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Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancersTurner, Jeffrey ; Welch, Michael ; Sun, Xiankai ; Taylor, John-Stephen ; Rossin, Raffaella ; Pan, Dipanjan ; Fang, Huafeng ; Becker, Matthew ; Wooley, Karen
T-004487
— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.
Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)Rachakonda, Tara ; Jeffe, Donna ; Lieu, Judith
T-013745
— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…
System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s DiseaseWang, Qing ; Benzinger, Tammie ; Wang, Yong
T-016125
— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…
Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric SitesMyers, Connie ; Qi, Zongtai ; Zhang, Chi ; Mitra, Robi ; Corbo, Joseph ; Havranek, James
T-015523
— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…
New Method to Produce a DNA Mutation LibraryGurnett, Christina ; Dobbs, Matthew ; Alvarado, David ; Haller, Gabriel
T-015343
— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …
Radiation Oncology Dashboards (LATTICE)Scholle, Glen ; Santanam, Lakshmi ; Mutic, Sasa ; Danieley, Jonathan ; LaBrash, Jason
T-014089
— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.
Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in InfantsMcDonald, Keely ; Knoop, Kathryn ; Newberry, Rodney
T-016480
— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…
Tri-heterocyclic ring compounds as alpha-synuclein ligandsYu, Lihai ; Mach, Robert ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-011942
— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…
Compressed-sensing Ultrafast Photography (CUP)Liang, Jinyang ; Gao, Liang ; Wang, Lihong
T-014733
— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…
PARTNER programStrunk, Robert ; Rook, Shannon ; Highstein, Gabrielle ; Dodd, Sherry ; Garbutt, Jane
T-014455
— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…
Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteriesRamadesigan, Venkatasailanathan ; Suthar, Bharatkumar ; Northrop, Paul ; Lawder, Matthew ; De, Sumitava ; Subramanian, Venkat
T-013089
— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…
Modulation of Lymphocyte ActivityYang, Jianfei ; Watanabe, Norihiko ; Murphy, Theresa ; Murphy, Kenneth
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
Dual Light-Emitting Systems and Biological Applications ThereofZhang, Zongren ; Berezin, Mikhail ; Achilefu, Samuel
T-007596
— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…
Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal DegenerationNo items found
T-008422
— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…
PET/SPECT Agents for Applications in Biomedical ImagingSivapackiam, Jothilingam ; Piwnica-Worms, David ; Sharma, Vijay
T-010438
— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…
Planar storage phosphor dosimeter for radiation therapy dosimetryLi, Hui
T-009252
— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…
FES Recovery of Neurologic Function and RegenerationMcDonald, John W.
T-003694
— Washington University inventors have found that FES enhances spontaneous neurological recovery. This can be used in the development of FES systems for regeneration of recovery of function.
Coupled Visualization and Ablation of Specific Cells and Tissues in ZebrafishSchroeter, Eric ; Mumm, Jeffrey
T-003399
— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…
MR Method for Quantification of Anisotropic DiffusionSukstansky, Alexander ; Conradi, Mark ; Yablonskiy, Dmitriy
T-003068
— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…
Managing Diabetes status in diabetic patientsRavi, V. Nathan
T-005389
— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…