Advanced Search
Select the Categories and/or Inventors to begin filtering. To narrow search results, use the search bar for additional keywords.
Search returned 729 results
Tumor detection by targeting and monitoring integrin expression using synergistic effects of molecular beacons and peptidesAchilefu, Samuel
T-005371
— Background: Integrins are multi-subunit transmembrane proteins involved in a wide range of cellular processes including the induction of new blood vessel formation and tumor metastasis. The growth of new blood vessels, termed angiogenesis, is associated with an altered integrin expression profile wh…
Disulfide trapped antigenic peptide in an MHC molecule.Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven ; Fremont, Daved ; Connolly, Janet ; Hansen, Ted
T-004551 Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Suthar, Bharatkumar ; Lawder, Matthew ; De, Sumitava ; Subramanian, Venkat
T-013089
— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…
Conformationally-flexible benzamide analogs as sigma-2 selective ligandsTu, Zhude "Will" ; Welch, Michael ; Rowland, Douglas ; Mach, Robert
T-004063
— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …
Modulation of Lymphocyte ActivityWatanabe, Norihiko ; Yang, Jianfei ; Murphy, Theresa ; Murphy, Kenneth
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancersTaylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Fang, Huafeng ; Becker, Matthew ; Wooley, Karen
T-004487
— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.
Phospholipase A2 EpsilonJenkins, Christopher ; Gross, Richard
T-004045
— This features an enzymatic function for a protein so that Washington University can obtain composition of matter rights and use rights for screening for inhibitors. This can be used for weight loss, diabetes, treatment of obesity and associated lipotoxicity, body sculpting, heart disease, stroke a…
Tri-heterocyclic ring compounds as alpha-synuclein ligandsMach, Robert ; Yu, Lihai ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-011942
— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…
Copy number Aberration Driven Endocrine Response (CADER) gene signatureLuo, Jingqin ; Ellis, Matthew
T-011920
— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…
Urinary Biomarker of Uropathogen ColonizationParker, Kaveri ; Hung, Chia ; Henderson, Jeffrey P.
T-011741
— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …
Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtiiGoodson, Carrie ; Goodenough, Ursula
T-011504
— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…
MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPRLiu, Xianyu ; Chen, Zhou-Feng
T-011473
— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…
Artificial Materials with Enhanced NonlinearityIronside, Daniel ; Shen, Jung-Tsung
T-011141
— Background: Advances in nonlinear materials give rise to a multitude of optical phenomena that have important applications as switches and modulators in telecommunications and optical computing industry. The degree of optical nonlinearity in a material depends upon the strength of the optical field…
Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided SurgeryLiu, Yang ; Culver, Joseph ; Bauer, Adam ; Akers, Walter ; Achilefu, Samuel
T-010825
— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …
Autosegmentation toolRao, Yuan ; Ma, Daniel ; Grigsby, Perry
T-010736
— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…
PET/SPECT Agents for Applications in Biomedical ImagingSivapackiam, Jothilingam ; Piwnica-Worms, David ; Sharma, Vijay
T-010438
— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…
Single Nanoparticle Detection by Mode Splitting in Active Microresonators using Heterodyne TechniqueYang, Lan ; Ozdemir, Sahin ; He, Lina
T-010140
— Dr. Lan Yang, Professor at Washington University in St. Louis, is a pioneer in the field of micro- and nano photonics. She recently developed a uniquely sensitive and versatile particle detector using whispering gallery mode (WGM) optical microresonators. Realtime detection and accurate sizing of la…
Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for ChildrenUmansky, Amy ; Jeffe, Donna ; Lieu, Judith
T-010222
— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…
Nanofiber scaffolds for delivery of heparin binding growth factors.Silva, Matthew ; Xia, Younan ; Xie, Jingwei ; Schwartz, Andrea "Annie" ; Sakiyama-Elbert, Shelly ; Gelberman, Richard ; Thomopoulos, Stavros
T-010125
— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …
Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological TissueAn, Woo Jin ; Wang, Lihong
T-010123
— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…