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Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probeYao, Junjie ; Li, Lei ; Wang, Lihong
T-015670
— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…
Patient Access Scheduling SystemReynolds, Steven ; Whipple, Toni ; Hughes, Scott ; Melnek, Christine ; Dodt, Jeremy ; Mantia, Jill
T-015846
— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…
Zuum – appCorcoran, Heather ; Colditz, Graham
T-011983
— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.
Quit HelpersSumner, Walton ; Colditz, Graham ; McQueen, Amy
T-014916
— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…
Pediatric Hematology-Oncology Roadmap BuilderJones, Sally ; Lackey, Ian ; Drozda, Mandy ; Brown, Robert ; Rich, Eliot
T-010823
— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …
VISIT-TS Version 2Striley, Catherine ; Vachon, Matthew ; Schroeder, Miriam ; Gordon, Mollie ; Black, Kevin
T-016526
— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…
Agonistic Anti-CD40 Monoclonal AntibodiesKlechevsky, Eynav
T-015344
— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.
Neonatal Eating Outcome (NEO) AssessmentPineda, Roberta
T-014917
— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …
Therapeutic Approach for Huntington’s Disease (HD)Kim, Albert ; Yano, Hiroko
T-016079
— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…
Treating Tuberculosis with Host-Directed Drug TargetingChandra, Pallavi ; Philips, Jennifer
T-017060
— Background: Worldwide, there are over 10 million new cases of tuberculosis (TB) annually, resulting in 1.8 million deaths. This makes Mycobacterium tuberculosis (Mtb), the bacterium causing TB, the world’s leading infectious disease killer. Even for drug susceptible TB, the treatment courses a…
Cytokines-induced-memory-like NK cells with reduced NKG2A checkpoint signalingRomee, Rizwan ; Berrien-Elliott, Melissa ; Fehniger, Todd
T-017001
— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…
Antiviral therapy targeting viruses within parasitic protozoansKuhlmann, Frederick ; Beverley, Stephen
T-016969
— Background: Parasitic infections remain global health threats and often lead to high death rates in endemic countries. Found in 98 countries, the Leishmania parasite is particularly dangerous and accounts for an estimated 2 million cases and 50,000 deaths per year across the world. However, Leishman…
Drugs to supplement microglial metabolism during treatment of Alzheimer’s diseaseUlland, Tyler ; Colonna, Marco
T-017401
— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…
Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal EnzymesLiu, Lin ; Lee, Wang ; Doray, Balraj ; Kornfeld, Stuart
T-016569
— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…
Itaconate Immunomodulatory Properties-Ischemia ReperfusionLampropoulou, Vasiliki "Vicky" ; Artyomov, Maxim
T-016181
— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…
Styryl Heteroaromatic Ring Containing Analogues for Alpha-SynucleinYue, Xuyi ; Li, Junfeng ; Kotzbauer, Paul ; Tu, Zhude "Will"
T-014558
— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…
Tetrahedron Beam Computed Tomography with Multi-pixel X-ray SourceZhang, Tiezhi
T-015342
— About 70 million computed tomography (CT) scans are performed in the United State alone each year. Traditional helical scanners use a single point x-ray source that rotates around the patient, acquiring images in sequential slices, which results in high quality images. But these helical scanners a…
A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and TreatmentXu, Mai
T-016998
— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…
High Throughput Acoustic Particle SeparationBinkley, Michael ; Berezin, Mikhail ; Meacham, John
T-017364
— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…
Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCL9Sheehan, Kathleen ; Schreiber, Robert
T-005944
— Target: Inflammatory chemokine CXCL9, monokine induced by IFN-gamma. Secreted mainly by macrophages. Notes: Clone MIG-2F5-5. Use in ELISA, neutralizing and binding assays.
