ; Lu, Yun Hsuan ; Fremont, Daved
T-017443
— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…