Summaries by Inventor

Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materials
Bowen, Christopher ; Dai, Bin ; Zhang, Fuzhong
T-018602

— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…

IL33 tm1b and tm1c
Colonna, Marco ; Gilfillan, Susan ; Yoshita, Satoru
T-019314

— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

Plasma oxysterols as biomarkers for Niemann-Pick C disease
Ory, Daniel
T-007594

— Background Niemann-Pick type C is a rare, progressive neurodegenerative disease characterized by accumulation of cholesterol and other lipids in the viscera and central nervous system. For cases caused by mutations in the NPC1 or NPC2 gene, egress of lipids from endosomes or lysosomes are impaired, resulting in clinical symptoms such as abnormal eye movements, hearing loss, cerebellar ataxia, difficulty swallowing, and cognitive impairment. However, patients with Neimann-Pick disease have highly variable clinical presentation and symptom progression, making diagnosis challenging. Technology Summary A panel of oxygenated forms of cholesterol (oxysterols) in plasma that can be used as a diagnostic test for Neimann-Pick type C1 disease. The mass spectrometry-based panel is able to discriminate between subjects with NPC1 and normal control subjects. The oxysterol biomarkers have clinical utility in newborn screening for early diagnosis of NP1C disease, as markers for disease severity, and as biomarkers to aid in evaluation of new therapies for NPC1. Key Advantages High sensitivity Rapid diagnostic for screening infants Patents US 8,497,122 Issued US 9,012,216 Issued Publications Porter et al., 2010 – Cholesterol oxidation products are sensitive and specific blood-based biomarkers for NPC1 disease.

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Rat Hybridoma producing Monoclonal Antibodies against Mouse PDCA1
Blasius, Amanda ; Cella, Marina ; Colonna, Marco
T-004377

— Target: Antibodies recognize a small leukocyte population of cells called intereron producing cells or plasmacyt-oid dendritic cells. Notes: Clone names 129c1 and 927Antibodies were produced by immunizing Wistar/CRL rats with CpG oligodeoxynucleotide 1826 or heat-killed Mycobacteria tuberculosis. The antibodies are specific for mouse IFN-producing cells (IPC). Publication: Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in …

Human HLA Monomers and Murine MHC-1 Monomers
Schreiber, Robert
T-019046

— This technology contains a panel of human or mouse specific monomers for staining T cells to enumerate antigen specific cells. The proteins have been produced in E coli after the generation of plasmids encoding each monomer. The proteins are folded in association with unique peptides and purified by…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

IL-33 mCherry Mice
Colonna, Marco ; Gilfillan, Susan ; Joshita, Satoru
T-019315

— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:

STING N153S knock-in mice
Miner, Jonathan
T-019131

— STING N153S knock-in mice These mice carry a N153S (asparagine to serine) substitution in the Tmem173 (transmembrane protein 173 or STING) gene. The mice were created using CRISPR/Cas9 with a single guide RNA designed based on specificity and proximity to the targeted STING mutation site. Two indep…

Washington University Satisfaction and Function Survey
Barrack, Robert ; Nunley, Ryan
T-015700

— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Treatment for Age-Related Macular Degeneration (AMD) by Targeting Cholesterol Transport in Macrophages
Apte, Rajendra
T-011268

— Technology Description Researchers in Prof. Rajendra Apte’s laboratory developed novel methods for treating macular degeneration and other eye diseases by targeting a cholesterol transport pathway involved in the formation of new blood vessels. Age-related macular degeneration (AMD) is a lea…

Polyclonal antibody for straining human Cytokeratin 13 (HuCK13)
Ladenson, Jack
T-004395

— Rabbit polyclonal antibodies were generated using two distinct 20-mer synthetic peptides corresponding to the unique C-terminal extension of HuCKI 3 using standard protocols. Final purification used the corresponding peptide immunogen affinity column. Possible uses: histological detection in tumors …

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

Development of a Preclinical NF1-MPNST Platform Suitable for Precision Oncology Drug Discovery and Evaluation
Hirbe, Angela ; Li, Shunqiang
T-019044

— This technology contains a set of patient derived xenograft cell lines. These cell lines represent the heterogeneity of human malignant peripheral nerve sheath tumors (MPNSTs) that can be used to test novel agents to move forward into clinical trials.

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Tumor treatment for patients with neurofibromatosis type 1 (NF1)
Gutmann, David ; Weber, Jason
T-007548

— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

CD36 floxed mice
Abumrad, Nada
T-019340

— Mouse line with CD36 floxed allele. CD36 is a multifunctional glycoprotein that acts as receptor for a broad range of ligands. The CD36 flox mice were generated using a BAC with a 1.7kb sequence with exons 3 and 4. Publication: Endothelial cell CD36 optimizes tissue fatty acid uptake

Immunohistochemical diagnosis of human renal chromophobe carcinoma
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack
T-011164

— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

DNA plasmids to control gene expression in E. coli
Hoynes-O'Connor, Allison ; Moon, Tae Seok
T-019135

— These plasmids contain target binding regions (TBRs) targeting rfp that were placed under the control of pTet via blunt end lifgation. Hfq binding sites that had been identified from the literature were inserted adjacent to the TBR sequence using either blunt end ligation or Golden Gate assembly, de…

LS301 and LS301 dimer
Achilefu, Samuel ; Sharmah Gautam, Krishna
T-019177

— Fluorescent tagged octapeptide for cancer detection

hNALCN Promoter-PGL3 Basic Luc Plasmid
Amazu, Chinwendu ; England, Sarah
T-019342

— The promoter region of the NALCN, sodium leak current, was amplified and inserted into the PGL3 Basic Luc backbone. The plasmid has applications in studying interactions of transcription factors with NALCN.

Antibodies to Troponin
Ladenson, Jack
T-000093

— Antibody codes: 2B1.9 (3268) and 2F6.6 Publication: Bodor GS, Porter S, Landt Y, Ladenson JH. Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction. Clin Chem. 1992 Nov;38(11):2203-14. Antibody codes: 5…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Xcr1 IRES mCherry-hCre Mouse Strain
Durai, Vivek ; Murphy, Kenneth ; Murphy, Theresa
T-019142

— Xcr1 IRES mCherry-hCre Mouse Strain This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…

Grueneisen-memory photoacoustic microscopy
Wang, Lidai ; Wang, Lihong ; Zhang, Chi
T-014165

— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Flag tagged BK(MDAL) in pBUD mch
England, Sarah ; Lorca, Ramon
T-019344

— Plasmid for flag tagged BK(MDAL) in a pBUD mcherry vector.

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Antibodies to transferrin receptor
Ladenson, Jack ; Porter, Sharon
T-000757

— Analyte: Transferrin Receptor (CD71) Antibody codes: 2B7.4 (4065) and 2F6.3 (4077) Publications:

Murine neoantigen containing plasmids
Schreiber, Robert
T-019238

— Two plasmids each containing a single murine mutant tumor neoantigen: a) retroviral MSCV-IRES encoding full length mutant lamanin alpha 4 (mLama4) b) retroviral MSCV plasmid encoding full length mutant integrin beta 1 (mItgb1)

Grp Floxed mouse strain
Chen, Zhou-Feng
T-019157

— Grp floxed mouse strain These mice have loxP sites flanking exon 1 of the Grp gene. It was used to study the mechanism of itch and further interrogation of itch-nerve fibers in the skin under chronic pruritus. Publication: Exploration of Sensory and Spinal Neurons Expressing GRP in Itch and Pain …

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Early, specific, blood-based diagnostic for septic arthritis
Luhmann, Scott
T-018905

— Technology Description: Researchers at Washington University in St. Louis have identified blood-based cytokine signatures that could be used to specifically detect, distinguish and monitor septic arthritis, synovitis and osteomyelitis. This assay could enable timely, accurate treatment to avoid joi…

Blockchain-based algorithms for secure, collaborative risk assessment and decision making
Jain, Raj ; Salman, Tara
T-018710

— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Troponin T2-DTR transgenic mice
Lavine, Kory
T-019483

— This is a transgenic mouse line that expresses the Diphtheria toxin receptor in the myocardium of the mouse heart. Upon administration of Diphtheria toxin cardiomyocytes undergo rapid cell death and mice develop heart failure. This mouse line provides a simple a noninvasive method to model cardiac i…

Antibody to Myoglobin
Ladenson, Jack
T-000126

— Analyte: Myoglobin Antibody codes: Notes: Suitable for two-site immunoassay Publication: Silva DP Jr, Landt Y, Porter SE, Ladenson JH. Development and application of monoclonal antibodies to human cardiac myoglobin in a rapid fluorescence immunoassay. Clin Chem. 1991 Aug;37(8):1356-64.

Mutant Zebrafish with chemically induced point mutations
Solnica-Krezel, Lilianna
T-017763

— Mutant zebrafish animals harboring chemically induced point mutations in the genome. Animals: spon1b fh440, kiss1 stl82, kiss1rb fh438, pon2 fh450

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Broad spectrum chemokine receptor imaging agent
Liu, Yongjian
T-019607

— 64Cu-DOTA-vMIP-II is a broad spectrum PET imaging agent that provides a non-invasive measurement of up to 10 chemokine receptors involved in the inflammatory processes of various diseases. This agent is based on the peptide vMIP-II (viral macrophage inflammatory protein-II), a viral CC chemokine enc…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Managing Diabetes status in diabetic patients
Ravi, V. Nathan
T-005389

— Background: About 422 million people worldwide and over 29 million Americans have diabetes. The prevalence of diabetes is increasing and an important cause of blindness, amputation, kidney failure, and one of the leading causes of premature death. Diabetes is associated with significant costs. In th…

Plasmids harboring 3HB with different split intein
Bai, Wenqin ; Zhang, Fuzhong
T-019213

— Plasmids harboring 3HB with different split intein: pWB076-pE8a-GpC10-3HBt-CfaN10; pWB088-pE8a- CfaC10-3HBt-NrdJN10; pWB079-pE8a-NrdJC10-3HBt-GpN10. Enabling a new process to compare nanostructures.

Error correcting codes for robust, secure deep neural networks
Raviv, Netanel
T-019252

— Technology Description Researchers in Prof. Netanel Raviv’s laboratory have developed a provable error correcting code (ECC) system that could guarantee deep neural networks (DNN) are resilient to noise for robust, secure and private neural computation. This technology could be deployed in n…

Antibody to Calmodulin
Ladenson, Jack
T-000190

— Analyte: Calmodulin Antibody code: 2D1.15 Publication: Sacks DB, Porter SE, Ladenson JH, McDonald JM. Monoclonal antibody to calmodulin: development, characterization, and comparison with polyclonal anti-calmodulin antibodies. Anal Biochem. 1991 May 1;194(2):369-77

Six2-GFP reporter iPSC line (subject to GE – GFP license)
Humphreys, Benjamin
T-017760

— Researchers used CRISPR/Cas9-mediated gene targeting to knock in a GFP-P2A cassette into the ATG of the Six2 gene in human BJFF.6 induced pluripotent stem cells. The cells exhibit GFP expression in Six2+ cells when induced to differentiate towards the renal lineage. Six2 expression marks a progenito…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide & NAD) on blood glucose levels.
Imai, Shin-Ichiro ; Revollo, Javier
T-005815

— The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide & NAD) on blood glucose levels.

ABCA3-GFP expression constructs
Cole, F. Sessions ; Wambach, Jennifer
T-017958

— This technology includes a plasmid with the full length ATP-binding cassette transporter A3 (ABCA3) cDNA cloned into the pAcGFP1-N1 vector and another plasmid with the ABCA3-GFP cDNA inserted into the pShuttle vector. Mutations in ABCA3 lead to severe neonatal respiratory distress syndrome and child…

Broadly cross-reactive anti-HA stalk antibodies
Ellebedy, Ali
T-019212

— Six recombinant human monoclonal antibodies that are directed against the conserved stalk region of influenza virus HA. This stalk region is currently being assessed as a potential candidate as a universal influenza vaccine. These antibodies can be used as diagnostics and also as validation tools fo…

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Influenza GFP reporter virus
Boon, Adrianus "Jacco"
T-019202

— Influenza virus containing a GFP reporter gene in one of the gene-segments. It allows for high throughput screening of compounds or host factors required for influenza virus infection and replication.

Nf1 Optic Glioma Stem Cells
Gutmann, David
T-017720

— Using a series of Nf1 genetically-engineered mouse strains, researchers isolated low-grade glioma stem cells (CD133+ cells) for in vitro and in vivo brain tumor studies. These lines are authenticated optic glioma stem cells, with the ability to self-renew at limiting dilutions; express stem cell mar…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

FES Recovery of Neurologic Function and Regeneration
McDonald, John W.
T-003694

— Washington University inventors have found that FES enhances spontaneous neurological recovery. This can be used in the development of FES systems for regeneration of recovery of function.

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Transgenic mouse DNAJB6/F90I
Weihl, Conrad
T-019285

— Transgenic mouse strain designed and developed by Dr. Conrad Weihl with a mutation of the DNAJB6 gene at the F90I protein. This homologous with the human form of muscular dystrophy with patients having a genetic variant at the F89I protein.

E. coli plasmids and strains for biofuel synthesis
Jiang, Wen ; Xiao, Yi ; Zhang, Fuzhong
T-017688

— pA5c-tesA, pA8c-tesA-mleuABCD, pE2k-alsS-ilvCD Researchers used a standard restriction digestion cloning based on the Biobrick platform or Gibson assembly to construct the plasmids. E. coli DH10B was used for cloning. These plasmids were designed to increase branch chain fatty acid production. Pub…

Grpr Flox Mouse Strain
Chen, Zhou-Feng
T-019158

— Grpr floxed mouse strain This mouse strain has loxP sites flanking exon 2 of the Grpr gene. Inventors backcrossed the mice into the C57Bl/6J background. The mouse strain was used to study contagious itch and demonstrated that GRP-GRPR signaling is necessary and sufficient for transmitting contagiou…

Insert device that enhances MR and PET image resolution for MR-PET machines
Tai, Yuan-Chuan
T-007555

— Background PET-CT scanners have been widely used in the identification of tumors and localization for biopsies due to its superior ability to detect biochemical and physiological functions. However, one of the main limitations of PET-CT is the inability to visualize soft tissues, which may be impor…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Eye test to diagnose preclinical Alzheimer’s disease
Apte, Rajendra ; Van Stavern, Gregory
T-018518

— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Coupled Visualization and Ablation of Specific Cells and Tissues in Zebrafish
Mumm, Jeffrey ; Schroeter, Eric
T-003399

— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…

Plasmids for expression of the enzyme PheRS
Sibley, Laurence
T-019246

— Plasmids for expression of phenyl alanine tRNA synthase from Toxoplasma gondii, Plasmodium falciparum and Homo sapiens. These include wild type and various mutant forms.

Hnf4a-Foxa1 fusion plasmid
Morris, Samantha
T-019160

— Plasmid with fused Hnf4a and Foxa1 genes to express as a single transcript. Individual genes were obtained from Addgene.

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Clifednamide compounds
Qi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

IRF8 +32 KO mice
Murphy, Kenneth
T-018830

— Researchers first identified and then used CRISPR to delete an enhancer located at +32 kb of the Irf8 transcriptional start site in mice. Knocking out this enhancer revealed that interferon regulatory factor 8 (IRF8) is required for the development of classical type 1 dendritic cells (cDC1s) but not…

human iPSC cells to model VCP
Weihl, Conrad
T-019162

— Valosin Containing Protein (VCP) patient derived fibroblasts, reprogrammed into iPSC cells and corresponding gene corrected line. These cells can be used to model VCP associated muscle disease, ALS, and dementia.

Algorithm and alert process for the prediction and prevention in-patient Treatment-related severe hypoglycemia
Tobin, Garry
T-012472

— Technology Description: A hospital-based algorithm and associated software that is able to predict which in-patients on diabetic therapy will develop hypoglycemia. It is able to predict in real time which patients are at risk and alert MDs to start interventions to prevent possible side effects or d…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

LDLR luciferase reporter in U87 cells
Holtzman, David
T-017684

— U87 cells that express guassia luciferase under the control of the human LDLR promoter with constitutive HRP expression. WU878: PhLDLR/guassia luciferase WU988: pTL/guassia luciferase

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

Energy efficient, scalable neuromorphic computing with Growth Transform Neural Network
Chakrabartty, Shantanu ; Gangopadhyay, Ahana
T-019112

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Mpc2 floxed mice
Finck, Brian
T-018821

— Using embryonic stem cells from the European knockout mouse consortium (EUCOMM), researchers developed transgenic mice with loxP sites flanking exon 3 of the mitochondrial pyruvate carrier 2 (Mpc2) gene. MPC2 is a component of the MPC complex, which is involved in the transport of pyruvate across th…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

Mouse Anti-Human PLD3 (Phospholipase D3) antibody HJ16.6
Holtzman, David
T-019280

— Anti-human hPLD3 antibody raised in mice. The antibody isotype is islgG2b.

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Photon tunneling
An, Woo Jin ; Wang, Lihong
T-012515

— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…

Manipulating Tricellular Junction Permeability in Blood Brain Barrier to Treat Brain Tumors
Gong, Yong-feng ; Hou, Jianghui
T-017092

— Background: Brain tumors are the most lethal disease known to mankind with approximately 170,000 annual diagnoses and 13,000 deaths attributed to brain cancer. Glioblastoma, the most common and aggressive, has a median survival of approximately 18 months. Chemotherapeutic agents have been approved b…

Low-cost, flexible paper substrate for sensitive trace chemical and biological detection using SERS (surface enhanced Raman scattering)
Kharasch, Evan ; Lee, Chang Hee ; Morrissey, Jeremiah ; Singamaneni, Srikanth
T-010600

— Technology Description Researchers in Prof. Srikanth Singamaneni’s laboratory have developed a patented, low-cost, flexible substrate designed to improve sample collection and enhance analyte detection with surface enhanced Raman scattering (SERS) or localized surface plasmon resonance (LSPR…

Irg1 point mutant mice
Diamond, Michael ; Nair, Sharmila
T-018684

— Description: CRISPR-Cas9 gene edited mice with point mutation in Irg1 (ACOD1). Note: Please contact for additional information.

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Detecting and Measuring Single Nanoparticles & Molecules with a Tapered Optical Fiber CIP
Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-011617

— The invention describes an instrument for detecting single particles, and measuring their properties (size or mass). The device contains only a tapered optical fiber. A laser diode as the light source and a photo-detector to measure the light intensity are also needed to complete the sensing system.…

Single Nanoparticle Detection by Mode Splitting in Active Microresonators using Heterodyne Technique
He, Lina ; Ozdemir, Sahin ; Yang, Lan
T-010140

— Dr. Lan Yang, Professor at Washington University in St. Louis, is a pioneer in the field of micro- and nano photonics. She recently developed a uniquely sensitive and versatile particle detector using whispering gallery mode (WGM) optical microresonators. Realtime detection and accurate sizing of la…

Murine Hybridoma producing IgG2b Monoclonal Antibody to Human CD85h (ILT1)
Colonna, Marco
T-005807

— Target: Cluster of Differentiation 85h protein, a.k.a. Ig-Like Transcripts 1. Notes: Clone name is 24.Wistar rats were immunized with ILT1/FLAG-transfected RBL cells. ILT1 mAb was selected by flow cytometry for staining ILT1/FLAG-transfected RBL cells. This antibody can be used to study myeloid cell activation. Publication: Human Myeloid Cells Express an Activating ILT1 Receptor (ILT1) That Ass…

Dnmt3b transgenic mice
O'Keefe, Regis
T-018661

— Description: Dnmt3b transgenic mouse contains a full-length Flag-tagged murine Dnmt3b cDNA which is under the control of a rtTA promoter. The Dnmt3b transgenic mouse will provide both cell specific and temporal regulation for Dnmt3b over-expression upon recombination with addition of doxycycline (D…

Ifnl2/Ifnl3 double knock-out mouse
Baldridge, Megan
T-019187

— Ifnl2/Ifnl3 double knock-out mouse strain This mouse strain is in the C57BL/6 background with Ifnl2, Ifnl3 genes disrupted to create a double knock-out. It was generated with assistance from the Washington University GEIC. This strain was used to study the regulation of the innate immune response t…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

Ebola VP30 proteins
Amarasinghe, Gaya
T-019593

— Ebola viral protein 30 (eVP30) plays a critical role in transcription initiation for viral RNA synthesis. These materials could be used to test for Ebola virus infection. Publication: Xu, W., Luthra, P., Wu, C., Batra, J., Leung, D. W., Basler, C. F., & Amarasinghe, G. K. (2017). Ebola virus VP…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Murine Hybridoma producing IgG2a Monoclonal Antibody to Mouse Rae1 Delta
Colonna, Marco
T-005805

— Target: Retinoic Acid Early 1 Delta protein. Notes: Clone Charlotte O1.23.

Technique to reduce juxta-anastomotic stenosis development in AV fistulae
Shenoy, Surendra
T-010339

— Technology Description Researchers at Washington University in St. Louis have developed a technique for arteriovenous fistula creation that reduces the incidence of juxta-anastomotic stenosis, which often leads to graft failure. The procedure involves clamping closed one end of the graft and attac…

pDD82, pDD112 and pDD120 plasmids
Moon, Tae Seok
T-018659

— Description: Plasmids- Publication: DeLorenzo DM, Rottinghaus AG, Henson WR, Moon TS. Molecular Toolkit for Gene Expression Control and Genome Modification in Rhodococcus opacus PD630. ACS Synth Biol. 2018 Feb 16;7(2):727-738. doi: 10.1021/acssynbio.7b00416. Epub 2018 Feb 5.

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

Piggybac vectors for gene delivery and fluorescent reporter assays
Madison, Blair
T-019191

— Plasmid vectors for shRNA expression, CRISPR reagent delivery, protein expression, reporter (promoter or 3’UTR) assays, and non-coding RNA delivery Efficient gene delivery is problematic, especially in hard to transfect primary cells (e.g. organoids). Commercial piggybac vectors are sparse and …

IL-34-deficient reporter mice (IL34 LacZ/LacZ)
Colonna, Marco
T-019588

— Mouse strain deficient in IL-34 production with defective Langerhans cells and microglia. These mice can be used to assess the role of the cytokine IL-34 in the development and maintenance of peripheral macrophage populations. Publication: Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossin…

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human ILT3
Colonna, Marco
T-005803

— Target: Immunoglobulin transcript 3 (ILT3). Notes: Clone name is ZM4.1.To generate the hyrbidomas, 10-week-old, female BALB/c mice received an initial injection of ILT3 human IgG1 fusion protein mixed with Alu-Gel-S behind the neck. 4 weeks later, they were given a booster immunization with the same immunogen, followed after 2 weeks by a final injection of purified ILT…

Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique Compositions
Biswas, Pratim ; McDonald, Rafael ; Thimsen, Elijah
T-006824

— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …

Calcium Carbonate nanoparticles for normalizing tumor microenvironment
Achilefu, Samuel
T-018647

— Description: Calcium Carbonate nanoparticles for normalizing tumor microenvironment Publication: Som A, Raliya R, Tian L, Akers W, Ippolito JE, Singamaneni S, Biswas P, Achilefu S. Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo. Nanoscale. 2016 Jul …

Inducible PiggyBac transposase constructs
Mitra, Robi ; Qi, Zongtai
T-019209

— Chemically inducible PiggyBac transposase constructs. The plasmids that contain mutated destabilized domains, FKBP and DHFR, were purchased from Addgene with ID 31763 and 29326, respectively. The PBase-ERT2 plasmid (mPBase-L3-ERT2) was a kind gift from Dr. Allen Bradley . The coding sequence of mPBa…

Mouse anti-MR1 hybridomas, clone 4E3 and 6D1
Hansen, Ted ; Wang, Xiaoli
T-017622

— mAb 4E3 was derived by immunization of β2m-deficient BALB/c mice with a keyhole limpet hemocyanin-conjugated peptide corresponding to mMR1 residues 130–153 (L A M D Y V A H I T K Q A W E A N L H E L Q Y Q). Hybridomas were produced by standard methods and screened by anti-peptide ELISA. …

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96
Colonna, Marco
T-005414

— Target: Cluster of Differentiation 96 protein, a.k.a. T Cell-Activated Increased Late Expression protein. Notes: Clone name is MX92.39.mAbs against CD96 (clone NK92.39, mouse IgG1) was obtained by immunizing mice with NK92 cells. This antibody can be used to study how NK cells recognize tumors. Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)

2ftgh-ISRE-CBG99 cell line
Holtzman, Michael
T-018629

— Description: 2ftgh-ISRE-CBG99 cell line- a report line for interferon stimulation. To create these cells the inventors generated a report plasmid of interferon-stimulated response element (5xISRE)-driven luciferase, and co-transfected this vector together with pPUR plasmid into the human 2ftgh fibr…

Algorithm for Multi-Agent Coordination Through Adaptively Regularized Parallel Distributed Optimization
Gilboa, Elad
T-012524

— Many problems require the analysis of large, high-dimensional datasets, which make the problem intractable to most optimization algorithms. Gilboa has developed a new parallel distributed algorithm for block optimization problems using adaptive regularizer PDAR. PDAR is able to solve both t…

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human SIRP Alpha + Beta
Colonna, Marco
T-005413

— Target: Cluster of Differentiation 172g protein, a.k.a. Signal Regulatory Protein Alpha and Beta. Notes: Clone name is 148.

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

PhOTseq and VNO ectopic expression plasmids
Holy, Timothy ; Lee, Donghoon
T-019206

— These plasmids contain mammalian cell expression promoters and can be used for AAV production. Some plasmids encode a calcium reporter (GCaMP) and photoactivatable fluorescent reporter (PAmCherry). Others plasmids encode a calcium reporter (GCaMP) and one of the vomeronasal receptor genes; two gen…

P301Stau/E4 cross-bred mice
Holtzman, David
T-018531

— Description: P301Stau/E4 cross-bred mice Publication: Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cru…

St. Louis isolate of Bourbon virus (BRBV-STL)
Boon, Adrianus "Jacco"
T-018815

— This strain of the Bourbon virus was isolated from the serum of an infected St. Louis-area patient. The isolated virus was used to demonstrate in vitro and in a mouse model that the antiviral drug favipiravir has prophylactic and therapeutic efficacy against the Bourbon virus, indicating it as a goo…

Dementia Screening test: the AD8
Galvin, James ; Morris, John ; Roe, Catherine
T-007516

— The AD8 is an 8 question interview tool which distinguishes individuals with very mild dementia from those without dementia, regardless of etiology. The AD8 is based on intraindividual decline and has been demonstrated to be a valid and reliable screening tool for dementia.

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human SIRP-B2
Colonna, Marco
T-005412

— Target: Cluster of Differentiation 172g protein, a.k.a. Signal Regulatory Protein Beta-2. Notes: Clone name is LSB2.20.Monoclonal antibodies were raised in a 4-to 8 week-old female Balb/c mouse by immunozation with a recombinant GST fusion protein containing the whole extracellular domain of SIRPB1. These can be used to study T-cell activation and the induction of antigen-specific cytotoxic T-lymphocyte responses by…

Photoacoustic tomography of human brain
Anastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043

— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

ANKO mice and ANKI mice
Imai, Shin-Ichiro ; Rosen, Evan
T-018529

— Description: Publications:

TZ4877 and 18F-radiolabeling precursor TZ50153
Tu, Zhude "Will"
T-017602

— TZ4877 is a ligand for the sphingosine-1-phosphate (S1P) receptor 1 in the CNS, developed and radiolabeled with fluorine-18. TZ4877 is the standard (non-radioactive compound) which is used for HPLC analysis of the S1P1 PET tracer, [18F]TZ4877. TZ50153 is the radiolabeling precursor of the PET tracer…

A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma
Wang, Xiaowei
T-012911

— Oropharyngeal squamous cell carcinoma (OSCC) rates have increased significantly in recent years, and because of the different underlying causes of the disease no single treatment regime seems to be advantageous over another. Currently, the prognosis of OSCC is based on clinical features of the OSCC…

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Two color HRas and single color CD86 plasmids
Foust, Daniel ; Piston, David
T-019195

— New combinations of labeled membrane proteins and G-protein subunits. These include twocolor HRas and single color CD86 controls as well as labels beta and gamma subunits of the heterotrimeric G-protein complex. All of these have been built using plasmids from Addgene.

Deep Learning-Assisted Image Reconstruction for Tomographic Imaging
Anastasio, Mark ; Kelly, Brendan ; Matthews, Thomas
T-017311

— Background Image reconstruction for any modern imaging technique is an optimization problem. Most image reconstructions methods are iterative in nature and produce sequential intermediate images that are compared to the raw acquisition data and subsequently updated to maximize the likelihood that t…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155
Colonna, Marco
T-005410

— Target: Cluster of Differentiation 155 protein, a.k.a. Poliovirus Receptor. Notes: Clone name is SKII.4.

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

LDLR-Tg Mice
Holtzman, David
T-018027

— Description: LDLR transgenic mice Publication:

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD226 (DNAM-1)
Colonna, Marco
T-005408

— Target: CD226 is a glycoprotein expressed on natural killer cells, platlets, monocytes and a subset of T cells. Notes: Clone name is 11A8, used for flow cytometry.

Treatment for Centrally Mediated Itching
Chen, Zhou-Feng ; Sun, Yan Gang
T-006757

— Background: Severe itch (or pruritus) is associated with multiple diseases such as liver disease, non-Hodgkin’s lymphoma, psoriasis, and common eczema and is also a side effect of many treatments including analgesics (like morphine) and renal dialysis. Chronic pruritus is a top reason for derm…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

BOOM-TCRtg mice
Allen, Paul ; Donermeyer, David
T-019192

— BOOM TCRtg mice express a T cell receptor specific for the Bt4295(541-554) epitope of the commensal bacteria Bacteroids thetaiodaomicron. This is the first mouse TCRtg line developed specific for B. theta.

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean
T-019338

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…

pAAV-CBA/LDLR and pAAV-CBA/mTFP plasmids
Holtzman, David
T-017612

— Description: Plasmids encoding LDLR and TFP developed by Dr. David Holtzman and colleagues. Note: Contact for additional information. Plasmid maps are available.

Chimeric Artificial Interference RNA (aiRNA) for RNAi-based cancer therapy
Wang, Xiaowei
T-014021

— Technology Description In search of more effective cancer treatments, inventors in Dr. Xiaowei Wang’s lab at Washington University School of Medicine have developed artificial interference RNA (aiRNA). aiRNA is a patented chimeric RNAi that combines the multi-target abilities of miRNAs and t…

Anti-PDZ TIP1 Antibody Therapy for Cancer
Hallahan, Dennis ; Kapoor, Vaishali ; Yan, Heping
T-017064

— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human NKp30
Colonna, Marco
T-005378

— Target: NKp30 (aka CD337) is an natural killer cell receptor. Notes: Clone name is AF29-4D12.

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

Brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers
Grigsby, Perry
T-012905

— Technology Description Researchers in Dr. Perry Grigsby’s lab have developed a patented brachytherapy device for outpatient, MRI-guided treatment of gynecological cancers. Gynecological cancers, such as recurrent endometrial and cervical cancers, can be treated with brachytherapy, but requir…

anti-IL-26 antibodies
Cella, Marina ; Colonna, Marco
T-019424

— Mouse monoclonal antibodies recognizing human IL-26

Chinese Hamster Ovary Cell Line Expressing Human Follicle-Stimulative Hormone (FSH) / Human Luteinizing Hormone (FSH)
Boime, Irving
T-012328

— Description: Cell lines individually expressing the following hormones: Lutenizing hormone (LH), Thyrotropin (TSH) and Follitropin (FSH). Publications:

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD158i
Colonna, Marco
T-005376

— Target: A member of the killer immunoglobulin-like receptor (KIR) family expressed on natural killer cells. Notes: Clone JJC116

Intraocular Artificial Lenses
Ravi, V. Nathan
T-006771

— The present hydrogel technology can be used as a lens replacement material for the permanent treatment of cataracts and presbyopia as well as a vitreous substitute. This co-polymeric hydrogel system can be reversibly converted between a hydrogel in the oxidized state and a solution in the reduced st…

MR-HIFU acoustic coupling device to improve performance and reduce side effects
Altman, Michael ; Chen, Hong ; Kothapalli, Veera "Satya" ; Xie, Kevin
T-017089

— Technology Description Engineers in Prof. Hong Chen’s laboratory have developed a multifunctional, MR-compatible device designed to improve the performance of Magnetic Resonance High Intensity Focused Ultrasound (MR-HIFU) by increasing the efficiency of the ultrasound transmission, cooling t…

Hamster Monoclonal IgG2a Antibody against Mouse IFN-Beta
Schreiber, Robert ; Sheehan, Kathleen
T-012057

— Description: HDbeta-4A7- mouse IgG2a monoclonal antibody reactive with murine Interferon-beta. This mAb has neutralizing activity. Publication:

Spinning Spheres for Magnetic Resonance
Albert, Brice ; Barnes, Alexander
T-017912

— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD155 (PVR)
Colonna, Marco
T-005375

— Target: CD155 is a adhesion receptor, orginally known as the cellular receptor for Polio Virus. Notes: Clone name is SK II 4.3Information on antibody against poliovirus receptor (CD155) Herein, we describe the generation of a murine antibody that recognizes poliovirus receptor (CD155). We made this antibody by immunizing mice with SK-N-S1 human neuroblastoma cells. We then validated this antibody using flow cytometry. …

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

C3-knockout mice
Atkinson, John ; Wu, Xiaobo
T-019398

— Genetic disruption of murine C3 promotor region generates deficient mice with extrahepatic expression of C3 mRNA

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human CD96 (Tactile)
Colonna, Marco
T-005374

— Target: CD96 is a T cell-specific receptor indicative of T cell activation. Notes: Clone name NK92.39.1. For use in flow cytometry.Researchers generated the antibodies by immunizing mice with NK92 cells and selected hybridomas that plocked binding of PVR to NK92. These antibodies have been used to study natural killer cell target cell adhesion. Publication: Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by …

Novel Method and Device to Produce Fluorine-18 PET Tracers
Chu, Wenhua ; Zhou, Dong
T-015970

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Hamster Monoclonal IgG Antibody against Mouse IFN-Alpha
Schreiber, Robert ; Sheehan, Kathleen
T-012056

— Description: TIF-3C5- Armenian hamster monoclonal antibody reactive with murine Type I Interferons, including IFN alpha A, 1, 4, 5, 11 and 13 but not IFNbeta. This mAb can block functional activity. Publication:

Cochlear Fluids Simulator
Salt, Alec
T-018692

— Background: Local drug therapy of the inner ear became popular in the 1990s to treat a number of ear disorders. Local therapy allows the drug to bypass entry barriers, reducing systemic toxicities. For novel drugs to be delivered to the inner ear, pharmacokinetic (PK) values such as half-life and ma…

Methods to Treat Vasodilatory Septic Shock
Boyle, Walter
T-007528

— Background: Vasodilatory shock, a reduction in effective blood circulation, occurs when endogenous vasoconstrictor mechanisms fail as a result of an often lethal combination of severe infections. Sepsis, as one of the causes, alone affects 1 million people resulting in more than 258,000 deaths each …

pAH198 — plasmid containing ColE1
Hoynes-O'Connor, Allison ; Moon, Tae Seok
T-019379

— A plasmid containing the E. colil ColE1 origin of replication, a chloramphenicol (antibiotic) resistance cassette, and a tetracycline-inducible antisense RNA gene regulator containing a target binding region (TBR) and the synthetic MicF M7.4 Hfq binding site for additional stability in the RNA molec…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Murine Hybridoma producing Monoclonal Antibodies against Human NKp44
Colonna, Marco
T-004356

— Target: NKp44 is a novel triggering surface molecular specifcially expressed by activated natural killer cells. Notes: Clone name 448.189 Marco Colonna, MDInventors generated NKp44 monocolonal antibodies by immunizing mice with a NKp44-human crystallizable fragment (Fc) fusion protein. The antibodies have been used to study innate and adaptive immune responses. Publication: Paradoxic inhibition of human natural interferon-producing cells by the activ…

STAT1 Knockout Mice
Schreiber, Robert
T-001007

— Notes: STAT1-/- knockout mouse with a 129S6 backgroundInventors used homologous recombination techniques to create mice that lack functionally active STAT1. Characterization studies reveal that STAT1-deficient mice display a global state of unresponsiveness to either IFNα or IFNγ and are unable to resolve infections by microbial pathogens a…

High resolution imaging using subwavelength grating structures
Shen, Jung-Tsung ; Shen, Yuecheng ; Wang, Lihong
T-012856

— Conventional optics are generally restrained by a law of physics known as the diffraction limit, which dictates that optical systems can only resolve images down to about half the wavelength of the light used to produce the image (λ/2), or down to about 200 nanometers for most standard optics…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Chikungunya Monoclonal Antibodies
Diamond, Michael ; Fremont, Daved
T-010020

— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus Publication:

New PARP-1 Inhibitors for Imaging PARP-1 Expression in Vivo
Chu, Wenhua ; Rogers, Buck ; Xu, Jinbin ; Zhou, Dong
T-018730

— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Portable patient isolation and sample collection system to prevent spread of COVID-19 and other respiratory infections
Iqbal, Zahid
T-019400

— Technology Description Dr. Zahid Iqbal at Washington University in St. Louis has devised a portable, wearable patient isolation/oxygenation system designed to protect health care workers from respiratory infections (e.g., COVID-19) while facilitating diagnostic sample collection. This viral contai…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Armenian Hamster Anti-Mouse Properdin Monoclonal Antibody (clone H4)
Bertram, Paula ; Hourcade, Dennis
T-014378

— Target: Full length mouse properdin Application(s): Western blot and immunofluorescenceTwo functional properties of one of the two hamster antibodies have been examined, the H4 subclone of the 3D12 clone. In experiments the H4 antibody was used to identify mouse properdin present in histological sections, to block mouse properdin function in vitro, and to ameliorate complement alterna…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Isochoric Actuator
Cashin, John ; Genin, Guy ; Lee, Sanghun ; Zayed, Mohamed
T-019219

— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.

Drug target and biomarker for multiple sclerosis
Klein, Robyn ; Williams, Jessica
T-017623

— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…

Software to assemble HLA alleles using short paired reads from exome sequencing data
Liu, Chang ; Pfeifer, John
T-013332

— Technology Description: In collaboration with the scientists at Broad Institute, WU scientists have developed a new software with a new algorithm that enables HLA high resolution typing from exome sequencing data. It will provide a significantly better tool to guide the bone marrow transplantation a…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Crispr developed SARM1 Knockout Rat
DiAntonio, Aaron ; Milbrandt, Jeffrey
T-018728

— Crispr developed SARM1 Knockout Rat

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Crry-deficient mouse strain
Atkinson, John ; Molina-Vicenty, Hector
T-003105

— Crry-knockout mouse strain (Crry -/-)Researchers generated mice deficient in Crry by disrupting exon 5 of the mouse Crry gene. The mice are sensitive to complement deposition and activation, especially the C3 component of complement on the surface of the placenta. Publication: A Critical Role for Murine Complement Regulator Crry in Fe…

Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)
Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450

— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Novel Method and Device to Produce Fluorine-18 PET Tracers
Zhou, Dong
T-019276

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Enantiomeric16-ketosteroids and Related Tetracyclic & Tricyclic Analogues with Neuronal Actions
Covey, Douglas
T-011272

— Neurosteroids are of great interest because of their ability to alter brain function. Compounds of the type disclosed here have potential to be new drugs useful for causing anesthesia and treating depression, anxiety, sleep disorders, seizures.

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Eastern Equine Encephalitis virus (EEEV) antibodies
Diamond, Michael
T-018711

— Eastern Equine Encephalitis virus (EEEV) antibodies

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Comfortable radiotherapy couch to improve precision and accuracy
Mutic, Sasa ; Zhao, Tianyu
T-018538

— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

AAVLenti-WFS1 (adeno-associated virus expressing WFS1, lentivirus expressing WFS1)
Urano, Fumihiko
T-018716

— Adeno-associated virus expressing WFS1, lentivirus expressing WFS1

Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCL9
Schreiber, Robert ; Sheehan, Kathleen
T-005944

— Target: Inflammatory chemokine CXCL9, monokine induced by IFN-gamma. Secreted mainly by macrophages. Notes: Clone MIG-2F5-5. Use in ELISA, neutralizing and binding assays.

pTrc-eYFP Construct
Pakrasi, Himadri
T-018769

— This self-replicating plasmid is a derivative of pPMQAK1-BBa_P1010 and contains an expression-enhanced YFP gene under the control of an inducible Trc promoter. This plasmid was used to demonstrate that transgenic DNA could be introduced to Synechococcus UTEX 2973 cyanobacteria cells using conjugatio…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Stable, non-toxic lead-free perovskite materials for high efficiency solar cells and other semiconductor applications
Biswas, Pratim ; Kavadiya, Shalinee ; Mishra, Rohan ; Thind, Arashdeep Singh
T-018532

— Engineers at Washington University in St. Louis have discovered a new class of stable, benign perovskite semiconductor materials with performance properties optimized for solar cell and photocatalysis applications. Traditional lead-halide perovskites show remarkable power conversion efficiency in ph…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCR3
Schreiber, Robert
T-005883

— Target: C-X-C chemokine family member (CXCR3). Expressed on NK cells, activated T lymphocytes, select endothelial and epithelial cells.Hamsters were immunized with a multiple antigens peptide-8 (MAPS-8) encompassing amino acids 1 to 37 of mouse CXCR3 in complete Freund’s adjuvant, and boosted with peptide in incomplete Freund’s adjuvant. Hamsters showing ELISA seropositivity for CXCR3 peptide were boosted and hybridomas gen…

VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745

— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

geOMV: Bacterial vaccine development platform using glycoengineered microbes
Feldman, Mario
T-015094

— Technology Description Researchers in Prof. Mario Feldman’s laboratory have developed a patented, versatile, cost-effective platform for creating new multivalent vaccines for a variety of Gram-negative and Gram-positive bacteria. This technology, glycoengineered outer membrane vesicles (geOM…

cryaa-R49C knock-in mice
Andley, Usha
T-018903

— Knock-in mice with a mutation in alpha-crystallin (cryaa-R49C) that causes cataracts. A knock-in plasmid was generated by cloning the 5′ and 3′ arms of the mouse RAcrystallin gene, followed by mutation and homologous recombination in mouse embryonic stem cells, which were implanted into …

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

New diagnostic test method for infectious diseases
Storch, Gregory
T-013735

— Background: Viral infections are common causes of fever without an apparent source (FWS) in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leuko…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hamster Hybridoma producing Monoclonal Antibody against Murine IFNAR-1
Schreiber, Robert ; Sheehan, Kathleen
T-004451

— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway. Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization. Publication:

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

HoxB5 cDTR mice
DiPersio, John ; Karpova, Darja
T-018897

— Transgenic HoxB5 conditional DTR (cDTR) mice have been generated using CRISPR mediated targeting of the HoxB5 gene (exon2) in fertilized wildtype C57Bl/6 eggs that were then microinjected into pseudopregnant wildtype female mice. The construct targeted under the controls of the endogenous HoxB5 prom…

Macrocyclic Molecular Beacons Useful for Medical applications
Achilefu, Samuel ; Ye, Yunpeng
T-004044

— Technology Description: Macrocyclic Molecular Beacons Useful for Medical applications :US 20070098638 (published US application) : The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocy…

Scanning Apparatus for Reflection-Mode Photoacoustic Tomography
Maslov, Konstantin ; Wang, Lihong
T-007645

— The greatest limitation on clinical use of existing photo-acoustic imaging technologies is the slow scanning speed caused by mechanical scanning, the bulky design of the scanning apparatus, and the necessity to immerse the body part into a ultrasonic coupling liquid. The present invention overcomes…

Paper-Based Assays for Primary Hemostasis and Thrombosis
Bark, David
T-019975

— Paper-Based Assays for Primary Hemostasis and Thrombosis Technology Description Researchers in Dr. David Bark’s laboratory at Washington University have developed a method that allows for the evaluation of various flow-dependent pathways of hemostasis on microfluidic paper-based analytical d…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Huang, Li-Hao ; Randolph, Gwendalyn ; Zinselmeyer, Bernd
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

Software that Generates Radiology Reports using Deep Learning
Kansagra, Akash ; Rahbar, Kasra
T-018976

— T-018976 Software that Generates Radiology Reports using Deep Learning Technology Description Researchers at Washington University in St. Louis have developed a computational software method designed to assist radiologists with generating and correcting patient reports more effectively. Radiolo…

Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological Tissue
An, Woo Jin ; Wang, Lihong
T-010123

— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…

Plasmids for pDD56, pDD57, pDD87, pDD103, pDD108, pDD112, pDD120, pDD131, pDD132, and pDD143
Moon, Tae Seok
T-018853

— o pDD56: a shuttle vector between Escherichia coli and Rhodococcus opacus PD630 that contains arabinose inducible EYFP on pAL5000/pMB1 backbone with kanamycin resistance. o pDD57: a shuttle vector between Escherichia coli and Rhodococcus opacus PD630 that contains a constitutively expressed GFP+ on…

Armenian hamster anti-mouse TCR Vb 8.3 IgG3 monoclonal antibody (clone 1B3.3)
Allen, Paul
T-000304

— Target: Full length mouse Vb 8.3 TCR but not 8.1 or 8.2. Vb 8.3. Application: Flow cytometryThis antibody was made by immunizing Armenian hamsters. It was used to study the mechanisms that act to keep only one functional TCR beta-chain per cell and the effect of selecting ligand density on positive selection and endogenous receptor usage in mice. Publication: TCR transgenic mice in which …

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Cryopreserved sperm from Bnip3-KO mice, Nix KO mice, and Nix floxed allele mice
Dorn, Gerald
T-018843

— Bnip3-KO mice: These were generated by replacing exons 2 and 3 with a neomycin resistance cassette. Recombinations were identified via southern blot. Publication: Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice Nix KO m…

B-122 and Alf-161 – Hamster IgG Monoclonal Antibodies against Mouse/Rat IL-1 Beta and Mouse IL-1 Alpha
Schreiber, Robert
T-000125

— Target: Mouse/rat interleukin-1 beta and mouse interleukin-1 alpha. Located on macrophages, dendritic cells, T and B cells. Notes: Clone name is B-122 and Alf-161Information on antibodies against IL-1 beta: The role of murine IL-1 beta in vitro and in vivo has not been defined. We describe here the production of neutralizing and immunoprecipitating mAb and polyclonal antibodies specific for murine IL-1 beta and their application to a characterization of the…

Miniature, portable device for measuring exposure to airborne nanoparticles
Chen, Da-Ren ; Qi, Chaolong
T-006838

— Technology Description Engineers in Prof. Daren Chen’s laboratory have developed a patented portable device for sampling and measuring nanoaerosols for industrial hygiene and aerosol science applications. Currently, a variety of industrial applications require the chemical synthesis of submi…

Absolute Perfusion Reserve (T-020127)
Bugenhagen, Scott
T-020127

— Ask Experimental de-risking strategy Regulatory advice Background: Fractional flow reserve (FFR) is the current gold standard for grading coronary artery stenoses; however, more recent studies have demonstrated no significant improvement in primary patient outcomes when using FFR…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Intestinal biomarker predicts response to treatment for inflammatory bowel disease
Stappenbeck, Thaddeus ; VanDussen, Kelli
T-019186

— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Deep Tissue Diagnostics with Disposable Fiber-Optic Device
Hu, Song ; Ling, Jingwei ; Yang, Shuo
T-020656

— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…

IL-1 beta deficient mice
Chaplin, David ; Ferguson, Thomas
T-001876

— Mouse strain deficient in IL-1 betaInventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Targeting CD5+ Dendritic Cell in Skin for the Treatment of Chronic Diseases
Klechevsky, Eynav
T-016609

— Background Dendritic cells (DCs) are antigen-presenting cells that are essential to the adaptability of the immune system. Several subsets of DCs have been identified in tissues that interface with the environment (e.g. skin, mucosal lining). While the role of specific DC subsets are unknown, DCs p…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Lrp1 and the Blood Brain Barrier
Amarasinghe, Gaya ; Ganaie, Safder ; Leung, Daisy ; Virgin, Herbert
T-019577

— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

T-018741 & T-019450 – Computational Improvements of Immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— T-018741 & T-019450 – Computational Improvements of Immunoassays Technology Description Researchers in Mark Zaydman’s laboratory at Washington University have optimized a new method to improve the analytical measurement range (AMR) in homogeneous turbidimetric immunoassays. The method ut…

TREM2 blockade as an adjuvant for checkpoint inhibitors
Colonna, Marco
T-019371

— Disease indication – In combination with anti-PD-1 therapy for cancer. Anti-PD-1 therapy is currently approved for: Drug format – Monoclonal antibody Drug class – First-in-class Target – TREM2 Research stage and preliminary data – The inventors performed initia…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Humanized rat model of Wolfram Syndrome
Urano, Fumihiko
T-019403

— A humanized rat model of Wolfram Syndrome carrying a Wfs1 gene mutation corresponding to human WFS1 gene point mutation with a stop codon at position a.a. 452.

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Steerable Thermoablation Probe for Improved Access to Brain Lesions
Leuthardt, Eric
T-015768

— Technology Description An interdisciplinary team led by Professor Eric Leuthardt has developed a steerable device that can be integrated into existing thermoablation systems to treat abnormal brain lesions. Thermoablation is a more targeted and less disruptive method for treating lesions than chem…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Humanized mouse model for Wolfram Syndrome
Urano, Fumihiko
T-019402

— A mouse model of Wolfram Syndrome carrying a pathogenic variant of Wfs1 gene corresponding to human WFS1, c.1672C > T (p.R558c) missense mutation in exon 8 of WFS1.

Simple, universal DNA motifs for modulating protein production
Djuranovic, Sergej
T-016819

— Technology Description Researchers in Prof. Sergej Djuranovic’s laboratory have discovered short DNA coding motifs that can increase or decrease expression of recombinant proteins by 3-4 orders of magnitude in a variety of organisms. Together, these universal tools can provide tightly contro…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Vectors for study of Wolfram Syndrome
Abreu, Damien ; Urano, Fumihiko
T-019395

— Dr. Fumihiko Urano is director of the Wolfram Syndrome International Registry at WU and has developed many research tools for studying Wolfram Syndrome. The following constructs contain the wildtype WFS1 gene with various flags, or mutations of WFS that cause mild forms of Wolfram Syndrome (019395)…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …

Stem cells that produce decorin
Guilak, Farshid ; Pferdehirt, Lara
T-019343

— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Toolkit to efficiently design exact pulse code sequences for MRI, NMR or quantum computing
Li, Jr-Shin
T-017456

— Technology Description Engineers in Prof. Jr-Shin Li’s laboratory have developed a computationally efficient analytical technique to design exact RF pulse code sequences which optimize quantum applications such as MRI for medical diagnosis, NMR spectroscopy for uncovering protein structures …

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Optical Coherence Computed Tomography
Li, Li ; Wang, Lihong
T-008832

— Optical coherence tomography (OCT) utilizes optical light to obtain an image of opaque or translucent objects, ie tissue. Because scattered light contributes to the bluring found in other optical imaging techniques, OCT filters out all the scattered light. An image is formed using only the back refl…

Ncr1-ERT2iCre Mice
Fehniger, Todd
T-018981

— This mouse strain is a novel Natural Killer cell specific inducible cre that is useful for studying the development, maturation, and function of NK cells. It has a tamoxifen inducible Ncr1-ERT2iCre mouse allele that is used for floxing gene(s) of interest out of NK cells. This model was designed, cr…

Breath-based testing for malaria
John, Audrey Odom "Audrey Odom" ; Schaber, Chad ; Trehan, Indi
T-016183

— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…

CellTags: Tracking Individual Cells during Cell Reprogramming
Morris, Samantha
T-018555

— Background Cell populations are quite heterogeneous yet are typically analyzed in bulk, masking unique behavioral features. This is particularly problematic in cell reprogramming, where in a given population of cells, only a small number complete reprogramming. Single-cell technologies address the …

A Truly Tumor-Specific Epitope Carried by BG-A Antigen for Cancer Diagnosis and Treatment
Xu, Mai
T-016998

— Background: In the US alone, 154,000 new cases of colorectal cancer (CRC) are diagnosed each year. Unfortunately, a third of those patients will die due to diagnosis at late stages – the 5-year survival rate is 11%, compared to 91% for those who are diagnosed with only localized CRC. A colonos…

Radiotracers to detect early Parkinson’s disease
Kotzbauer, Paul ; Qiu, Lin ; Tu, Zhude "Will" ; Yu, Yanbo
T-020559

— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…

Mouse with Arg1809Cys Nf1 gene mutation
Gutmann, David
T-019336

— This mouse strain was designed to harbor a specific NF1 patient germline NF1 gene mutation.

Wfs1 gene knockout INS-1 cells
Urano, Fumihiko
T-018980

— Pancreatic beta cell line lacking Wfs1 gene created by CRISPR/CAS9

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

Small molecules that inhibit Ebola viral VP35
Amarasinghe, Gaya
T-019326

— VP35 is involved in multiple functions crticial to viral replication in filoviruses such as Ebola and Marburg virus. Viruses with VP35 mutations are attenuated in in vivo models. 5.4 million compounds were screened for their ability to bind to VP35 at the key protein-to-protein interface. The screen…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Wfs1 gene knockout NSC34 cells
Urano, Fumihiko
T-018979

— Neuronal cell line lacking Wfs1 gene by CRISPR/CAS9

8IGHT WAYS to Stay Healthy and Prevent Disease
Colditz, Graham
T-013927

— One important aspect for individuals to maintain health and prevent disease is through an educational understanding of making healthy choices while avoiding unhealthy choices. Clinicians at Washington University in St. Louis have created an evidence-based guide to disease prevention and healthy liv…

Tetrahedron Beam Computed Tomography with Multi-pixel X-ray Source
Zhang, Tiezhi
T-015342

— About 70 million computed tomography (CT) scans are performed in the United State alone each year. Traditional helical scanners use a single point x-ray source that rotates around the patient, acquiring images in sequential slices, which results in high quality images. But these helical scanners a…

Real-time 3D MRI
Kim, Taeho ; Park, Chunjoo (Justin)
T-019011

— Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used in diagnostic MRI and MRI-guided radiotherapy (MRgRT). MRgRT combines medical imaging with radiation therapy to provide visualization of the tumor…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Small molecules targeting KCNQ in ventricular arrhythmia
Cui, Jianmin
T-013554

— Disease indication – Long QT Syndrome (resulting in ventricular arrhythmia, epilepsy, deafness) Drug format – Small molecule Drug class – Lead compounds are repurposed drugs Research stage and preliminary data – Based on in silico screening of KCNQ, the researchers selecte…

MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trials
Yablonskiy, Dmitriy ; Zhao, Yue
T-015754

— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …

Antibodies to MDK
Hallahan, Dennis ; Kapoor, Vaishali
T-018978

— MDK is a molecular target for treatment of cancer. These antibodies are to the functional domain of MDK.

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-016668

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

Antibody to SPRR3
Ladenson, Jack ; Young, Pampee
T-004462

— Analyte: Small proline rich protein 3 (gene SPRR3) Antibody codes: 3E9.1 (4587), 4G3.1 (4563), and 2F10.2 (4604) Publications:

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

CHIKV-3’Cre – recombinant Chikungunya virus expressing Cre
Lenschow, Deborah
T-019567

— This is a recombinant clone of the Chikungunya LR2006 virus expressing Cre recombinase inserted downstream of a subgenomic promoter. In vitro transcription and transfection of RNA derived from this plasmid into cells will result in the generation of Chikungunya virus that expresses Cre recombinase i…

Plasmid (pHW2000): Development of a reverse genetics system for Bourbon virus
Boon, Adrianus "Jacco"
T-019027

— A plasmid based reverse genetics system for Bourbon virus was created. This system and related plasmids allow for the creation of infectious Bourbon virus and evaluate the impact of genetic variation on the virus (replication, disease, antibody-mediated neutralization etc.). It also allows for the c…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Engineered Oncolytic Zika Virus Therapy for Glioblastoma
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

MAP3K6-knockout mouse
Boon, Adrianus "Jacco"
T-019026

— CRISPR-Cas9 gene editing was used to modify the coding region of the MAP3K6 mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6J genetic background. MAP3K6 is a signaling molecule and could be the target …

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

NMI knockout mice
Boon, Adrianus "Jacco"
T-019025

— CRISPR-Cas9 gene editing was used to modify the coding region of the NMI mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made the C57BL/6J genetic background. NMI is a host protein involved in innate immune signaling a…

Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Gaehle, Gregory ; Lawrence, Luke ; Zerkel, Patrick
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

PET Radiotracers for Imaging Free Radicals and Reactive Oxygen Species (Materials: WC-4-77)
Chu, Wenhua ; Dugan, Laura ; Mach, Robert ; Mintun, Mark
T-009254

— Many diseases can be associated with abnormal production of reactive oxygen species (ROS) due to oxidative stress. Currently there is no way to image this in situ. Dihydroethidium (DHE) naturally produces a fluorescent product when oxidized by an ROS. The signal is not strong enough for practical im…

Irg1 conditional knockout mouse
Diamond, Michael
T-019215

— Irg1−/− mice were generated after receiving embryonic stem cells (ESCs) from the Knockout Mouse Project Repository containing an insertion cassette between exons 3 and 4. This cassette prevents transcription of downstream exons 4 and 5 and production of mature protein. Irg1−/&minu…

Parity-Time Symmetric Whispering-Gallery-Mode Microcavities Sensor
Ozdemir, Sahin ; Peng, Bo ; Yang, Lan
T-014053

— A non-reciprocal transmission device based on PT symmetry was previously theorized but never before constructed and shown to work at useful optical wavelengths. The new structure allows creation of the miniaturized optical isolation function without use of the century+ known Faraday effect. Optica…

Tumor detection by targeting and monitoring integrin expression using synergistic effects of molecular beacons and peptides
Achilefu, Samuel
T-005371

— Background: Integrins are multi-subunit transmembrane proteins involved in a wide range of cellular processes including the induction of new blood vessel formation and tumor metastasis. The growth of new blood vessels, termed angiogenesis, is associated with an altered integrin expression profile wh…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Data security for IoT and mobile devices using Bit2RNG random number generator with no additional hardware
Yan, Wei ; Zhang, Xuan "Silvia"
T-019418

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a robust true random number generator (RNG) designed to be used as a low-resource security system for mobile and internet-of-things (IoT) devices. This technology, called “Bit2RNG&rdqu…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

pRRLsinPGK-GFPppt and FCIV plasmids
Li, Mingjie
T-019021

— pRRLsinPGK-GFPppt : Plasmid DNA directing expression of green fluorescent protein in a lentiviral shuttle vector under the control of the phosphoglycerate kinase (PGK) promoter. FCIV: Plasmid DNA directing expression of Venus (a fluorescent protein) in a lentiviral shuttle vector under the control o…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Suicide plasmid pSL2231
Pakrasi, Himadri
T-019201

— pSL2231 is a derivative of pBR322 that can be used to delete the nblA gene in Synechococcus UTEX 2973. Publication: Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2

Human Monoclonal Antibodies for Influenza Virus
Ellebedy, Ali
T-019018

— These are recombinant human monoclonal antibodies that are directed against two conserved internal proteins of the influenza virus.

Universal Targeted Drug Delivery and Imaging Platform
Barnes, Jonathan ; Delawder, Abigail "Abby" ; Li, Ruihan ; Li, Xuesong
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

UPAB1 plasmid lacking pAB5
Di Venanzio, Gisela ; Feldman, Mario
T-019205

— An UPAB1 derivative, UPAB1p-, that spontaneously loss pAB5 was identified by detection of restored Hcp secretion and isolated via an ELISA. Compared to wildype UPAB1, UPAB1p- displayed comparable growth in vitro in both rich medium and urine from healthy donors, indicating that less pAB5 did not in…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

CD226 (DNAM1) knockout mice
Colonna, Marco ; Gilfillan, Susan
T-019563

— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…

SAMD9L-knockout mice
Boon, Adrianus "Jacco"
T-019004

— CRISPR-Cas9 gene editing was used to modify the coding region of the SAMD9L mouse gene. The genetic modification resulted in the deletion of the full length production of the protein. This modification was made in a C57BL/6 genetic background.

Target and small molecule drugs to selectively neutralize bacteria in urinary tract infections
Henderson, Jeffrey P.
T-018628

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have discovered a drug target and a class of small molecule candidates that could be used to selectively prevent pathogenic enterobacteria from causing diseases such as urinary tract infections (UTIs). Currently, UTI…

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal Inoculation
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064

— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Albring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Barbed mesh for fast, suture-less surgical wound closure
Felder, John
T-018828

— Technology Description: A surgeon at Washington University in St. Louis has designed a barbed mesh wound closure device with the potential to save time and improve outcomes by eliminating the need for surgical suturing to close incisions of the skin and fascia. This device has applications in a var…

Shuttle vectors for gene expression in E. Coli and Cyanobacteria
Pakrasi, Himadri
T-019193

— Two shuttle vectors, pCA-UC118 and pCB-SC101, capable of replication in both Synechocystis 6803 and E. coli. Expression of reporter proteins were significantly enhanced in cells containing these new plasmids, thus providing superior gene expression platforms in this cyanobacterium. Publication: …

S1PR2-targeted PET tracers
Klein, Robyn ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-018580

— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

Irf8 Delta32 Mice
Murphy, Kenneth
T-019003

— Irf8 Delta32 mice have a CRISPR targetted deletion in the enhancer of the mouse Irf8 gene located at +32 kilobases from the Irf8 gene promoter. This deletion removes the binding site for the Jun/Batf3/Irf8 complex and results in a complete and permanent elimination of the development of the cDC1 lin…

Plasmid to test regulation 5′ untranslated sequences in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019560

— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…

Venezuelan equine encephalitis virus (VEEV) E2 DNA plasmid
Diamond, Michael ; Kim, Arthur
T-019082

— VEEV E2 DNA plasmid

SILTmass software
Bateman, Randall ; Elbert, Donald
T-008416

— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…

Plasmids for cyanobacterial CRISPRi and high sucrose production
Pakrasi, Himadri
T-019345

— Plasmid for CRISPR interference in Synechococcus sp. UTEX 2973: pSL3287 (Addgene), included in publication: Tunable repression of key photosynthetic processes using Cas12a CRISPR interference in the fast-growing cyanobacterium Synechoccoccus sp. UTEX 2973 Plasmids for high level of sucrose produ…

DNA Plasmids for the Modulation of Gene Expression
Lee, Young Je (Ryan) ; Moon, Tae Seok
T-019002

— These set of plasmids allow for the repression and de-repression of fluorescent proteins (GFP and mCherry) through CRISPR interference and antisense RNA. Publication: Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system

Decision support process for cerebral aneurysm pattern recognition in microsurgical/endovascular decision support system
Dacey, Ralph ; Ju, Tao ; Washington, Chad
T-012982

— Cerebral Aneurysms are weak areas in the wall of a blood vessel causing it to bulge out. These aneurysms can take on many sizes, shapes, and be in different locations. Currently cerebral angiographies, spinal tap, CT or MRI are used to diagnose cerebral aneurysm. Treatment options are chosen by a do…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

IP-10 as a blood biomarker of respiratory failure
Mudd, Philip
T-019671

— Technology Description Researchers in Philip Mudd’s lab at Washington University have developed a blood biomarker test that detects impending respiratory failure before existing diagnostics. High levels of the biomarker IP-10 in the blood are correlated with the subsequent development of acu…

Mouse bladder cancer organoid cell line MCB6A
Arora, Vivek ; Bolzenius, Jennifer
T-019309

— MCB6A organoids generate urothelial tumors with features similar to the basal-squamous subtype of urothelial carcinoma, the most common bladder cancer. MCB6A harbors 1,524 mutations, including mutations in Kdm6a and Trp53. Publication: CD4+ T cells induce rejection of urothelial tumors after imm…

Cd40lg-Cre mouse
Chou, Chun ; Egawa, Takeshi
T-018831

— Cd40lg-Cre mouse

Microbiome Biomakers of Obesity
Gordon, Jeffrey ; Turnbaugh, Peter
T-007697

— Technology Summary: Obesity rates worldwide are increasing at an astounding rate. While diet, lifestyle, and physical activity have traditionally been identified as the main causative factors, researchers at Washington University are the first to implicate gut bacteria (microbiome) as a new drivin…

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Vaccines and antibodies against malaria and other parasitic diseases in humans and animals
Jimah, John ; Tolia, Niraj
T-016150

— Technology Description Researchers in Prof. Niraj Tolia’s laboratory have exploited structure-based vaccine design to develop immunogenic compositions and neutralizing antibodies that could protect against malaria and a range of other parasitic diseases that affect humans, livestock and comp…

Cas9-based plasmids for engineering Synechocystis sp. PCC 6803 cyanobacteria
Zhang, Fuzhong
T-018507

— These plasmids were developed by Washington University researchers as tools for genetically engineering Synechocystis sp. PCC 6803 (S6803), a model cyanobacterium used commonly in research and biotechnology applications. Because S6803 is polyploid, genetic modification of this strain typically requi…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Plasmids to express tagged genes in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019559

— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…

Elastin conditional knockout mouse
Mecham, Robert ; Wagenseil, Jessica
T-019289

— Mouse with floxed elastin gene to conditionally inactivate elastin gene expression. Publication: Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development

Egr1Cre;Snap25Flp mice (On deposit with Jackson Labs – Strain 033895)
Dougherty, Joseph
T-018757

— Egr1Cre;Snap25Flp mice

αB-crystallin (cryAB) R120G mutant knock-in mice
Andley, Usha
T-018700

— Researchers developed these knock-in mice by using homologous recombination to clone the R120G mutation into exon 3 of the αB-crystallin gene (cryab). αB-crystallin (cryAB) helps to maintain protein stability in the eye lens, which is necessary for transparency. The R120G mutation causes…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Human Monoclonal Antibodies: MD.03.1H06, MD.03.1B06, MD.03.1D11, MD.031F03, MD.03.1F11, MD.03.1H01, MD.025.2H09, MD.03.1G01, MD.025.2F10, MD.025.2B07, MD.025.2G11, MD.025.1F09, MD.025.1D01, MD.025.1H07, 306.012.7.1C10, 306.012.7.1A05, 10.036.7.1B04, 10.04.7.1B03
Ellebedy, Ali
T-018756

— Human Monoclonal Antibodies: MD.03.1H06, MD.03.1B06, MD.03.1D11, MD.031F03, MD.03.1F11, MD.03.1H01, MD.025.2H09, MD.03.1G01, MD.025.2F10, MD.025.2B07, MD.025.2G11, MD.025.1F09, MD.025.1D01, MD.025.1H07, 306.012.7.1C10, 306.012.7.1A05, 10.036.7.1B04, 10.04.7.1B03

Lactobacillus reuteri deltaArat
Caparon, Michael ; Cervantes-Barragan, Luisa ; Colonna, Marco ; Di Luccia, Blanda
T-018589

— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes
Asadi Jomnani, Farzad ; Dolle, Roland "Ron" ; Piston, David
T-020153

— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Superficieibacter electus
Andleeb, Saadia ; Burnham, Carey-Ann
T-018501

— Superficieibacter electus

pTAT/pTAT-HA plasmids and protein purfication protocol (Vectors are on deposit with Addgene)
Dowdy, Steven
T-000717

— Technology Description: Researchers at Washington University have developed a method that allows the transduction of full-length proteins by utilizing the pTAT or pTAT-HA protein expression plasmids. A protein of choice can be fused to a HIV-TAT transduction domain under the expression system. Ba…

Toxoplasma strains
Sibley, Laurence
T-018972

— The inventors have generated multiple gene knockout strains of T. gondii, listed below. RH∆hx∆ku80 TIR1 (RH∆ku80∆hxgprt/pTub 5’UTR-OsTir1-3xFlag-DHFR 3’UTR-CAT): The inventors used the CRISPR/Cas9 system for genome editing, comined with the AID degradation system to generate th…

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Song, Sheng-Kwei "Victor" ; Wang, Qing ; Wang, Yong
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Triblock Copolymer Based Anion Exchange Membranes (Aems) As Separators in Electrochemical Devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-017637

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

Red-Shifted Chromophore Substitution for Optogenetic Applications
Corbo, Joseph ; Enright, Jennifer ; Toomey, Matthew
T-014377

— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …

APT1 deficient mouse
Semenkovich, Clay ; Wei, Xiaochao
T-017904

— APT1 deficient mouse

Plasmid pHLFcHis-Glycophorin A
Tolia, Niraj
T-018578

— Plasmid comprising the signal peptide and extracellular domain of human glycophorin A fused to antibody Fc domain and a his tag. This plasmid has been used to study malaria treatments. Publications:

iPSC reporter BJFF6 cell lines
Jain, Sanjay
T-018986

— These induced pluripotent stem cell reporter cell lines were generated by introducing the following fluorescent reporters at the indicated loci: BJFF6 cells were modified with CRISPR/Cas9 to generate these cell lines.

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Systems and Methods for Detection and Quantification of Axial Spondyloarthritis
Paley, Michael ; Yokoyama, Wayne
T-020486

— T-020486 – Systems and Methods for Detection and Quantification of Axial Spondyloarthritis Technology Description Researchers at Washington University in St. Louis, led by Dr. Michael Paley, have developed an assay to diagnose axial spondyloarthritis (axSpA) in HLA-B*27-positive patients.…

Neuroactive steroid anesthetic compounds
Covey, Douglas ; Jiang, Xin
T-004034

— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

anti-Powassan virus antibodies and hybridoma cell lines
Diamond, Michael ; VanBlargan, Laura
T-018559

— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

Antibodies against Toxoplasma gondii proteins ROP1, ROP5, GRA7
Sibley, Laurence
T-018971

— Polyclonal or monoclonal antibodies against Toxoplasma gondii proteins (ROP1, ROP5, GRA7) Mouse anti-body ROP1 publication: Localization of a Toxoplasma gondii Rhoptry Protein by Immunoelectron Microscopy During and After Host Cell Penetration Polyclonal rabbit antibody ROP5 publication: Virulence…

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

GL-261 Single Chain Trimer cells, CL251.puro – Mouse brain tumor cell line transduced with antigen
Dunn, Gavin
T-017659

— Mouse brain tumor cell line transduced with antigen

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for Children
Jeffe, Donna ; Lieu, Judith ; Umansky, Amy
T-010222

— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…

Hybridoma Cell Lines SAG1 and MIC2
Sibley, Laurence
T-018970

— 2 murine hybridoma cell lines producing antibodies agains Toxoplasma gondii proteins SAG1 and MIC2 SAG1 (DG52) publication: Molecular analysis of the gene encoding the major surface antigen of Toxoplasma gondii MIC2 (6D10) publication: The Toxoplasma Adhesive Protein MIC2 Is Proteolytically Proces…

Drugs to supplement microglial metabolism during treatment of Alzheimer’s disease
Colonna, Marco ; Ulland, Tyler
T-017401

— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…

Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser Systems
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…

LDLRAD3 KO mice
Diamond, Michael ; Thackray, Larissa
T-019372

— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…

F-18 radiotracer for alpha-synuclein
Tu, Zhude "Will"
T-018513

— These materials are an alpha-synuclein binding compound (standard), and the precursor for PET radiolabeling the compound. Precursor’s code name: TZ61-23; chemical name: 2-((6-methoxypyridin-3-yl)amino)quinolin-6-ol. Standard’s code name: TZ61-44; chemical name: 6-(2-fluoroexthoxy)-N-(6-metho…

Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Nanothermometers for cellular-level temperature monitoring in ablation therapy or research
Berezin, Mikhail ; Gustafson, Tiffany
T-012606

— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…

Rational drug design using Boltzmann docking
Bowman, Gregory
T-016234

— Technology Description Researchers in Greg Bowman’s lab at Washington University have developed an improved method for rational drug and protein design called Boltzmann docking. This process better incorporates the dynamic structures of proteins to identify sites for binding that are not rev…

HFF Cell Line
Sibley, Laurence
T-018969

— This human cell line is a generic source for culturing Toxoplasma gondii in the laboratory. It was generated by Michael White’s laboratory.

pBAD.dCas9sth1.pAL5000 plasmid
Moon, Tae Seok
T-018499

— A plasmid constuct containing the Streptococcus thermophilus dCas9 (dCas9sth 1) gene under the control of the arabinose inducible pBAD promoter and a constitutively expressed single guide RNA (sgRNA) on the pAL5000 vector backbone. Publication: Molecular Toolkit for Gene Expression Control and Geno…

Antiviral therapy targeting viruses within parasitic protozoans
Beverley, Stephen ; Kuhlmann, Frederick
T-016969

— Background: Parasitic infections remain global health threats and often lead to high death rates in endemic countries. Found in 98 countries, the Leishmania parasite is particularly dangerous and accounts for an estimated 2 million cases and 50,000 deaths per year across the world. However, Leishman…

Plasmids for Cryptosporidium parvum
Funkhouser-Jones, Lisa ; Shen, Bang ; Sibley, Laurence
T-018967

— These plasmids are for performing CRISPR/Cas9 gene editing in Cryptosporidium parvum To generate a CRISPR/Cas9 plasmid for use in C. parvum, researchers used restriction cloning with SacI to insert the C. parvum U6 gene into a pUC19 vector to create pUC19-CpU6. We then inserted the C. parvum actin …

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cytokines-induced-memory-like NK cells with reduced NKG2A checkpoint signaling
Berrien-Elliott, Melissa ; Fehniger, Todd ; Romee, Rizwan
T-017001

— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…

Subtyping of schizophrenia based on genome and pathology
Cloninger, C. Robert ; Svrakic, Dragan ; Zwir, Jorge "Igor"
T-015118

— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…

Passive and Compact Liquid Metal Heat Switch
Weisensee, Patricia
T-019180

— Technology Description Researchers in Patricia Weisensee’s lab at Washington University have developed a compact liquid metal heat switch with a passive mechanism to control the thermal management system of spacecraft. Unlike other switch mechanisms, the liquid metal version produces high co…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response
Lomonosova, Elena ; Mullen, Mary ; Verma, Priyanka ; Zhao, Peinan
T-020659

— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response Technology Description Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Precise, dynamic control of macromolecule adhesion to glass slides and other surfaces
Bridgman, Paul ; Turney, Steve
T-005874

— Technology Description This technology is a patented method for producing microarrays or directing cell growth on a surface by precisely and dynamically manipulating the adhesion of macromolecules. While many techniques exist for adhering proteins, nucleic acids, and other macromolecules to solid …

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

In vivo editing via targeted adenoviral vectors
Curiel, David
T-016332

— Background: Viral vectors have been used for in vivo delivery of CRISPR/Cas9. However, it’s applications have been limited by the native tropism of the viral vector. To better utilize in vivo editing, methods must be developed to accomplish efficient, selective and coordinated delivery of CRI…

Treating Tuberculosis with Host-Directed Drug Targeting
Chandra, Pallavi ; Philips, Jennifer
T-017060

— Background: Worldwide, there are over 10 million new cases of tuberculosis (TB) annually, resulting in 1.8 million deaths. This makes Mycobacterium tuberculosis (Mtb), the bacterium causing TB, the world’s leading infectious disease killer. Even for drug susceptible TB, the treatment courses a…

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Plasmids with genetic variants of CEL
Lowe, Mark ; Xiao, Xunjun
T-018959

— These plasmids encode carboxyl ester lipase (CEL) with and without genetic variants that are associated with chronic pancreatitis. To make the plasmids, the researchers used a full-length human CEL cDNA clone. The cDNA encoded for a 14-repeat VNTR, the variant present in the CEL MODY family. The Ec…

Autosegmentation tool
Grigsby, Perry ; Ma, Daniel ; Rao, Yuan
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Zbtb46, a novel target for cancer therapy
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-020458

— T-020458 — Zbtb46, a novel target for cancer therapy Technology Description Solid neoplasms are difficult to treat using immune checkpoint inhibitors in part because of the immunosuppressive nature of the tumor microenvironment. Researchers at Washington University School of Medicine, led b…

PEGylated-GIRLRG Peptide for Radiopharmaceutical Delivery
Hallahan, Dennis
T-014562

— Technology: GRP78 is a chaperone that is part of a complex that controls the maturation of glycoproteins in the ER and senses cellular stress in normal cells. However, following radiation treatment, GRP78 is also expressed on the surface of cancer cells and has anti-apoptotic and pro-angiogenesis ac…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

B2m Floxed mouse
Bern, Michael ; Yokoyama, Wayne
T-018951

— To generate the mice, the researchers micro-injected ES cell clones carrying the targeted allele B2mtm1a(EUCOMM)Hmgu (B2mtm1a) into Albino B6 blastocysts.Chimeric mice were bred to Albino B6 to identify germline transmission by coat color. Mice containing the germline-transmitted B2mtm1a allele were…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Therapeutic Approach for Huntington’s Disease (HD)
Kim, Albert ; Yano, Hiroko
T-016079

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Wireless, dissolvable electrical stimulation device for nerve or bone regeneration
MacEwan, Matthew ; Ray, Wilson
T-017504

— Technology Description An interdisciplinary team of inventors has developed an implantable, bioabsorbable device to accelerate nerve or bone repair by delivering programmable electrical stimulation over the course of days or weeks following surgery. Direct electrical stimulation during surgery for…

Development of CD163 targeting agent for imaging and therapy
Heo, Gyu Seong ; Liu, Yongjian ; Zhang, Xiuli
T-020196

— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…

Niemann-Pick C1 P1007A mouse model
Ory, Daniel
T-018918

— Mouse model for Niemann-Pick C1 (NPC1) disease This mouse model was generated by CRISPR KI of the P1007A mutation into the NPC1 protein. Mice heterozygous or homozygous for this mutation do not have an apparent phenotype. However, when the heterozgous P1007A mouse is crossed with the NPC1 I1061T m…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

High Affinity Mannose Receptor Ligand
Stahl, Philip
T-000197

— Technology Description: The mannose receptor is uniquely found on macrophages and not on monocytes, making the mannose receptor a target for macrophage activation. Researchers at Washington University have developed polypeptide backbones to target the mannose receptor on macrophages. This technology…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species
Satham, Lakshminarayana ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-020300

— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there…

Chimeric antigen receptor dendritic cells
DeSelm, Carl
T-019199

— Technology Description Researchers at Washington University in St. Louis have developed a genetic method to produce chimeric antigen receptor dendritic cells (CAR-DCs) for the treatment of solid tumors. The team generated a CAR that drives differentiation of cDC1s and mediates tumor-specific uptak…

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Engineered Adenovirus Vector for Efficient Dendritic Cell Antigen Loading in Cancer Immunotherapy
Curiel, David
T-011681

— Disease indication – Cancer Drug format – Adenoviral vector for immunotherapy/dendritic cell therapy Drug class – Improvement Research stage and Preliminary data: Target – Carbohydrate biomarkers of cancer Background: Dendritic cells (DCs) are potent antigen presenting cell…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Artificial Materials with Enhanced Nonlinearity
Ironside, Daniel ; Shen, Jung-Tsung
T-011141

— Background: Advances in nonlinear materials give rise to a multitude of optical phenomena that have important applications as switches and modulators in telecommunications and optical computing industry. The degree of optical nonlinearity in a material depends upon the strength of the optical field…

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation
Sharma, Vijay ; Sivapackiam, Jothilingam
T-019479

— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation. Technology Description 18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…

Plasmids for calling cards and single cell calling cards
Chen, Xuhua ; Lalli, Matthew ; Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019487

— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Mouse embryonic fibroblasts from IRF 3/5/7 knock out animals
Diamond, Michael
T-018546

— Mouse fibroblasts are isolated from Irf3-/-xlrf5-/-xlrf7-/-TKO mice. Researchers generated the mouse strains from an inbred C57BL/6 background. Associated Publication: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Personalized Virtual Reality Training
Engsberg, Jack ; Foreman, Matthew ; Janes, William
T-014603

— Many patients require physical therapy each year as a result of their suffering from a variety of neurological and musculoskeletal disorders including stroke, cerebral palsy, trauma and many others. Repetitive movements can increase muscle tone, range of motion and stamina to aid in their daily act…

MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPR
Chen, Zhou-Feng ; Liu, Xianyu
T-011473

— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…

Bacterial Strains isolated from fecal samples
Gordon, Jeffrey
T-017911

— Cultured and sequenced bacterial strains isolated from fecal samples. The samples were collected from the Bill and Melinda Gates Foundation sponsored studies of childhood undernutrition in Bangladesh.

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

A long non-coding RNA in early and late-stage breast cancer as a prognostic marker, diagnostic marker, and therapeutic target.
Eteleeb, Abdallah ; Maher, Christopher ; Silva-Fisher, Jessica
T-020366

— Technology Description Researchers in Dr. Jessica Silva-Fisher’s laboratory have developed antisense oligonucleotide targeting a long non-coding RNA (lncRNA), LINC00355, as a treatment for late-stage relapse (LSR) breast cancer. LINC00355 is highly expressed in LSR breast cancer patients and…

New nerve cap arrests axon growth in neuroma management
Bichanich, Miles ; Hong, Thomas ; Mackinnon, Susan ; Moore, Amy ; Wood, Matthew
T-017285

— Background Neuromas (a.k.a. pinched nerve, or nerve tumor) form on peripheral nerves following trauma and possess exposed sensory axons mixed with fibrotic scar tissue. Symptomatic or painful neuromas have a profound impact on a patient’s quality of life and productivity. Pain medication offe…

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

MOG.15 hybridoma
Wu, Gregory
T-017899

— MOG.15 is a T cell hybridoma that will be active when engaged with an antigen presenting cell that is presenting MOG35-55 peptide. Publication: Conditional MHC Class II Expression Reveals a Limited Role for B Cell Antigen Presentation in Primary and Secondary CD4 T Cell Responses

Alphavirus-Resistant Fish
Diamond, Michael ; Zhang, Rong
T-018625

— Background: Aquaculture is the most resource-efficient method to produce protein, improve nutrition, and food security and is vital for supporting seafood production. The Food and Agriculture Organization of the United Nations estimates over 50% of all global seafood for human consumption is produce…

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

Murine Hybridoma produing IgG2b Monoclonal Antibody to Human CRTAM – Cr24.1
Colonna, Marco
T-007608

— Target: Cluster of Differentation 355 protein, a.k.a. Cytotoxic and Regulatory T-Cell Molecule. Notes: Clone available is Cr 24.1. Used in flow cytometry.Monoclonal antibody to human CRTAM Monoclonal antibody (mAb) Cr24.1 was generated by immunizing BALB/c mice with CRTAM-P815 cells. Cells were injected bilaterally 4 times at weekly intervals into the hind leg. Cytosine-phosphate-guanosine (CpG) oligonucleotide was used as adjuvant (CpG 1826, 25…

High-yield, heat tolerant tomatoes
Frick, Elizabeth ; Strader, Lucia
T-018506

— Technology Description Researchers in Prof. Lucia Strader’s laboratory have cultivated genetically-stable, high-yield tomato plants that are tolerant to high temperature growing conditions (40oC). These plants were identified using a screen for mutants. Excitingly, two mutants (IR-12 an IR-1…

Mayaro virus monoclonal antibodies and hybridomas
Diamond, Michael ; Earnest, James
T-019543

— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values

pTet-T – A plasmid for chromosomal integration of pTet-fbfp & kanamycin antibiotic resistance into Synechocystis sp. PCC6803
Moon, Tae Seok
T-017841

— The plasmid was constructed in E. coli DH10B which was grown in LB at 37°C and 250 rpm in 14 mL BD FalconTM round‐bottom tubes. Kanamycin (kan) (20 µg/mL) and spectinomycin (spec) (100 µg/mL) were added as appropriate. Plasmids were constructed using the…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

Neonatal Eating Outcome (NEO) Assessment
Pineda, Roberta
T-014917

— To order a NEO Assessment, Click Here. If the link does not work, copy and paste https://commerce.cashnet.com/NEO into your search bar. Summary: Eating is an important part of daily life; it ensures nutrition for growth and is an important activity of daily living with strong social implications. …

Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtii
Goodenough, Ursula ; Goodson, Carrie
T-011504

— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…

Multi-energy window approaches for quantitative SPECT
Jha, Abhinav Kumar ; Li, Zekun ; Thorek, Daniel
T-019824

— T-019824 Multi-energy window approaches for quantitative SPECT Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised a method to reliably obtain and significantly improve quantification of alpha-particle based SPECT tracer uptake, particularly …

Rat Hybridoma producing IgG Monoclonal Antibody to Human CD177 – Clone 4127
Colonna, Marco
T-007606

— Target: Cluster of Differentation 177 protein, a.k.a. Neutrophil Specific Antigen 1. Notes: Clone available is 4127.

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

Adenovirus: Ad-GFP-LC3, Ad-FLAG-BNIP3, Ad-mBECLIN-1, Ad-Parkin(HA), Ad-TRAF2(FLAG), Ad-TRAF2-Rm, Ad- TRAF2-deltaN. Plasmids: mCherry-GFP-LC3, DsRed-BNIP3, GFP-Parkin, GFP-LC3, DsRed-monomer-GFP fusion positive control
Diwan, Abhinav
T-017834

— Adenoviruses were generated using the Invitrogen Virapower system, which uses Clonase mediated recombination. They were generated in HEK293A cells and titered per the manufacturer’s instructions. Publications: Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death; Impaired …

iPSC line AN1.1
Neilson, Amber
T-019532

— AN1.1 is an iPSC line that was reprogrammed from healthy renal epithelial cells. Has proven easy to use for gene editing and efficient for differentiating into a number cell/tissue types. Whole genome sequencing data is available.

CemOrange2 gene fusions for subcellular imaging in C. elegans
Luke, Clifford ; Pak, Stephen ; Silverman, Gary ; Thomas, Brian
T-018982

— Plasmids were generated with the NHX-2 promoter, to restrict gene expression to the C. elegans intestinal cells, driving C. elegans genes or targeting peptides, known to target different subcellular organelles, fused to a C. elegans optimized mOrange2 fluorescent protein (CemOrange2). These expressi…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

Recombinant Alpha-synuclein monomer and fibrils produced from Recombinant Alpha-synuclein monomer
Kotzbauer, Paul
T-017809

— Alpha synuclein is a 140 amino acid protein. The accumulation of aggregated alpha-synuclein within neuronal cells is the defining pathologic change in Parkinson’s disease. We produced recombinany human alpha-synuclein protein in E. Coli and purified it. We developmed an incubation procedure unde…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

Anti-Influenza HA monoclonal antibodies
Ellebedy, Ali
T-019529

— Panel of 300 recombinant human monoclonal antibodies that are directed against influenza virus HA. These antibodies were derived from plasmablasts and germinal center B cells that were isolated from three healthy volunteers after influenza vaccination. Turner, J. S., Zhou, J. Q., Han, J., Schmitz, …

Agonistic Anti-CD40 Monoclonal Antibodies
Klechevsky, Eynav
T-015344

— The monoclonal antibodies developed are agaonistic monoclonal antibodies. These antibodies can help in enhancing the immune system by activating dendritic cell subsets. Furthermore, these antibodies are unique, as they can activate Dendritic cells without the need for cross-linking the receptor.

CEPT1 floxed mice
Lodhi, Irfan ; Semenkovich, Clay
T-019637

— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…

DH1, DH1(tesA) & BC33 – E. coli strains for producing branched-chain fatty acids
Zhang, Fuzhong
T-017808

— CL111 was first transformed with the plasmids containing BCFA-producing pathway. The straight-chain-specific fabH was then eliminated by phage P1 transduction with lysates grown on strain CAG12094. The transduction mixtures were plated on LB-agar medium supplemented with appropriate anti-biotics (te…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

A biomarker to monitor CNS efficacy of 2-hydroxypropyl-β-cyclodextrin (HPBCD)
Ory, Daniel
T-012136

— Background: Niemann-Pick type C1 (NPC1) disease is a rare neurological disorder characterized by cholesterol and lipid accumulation in the central nervous system. Individuals with the abnormal buildup of cholesterol and other lipids in the brain often suffer from cognitive and movement difficulties,…

Phospholipase A2 Epsilon
Gross, Richard ; Jenkins, Christopher
T-004045

— This features an enzymatic function for a protein so that Washington University can obtain composition of matter rights and use rights for screening for inhibitors. This can be used for weight loss, diabetes, treatment of obesity and associated lipotoxicity, body sculpting, heart disease, stroke a…

Grp-iCre mice
Chen, Zhou-Feng
T-019525

— Gastrin-releasing peptide (GRP) functions as neurotransmitter for non-histaminergic itch. This mouse line has the Cre gene knocked into Grp locus and could be used for studies of GRP function in different tissues. Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., … & Tao, A. …

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Cyanobacteria engineered for enhanced sucrose production
Pakrasi, Himadri
T-019524

— Cyanobacterial strains, including one with the highest productivity of sucrose in cyanobacteria to date. Lin, P. C., Zhang, F., & Pakrasi, H. B. (2020). Enhanced production of sucrose in the fast-growing cyanobacterium Synechococcus elongatus UTEX 2973. Scientific reports, 10(1), 1-8.

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Novel bile acids as biomarkers for Niemann-Pick type C disease
Jiang, Xuntian ; Ory, Daniel
T-014292

— Technology Description Researchers at Washington University have developed and validated a set of bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick disease type C (NPC), a genetic lysosomal storage disorder resulting from a defect in lipid transport. Previous ef…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

VSV-BSL2 reporter of SARS CoV infection
Bloyet, Louis-Marie ; Whelan, Sean
T-019518

— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

Transgenic mouse lines with markers of muscle development
Sanes, Joshua

— Myl-CFP Mice The coding sequence for the enhanced CFP was inserted downstream of ~5kb of putative regulatory sequences from the mouse myosin Type I heavy chain gene. Transgenic mice were generated by pronuclear injection using standard methods. JAX Stock No. 06922 MyIIA-RFP Mice A ~100kb genomic…

Conditional Lama5 Mutant Mice
Miner, Jeffrey
T-017526 Leishmania guyanensis with mCherry and luciferase
Beverley, Stephen
T-019515

— Leishmania guyanensis strain M4147 (+/- LRV) engineered to express two markers, mCherry and firefly luciferase. The constructs are stably integrated into the ribosomal RNA SSU locus. Parasites with these markers can be followed by fluorescence or bioluminescence approaches which is faster and requir…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

Whole Body Knockout Mouse on CISD2 Gene
Urano, Fumihiko
T-017431 VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Plasmid library for miRNA, Pumilio, Smaug and AU-rich elements
Djuranovic, Sergej
T-019514

— This is the pcDNA-5 plasmid library with 6500 barcoded constructs containing eGFP followed by 650 combinations of 3’UTRs with miRNA, Pumilio, Smaug and AU-rich. This library can be used to optimize gene expression and to study gene regulation by different micro RNAs and RNA-binding proteins. …

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo (Justin) ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

B6.129.Btla tm1kmm/J Mouse
Murphy, Kenneth ; Murphy, Theresa
T-014100

— Notes: Btla-/- knockout mouse with a 129S/SvEv background. B6.129.Btla tm1kmm/J Mouse.

Improved MRI resolution with Diffusion Dictionary Imaging (DDI)
Wang, Qing ; Wang, Yong
T-019608

— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Ultra High Quality Tunable Add-Drop Filter Based on Active Whispering Gallery Mode resonators
Monifi, Faraz ; Ozdemir, Sahin ; Yang, Lan
T-013642

— Whispering Gallery Mode (WGM) Resonators have been shown to have unique properties holding great promise for use in optical communication systems. Recent innovations from Dr. Lan Yang’s Nano-Photonics lab at Washington University in St Louis bring the promise much closer to reality. In particu…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Transcription factor EB (TFEB) materials
Diwan, Abhinav
T-019513

— Materials that have been used to study transcription factor EB (TFEB), a lysosomal biogenesis factor:

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Niemann Pick Type C (NPC) Mouse Model
Ory, Daniel
T-012764

— Notes: Mouse model with the mutation for NPC knocked in.

Mouse monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019510

— These are six monoclonal antibodies specific to SARS-CoV-2 Nucleocapsid protein that could potentially be used for COVID-19 diagnostics.

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Human monoclonal antibodies against SARS-CoV-2 nucleocapsid protein
Ellebedy, Ali
T-019492

— Species: Human Target: SARS-CoV-2 nucleocapsid protein Applications: Description: Two recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab

Tumor-targeted fusion protein platform for enhanced cancer immunotherapy
Pachynski, Russell
T-015906

— Disease indication – cancer, particularly lung, breast, colon, and prostate cancer or melanoma (cancers where chemerin is down-regulated at the tumor site) Drug format – engineered fusion protein Drug class – first in class Research stage and Preliminary data Target &ndash…

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Chimeric murine anti-FimH Monoclonal Antibodies
Ellebedy, Ali
T-019117

— These are recombinant chimeric murine monoclonal antibodies that are directed against FimH, an adhesin within uropathogenic E coli (UPEC). The monoclonal antibodies were isolated from mice immunized with adjuvanted FimCH, but are expressed on a human IgG1 backbone and hence they are chimeric.

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein – Colonna lab
Cella, Marina ; Colonna, Marco
T-019509

— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Mutant PDGF-B as a VEGFR inhibitor
Imoukhuede, Princess
T-018996

— Technology Description Researchers in the Imoukhuede lab at Washington University have developed a library of mutant PDGF-B proteins to develop more effective VEGF pathway inhibitors. As PDGF-B also binds to VEGF receptors, a mutant form can be used to block VEGF binding and stop tumor angiogenesi…

Method to create designer stem cells for safer, more effective therapeutics
Guilak, Farshid
T-018758

— Technology Description Researchers at Washington University in St. Louis have developed a method to create designer stem cells which provide a safer, more effective cell therapy approach to treating disease. Cell-based regenerative therapies could potentially be used to treat many diseases and res…

Improved NMR sensitivity with an integrated EPR-NMR spectrometer
Barnes, Alexander
T-014431

— Technology Description Researchers in Dr. Alexander Barnes’s lab at Washington University have developed a low-noise integrated EPR-NMR spectrometer with improved NMR sensitivity and faster acquisition times. This patented device can increase sensitivity in NMR experiments (potentially by a …

Floxed ChAT mouse strain
Burgess, Robert ; Sanes, Joshua
T-019107

— This mouse strain has loxP sites flanking exons 3 and 4 of the ChAT gene. There is a Neo gene in the intron between exons 4 and 5. Mating these mice to A-Cre mice generates a null allele in subsequent generations, in which no ChAT protein or activity is detectable. The mice are maintained in the C57…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Biomarker to predict cancer response to chemotherapy
Diamond, Marc ; Shao, Jieya
T-015631

— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…

scFv-TR3: TRAIL trimers targeted to mesothelin
Hawkins, William ; Spitzer, Dirk
T-016481

— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical Applications
Chen, Qinghao ; Tan, Yuewen ; Zhang, Tiezhi ; Zhou, Shuang
T-019620

— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…

Wolfram syndrome conditional knock-out mice
Urano, Fumihiko
T-019506

— Genetically engineered mice and frozen sperm with two loxP sites flanking the mouse Wfs1 gene. These mice can be used to study the mechanisms of neurodegeneration in Wolfram syndrome.

Achondroplasia (ACH) Mouse Model
Ornitz, David
T-000483

— Target: Mouse model with the mutation for ACH knocked in.Description: Inventors created a transgenic mouse model of achondroplasia by targeting the expression of activated FGFR3 to growth plate cartilage in mice using regulatory elements from the collagen II gene. As with humans carrying the achondroplasia mutation, the resulting transgenic mice were dwa…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

Leishmania major mutant lacking TOR3 gene
Beverley, Stephen
T-019505

— The creators used classical homologous recombination to remove both copies of the Leishmania major target of rapamycin (TOR3). This mutant was used to study TOR3’s suitability as a potential drug candidate. Da Silva, L. M., & Beverley, S. M. (2010). Expansion of the target of rapamycin (T…

Gaussian Process Audiogram
Barbour, Dennis ; Gardner, Jacob ; Ledbetter, Noah ; Song, Xinyu ; Weinberger, Kilian
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Leishmania major mutant lacking IPCS gene
Beverley, Stephen
T-019504

— The creators used homologous gene recombination to delete the gene encoding inositol phosphoryl ceramide synthase (IPCS) from the genome of the protozoan parasite Leshmania major.

Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and death
Ory, Daniel ; Peterson, Linda ; Schaffer, Jean
T-014627

— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…

Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activity
Hawkins, William ; Spitzer, Dirk
T-011885

— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

VSV-SARS2-mutants to characterize antibody panels
Liu, Zhuoming ; Whelan, Sean
T-019501

— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…

Planar storage phosphor dosimeter for radiation therapy dosimetry
Li, Hui
T-009252

— Radiation dosimetry is a type of quality assurance for radiation therapy (RT) treatment to verify performance and dosage of the therapy to ensure accuracy and patient safety. To determine beam delivery accuracy, phantom patients (made to mimic necessary properties of the body) are used daily to cali…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Monoclonal antibodies against pSer784-VCP
Shao, Jieya
T-019491

— VCP is an essential AAA+ ATPase that regulates proteostasis under normal and stressed cellular conditions. These monoclonal antibodies specifically recognize pSer784-VCP, which is phosphorylated during the DNA damage response and plays a crucial role in cellular survival upon genotoxic chemotherapy …

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Fibroblast-Derived Cell Line Producing Wnt3a, R-spondin 3, & Noggin
Miyoshi, Hiroyuki ; Stappenbeck, Thaddeus
T-014239

— Tangible Tool: Growth factor over-expressing cell line. Notes: Produces conditioned media to grow various mammalian tissue stem cells.These supportive L-WRN cells can produce conditioned media containing Wnt3a, R-spondin, and Noggin for the the support of gastrointestinal stem cells. This system can be used to make stem cell enriched epithelial spheroids from the mouse gastrointestine. Publication: In vitro expansion and genetic…

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

MRI neural network segmentation in atherosclerosis
Jha, Abhinav Kumar ; Li, Ran ; Woodard, Pamela ; Zheng, Jie
T-020254

— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

Anti-prM Monoclonal Antibody against all four Dengue Virus Serotypes
Diamond, Michael
T-015814

— Target: Dengue Virus Notes: PrM-12 and -22

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Venezuelan Equine Encephalitis Virus (VEEV) Antibodies
Diamond, Michael
T-015386

— Primary Inventor: Michael S. Diamond, MD Target: Venezuelan Equine Encephalitis Virus

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Stat1-flox mouse
Holtzman, Michael
T-019075

— This is a trangenic mouse with the floxed Stat1 gene. This mouse can be breed with whole body or tissue specific Cre lines to knockout out STAT1 – which is a transcription factor that is essential for the interferon signaling pathway. Publication: Respiratory Enterovirus (Like Parainfluenza Virus)…

Monoclonal Antibodies to Enterococcus Faecalis Secreted Proteins
Shaikh, Nurmohammad ; Tarr, Phillip
T-011162

— Target: SalB (mAb 6H3) Notes: Reduces inflammatory response.We have identified and characterized monoclonal antibodies that recognize secreted proteins of Enterococcus faecalis, and that neutralize the abilities of whole, viable, E. faecilis to stimulate a pro-inflammatory cytokine in cultured epithelial cells. The monoclonal antibodies are directed against …

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

A genetic mouse model of human Cantu Syndrome based on Kcnj8em1Nich[V65M] mutation
Nichols, Colin ; Remedi, Maria
T-019073

— This is a CRISPR/Cas9 germline mutation in the KCNJ8 gene, equivalent to a human Cantu Syndrome mutation. The mouse is therefore a genetic model of human Cantu Syndrome. This mouse model can be used for pre-clinical testing of targeted therapy for Cantu Syndrome. Publication: Cardiovascular consequ…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila
T-009276

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

Chaotic Optomechanical Resonators
Ozdemir, Sahin ; Yang, Lan
T-016229

— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

A genetic mouse model of human Cantu Syndrome based on Abcc9em1Nich SUR2[A476V] mutation
Nichols, Colin ; Remedi, Maria
T-019072

— This mouse model was generated by using CRISPR/Cas9 to mutate the ABCC9 gene. The mouse model described here could be used as a pre-clinical model for testing Cantu Syndrome therapies. Publication: Cardiovascular consequences of KATP overactivity in Cantu syndrome

Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer Treatments
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Lyz2Cre;Talin-1fl/fl mice
Randolph, Gwendalyn
T-019085

— Lyz2Cre;Talin-1fl/fl mouse strain Inventors crossed Talin-1fl/fl mice (received from Oklahoma Medical Research Foundation) with Lyz2Cre mice (available at the Jackson Laboratory) to generate Lyz2Cre;Talin-1fl/fl mice.

Exosome-based therapy for tendon injuries and other soft tissue repair
Shen, Hua
T-018565

— Technology Description: A team of researchers at Washington University has developed a cell-free, nano-sized extracellular vesicle (EV/exosome) system to enhance repair of soft musculoskeletal tissue. This technology leverages the natural anti-inflammatory effects of adipose-derived stem cells (ASC…

Rat Hybridoma producing IgG1 Monoclonal Antibodies to Mouse CD96
Colonna, Marco
T-010940

— Target: Cluster of Differentiation 96 protein. Notes: Clone available is 3.3.1We generated the mAb 480.1 anti – mouse DNAM-1 (mDNAM-1) or mAb 3.1 anti – mouse CD96 (mCD96) by immunizing rats with RBL cells transfected with mDNAM-1 cDNA (RBL – mDNAM-1) or mouse CD96 cDNA (RBL-mCD96) and selecting hybridomas that reacted with 293 – mDNAM-1 or 293-mCD96 t…

Gadd7 haploinsufficient mutant CHO cell line
Listenberger, Laura ; Ory, Daniel ; Schaffer, Jean
T-019113

— Gadd7 haploinsufficient mutant CHO cell line Inventors generated a mutant Chinese Hamster Ovary (CHO) cell line with disruption of one allele encoding Gadd7, a non-coding RNA. CHO cells were transduced with retrovirus at a low multiplicity of infection and mutants were isolated. Number of retrovira…

Rat Hybridoma producing IgG2a Monoclonal Antibodies to Murine CD155 (TAGE4)
Colonna, Marco
T-007611

— Target: Cluster of Differentiation 155 protein, a.k.a. the Polio Virus Receptor. Notes: Clone available is 4.24. Used in flow cytometry.To generate the antibodies, the researchers immunized rats with a recombinant protein consisting of the mCD155 extracellular region fused to human Fc and selected hybridomas that reacted with RMA-S–mCD155 transfectants but not with untransfected RMA-S cells. Publication: DNAM-1 promotes activ…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Treatments for multi-drug or broad addiction liability
Hatoum, Alexander
T-020521

— Technology Description Researchers at Washington University in St. Louis, led by Dr. Alexander Hatoum, have developed a computational model for improving the diagnosis and treatment of drug addiction. Using genome-wide association study (GWAS) of over 1 million subjects, Dr. Hatoum’s group d…

Rat Hybridoma producing IgG2a Monoclonal Antibodies to Murine CD226 (DNAM-1)
Colonna, Marco
T-007610

— Target: Cluster of Differentiation 226 protein, a.k.a. DNAX Accessory Molecule 1. Notes: Clone available is 480.1Inventors generated the antibodies by immunizing rats with RBL cells transfected with mDNAM-1 cDNA (RBL–mDNAM-1) or mouse CD96 cDNA (RBL-mCD96) and selecting hybridomas that reacted with 293–mDNAM-1 or 293-mCD96 transfectants but not with untransfected 293 cells. Publication: DNAM-1 pro…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Automated, Improved Deformable Image Registration for Radiation Therapy and other Clinical Applications
Yang, Deshan
T-017324

— Technology Description Prof. Deshan Yang and colleagues have developed automated systems and software toolkits to provide more accurate deformable image registration (DIR) for adaptive radiotherapy and other clinical applications. In particular, they have automated tedious and labor-intensive DIR …

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

d42m1 & F279 tumor cell lines
Schreiber, Robert
T-011286

— D42m1 is a methycholanthrene (MCA) induced sarcoma cell line generated in 129S6 strain RAG2 gene targeted mice. These cells are highly immunogenic and are rejected when transplanted into syngeneic naive wild type mice. F244 is an MCA induced sarcoma cell line generated in wild type 129S6 mice. Thes…

Expression plasmid to examine Kelch domain of Keap 1
Amarasinghe, Gaya
T-019071

— This expression plasmid can be used to identify inhibitors for Keap1 – a pathway that is invoIved in oxidative stress response and implicated in Marburg virus infection. Publication: Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

Rat Hybridoma producing IgG2b mAB to Mouse Natural IPC-Specific Antigen
Colonna, Marco
T-005806

— Target: Natural Interferon-Producing Cell-Specific Antigen Notes: Clone available is 440c

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Murine Tumor Cell Lines
Schreiber, Robert
T-019119

— Murine tumor cell lines Murine syngeneic MCA induced tumor lines have been developed and characterized by the Schreiber Lab and provide critical models to study drugs or pathways that impact tumor growth or rejection. In particular they are used to study mechanism of action of immune checkpoint blo…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Blood-based prognostic marker for respiratory distress from influenza and other viral infections
Mudd, Philip
T-019387

— Technology Description A team of researchers at Washington University has discovered an easily-measured, blood-based marker that could provide an early indicator to identify patients who will develop very severe disease following a viral infection. This immune cell marker for acute respiratory dis…

Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probe
Li, Lei ; Wang, Lihong ; Yao, Junjie
T-015670

— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Col4a3-/- Alport Mice on the 129S1/SvImJ strain background
Miner, Jeffrey
T-019330

— Mouse line carrying a mutation in Col4a3 backcrossed to 129S1/Sv1mJ strain. The mice show kidney failure at 10-12 weeks of age to enable rapid drug screening. Publication: A mouse collagen4α4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trime…

pAAV5-CaMKII-mSK2-AqAA-Flag-eYFP packaged into an AAV5 capsid
Bruchas, Michael ; Moron-Concepcion, Jose
T-019068

— This capsid expresses a dmoninant negative non-functional form of the SK2 channel present in neurons. This allows us to directly measure the effects of SK2 in hippocampal neurons.

In vivo PopQC – Simple quality control system to enhance industrial-scale microbial production of chemicals, biofuels and pharmaceuticals
Xiao, Yi ; Zhang, Fuzhong
T-014647

— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Antisense oligo to enhance neuronal survival in Huntington’s Disease
Oh, Youngmi ; Yoo, Andrew
T-020121

— Technology Description Researchers in Andrew Yoo’s laboratory at Washington University have developed an antisense oligonucleotide targeting a miRNA (miR-29b-3p) as a treatment for Huntington’s disease (HD). Inhibiting miR-29b-3p promotes neuronal survival by rescuing neurons from deg…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Antibodies to Type IV Collagen alpha3/4/5 Chains, Collagen IV alpha3 chain: 353; Collagen IV alpha4 chain: 356; Collagen IV alpha5 chain: 358
Miner, Jeffrey
T-019417

— Collagen antibodies that bind to the major collagen IV component of the kidney glomerular basement membrance. The antbiodies reaction with mouse, rat, and human chains and were derived using the noncollagenous NCI domains at the COOH-termini in rabbit antiserum to mouse. Collagen IV alpha3 chain: 353 Collagen IV alpha4 chain: 356 Collagen IV alpha5 chain: 358

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Mice with genetic alteration in STAT3
Cooper, Megan
T-019059

— This mouse strain has a genetic alteration in STAT3 and can be used to understand the role of STAT3 in human disease. Publication: Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

Biodegradable beads for capturing phosphorus from water and releasing it as fertilizer
Jun, Young-Shin ; Kim, Doyoon
T-017987

— Engineers in Prof. Young-Shin Jun’s laboratory at Washington University in St. Louis have developed a scalable, effective, environmentally-friendly system for removing phosphorus from water using biodegradable alginate beads that can then be recycled as a slow release fertilizer in soil. This …

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

ABCA3-GFP plasmid
Wambach, Jennifer ; Yang, Ping
T-019241

— ABCA3-GFP (ATP binding cassette transporter A3 gene cDNA fused to GFP) plasmid that lavels lamellar bodies. Publication: Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

SARS-CoV-2 neutralizing antibodies with distinct epitopes effective against multiple variants
Ellebedy, Ali
T-019707

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized these antibodies, creating a chimeric version with a human IgG backbone for SARS2-38. The antibodies have …

Gfrα1FloxEGFP mice
Jain, Sanjay ; Milbrandt, Jeffrey
T-017997

— Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were the…

Plasmids for luciferase expression in Cryptosporidium
Funkhouser-Jones, Lisa ; Sibley, Laurence
T-019121

— Plasmids for luciferase expression in Cryptosporidium The plasmids listed below are for targeting insertion into the TK and UPRT loci in Cryptosporidium parvum. To generate the plasmids, the inventors modified a previously described nanoluciferase (Nluc) reporter fused to neomycin resistance (NeoR)…

Mouse Hybridoma producing IgG3 Antibodies against Human TIGIT (WUCAM)
Boles, Kent ; Colonna, Marco
T-008862

— Target: T Cell Immunoreceptor with Ig and ITIM domains, a.k.a. WUCAM Notes: Clone available is 4E1.2. Used in flow cytometry and functional studies.Mouse IgG3 was generated by immunizing BALB/c mice with WUCAMFLAG-Baf3 cells. This can be used to study T cell-dependent antibody responses. Publication: A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Mice with Mutant Gtf2i and Gtf2ird1 Alleles
Dougherty, Joseph ; Kopp, Nathan
T-019290

— Dr. Dougherty developed a collection of mouse lines with deletions of Gft2i and Gtfird1 in various combinations. The genes are related to Williams Beuren locus. Publications:

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Carbon aerosol gel from continuous negative gravity reactor
Chakrabarty, Rajan ; Liu, Pai
T-017977

— A team of engineers from Washington University has developed a unique aerosol gel made from volume-spanning, semirigid networks of organic nanoparticles. Although the ultralow density and high surface area of these types of aerogels make them extremely useful for air and water purification, their pr…

CHO Gadd7 knockdown clones and control
Brookheart, Rita ; Schaffer, Jean
T-019114

— CHO Gadd7 knockdown cell lines Inventors generated two stable Chinese Hamster Ovary (CHO) cell lines with knockdown of gadd7 by transfecting cells with a custom siRNA plasmid targeting hamster gadd7 (KD1 and KD2) and a control CHO cell line by transfecting cells with a custom scrambled siRNA plasmi…

Mouse Hybridoma producing IgG2b Monoclonal Antibodies to Human FcRL4
Colonna, Marco ; Wilson, Timothy
T-007612

— Target: Fc Receptor Like 4 protein. Notes: Clone available is 413D12. Used in flow cytometry, immunoprecipitation, and functional studies.Balb/c mice were immunized three times at two week intervals with paraformaldehyde-fixed FcRL4 stable transfectants, first in CFA, then twice in IFA + CpG 1826. Three days prior to fusion with SP2/0 cells, the final immunization was performed by IP injection of irradiated cells in PBS. Hybridoma clo…

Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
Anastasaki, Corina ; Gutmann, David
T-015422

— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

Transgenic zebrafish line expressing gCAMP in the pancreatic beta cell
Emfinger, Christopher ; Nichols, Colin
T-019302

— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor. Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

Transgenic mouse lines with markers of muscle development
Sanes, Joshua
T-019127

— Myl-CFP Mice The coding sequence for the enhanced CFP was inserted downstream of ~5kb of putative regulatory sequences from the mouse myosin Type I heavy chain gene. Transgenic mice were generated by pronuclear injection using standard methods. JAX Stock No. 06922 MyIIA-RFP Mice A ~100kb genomic…

Murine Hybridoma producing IgG2b Monoclonal Antibody to Human CRTAM – Clone 134
Colonna, Marco
T-007609

— Target: Cluster of Differentation 355 protein, a.k.a. Cytotoxic and Regulatory T-Cell Molecule. Notes: Clone available is 134.

IL34 tm1b and tm1c mice
Colonna, Marco ; Gilfillan, Susan ; Wang, Yaming
T-019313

— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue Injury
Gelman, Andrew ; Puyo, Carlos
T-015918

— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…

Bhlhe40 flox/flox mice
Edelson, Brian
T-019054

— The Bhlhe40 flox/flox mice on the C57BL/6 background originated as a KO-first promoter-driven mouse line from the Knockout Mouse Project and were purchased from the Jackson Laboratory. These initial mice contained a Bhlhe40 allele with a splice acceptor-LacZ reporter and a Neo cassette flanked by tw…

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Murine Hybridoma producing IgG1 Monoclonal Antibody to Human B7-H3
Colonna, Marco
T-007604

— Target: Cluster of Differentiation, a.k.a. Neural Cell Adhesion Molecule. Notes: Clone name is DCN.70.

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

ACE2 expressing cells
Kumar, Sandeep ; Peterson, Timothy
T-019619

— These cells are K562 cells that express ACE2 (the receptor for SARS-CoV-2) from the endogenous locus and not a transgene.

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

Antibodies to Western Equine Encephalitis Virus (WEEV)
Austin, Stephen ; Diamond, Michael ; VanBlargan, Laura
T-019128

— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…

Deforming Diagnostic to Radiotherapy Images for the Initial Treatment Plan
Mutic, Sasa ; Zhao, Tianyu
T-018603

— Background: Prior to undergoing radiation treatment, the patient is required to undergo a simulation scan. This involves positioning the patient body on a platform that resembles the radiotherapy machine couch. Then the scanning computerized tomography (CT) or magnetic resonance imaging (MRI) device…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

ACE2 expressing cells
Kumar, Sandeep ; Peterson, Timothy
T-019619

— These cells are K562 cells that express ACE2 (the receptor for SARS-CoV-2) from the endogenous locus and not a transgene.

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

Antibodies to Western Equine Encephalitis Virus (WEEV)
Austin, Stephen ; Diamond, Michael ; VanBlargan, Laura
T-019128

— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…

Deforming Diagnostic to Radiotherapy Images for the Initial Treatment Plan
Mutic, Sasa ; Zhao, Tianyu
T-018603

— Background: Prior to undergoing radiation treatment, the patient is required to undergo a simulation scan. This involves positioning the patient body on a platform that resembles the radiotherapy machine couch. Then the scanning computerized tomography (CT) or magnetic resonance imaging (MRI) device…

Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materials
Bowen, Christopher ; Dai, Bin ; Zhang, Fuzhong
T-018602

— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…

IL33 tm1b and tm1c
Colonna, Marco ; Gilfillan, Susan ; Yoshita, Satoru
T-019314

— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Rat Hybridoma producing Monoclonal Antibodies against Mouse PDCA1
Blasius, Amanda ; Cella, Marina ; Colonna, Marco
T-004377

— Target: Antibodies recognize a small leukocyte population of cells called intereron producing cells or plasmacyt-oid dendritic cells. Notes: Clone names 129c1 and 927Antibodies were produced by immunizing Wistar/CRL rats with CpG oligodeoxynucleotide 1826 or heat-killed Mycobacteria tuberculosis. The antibodies are specific for mouse IFN-producing cells (IPC). Publication: Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in …

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

IL-33 mCherry Mice
Colonna, Marco ; Gilfillan, Susan ; Joshita, Satoru
T-019315

— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:

Washington University Satisfaction and Function Survey
Barrack, Robert ; Nunley, Ryan
T-015700

— Background: Over 7 million people in the United States are living with total hip (THR) or total knee (TKA) replacements. In the past decade, the number of THRs and TKAs have dramatically increased, particularly in the younger population. However, it is unclear if greater utilization of THRs and TKAs…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

Development of a Preclinical NF1-MPNST Platform Suitable for Precision Oncology Drug Discovery and Evaluation
Hirbe, Angela ; Li, Shunqiang
T-019044

— This technology contains a set of patient derived xenograft cell lines. These cell lines represent the heterogeneity of human malignant peripheral nerve sheath tumors (MPNSTs) that can be used to test novel agents to move forward into clinical trials.

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Tumor treatment for patients with neurofibromatosis type 1 (NF1)
Gutmann, David ; Weber, Jason
T-007548

— Technology Description Scientists at the Washington University Neurofibromatosis Center have developed a patented, first-in-class method for treating neurofibromatosis type 1 (NF1) with small molecule inhibitors of targets in the mTOR (mammalian target of rapamycin) signaling pathway. NF1 is a rel…

MRI and PET nanoparticle imaging agents for kidney disease diagnostics and transplant evaluation
Baldelomar, Edwin ; Bennett, Kevin
T-019017

— Technology Description: Researchers at Washington University in St. Louis have developed targeted, natural nanoparticle imaging agents that may be used to quantify kidney nephron endowment and diagnose renal disease with MRI or PET imaging. Nephrons are the functional units of the kidney responsi…

Immunohistochemical diagnosis of human renal chromophobe carcinoma
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack
T-011164

— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

DNA plasmids to control gene expression in E. coli
Hoynes-O'Connor, Allison ; Moon, Tae Seok
T-019135

— These plasmids contain target binding regions (TBRs) targeting rfp that were placed under the control of pTet via blunt end lifgation. Hfq binding sites that had been identified from the literature were inserted adjacent to the TBR sequence using either blunt end ligation or Golden Gate assembly, de…

LS301 and LS301 dimer
Achilefu, Samuel ; Sharmah Gautam, Krishna
T-019177

— Fluorescent tagged octapeptide for cancer detection

hNALCN Promoter-PGL3 Basic Luc Plasmid
Amazu, Chinwendu ; England, Sarah
T-019342

— The promoter region of the NALCN, sodium leak current, was amplified and inserted into the PGL3 Basic Luc backbone. The plasmid has applications in studying interactions of transcription factors with NALCN.

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Scalable synthesis of stable, highly conductive, solution-processable PEDOT particles for organic electronics
D'Arcy, Julio M. ; Lu, Yang
T-019278

— Technology Description Researchers in Prof. Julio D’arcy’s laboratory have developed aerosol vapor polymerization (AVP), a scalable continuous batch-processing platform to produce bulk quantities of stable submicron conductive particles for organic electronics. Unlike traditional PEDOT…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Xcr1 IRES mCherry-hCre Mouse Strain
Durai, Vivek ; Murphy, Kenneth ; Murphy, Theresa
T-019142

— Xcr1 IRES mCherry-hCre Mouse Strain This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…

Grueneisen-memory photoacoustic microscopy
Wang, Lidai ; Wang, Lihong ; Zhang, Chi
T-014165

— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Flag tagged BK(MDAL) in pBUD mch
England, Sarah ; Lorca, Ramon
T-019344

— Plasmid for flag tagged BK(MDAL) in a pBUD mcherry vector.

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Anti-fungal treatment and companion diagnostic for Crohn’s Disease
Jain, Umang ; Stappenbeck, Thaddeus
T-019293

— Technology Description: Researchers at Washington University in St. Louis have identified a new avenue for treatment of non-healing ulcers in patients with Crohn’s disease by targeting Debaryomyces hansenii. While the cause of Crohn’s disease is unknown, the fungus D. hansenii colonize…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Antibodies to transferrin receptor
Ladenson, Jack ; Porter, Sharon
T-000757

— Analyte: Transferrin Receptor (CD71) Antibody codes: 2B7.4 (4065) and 2F6.3 (4077) Publications:

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Blockchain-based algorithms for secure, collaborative risk assessment and decision making
Jain, Raj ; Salman, Tara
T-018710

— Technology Description Researchers in Prof. Raj Jain’s laboratory have developed a new type of algorithm that extends the security of decentralized blockchains from consensus validation to efficient group decision making. This technology, called “probabilistic blockchains”, provi…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Plasmids harboring 3HB with different split intein
Bai, Wenqin ; Zhang, Fuzhong
T-019213

— Plasmids harboring 3HB with different split intein: pWB076-pE8a-GpC10-3HBt-CfaN10; pWB088-pE8a- CfaC10-3HBt-NrdJN10; pWB079-pE8a-NrdJC10-3HBt-GpN10. Enabling a new process to compare nanostructures.

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

Low-cost, environmentally friendly synthesis of delta-MnO2 nanosheets for battery cathodes, catalysts and remediation
Jun, Young-Shin ; Jung, Haesung
T-018510

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory have developed a cost-effective, fast, green chemistry process to produce birnessite (δ-MnO2) nanosheets with naturally abundant resources. This method uses sunlight and nitrate to oxidize Mn2+ (aq) to Mn (IV) and ha…

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide & NAD) on blood glucose levels.
Imai, Shin-Ichiro ; Revollo, Javier
T-005815

— The novel effects of NAD-related compounds (nicotinamide, nicotinamide mononucleotide & NAD) on blood glucose levels.

ABCA3-GFP expression constructs
Cole, F. Sessions ; Wambach, Jennifer
T-017958

— This technology includes a plasmid with the full length ATP-binding cassette transporter A3 (ABCA3) cDNA cloned into the pAcGFP1-N1 vector and another plasmid with the ABCA3-GFP cDNA inserted into the pShuttle vector. Mutations in ABCA3 lead to severe neonatal respiratory distress syndrome and child…

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

E. coli plasmids and strains for biofuel synthesis
Jiang, Wen ; Xiao, Yi ; Zhang, Fuzhong
T-017688

— pA5c-tesA, pA8c-tesA-mleuABCD, pE2k-alsS-ilvCD Researchers used a standard restriction digestion cloning based on the Biobrick platform or Gibson assembly to construct the plasmids. E. coli DH10B was used for cloning. These plasmids were designed to increase branch chain fatty acid production. Pub…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Eye test to diagnose preclinical Alzheimer’s disease
Apte, Rajendra ; Van Stavern, Gregory
T-018518

— Technology Description Researchers at Washington University in St. Louis have developed a non-invasive screening method using optical coherence tomography angiography (OCTA) to detect Alzheimer’s disease (AD) at the early, preclinical stage. AD is characterized by progressive memory loss, be…

Ultrasound-guided diffuse optical tomography for fast, low-cost functional imaging of breast lesions
Mostafa, Atahar ; Zhu, Quing
T-018800

— Technology Description Prof. Quing Zhu and colleagues have pioneered a compact, low-cost ultrasound-guided optical tomography system designed to differentiate between benign and malignant breast lesions and reduce the need for costly and invasive biopsies. This technology enables fast, robust imag…

Coupled Visualization and Ablation of Specific Cells and Tissues in Zebrafish
Mumm, Jeffrey ; Schroeter, Eric
T-003399

— Background: Zebrafish is a standard model system in the field developmental biology and is particularly useful due to its extensive regenerative capabilities. The system has been used to study development by removal of cells by physical surgery and laser-mediated ablation; however these are labor in…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Clifednamide compounds
Qi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Novel benzo crown-ethers to create synthetic ion channels
Carrasquel Ursulaez, Willy ; Chanda, Baron
T-019832

— Technology Description Researchers in Baron Chanda’s lab at Washington University and Jennifer Schomaker’s lab at University of Wisconsin-Madison have developed a library of benzo(crown-ether) compounds capable of self-assembly into ion channels. These monoacylated and monoalkylated be…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

Energy efficient, scalable neuromorphic computing with Growth Transform Neural Network
Chakrabartty, Shantanu ; Gangopadhyay, Ahana
T-019112

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed Growth Transform Neural Network (GTNN), a flexible system for designing scalable neuromorphic processors for use in deep learning systems and support vector machines. GTNN frames the neuromorphic syst…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Self-powered, solid-state devices for remote sensing, timing and security of internet-of-things and other passive assets
Chakrabartty, Shantanu ; Zhou, Liang
T-015908

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a self-powered, CMOS-based, nano-scale “smart sensor” and timer system that uses quantum-tunneling for reliable, long-lasting memory or authentication. This technology is a floating gate …

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Photon tunneling
An, Woo Jin ; Wang, Lihong
T-012515

— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…

Manipulating Tricellular Junction Permeability in Blood Brain Barrier to Treat Brain Tumors
Gong, Yong-feng ; Hou, Jianghui
T-017092

— Background: Brain tumors are the most lethal disease known to mankind with approximately 170,000 annual diagnoses and 13,000 deaths attributed to brain cancer. Glioblastoma, the most common and aggressive, has a median survival of approximately 18 months. Chemotherapeutic agents have been approved b…

Low-cost, flexible paper substrate for sensitive trace chemical and biological detection using SERS (surface enhanced Raman scattering)
Kharasch, Evan ; Lee, Chang Hee ; Morrissey, Jeremiah ; Singamaneni, Srikanth
T-010600

— Technology Description Researchers in Prof. Srikanth Singamaneni’s laboratory have developed a patented, low-cost, flexible substrate designed to improve sample collection and enhance analyte detection with surface enhanced Raman scattering (SERS) or localized surface plasmon resonance (LSPR…

Irg1 point mutant mice
Diamond, Michael ; Nair, Sharmila
T-018684

— Description: CRISPR-Cas9 gene edited mice with point mutation in Irg1 (ACOD1). Note: Please contact for additional information.

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Detecting and Measuring Single Nanoparticles & Molecules with a Tapered Optical Fiber CIP
Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-011617

— The invention describes an instrument for detecting single particles, and measuring their properties (size or mass). The device contains only a tapered optical fiber. A laser diode as the light source and a photo-detector to measure the light intensity are also needed to complete the sensing system.…

Single Nanoparticle Detection by Mode Splitting in Active Microresonators using Heterodyne Technique
He, Lina ; Ozdemir, Sahin ; Yang, Lan
T-010140

— Dr. Lan Yang, Professor at Washington University in St. Louis, is a pioneer in the field of micro- and nano photonics. She recently developed a uniquely sensitive and versatile particle detector using whispering gallery mode (WGM) optical microresonators. Realtime detection and accurate sizing of la…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Radium Chelation For Targeted Alpha Particle Therapy
Abou, Diane ; Thorek, Daniel
T-019039

— Technology Description Researchers at Washington University in St. Louis have developed a method to chelate radium-223 and increase its utility in targeted alpha-particle therapy (TAT). TAT aims to deliver cytotoxic alpha-particles to cancer cells. Radium-223 is an alpha particle emitting isotope …

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique Compositions
Biswas, Pratim ; McDonald, Rafael ; Thimsen, Elijah
T-006824

— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …

Inducible PiggyBac transposase constructs
Mitra, Robi ; Qi, Zongtai
T-019209

— Chemically inducible PiggyBac transposase constructs. The plasmids that contain mutated destabilized domains, FKBP and DHFR, were purchased from Addgene with ID 31763 and 29326, respectively. The PBase-ERT2 plasmid (mPBase-L3-ERT2) was a kind gift from Dr. Allen Bradley . The coding sequence of mPBa…

Mouse anti-MR1 hybridomas, clone 4E3 and 6D1
Hansen, Ted ; Wang, Xiaoli
T-017622

— mAb 4E3 was derived by immunization of β2m-deficient BALB/c mice with a keyhole limpet hemocyanin-conjugated peptide corresponding to mMR1 residues 130–153 (L A M D Y V A H I T K Q A W E A N L H E L Q Y Q). Hybridomas were produced by standard methods and screened by anti-peptide ELISA. …

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Atrial fibrillation treatment with patient-specific model to design ablation lesions
Damiano, Ralph ; Schuessler, Richard
T-005819

— Technology Description This technology is a patented method aimed at increasing the success rate of atrial fibrillation (AF) treatment by designing customized, patient-specific cardiac ablation lesion sets. AF, the most common sustained cardiac arrhythmia, has traditionally been treated with a ma…

PhOTseq and VNO ectopic expression plasmids
Holy, Timothy ; Lee, Donghoon
T-019206

— These plasmids contain mammalian cell expression promoters and can be used for AAV production. Some plasmids encode a calcium reporter (GCaMP) and photoactivatable fluorescent reporter (PAmCherry). Others plasmids encode a calcium reporter (GCaMP) and one of the vomeronasal receptor genes; two gen…

Dementia Screening test: the AD8
Galvin, James ; Morris, John ; Roe, Catherine
T-007516

— The AD8 is an 8 question interview tool which distinguishes individuals with very mild dementia from those without dementia, regardless of etiology. The AD8 is based on intraindividual decline and has been demonstrated to be a valid and reliable screening tool for dementia.

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Photoacoustic tomography of human brain
Anastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043

— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

ANKO mice and ANKI mice
Imai, Shin-Ichiro ; Rosen, Evan
T-018529

— Description: Publications:

Light Sheet Microscopy with Objective-Coupled Selective Plane Illumination
Holekamp, Terrence ; Holy, Timothy
T-005916

— Technology Description Researchers in Prof. Timothy Holy’s laboratory at Washington University in St. Louis are among the independent inventors of light sheet fluorescence microscopy and the first to use it for large-scale calcium imaging. This patented technology, OC-SPIM (objective-coupled…

Two color HRas and single color CD86 plasmids
Foust, Daniel ; Piston, David
T-019195

— New combinations of labeled membrane proteins and G-protein subunits. These include twocolor HRas and single color CD86 controls as well as labels beta and gamma subunits of the heterotrimeric G-protein complex. All of these have been built using plasmids from Addgene.

Deep Learning-Assisted Image Reconstruction for Tomographic Imaging
Anastasio, Mark ; Kelly, Brendan ; Matthews, Thomas
T-017311

— Background Image reconstruction for any modern imaging technique is an optimization problem. Most image reconstructions methods are iterative in nature and produce sequential intermediate images that are compared to the raw acquisition data and subsequently updated to maximize the likelihood that t…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Treatment for Centrally Mediated Itching
Chen, Zhou-Feng ; Sun, Yan Gang
T-006757

— Background: Severe itch (or pruritus) is associated with multiple diseases such as liver disease, non-Hodgkin’s lymphoma, psoriasis, and common eczema and is also a side effect of many treatments including analgesics (like morphine) and renal dialysis. Chronic pruritus is a top reason for derm…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

BOOM-TCRtg mice
Allen, Paul ; Donermeyer, David
T-019192

— BOOM TCRtg mice express a T cell receptor specific for the Bt4295(541-554) epitope of the commensal bacteria Bacteroids thetaiodaomicron. This is the first mouse TCRtg line developed specific for B. theta.

Recombinant VSV vector for COVID-19 vaccine or drug screening
Rothlauf, Paul ; Whelan, Sean
T-019338

— Background: Recombinant vesicular stomatitis virus (VSV) has successfully been used to create a vaccine for Ebola virus that is currently on the market. Previously, Professor Sean Whelan and colleagues have exploited the VSV platform to create similar vectors for both SARS and MERS. Technology: The…

Anti-PDZ TIP1 Antibody Therapy for Cancer
Hallahan, Dennis ; Kapoor, Vaishali ; Yan, Heping
T-017064

— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

anti-IL-26 antibodies
Cella, Marina ; Colonna, Marco
T-019424

— Mouse monoclonal antibodies recognizing human IL-26

MR-HIFU acoustic coupling device to improve performance and reduce side effects
Altman, Michael ; Chen, Hong ; Kothapalli, Veera "Satya" ; Xie, Kevin
T-017089

— Technology Description Engineers in Prof. Hong Chen’s laboratory have developed a multifunctional, MR-compatible device designed to improve the performance of Magnetic Resonance High Intensity Focused Ultrasound (MR-HIFU) by increasing the efficiency of the ultrasound transmission, cooling t…

Hamster Monoclonal IgG2a Antibody against Mouse IFN-Beta
Schreiber, Robert ; Sheehan, Kathleen
T-012057

— Description: HDbeta-4A7- mouse IgG2a monoclonal antibody reactive with murine Interferon-beta. This mAb has neutralizing activity. Publication:

Spinning Spheres for Magnetic Resonance
Albert, Brice ; Barnes, Alexander
T-017912

— Background: A commonly used approach for the analysis of the molecular structure, content, and purity of solid and liquid samples is magic angle spinning nuclear magnetic resonance (MAS NMR). This technique provides greater resolution to better identify and analyze chemical spectra compared to solid…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

C3-knockout mice
Atkinson, John ; Wu, Xiaobo
T-019398

— Genetic disruption of murine C3 promotor region generates deficient mice with extrahepatic expression of C3 mRNA

Novel Method and Device to Produce Fluorine-18 PET Tracers
Chu, Wenhua ; Zhou, Dong
T-015970

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a new method and device for the preparation of flourine-18 (F-18) radiolabeled compounds as positron emission tomography (PET) tracers. PET is a widely used clinical and research imaging tool that will …

Hamster Monoclonal IgG Antibody against Mouse IFN-Alpha
Schreiber, Robert ; Sheehan, Kathleen
T-012056

— Description: TIF-3C5- Armenian hamster monoclonal antibody reactive with murine Type I Interferons, including IFN alpha A, 1, 4, 5, 11 and 13 but not IFNbeta. This mAb can block functional activity. Publication:

pAH198 — plasmid containing ColE1
Hoynes-O'Connor, Allison ; Moon, Tae Seok
T-019379

— A plasmid containing the E. colil ColE1 origin of replication, a chloramphenicol (antibiotic) resistance cassette, and a tetracycline-inducible antisense RNA gene regulator containing a target binding region (TBR) and the synthetic MicF M7.4 Hfq binding site for additional stability in the RNA molec…

High resolution imaging using subwavelength grating structures
Shen, Jung-Tsung ; Shen, Yuecheng ; Wang, Lihong
T-012856

— Conventional optics are generally restrained by a law of physics known as the diffraction limit, which dictates that optical systems can only resolve images down to about half the wavelength of the light used to produce the image (λ/2), or down to about 200 nanometers for most standard optics…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Chikungunya Monoclonal Antibodies
Diamond, Michael ; Fremont, Daved
T-010020

— Description: Monoclonal antibodies that react with and/or neutralize Chikungunya virus Publication:

New PARP-1 Inhibitors for Imaging PARP-1 Expression in Vivo
Chu, Wenhua ; Rogers, Buck ; Xu, Jinbin ; Zhou, Dong
T-018730

— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Collagen Matrix Possessing Locally Controllable Internal and Surface Mineral Content
Smith, Lester ; Thomopoulos, Stavros
T-013230

— Background: Tissue engineered scaffold repair materials are currently modified with surface mineralization with simulated body fluids (SBF) of collagen provide a lower stiffness than desired in biosynthetic entheses and fail to replicate the naturally graded structure of the human connective tissue …

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Armenian Hamster Anti-Mouse Properdin Monoclonal Antibody (clone H4)
Bertram, Paula ; Hourcade, Dennis
T-014378

— Target: Full length mouse properdin Application(s): Western blot and immunofluorescenceTwo functional properties of one of the two hamster antibodies have been examined, the H4 subclone of the 3D12 clone. In experiments the H4 antibody was used to identify mouse properdin present in histological sections, to block mouse properdin function in vitro, and to ameliorate complement alterna…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Isochoric Actuator
Cashin, John ; Genin, Guy ; Lee, Sanghun ; Zayed, Mohamed
T-019219

— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.

Drug target and biomarker for multiple sclerosis
Klein, Robyn ; Williams, Jessica
T-017623

— Technology Description Researchers in Prof. Robyn Klein’s laboratory have discovered that interferon lambda (IFN-λ) is a potential target for treating multiple sclerosis (MS), particularly secondary progressive MS (SPMS). Most patients with MS present with relapsing remitting MS (RRM…

Software to assemble HLA alleles using short paired reads from exome sequencing data
Liu, Chang ; Pfeifer, John
T-013332

— Technology Description: In collaboration with the scientists at Broad Institute, WU scientists have developed a new software with a new algorithm that enables HLA high resolution typing from exome sequencing data. It will provide a significantly better tool to guide the bone marrow transplantation a…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Crispr developed SARM1 Knockout Rat
DiAntonio, Aaron ; Milbrandt, Jeffrey
T-018728

— Crispr developed SARM1 Knockout Rat

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Crry-deficient mouse strain
Atkinson, John ; Molina-Vicenty, Hector
T-003105

— Crry-knockout mouse strain (Crry -/-)Researchers generated mice deficient in Crry by disrupting exon 5 of the mouse Crry gene. The mice are sensitive to complement deposition and activation, especially the C3 component of complement on the surface of the placenta. Publication: A Critical Role for Murine Complement Regulator Crry in Fe…

Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)
Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450

— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Hydrogel substrate system with easy, robust protein functionalization for cell culture
Pathak, Amit ; Sarker, Bapi
T-018649

— Technology Description Researchers in Prof. Amit Pathak’s laboratory have developed a hydrogel system that utilizes an aldehyde-based compound to easily and reliably pre-functionalize polyacrylamide for conjugation of proteins, such as collagen and fibronectin, for cell culture applications.…

Comfortable radiotherapy couch to improve precision and accuracy
Mutic, Sasa ; Zhao, Tianyu
T-018538

— Background: High precision and accuracy is critically needed for the use of radiation treatment and diagnostic imaging (magnetic resonance imaging, computerized tomography, X-ray, positron emission tomography); each of these modalities uses the standard flat couch to manipulate the patient during pr…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Hamster Hybridoma producing Monoclonal Antibody against Mouse CXCL9
Schreiber, Robert ; Sheehan, Kathleen
T-005944

— Target: Inflammatory chemokine CXCL9, monokine induced by IFN-gamma. Secreted mainly by macrophages. Notes: Clone MIG-2F5-5. Use in ELISA, neutralizing and binding assays.

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Stable, non-toxic lead-free perovskite materials for high efficiency solar cells and other semiconductor applications
Biswas, Pratim ; Kavadiya, Shalinee ; Mishra, Rohan ; Thind, Arashdeep Singh
T-018532

— Engineers at Washington University in St. Louis have discovered a new class of stable, benign perovskite semiconductor materials with performance properties optimized for solar cell and photocatalysis applications. Traditional lead-halide perovskites show remarkable power conversion efficiency in ph…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745

— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…

Antibody blocking IL-12 and IL-23 receptors to treat inflammatory diseases
Colonna, Marco ; Secca da Silva, Cristiane
T-019316

— Disease indication – Autoimmune diseases (plaque psoriasis, psoriatic arthritis, Crohn’s disease) Drug format – Monoclonal antibody Drug class – First-in-class Research stage and preliminary data – Researchers have stimulated human ILC3s with IL-23 in vitro, with and…

MicroRNA-induced Direct Conversion of Human Adult Fibroblasts into Neurons
Abernathy, Daniel ; Yoo, Andrew
T-017136

— Background: Studying late-onset neurodegenerative disorders using patient-specific neurons is one of the primary goals of precision medicine. The ability to generate human neurons that mimic the neurons of elderly individuals will provide an instrumental platform to model and study adult-onset neuro…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Hamster Hybridoma producing Monoclonal Antibody against Murine IFNAR-1
Schreiber, Robert ; Sheehan, Kathleen
T-004451

— Target: Type-1 interferon receptor subunit, a key signaling receptor in the interferon pathway. Notes: Clones MAR1-5A3, MAR1 -1H5, MAR1-3A7, MAR1-4D12, MAR1-4F12Monclonal antibodies specific for MuIFNAR1 were isolated from hybridomas developed following immunization of IFNAR1 gene targeted mice with purified plasmid encoding the the extracellular domain of murine IFNAR1 expressed in pRK5 using a method of hydrodynamic immunization. Publication:

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

HoxB5 cDTR mice
DiPersio, John ; Karpova, Darja
T-018897

— Transgenic HoxB5 conditional DTR (cDTR) mice have been generated using CRISPR mediated targeting of the HoxB5 gene (exon2) in fertilized wildtype C57Bl/6 eggs that were then microinjected into pseudopregnant wildtype female mice. The construct targeted under the controls of the endogenous HoxB5 prom…

Macrocyclic Molecular Beacons Useful for Medical applications
Achilefu, Samuel ; Ye, Yunpeng
T-004044

— Technology Description: Macrocyclic Molecular Beacons Useful for Medical applications :US 20070098638 (published US application) : The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing compounds as contrast agents. Novel macrocyclic cyanine and indocy…

Scanning Apparatus for Reflection-Mode Photoacoustic Tomography
Maslov, Konstantin ; Wang, Lihong
T-007645

— The greatest limitation on clinical use of existing photo-acoustic imaging technologies is the slow scanning speed caused by mechanical scanning, the bulky design of the scanning apparatus, and the necessity to immerse the body part into a ultrasonic coupling liquid. The present invention overcomes…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

NanoTCE: a nanoparticle antibody system for immunotherapy against heterogeneous multiple myeloma
Alhallak, Kinan ; Azab, Abdel Kareem
T-018892

— Disease indication – multiple myeloma Drug format – antibodies conjugated to nanoparticles for T-cell immunotherapy Drug class – improved delivery platform Research stage and Preliminary data: In vivo: In vitro proof of concept – in a MM cell line: NanoMuTEs and NanoTC…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Huang, Li-Hao ; Randolph, Gwendalyn ; Zinselmeyer, Bernd
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

Software that Generates Radiology Reports using Deep Learning
Kansagra, Akash ; Rahbar, Kasra
T-018976

— T-018976 Software that Generates Radiology Reports using Deep Learning Technology Description Researchers at Washington University in St. Louis have developed a computational software method designed to assist radiologists with generating and correcting patient reports more effectively. Radiolo…

Method and Apparatus for Optical Time Reversal by Ultrasonic Encoding in Biological Tissue
An, Woo Jin ; Wang, Lihong
T-010123

— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

High-speed perovskite LED fabrication by inkjet printing
Wang, Chuan ; Zhao, Junyi
T-019910

— Technology Description Researchers in Chuan Wang’s lab at Washington University have developed a method of fabricating perovskite LEDs (PeLEDs) directly on an elastic substrate more than 10X faster than existing methods. Each layer of the PeLED is patterned using a highly scalable inkjet pri…

Miniature, portable device for measuring exposure to airborne nanoparticles
Chen, Da-Ren ; Qi, Chaolong
T-006838

— Technology Description Engineers in Prof. Daren Chen’s laboratory have developed a patented portable device for sampling and measuring nanoaerosols for industrial hygiene and aerosol science applications. Currently, a variety of industrial applications require the chemical synthesis of submi…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Intestinal biomarker predicts response to treatment for inflammatory bowel disease
Stappenbeck, Thaddeus ; VanDussen, Kelli
T-019186

— Technology Description Researchers in the Stappenbeck lab have discovered an objective histologic biomarker on intestinal cells that can predict a patient’s response to ustekinumab treatment for Crohn’s disease or ulcerative colitis. Specifically, the length of microvilli (MV) could pr…

Low cost electrode decoupled redox flow batteries for grid-scale energy storage
Ramani, Vijay ; Sankarasubramanian, Shrihari
T-018530

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed an electrode decoupled redox flow battery (RFB) with stable electrolyte materials that can generate power densities comparable to all-Vanadium RFBs at less than half the cost. RFBs are a promising option for …

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Deep Tissue Diagnostics with Disposable Fiber-Optic Device
Hu, Song ; Ling, Jingwei ; Yang, Shuo
T-020656

— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…

IL-1 beta deficient mice
Chaplin, David ; Ferguson, Thomas
T-001876

— Mouse strain deficient in IL-1 betaInventors created the IL-1 beta deficient mouse strain by targeting the IL-1 beta gene in embryonic stem cells. These mice develop and grow normally. Endotoxin-stimulated peritoneal macrophages from IL-1beta- deficient mice showed normal synthesis and cellular release of IL- 1alpha after treatment w…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Deep learning algorithm to expedite MRI-guided adaptive radiotherapy planning
Fu, Yabo ; Yang, Deshan
T-018708

— Technology Description Researchers in Prof. Deshan Yang’s laboratory have developed a deep-learning method for fast, robust, automated MRI segmentation to expedite treatment planning for patients undergoing MRI-guided adaptive radiotherapy (MR-IGART). Specifically, this technology utilizes a…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Lrp1 and the Blood Brain Barrier
Amarasinghe, Gaya ; Ganaie, Safder ; Leung, Daisy ; Virgin, Herbert
T-019577

— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

JAK inhibitor as conditioning agent for allogeneic hematopoietic stem cell transplantation
DiPersio, John ; Persaud, Stephen "Steve"
T-019132

— Technology Description Researchers at Washington University in St. Louis have developed an improved process for conditioning patients for allogeneic hematopoietic stem cell transplantation (alloHSCT) using JAK inhibitors. Commonly used to treat autoimmune diseases like rheumatoid arthritis, JAK inh…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

T-018741 & T-019450 – Computational Improvements of Immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— T-018741 & T-019450 – Computational Improvements of Immunoassays Technology Description Researchers in Mark Zaydman’s laboratory at Washington University have optimized a new method to improve the analytical measurement range (AMR) in homogeneous turbidimetric immunoassays. The method ut…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Single cell massively parallel reporter assays
Cohen, Barak ; Zhao, Siqi
T-019923

— Technology Description Researchers in Barak Cohen’s lab at Washington University have developed a method for single cell massively parallel reporter assay (scMPRA) to preserve cell type-specific information. This technology is scalable and sequencing platform agnostic. Massively parallel…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Vectors for study of Wolfram Syndrome
Abreu, Damien ; Urano, Fumihiko
T-019395

— Dr. Fumihiko Urano is director of the Wolfram Syndrome International Registry at WU and has developed many research tools for studying Wolfram Syndrome. The following constructs contain the wildtype WFS1 gene with various flags, or mutations of WFS that cause mild forms of Wolfram Syndrome (019395)…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells
Luff, Stephanie ; Sturgeon, Christopher
T-018886

— T-018886 — Scalable Generation of Hematopoietic Progenitors from Human Pluripotent Stem Cells Technology Description In vitro generation of CD34+ hematopoietic progenitor cells (HPC) that faithfully recapitulate in vivo behavior is an area of ongoing research. A key characteristic of CD34+ …

Stem cells that produce decorin
Guilak, Farshid ; Pferdehirt, Lara
T-019343

— Using CRISPR-based gene editing, decorin was inserted downstream of Smad7 to create autoregulated stem cells that can produce decorin. As Smad7 is activated during TGF-beta signaling, the stems cells produce decorin in response to TGF-beta. Decorin is a key modulator of extracellular matrix assembly…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Optical Coherence Computed Tomography
Li, Li ; Wang, Lihong
T-008832

— Optical coherence tomography (OCT) utilizes optical light to obtain an image of opaque or translucent objects, ie tissue. Because scattered light contributes to the bluring found in other optical imaging techniques, OCT filters out all the scattered light. An image is formed using only the back refl…

Breath-based testing for malaria
John, Audrey Odom "Audrey Odom" ; Schaber, Chad ; Trehan, Indi
T-016183

— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…

Radiotracers to detect early Parkinson’s disease
Kotzbauer, Paul ; Qiu, Lin ; Tu, Zhude "Will" ; Yu, Yanbo
T-020559

— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

Adenovirus- human ACE2 transduction system to sensitize mice to SARS-CoV-2
Diamond, Michael ; Hassan, Ahmed
T-019482

— Technology Description Researchers at Washington University in St. Louis have developed a method to sensitize commercially available laboratory mice to SARS-CoV-2 infection. SARS-CoV-2 is the cause of the coronavirus disease 2019 (COVID-19) pandemic that has had severe morbidity and mortality impa…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Real-time 3D MRI
Kim, Taeho ; Park, Chunjoo (Justin)
T-019011

— Technology Description Researchers at Washington University in St. Louis have developed a method for real-time, high-resolution 3D MRI that can be used in diagnostic MRI and MRI-guided radiotherapy (MRgRT). MRgRT combines medical imaging with radiation therapy to provide visualization of the tumor…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

MRI-based Alzheimer’s disease biomarkers for early diagnosis and clinical trials
Yablonskiy, Dmitriy ; Zhao, Yue
T-015754

— Technology Description Researchers in Prof. Dmitriy Yablonskiy’s laboratory have developed patented neuroimaging techniques to identify pre-clinical and early stage Alzheimer’s disease (AD) using MRI-based biomarkers of amyloid accumulation and other pathological changes in the brain. …

Antibodies to MDK
Hallahan, Dennis ; Kapoor, Vaishali
T-018978

— MDK is a molecular target for treatment of cancer. These antibodies are to the functional domain of MDK.

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-016668

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

Antibody to SPRR3
Ladenson, Jack ; Young, Pampee
T-004462

— Analyte: Small proline rich protein 3 (gene SPRR3) Antibody codes: 3E9.1 (4587), 4G3.1 (4563), and 2F10.2 (4604) Publications:

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

3D tissue culture device that mimics cancer metastasis for in vitro drug discovery
Nasrollahi, Samila ; Pathak, Amit
T-016671

— Technology Description Engineers in Prof. Amit Pathak’s laboratory have developed a 3D tissue culture device with chambers of variable, tunable stiffness to mimic the multiple microenvironments cancer cells experience in vivo as they metastasize. Traditional 3D extracellular matrix (ECM) mod…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Engineered Oncolytic Zika Virus Therapy for Glioblastoma
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Stimulating Innate Immune Cells for Cancer Therapy or Vaccine Adjuvants
Barrow, Alexander ; Colonna, Marco
T-016924

— Technology Description Researchers in Prof. Marco Colonna’s laboratory have identified a receptor-ligand interaction that could be harnessed to activate the innate immune system to treat cancer or enhance the response to vaccines for infectious disease. Specifically, platelet-derived growth f…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

Imaging and treatment of pathophysiologic conditions by Cerenkov Radiation
Achilefu, Samuel ; Kotagiri, Nalinikanth
T-013974

— Background: Around 1 million patients receive radiation therapy every year with an estimated cost of $2,000 per treatment. The market demands technologies that can provide efficacious therapeutics and diagnostic imaging while minimizing harmful side effects. Photodynamic therapy can simultaneously s…

Optimized MHC-independent T cell receptors as a CAR-T alternative
Chang, Ju Fang ; Singh, Nathan
T-019636

— Technology Description Researchers in Nathan Singh’s lab at Washington University have developed a construct for cell therapy that combines facets of existing CAR-T therapy and the endogenous T cell receptor (TCR) to better regulate adoptive cell activation. Unlike the traditional TCR, this …

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Gaehle, Gregory ; Lawrence, Luke ; Zerkel, Patrick
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

PET Radiotracers for Imaging Free Radicals and Reactive Oxygen Species (Materials: WC-4-77)
Chu, Wenhua ; Dugan, Laura ; Mach, Robert ; Mintun, Mark
T-009254

— Many diseases can be associated with abnormal production of reactive oxygen species (ROS) due to oxidative stress. Currently there is no way to image this in situ. Dihydroethidium (DHE) naturally produces a fluorescent product when oxidized by an ROS. The signal is not strong enough for practical im…

Parity-Time Symmetric Whispering-Gallery-Mode Microcavities Sensor
Ozdemir, Sahin ; Peng, Bo ; Yang, Lan
T-014053

— A non-reciprocal transmission device based on PT symmetry was previously theorized but never before constructed and shown to work at useful optical wavelengths. The new structure allows creation of the miniaturized optical isolation function without use of the century+ known Faraday effect. Optica…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

Data security for IoT and mobile devices using Bit2RNG random number generator with no additional hardware
Yan, Wei ; Zhang, Xuan "Silvia"
T-019418

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a robust true random number generator (RNG) designed to be used as a low-resource security system for mobile and internet-of-things (IoT) devices. This technology, called “Bit2RNG&rdqu…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Rapid Strep Throat Diagnostic Using Host Gene Expression Analysis
Storch, Gregory ; Yu, Jinsheng
T-019526

— Technology Description Researchers in Prof. Gregory Storch’s laboratory have developed a molecular assay that utilizes the patient/host gene expression pattern to rapidly identify acute group A streptococcus (GAS) infection in patients with pharyngitis (sore throat) to help guide appropriate…

Universal Targeted Drug Delivery and Imaging Platform
Barnes, Jonathan ; Delawder, Abigail "Abby" ; Li, Ruihan ; Li, Xuesong
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

UPAB1 plasmid lacking pAB5
Di Venanzio, Gisela ; Feldman, Mario
T-019205

— An UPAB1 derivative, UPAB1p-, that spontaneously loss pAB5 was identified by detection of restored Hcp secretion and isolated via an ELISA. Compared to wildype UPAB1, UPAB1p- displayed comparable growth in vitro in both rich medium and urine from healthy donors, indicating that less pAB5 did not in…

Small molecule inhibitors of G protein activity to treat uveal melanoma, and other cancers and disorders
Blumer, Kendall ; Onken, Michael
T-017344

— Disease indication – Uveal melanoma and other G protein-driven disorders, including other cancers (certain vascular tumors, colon, lung, adenocarcinoma, skin melanoma, thyroid adenoma), cholera and Sturge-Weber Syndrome Drug format – small molecule (FR900359, a bioavailable inhibitor of…

CD226 (DNAM1) knockout mice
Colonna, Marco ; Gilfillan, Susan
T-019563

— This is a mouse knockout strain for CD26, also known as DNAM-1 (DNAX accessory molecule 1). DNAM-1 is an adhesion molecule belonging to the immunoglobulin superfamily. This mouse model was used to study the role of DNAM-1 on CD8 T cell and NK cell function in vitro and in vivo. Publication: Gilfill…

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal Inoculation
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064

— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Albring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1PR2-targeted PET tracers
Klein, Robyn ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-018580

— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

Plasmid to test regulation 5′ untranslated sequences in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019560

— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…

Venezuelan equine encephalitis virus (VEEV) E2 DNA plasmid
Diamond, Michael ; Kim, Arthur
T-019082

— VEEV E2 DNA plasmid

SILTmass software
Bateman, Randall ; Elbert, Donald
T-008416

— Background Quantitation of relative or absolute amounts of proteins by mass spectrometry can be prone to large errors. The use of MS/MS ion intensities and stable isotope labeling, a method called isotope labeling tandem mass spectrometry (SILT), decreases the effects of contamination from unrelate…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

DNA Plasmids for the Modulation of Gene Expression
Lee, Young Je (Ryan) ; Moon, Tae Seok
T-019002

— These set of plasmids allow for the repression and de-repression of fluorescent proteins (GFP and mCherry) through CRISPR interference and antisense RNA. Publication: Programmable control of bacterial gene expression with the combined CRISPR and antisense RNA system

Decision support process for cerebral aneurysm pattern recognition in microsurgical/endovascular decision support system
Dacey, Ralph ; Ju, Tao ; Washington, Chad
T-012982

— Cerebral Aneurysms are weak areas in the wall of a blood vessel causing it to bulge out. These aneurysms can take on many sizes, shapes, and be in different locations. Currently cerebral angiographies, spinal tap, CT or MRI are used to diagnose cerebral aneurysm. Treatment options are chosen by a do…

Itaconate Immunomodulatory Properties-Ischemia Reperfusion
Artyomov, Maxim ; Lampropoulou, Vasiliki "Vicky"
T-016181

— Technology Summary: Approximately 1.3 million individuals each year in USA alone are affected by ischemia-reperfusion injuries. A substantial portion of such injuries is the result of macrophage-mediated inflammation. There are some conventional methods for treating macrophage-mediated inflammation,…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Mouse bladder cancer organoid cell line MCB6A
Arora, Vivek ; Bolzenius, Jennifer
T-019309

— MCB6A organoids generate urothelial tumors with features similar to the basal-squamous subtype of urothelial carcinoma, the most common bladder cancer. MCB6A harbors 1,524 mutations, including mutations in Kdm6a and Trp53. Publication: CD4+ T cells induce rejection of urothelial tumors after imm…

Cd40lg-Cre mouse
Chou, Chun ; Egawa, Takeshi
T-018831

— Cd40lg-Cre mouse

Microbiome Biomakers of Obesity
Gordon, Jeffrey ; Turnbaugh, Peter
T-007697

— Technology Summary: Obesity rates worldwide are increasing at an astounding rate. While diet, lifestyle, and physical activity have traditionally been identified as the main causative factors, researchers at Washington University are the first to implicate gut bacteria (microbiome) as a new drivin…

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Vaccines and antibodies against malaria and other parasitic diseases in humans and animals
Jimah, John ; Tolia, Niraj
T-016150

— Technology Description Researchers in Prof. Niraj Tolia’s laboratory have exploited structure-based vaccine design to develop immunogenic compositions and neutralizing antibodies that could protect against malaria and a range of other parasitic diseases that affect humans, livestock and comp…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Plasmids to express tagged genes in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019559

— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…

Elastin conditional knockout mouse
Mecham, Robert ; Wagenseil, Jessica
T-019289

— Mouse with floxed elastin gene to conditionally inactivate elastin gene expression. Publication: Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Ultra-Rare Variant Detection using Next Generation Sequencing
Druley, Todd ; Young, Andrew
T-014312

— Next Generation Sequencing (NGS) allows rapid sequencing of an individual’s entire genome or portions of the genome to identify thousands of genetic variants. Personalized genomic tests based on NGS technologies can be used to predict an individual’s risk of disease or monitor disease pr…

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Lactobacillus reuteri deltaArat
Caparon, Michael ; Cervantes-Barragan, Luisa ; Colonna, Marco ; Di Luccia, Blanda
T-018589

— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α…

Learnable, scalable, energy efficient analog-to-digital interfaces and their automated design
Chakrabarti, Ayan ; Zhang, Xuan "Silvia"
T-017967

— Technology Description Engineers in Prof. Xuan “Silvia” Zhang’s laboratory have developed a unifying design and optimization paradigm to automate the design of analog-to-digital interfaces and create scalable, general purpose analog and mixed signal (AMS) blocks that employ machi…

Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes
Asadi Jomnani, Farzad ; Dolle, Roland "Ron" ; Piston, David
T-020153

— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Superficieibacter electus
Andleeb, Saadia ; Burnham, Carey-Ann
T-018501

— Superficieibacter electus

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Song, Sheng-Kwei "Victor" ; Wang, Qing ; Wang, Yong
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Triblock Copolymer Based Anion Exchange Membranes (Aems) As Separators in Electrochemical Devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-017637

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

Red-Shifted Chromophore Substitution for Optogenetic Applications
Corbo, Joseph ; Enright, Jennifer ; Toomey, Matthew
T-014377

— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …

APT1 deficient mouse
Semenkovich, Clay ; Wei, Xiaochao
T-017904

— APT1 deficient mouse

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Systems and Methods for Detection and Quantification of Axial Spondyloarthritis
Paley, Michael ; Yokoyama, Wayne
T-020486

— T-020486 – Systems and Methods for Detection and Quantification of Axial Spondyloarthritis Technology Description Researchers at Washington University in St. Louis, led by Dr. Michael Paley, have developed an assay to diagnose axial spondyloarthritis (axSpA) in HLA-B*27-positive patients.…

Neuroactive steroid anesthetic compounds
Covey, Douglas ; Jiang, Xin
T-004034

— Technology Description Researchers at Washington University have developed a range of steroid anesthetic agents that share known neurosteroid structures but are more potent. These compounds share the basic structure of neurosteroids alphaxalone, allopregnanolone, and ent-androsterone, but the stru…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

anti-Powassan virus antibodies and hybridoma cell lines
Diamond, Michael ; VanBlargan, Laura
T-018559

— Murine anti-Powassan virus antibodies and hybridoma cell Publication: An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

MRI-based virtual histopathology for non-invasive diagnosis of prostate cancer, glioblastoma and other conditions
Song, Sheng-Kwei "Victor" ; Ye, Zezhong
T-016528

— Researchers in Prof. Sheng-Kwei (Victor) Song’s laboratory have developed diffusion histology imaging (“DHI”), a tool to provide a non-invasive diagnosis for accurately grading tumors and guiding treatment decisions. This “virtual histopathology” technology classifies mic…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for Children
Jeffe, Donna ; Lieu, Judith ; Umansky, Amy
T-010222

— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…

Drugs to supplement microglial metabolism during treatment of Alzheimer’s disease
Colonna, Marco ; Ulland, Tyler
T-017401

— Background: Alzheimer’s disease (AD) is the 6th leading cause of death in the United States, and yet causation of the disease is poorly understood and targets for therapeutic intervention are still being identified. Recently, mutations in the immune receptor TREM2 have been found to be strongl…

Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser Systems
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…

LDLRAD3 KO mice
Diamond, Michael ; Thackray, Larissa
T-019372

— Venezuelan equine encephalitis virus (VEEV) is an emerging infectious disease in South America transmitted by mosquitos. VEEV usually resides in forest and swamp areas where human populations are limited, however, VEEV has the potential to cause epidemics in humans and equines. LDLRAD3 has been foun…

Sensitive and Accurate Mass Spec-based assay for simultaneous quantification of glycosylsphingosine and galactosylsphingosine
Jiang, Xuntian ; Ory, Daniel
T-016077

— Background Gaucher and Krabbe disease are two types of lipid (fat) storage diseases that can result in progressive damage to the nervous system and other organ systems. Together, these diseases affect about 450,000 people worldwide. In both of these diseases, there is an undesirable accumulation of…

Nanothermometers for cellular-level temperature monitoring in ablation therapy or research
Berezin, Mikhail ; Gustafson, Tiffany
T-012606

— Technology Description Researchers in Prof. Mikhail Berezin’s laboratory have developed patented, fast-acting, gold nanoparticle-based optical “nanothermometers” that can detect temperature changes at the cellular level by emitting a fluorescent signal. These molecules were desig…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Antiviral therapy targeting viruses within parasitic protozoans
Beverley, Stephen ; Kuhlmann, Frederick
T-016969

— Background: Parasitic infections remain global health threats and often lead to high death rates in endemic countries. Found in 98 countries, the Leishmania parasite is particularly dangerous and accounts for an estimated 2 million cases and 50,000 deaths per year across the world. However, Leishman…

Plasmids for Cryptosporidium parvum
Funkhouser-Jones, Lisa ; Shen, Bang ; Sibley, Laurence
T-018967

— These plasmids are for performing CRISPR/Cas9 gene editing in Cryptosporidium parvum To generate a CRISPR/Cas9 plasmid for use in C. parvum, researchers used restriction cloning with SacI to insert the C. parvum U6 gene into a pUC19 vector to create pUC19-CpU6. We then inserted the C. parvum actin …

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cytokines-induced-memory-like NK cells with reduced NKG2A checkpoint signaling
Berrien-Elliott, Melissa ; Fehniger, Todd ; Romee, Rizwan
T-017001

— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…

Subtyping of schizophrenia based on genome and pathology
Cloninger, C. Robert ; Svrakic, Dragan ; Zwir, Jorge "Igor"
T-015118

— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

Therapy to treat and prevent respiratory disease in pre-term and at-risk neonates
Morley, Sharon "Celeste" ; Todd, Elizabeth (Betsy)
T-017434

— Technology Description Researchers in Prof. S. Celeste Morley’s laboratory have developed a long-lasting prophylactic therapy that could protect pre-term and at-risk infants from pneumonia, respiratory distress and bronchopulmonary dysplasia. Neonates born prematurely are at increased risk f…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response
Lomonosova, Elena ; Mullen, Mary ; Verma, Priyanka ; Zhao, Peinan
T-020659

— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response Technology Description Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Method to generate functionally mature, stem-cell derived, beta cells
Millman, Jeffrey ; Velazco-Cruz, Leonardo
T-019270

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to differentiate stem-cells into functionally mature, insulin-secreting beta cells (SC-beta cells). Pancreatic beta cells play an important role in controlling blood glucose levels as they se…

Precise, dynamic control of macromolecule adhesion to glass slides and other surfaces
Bridgman, Paul ; Turney, Steve
T-005874

— Technology Description This technology is a patented method for producing microarrays or directing cell growth on a surface by precisely and dynamically manipulating the adhesion of macromolecules. While many techniques exist for adhering proteins, nucleic acids, and other macromolecules to solid …

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Treating Tuberculosis with Host-Directed Drug Targeting
Chandra, Pallavi ; Philips, Jennifer
T-017060

— Background: Worldwide, there are over 10 million new cases of tuberculosis (TB) annually, resulting in 1.8 million deaths. This makes Mycobacterium tuberculosis (Mtb), the bacterium causing TB, the world’s leading infectious disease killer. Even for drug susceptible TB, the treatment courses a…

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Plasmids with genetic variants of CEL
Lowe, Mark ; Xiao, Xunjun
T-018959

— These plasmids encode carboxyl ester lipase (CEL) with and without genetic variants that are associated with chronic pancreatitis. To make the plasmids, the researchers used a full-length human CEL cDNA clone. The cDNA encoded for a 14-repeat VNTR, the variant present in the CEL MODY family. The Ec…

Autosegmentation tool
Grigsby, Perry ; Ma, Daniel ; Rao, Yuan
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Sustainable rare earth element extraction from coal ash
Jun, Young-Shin ; Zhu, Yaguang
T-019257

— Technology Description Researchers in Young-Shin Jun’s lab at Washington University have developed a more sustainable and efficient process for extracting rare earth elements from coal fly ash using supercritical fluids. Compared to the conventional roasting and acid leaching method, supercr…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Zbtb46, a novel target for cancer therapy
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-020458

— T-020458 — Zbtb46, a novel target for cancer therapy Technology Description Solid neoplasms are difficult to treat using immune checkpoint inhibitors in part because of the immunosuppressive nature of the tumor microenvironment. Researchers at Washington University School of Medicine, led b…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

B2m Floxed mouse
Bern, Michael ; Yokoyama, Wayne
T-018951

— To generate the mice, the researchers micro-injected ES cell clones carrying the targeted allele B2mtm1a(EUCOMM)Hmgu (B2mtm1a) into Albino B6 blastocysts.Chimeric mice were bred to Albino B6 to identify germline transmission by coat color. Mice containing the germline-transmitted B2mtm1a allele were…

Applicator device for reducing artifacts in MR-guided gynecological brachytherapy
Grigsby, Perry ; Zoberi, Jacqueline
T-011297

— Technology Description Radiation oncologists at Washington University in St. Louis have developed a patented plastic sheath applicator device to improve treatment planning and tumor targeting in image-guided brachytherapy (IGBT) for uterine and cervical cancer. Currently, high-dose rate brachyther…

Compound to treat alcohol use disorder
Covey, Douglas ; Mennerick, Steven
T-019232

— Technology Description Researchers at Washington University in St. Louis have developed new compounds that may be used to treat alcohol use disorder (AUD). AUD, a common condition that takes a high personal and public health toll, is characterized by severe problems with drinking- sufferers may co…

Therapeutic Approach for Huntington’s Disease (HD)
Kim, Albert ; Yano, Hiroko
T-016079

— Dr. Hiroko Yano and Dr. Albert Kim, and their research teams at the Washington University School of Medicine in St. Louis developed and extensively evaluated a novel therapeutic approach using DNMT inhibitors to treat Huntington’s Disease (HD) and other neurodegenerative disorders. Currently D…

Low-cost optical sensors for high performance, discrete hearing aids
Liao, Jie ; Yang, Lan
T-019167

— Technology Description A team of engineers in Prof. Lan Yang’s laboratory have developed ultra-sensitive, broad bandwidth optical sensors that could detect sound in low-cost, discrete hearing devices. This technology utilizes whispering gallery mode (WGM) resonators as compact photonic vibra…

Biological and Biochemical Production of Enantiopure L-Piperazic Acid
Hu, Yifei ; Van Dyke-Blodgett, Joshua
T-017073

— Background: Compounds containing piperazic acid (Piz), a nonproteinogenic amino acid, are of significant interest for drug discovery. Peptidic compounds incorporating Piz as a building block include antibacterial, antiviral, immunomodulatory and anticancer drug leads, and all naturally-occurring Pi…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Wireless, dissolvable electrical stimulation device for nerve or bone regeneration
MacEwan, Matthew ; Ray, Wilson
T-017504

— Technology Description An interdisciplinary team of inventors has developed an implantable, bioabsorbable device to accelerate nerve or bone repair by delivering programmable electrical stimulation over the course of days or weeks following surgery. Direct electrical stimulation during surgery for…

Development of CD163 targeting agent for imaging and therapy
Heo, Gyu Seong ; Liu, Yongjian ; Zhang, Xiuli
T-020196

— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species
Satham, Lakshminarayana ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-020300

— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there…

Photothermal disinfection of N95 respirators
Jun, Young-Shin ; Singamaneni, Srikanth
T-019477

— Technology Description A team of researchers led by Young-Shin Jun have developed a polymer coating for N95 respirators that would permit fast, easy, and cheap N95 disinfection using only direct sunlight. The researchers coated the outermost fabric layer in polydopamine, which converts photon energ…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Artificial Materials with Enhanced Nonlinearity
Ironside, Daniel ; Shen, Jung-Tsung
T-011141

— Background: Advances in nonlinear materials give rise to a multitude of optical phenomena that have important applications as switches and modulators in telecommunications and optical computing industry. The degree of optical nonlinearity in a material depends upon the strength of the optical field…

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation
Sharma, Vijay ; Sivapackiam, Jothilingam
T-019479

— T-019479 Tissue-penetrating PET radiotracer for non-invasive detection of ROS and inflammation. Technology Description 18F-fluorodeoxyglucose (18F-FDG) has long been used for the diagnosis of neoplasms, and recently Alzheimer’s disease. However, 18F-FDG signals are often not correlated with…

Plasmids for calling cards and single cell calling cards
Chen, Xuhua ; Lalli, Matthew ; Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019487

— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…

miRNA mimics to treat metabolic disease
Gong, Yong-feng ; Hou, Jianghui
T-017930

— Disease indication: metabolic disorders including insulin resistance and diabetic nephropathy Drug format: chemically modified synthetic microRNA (miRNA) Drug class: first-in-class for metabolic disease Research stage and Preliminary data: Target: miR-29 mimics can increase the gene expressio…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Personalized Virtual Reality Training
Engsberg, Jack ; Foreman, Matthew ; Janes, William
T-014603

— Many patients require physical therapy each year as a result of their suffering from a variety of neurological and musculoskeletal disorders including stroke, cerebral palsy, trauma and many others. Repetitive movements can increase muscle tone, range of motion and stamina to aid in their daily act…

MOR1D Mediates Opioid and Liver Disease-Induced Itch via GRPR
Chen, Zhou-Feng ; Liu, Xianyu
T-011473

— Background: Opioids, such as morphine, are used in pain management and have significant analgesic effects. However a common side effect of morphine is severe itching. Currently, morphine-induced itch is treated with antagonists against the mu opioid receptor. While these antagonists reduce itch, the…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

A long non-coding RNA in early and late-stage breast cancer as a prognostic marker, diagnostic marker, and therapeutic target.
Eteleeb, Abdallah ; Maher, Christopher ; Silva-Fisher, Jessica
T-020366

— Technology Description Researchers in Dr. Jessica Silva-Fisher’s laboratory have developed antisense oligonucleotide targeting a long non-coding RNA (lncRNA), LINC00355, as a treatment for late-stage relapse (LSR) breast cancer. LINC00355 is highly expressed in LSR breast cancer patients and…

New nerve cap arrests axon growth in neuroma management
Bichanich, Miles ; Hong, Thomas ; Mackinnon, Susan ; Moore, Amy ; Wood, Matthew
T-017285

— Background Neuromas (a.k.a. pinched nerve, or nerve tumor) form on peripheral nerves following trauma and possess exposed sensory axons mixed with fibrotic scar tissue. Symptomatic or painful neuromas have a profound impact on a patient’s quality of life and productivity. Pain medication offe…

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

Alphavirus-Resistant Fish
Diamond, Michael ; Zhang, Rong
T-018625

— Background: Aquaculture is the most resource-efficient method to produce protein, improve nutrition, and food security and is vital for supporting seafood production. The Food and Agriculture Organization of the United Nations estimates over 50% of all global seafood for human consumption is produce…

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

High-yield, heat tolerant tomatoes
Frick, Elizabeth ; Strader, Lucia
T-018506

— Technology Description Researchers in Prof. Lucia Strader’s laboratory have cultivated genetically-stable, high-yield tomato plants that are tolerant to high temperature growing conditions (40oC). These plants were identified using a screen for mutants. Excitingly, two mutants (IR-12 an IR-1…

Mayaro virus monoclonal antibodies and hybridomas
Diamond, Michael ; Earnest, James
T-019543

— Mayaro virus (MAYV) is an emerging mosquito-transmitted alphavirus. This is a panel of 18 neutralizing mAbs agains MAYV, 11 of which have activity that inhibited infection with EC50 values

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

Method for obtaining buoyant triacylglycerol-filled Chlamydomonas reinhardtii
Goodenough, Ursula ; Goodson, Carrie
T-011504

— There is currently keen interest in cultivating eukaryotic algae as sources of triacylglycerides (TAGs) to be converted into diesel and jet transportation fuel. Recent studies from numerous labs have shown that when stressed by nitrogen (N)-starvation, Chlamydomonas reinhardtii produce TAGs that ca…

Multi-energy window approaches for quantitative SPECT
Jha, Abhinav Kumar ; Li, Zekun ; Thorek, Daniel
T-019824

— T-019824 Multi-energy window approaches for quantitative SPECT Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised a method to reliably obtain and significantly improve quantification of alpha-particle based SPECT tracer uptake, particularly …

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

CemOrange2 gene fusions for subcellular imaging in C. elegans
Luke, Clifford ; Pak, Stephen ; Silverman, Gary ; Thomas, Brian
T-018982

— Plasmids were generated with the NHX-2 promoter, to restrict gene expression to the C. elegans intestinal cells, driving C. elegans genes or targeting peptides, known to target different subcellular organelles, fused to a C. elegans optimized mOrange2 fluorescent protein (CemOrange2). These expressi…

SPECT imaging nanoprobe for the detection of matrix metalloproteinase (MMP) activity
Achilefu, Samuel ; Black, Kvar
T-014635

— This invention is the formulation of a SPECT nanoparticle probe for the detection of MMP activity. The surface of a 10 nm-sized gold nanoparticle is functionalized through a thiol anchor with a peptide that is cleaved in the presence of MMP9. The surface is also functionalized with methoxy polyethyl…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

CEPT1 floxed mice
Lodhi, Irfan ; Semenkovich, Clay
T-019637

— C57BL/6 ES cells were targeted with a vector (European Conditional Mouse Mutagenesis Program) carrying loxP sites flanking exon 3 of mouse Cept1. A karyotypically normal clone (of 10 correctly targeted) was injected into B6(Cg)-Tyrc-2J/J blastocysts and chimeric mice were bred with B6(Cg)-Tyrc2J/J f…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

Phospholipase A2 Epsilon
Gross, Richard ; Jenkins, Christopher
T-004045

— This features an enzymatic function for a protein so that Washington University can obtain composition of matter rights and use rights for screening for inhibitors. This can be used for weight loss, diabetes, treatment of obesity and associated lipotoxicity, body sculpting, heart disease, stroke a…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Miniature, high resolution multi-spectral imaging for label-free image guided surgery and other applications
Garcia Hernandez, Nimrod Missael ; Gruev, Viktor
T-016872

— Technology Description Engineers in Prof. Viktor Gruev’s laboratory have developed a compact 27-band hyperspectral imaging system for high resolution, label-free, real-time imaging. This system can distinguish spectral signatures in image guided surgery (IGS) and other applications. The tech…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Novel bile acids as biomarkers for Niemann-Pick type C disease
Jiang, Xuntian ; Ory, Daniel
T-014292

— Technology Description Researchers at Washington University have developed and validated a set of bile acid biomarkers to screen, diagnose, and monitor the progression of Niemann-Pick disease type C (NPC), a genetic lysosomal storage disorder resulting from a defect in lipid transport. Previous ef…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

VSV-BSL2 reporter of SARS CoV infection
Bloyet, Louis-Marie ; Whelan, Sean
T-019518

— This VSV-SARS1 chimeric virus is a biosafety level 2 reporter of SARS COV 1 infection. It could be used to study shared mechanisms of neutralization by antibodies, selection of escape mutants and studies of viral entry.

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Targeted liposome drug delivery system to improve multiple myeloma treatment
Azab, Abdel Kareem ; Federico, Cinzia
T-019089

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a liposome drug delivery vehicle to improve efficacy and reduce side effects of multiple myeloma treatment. This system is designed to target compounds to the bone marrow microenvironment (BMME) and simultane…

Prognostic for Lymphoproliferative Disorders
Qavi, Abraham ; Swat, Wojciech
T-019271

— Technology Description Researchers at Washington University in St. Louis have developed an improved method to monitor the progression of lymphoproliferative disorders (LPDs) and guide treatment decisions. LPDs, including leukemia and lymphoma, are characterized by the abnormal proliferation of blo…

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

IgG Monoclonal Antibodies to Enterococcus Faecalis Gelatinase
Shaikh, Nurmohammad ; Tarr, Phillip
T-011748

— Primary Inventor: Phillip I. Tarr, MD Target: GelE(mAb 8A3)Monoclonal antibodies against E. faecalis gelatinase developed as a treatment for Crohn’s disease. E. faecalis secretes many proteins into the gastrointestinal enviroment – such as Gelatinase (GelE). GelE degrades several proteins including gelatin, collagin, hemoglobin, and bioactive peptides.…

Stent System for the Treatment of Aorto-Iliac Occlusive Disease
Wirtz, Alexander ; Zayed, Mohamed
T-018558

— Technology Description Researchers at Washington University in St. Louis developed an improved stent system to treat aorto-iliac occlusive disease. Aorto-iliac occlusive disease is caused by atherosclerotic plaque accumulation in the abdominal aorta where it connects to the common iliac arteries. …

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo (Justin) ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

B6.129.Btla tm1kmm/J Mouse
Murphy, Kenneth ; Murphy, Theresa
T-014100

— Notes: Btla-/- knockout mouse with a 129S/SvEv background. B6.129.Btla tm1kmm/J Mouse.

Improved MRI resolution with Diffusion Dictionary Imaging (DDI)
Wang, Qing ; Wang, Yong
T-019608

— Technology Description Researchers at Washington University in St. Louis have developed MRI post-processing software capable of imaging cellular components. The software matches specific patterns with a dictionary of signals corresponding to cellular components. While the researchers have previous…

Cell-based tumor targeting for delivering therapeutic and imaging agents
Azab, Abdel Kareem ; Muz, Barbara
T-018893

— Researchers in Prof. Abdel Kareem Azab’s laboratory have developed a biologically-targeted cellular drug delivery system to precisely target therapeutic or diagnostic agents to a wide range of cancers. Delivering drugs directly to cancer cells and not to healthy cells could improve outcomes by…

Ultra High Quality Tunable Add-Drop Filter Based on Active Whispering Gallery Mode resonators
Monifi, Faraz ; Ozdemir, Sahin ; Yang, Lan
T-013642

— Whispering Gallery Mode (WGM) Resonators have been shown to have unique properties holding great promise for use in optical communication systems. Recent innovations from Dr. Lan Yang’s Nano-Photonics lab at Washington University in St Louis bring the promise much closer to reality. In particu…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein – Colonna lab
Cella, Marina ; Colonna, Marco
T-019509

— This panel of antibodies against the SARS-CoV-2 spike protein has potential applications for research or diagnostics (e.g., sandwich ELISA to quantify or detect spikes in biological fluid).

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Floxed ChAT mouse strain
Burgess, Robert ; Sanes, Joshua
T-019107

— This mouse strain has loxP sites flanking exons 3 and 4 of the ChAT gene. There is a Neo gene in the intron between exons 4 and 5. Mating these mice to A-Cre mice generates a null allele in subsequent generations, in which no ChAT protein or activity is detectable. The mice are maintained in the C57…

Vascular graft to promote stem cell therapy for diabetes and other diseases
Millman, Jeffrey ; Zayed, Mohamed
T-016290

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed a multi-layered arteriovenous graft device that enhances the survival and function of stem cell transplants to treat Type 1 diabetes or other diseases. Artificial organs derived from stem cells cou…

Biomarker to predict cancer response to chemotherapy
Diamond, Marc ; Shao, Jieya
T-015631

— Technology Description Researchers at Washington University in St. Louis have developed a prognostic biomarker that can be used to predict response to genotoxic chemotherapy for patients with basal-like/triple-negative breast cancer. Basal-like/triple-negative breast cancer is considered to be mor…

scFv-TR3: TRAIL trimers targeted to mesothelin
Hawkins, William ; Spitzer, Dirk
T-016481

— WUSTL Technology 016481 Technology Description Researchers at Washington University in St. Louis have developed an additional targeting strategy to provide more flexibility and improve the bioactivity of the anticancer therapeutic TR3. This strategy targets TR3 to mesothelin, a tumor biomarker fr…

Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical Applications
Chen, Qinghao ; Tan, Yuewen ; Zhang, Tiezhi ; Zhou, Shuang
T-019620

— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…

Efficient multi-dimensional 4D MRI and PET/MR motion correction
An, Hongyu ; Eldeniz, Cihat
T-016414

— Technology Description Researchers in Prof. Hongyu An’s laboratory have developed a new image processing system for faster acquisition of motion-corrected MR or PET/MR images. This technology could be expanded to multiple sampling schema to correct both respiratory and cardiac motion. Liv…

Gaussian Process Audiogram
Barbour, Dennis ; Gardner, Jacob ; Ledbetter, Noah ; Song, Xinyu ; Weinberger, Kilian
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and death
Ory, Daniel ; Peterson, Linda ; Schaffer, Jean
T-014627

— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…

Mesothelin-TR3: targeted TRAIL trimers with superior anticancer activity
Hawkins, William ; Spitzer, Dirk
T-011885

— WUSTL Technology 011885 Technology Description Researchers at Washington University in St. Louis have developed a strategy to specifically target the anticancer therapeutic TR3 to cancer cells using the mesothelin/MUC16 interaction. Mesothelin is a GPI linked cell surface protein expressed in mes…

Low-cost, synthetic hydrogel scaffold to promote nerve growth and regeneration
Elbert, Donald ; Roam, Jacob
T-016599

— Technology Description Engineers led by Dr. Donald L. Elbert have developed a patented, self-assembling hydrogel microsphere scaffold system designed to improve tissue regeneration by creating cell migration pathways to repair large nerve gaps. This technology generates the migration pathways by c…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 Copy number Aberration Driven Endocrine Response (CADER) gene signature
Ellis, Matthew ; Luo, Jingqin
T-011920

— Identifying patients at risk of relapse while undergoing particular treatment protocols is critically important yet challenging to do in a timely manner. Researchers at Washington University have deveoped a new method to rapidly and accurately determine relapse risk in a human subject afflicted with…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

VSV-SARS2-mutants to characterize antibody panels
Liu, Zhuoming ; Whelan, Sean
T-019501

— This is a large panel of variants in the SARS-CoV-2 spike protein incorporated into a VSV-vector. These were largely selected as escape mutants to neutralizing antibodies or were designed to probe the function of circulating viral variants. These constructs can be used to screen antibodies and solub…

High-throughput blood biomarker test for peripheral atherosclerosis
Semenkovich, Clay ; Zayed, Mohamed
T-017421

— Technology Description Researchers from Mohamed Zayed’s lab at Washington University have developed a blood biomarker test for atherosclerosis more accurate than LDL. Circulating levels of Fatty Acid Synthase (cFAS) in the serum correlate to a high degree to severity of peripheral atheroscle…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Ion Channel Blockade of Radium-223 Gut Uptake
Abou, Diane ; Thorek, Daniel
T-018999

— Technology Description Researchers at Washington University in St. Louis have developed a method to reduce gut uptake of Radium-223 and improve its targeting to metastasized bone cancer. Prostate cancer is the most common cancer among men and a leading cause of cancer-related mortality. Prostate c…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Fibroblast-Derived Cell Line Producing Wnt3a, R-spondin 3, & Noggin
Miyoshi, Hiroyuki ; Stappenbeck, Thaddeus
T-014239

— Tangible Tool: Growth factor over-expressing cell line. Notes: Produces conditioned media to grow various mammalian tissue stem cells.These supportive L-WRN cells can produce conditioned media containing Wnt3a, R-spondin, and Noggin for the the support of gastrointestinal stem cells. This system can be used to make stem cell enriched epithelial spheroids from the mouse gastrointestine. Publication: In vitro expansion and genetic…

Protein to enhance T cell expansion for CAR-T cell therapy and other adoptive cellular immunotherapy
Chou, Chun ; Egawa, Takeshi
T-016284

— Technology Description Researchers in Prof. Takeshi Egawa’s laboratory have developed a mutant AP4 protein that is designed to reduce the time and expense of ex vivo T cell expansion for adoptive cellular immunotherapy, including CAR-T cell cancer immunotherapy. AP4 is a transcription factor…

Combination Artemisinin and Chemiluminescent Photodynamic Therapy for Treatment of Malaria and Cancer
Goldberg, Daniel ; Sigala, Paul
T-015173

— Background: Malaria, mainly caused by Plasmodium falciparum, results in over 200 million clinical cases a year and approximately 430,000 deaths a year. Tropical and sub-tropical countries have a high incidence of malaria cases because Anopheles mosquitoes thrive in warm temperatures and are able to …

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

MRI neural network segmentation in atherosclerosis
Jha, Abhinav Kumar ; Li, Ran ; Woodard, Pamela ; Zheng, Jie
T-020254

— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…

Targeting TPL2 in RAS-mutated cancers
Dodhiawala, Paarth ; Lim, Kian-Huat
T-019493

— Technology Description Researchers in Kian-Huat Lim’s lab at Washington University have developed a therapeutic strategy to target TPL2 in RAS-mutated cancers, which should work synergistically with chemotherapy and radiation. As TPL2 (MAP3K8) is necessary for upstream activation of both MAP…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Device for diabetes cell replacement therapy
Millman, Jeffrey ; Song, Jiwon
T-016681

— Technology Description Researchers at Washington University in St. Louis have developed a 3D-printed device for the subcutaneous transplantation of stem cell-derived beta (SC-beta) cells for diabetes cell replacement therapy. Diabetes mellitus, a disease characterized by loss of blood glucose cont…

Method to evaluate function of members of a gut microbiota
Gordon, Jeffrey ; Patnode, Michael
T-018760

— Technology Description Researchers at Washington University in St. Louis have developed a bead-based method to understand the functional states and metabolic capabilities of individual members of the human gut microbiota. The gut microbiota is increasingly linked to multiple aspects of human healt…

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Monoclonal Antibodies to Enterococcus Faecalis Secreted Proteins
Shaikh, Nurmohammad ; Tarr, Phillip
T-011162

— Target: SalB (mAb 6H3) Notes: Reduces inflammatory response.We have identified and characterized monoclonal antibodies that recognize secreted proteins of Enterococcus faecalis, and that neutralize the abilities of whole, viable, E. faecilis to stimulate a pro-inflammatory cytokine in cultured epithelial cells. The monoclonal antibodies are directed against …

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

A genetic mouse model of human Cantu Syndrome based on Kcnj8em1Nich[V65M] mutation
Nichols, Colin ; Remedi, Maria
T-019073

— This is a CRISPR/Cas9 germline mutation in the KCNJ8 gene, equivalent to a human Cantu Syndrome mutation. The mouse is therefore a genetic model of human Cantu Syndrome. This mouse model can be used for pre-clinical testing of targeted therapy for Cantu Syndrome. Publication: Cardiovascular consequ…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Zuum – app
Colditz, Graham ; Corcoran, Heather
T-011983

— Zuum is a health-risk assessment software that serves as a prognostic for various types of cancer.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila
T-009276

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Range finder to improve X-ray image collection
Clayton, William ; Don, Steven
T-014196

— Technology Description Researchers at Washington University in St. Louis have developed a device that automatically measures and displays body thickness to optimize X-ray image collection. This device will improve X-ray image quality and reduce the radiation exposure to patients. The device es…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

Chaotic Optomechanical Resonators
Ozdemir, Sahin ; Yang, Lan
T-016229

— Background: Chaos is considered hypersensitive to conditions of a system and is often thought to be unpredictable and difficult to explain. However, recent work has shown that chaos can be added as noise to improve amplification of weak signals through stochastic resonance. Stochastic resonance has …

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Nanocomposite fertilizer for efficient phosphorus uptake and sustainable agriculture
Biswas, Pratim ; Raliya, Ramesh
T-016378

— Technology Description Engineers in Prof. Pratim Biswas’ laboratory have developed a nanoparticle fertilizer that increases phosphorus uptake and plant yield while reducing environmental damage and strain on natural resources. Increasing global food demand has prompted the large-scale use o…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Method to characterize gut microbiome
Gordon, Jeffrey ; Raman, Arjun
T-018977

— Technology Description Researchers at Washington University in St. Louis have developed a method to stratify gut microbiota dysbiosis and monitor treatments to correct it. In order to efficiently treat microbiota imbalance, it would first be beneficial to understand the healthy organization and in…

A genetic mouse model of human Cantu Syndrome based on Abcc9em1Nich SUR2[A476V] mutation
Nichols, Colin ; Remedi, Maria
T-019072

— This mouse model was generated by using CRISPR/Cas9 to mutate the ABCC9 gene. The mouse model described here could be used as a pre-clinical model for testing Cantu Syndrome therapies. Publication: Cardiovascular consequences of KATP overactivity in Cantu syndrome

Optimized Non-Coplanar Radiation Delivery for Simpler, Faster, and Safer Treatments
Mutic, Sasa ; Zhang, Tiezhi
T-016307

— Existing LINACs inefficiently deliver non-coplanar beams The goal of radiation treatment is to precisely deliver a prescribed radiation dose to the targeted tissue, while avoiding dosing the surrounding normal tissues and organs. These treatments require radiation beams to be delivered from multipl…

Robust, scalable phase control system for non-invasive neuromodulation devices
Li, Jr-Shin ; Zlotnik, Anatoly
T-016206

— Technology Description: Researchers in Prof. Jr-Shin Li’s laboratory have developed a robust, scalable, patented technology to control and entrain complex, noisy, non-linear oscillating systems such as neuronal firing and circadian rhythms. This system uses a single global, open-loop control …

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Gadd7 haploinsufficient mutant CHO cell line
Listenberger, Laura ; Ory, Daniel ; Schaffer, Jean
T-019113

— Gadd7 haploinsufficient mutant CHO cell line Inventors generated a mutant Chinese Hamster Ovary (CHO) cell line with disruption of one allele encoding Gadd7, a non-coding RNA. CHO cells were transduced with retrovirus at a low multiplicity of infection and mutants were isolated. Number of retrovira…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probe
Li, Lei ; Wang, Lihong ; Yao, Junjie
T-015670

— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…

Controlling charge doping in 2D materials
Balgley, Jesse ; Henriksen, Erik
T-019602

— Technology Description Researchers at Washington University in St. Louis have developed a method to control charge doping in 2D materials like graphene. This method uses α-RuCl3 to create pn junctions at a smaller scale than silicon transistors. While α-RuCl3 efficiently removes el…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

pAAV5-CaMKII-mSK2-AqAA-Flag-eYFP packaged into an AAV5 capsid
Bruchas, Michael ; Moron-Concepcion, Jose
T-019068

— This capsid expresses a dmoninant negative non-functional form of the SK2 channel present in neurons. This allows us to directly measure the effects of SK2 in hippocampal neurons.

In vivo PopQC – Simple quality control system to enhance industrial-scale microbial production of chemicals, biofuels and pharmaceuticals
Xiao, Yi ; Zhang, Fuzhong
T-014647

— Researchers in Prof. Fuzhong Zhang’s laboratory have developed a simple, scalable, broadly-applicable system to enhance fermentation efficiency for biosynthetic production of biofuels, pharmaceuticals, materials and other useful chemicals. Currently, biosynthetic pathways have enabled renewabl…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Antisense oligo to enhance neuronal survival in Huntington’s Disease
Oh, Youngmi ; Yoo, Andrew
T-020121

— Technology Description Researchers in Andrew Yoo’s laboratory at Washington University have developed an antisense oligonucleotide targeting a miRNA (miR-29b-3p) as a treatment for Huntington’s disease (HD). Inhibiting miR-29b-3p promotes neuronal survival by rescuing neurons from deg…

Novel Acute Myocardial Injury Biomarker Profile
Bach, Richard ; Boyle, Walter
T-015345

— Background: Cardiovascular disease, including acute myocardial injury (AMI), is responsible for over 610,000 deaths per year in the US making it the number one cause of death. The gold standard for AMI diagnosis relies on determination of the cardiac troponin I (cTnI) plasma level. The rise in the l…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Real-time air and water quality monitoring with AI-based data analysis and low cost sensors
Biswas, Pratim ; Li, Jiayu
T-018523

— Technology Description Prof. Pratim Biswas and colleagues have developed an artificial intelligence platform to provide accurate, low-cost analysis of air and water quality by integrating data gathered from particulate matter (PM) sensors and other sources. This technology could be used to make th…

Biodegradable beads for capturing phosphorus from water and releasing it as fertilizer
Jun, Young-Shin ; Kim, Doyoon
T-017987

— Engineers in Prof. Young-Shin Jun’s laboratory at Washington University in St. Louis have developed a scalable, effective, environmentally-friendly system for removing phosphorus from water using biodegradable alginate beads that can then be recycled as a slow release fertilizer in soil. This …

Therapeutic targets for atopic dermatitis
Kim, Brian ; Wang, Fang
T-019333

— Researchers at Washington University’s Center for the Study of Itch & Sensory Disorders have discovered a novel histamine-independent pathway that could be targeted to treat atopic dermatitis. Atopic dermatitis (AD) is a chronic inflammatory skin disease that presents with itch as its mos…

ABCA3-GFP plasmid
Wambach, Jennifer ; Yang, Ping
T-019241

— ABCA3-GFP (ATP binding cassette transporter A3 gene cDNA fused to GFP) plasmid that lavels lamellar bodies. Publication: Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Gfrα1FloxEGFP mice
Jain, Sanjay ; Milbrandt, Jeffrey
T-017997

— Using the Cre-deletor strain Hoxb7-Cre, Washington University researchers developed transgenic mice with loxP sites flanking the gene for the glial cell line-derived neurotrophic factor (GDNF) family receptor α1 (GFRα1), which is involved in kidney tissue development. These mice were the…

Plasmids for luciferase expression in Cryptosporidium
Funkhouser-Jones, Lisa ; Sibley, Laurence
T-019121

— Plasmids for luciferase expression in Cryptosporidium The plasmids listed below are for targeting insertion into the TK and UPRT loci in Cryptosporidium parvum. To generate the plasmids, the inventors modified a previously described nanoluciferase (Nluc) reporter fused to neomycin resistance (NeoR)…

Mouse Hybridoma producing IgG3 Antibodies against Human TIGIT (WUCAM)
Boles, Kent ; Colonna, Marco
T-008862

— Target: T Cell Immunoreceptor with Ig and ITIM domains, a.k.a. WUCAM Notes: Clone available is 4E1.2. Used in flow cytometry and functional studies.Mouse IgG3 was generated by immunizing BALB/c mice with WUCAMFLAG-Baf3 cells. This can be used to study T cell-dependent antibody responses. Publication: A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Mice with Mutant Gtf2i and Gtf2ird1 Alleles
Dougherty, Joseph ; Kopp, Nathan
T-019290

— Dr. Dougherty developed a collection of mouse lines with deletions of Gft2i and Gtfird1 in various combinations. The genes are related to Williams Beuren locus. Publications:

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

Kidney disease biomarkers for diagnosis, prognosis or clinical trials monitoring
Chen, Ying ; Kim, Yeawon
T-016375

— Technology Description Researchers in Prof. Ying “Maggie” Chen’s laboratory have identified three sensitive, urine-based biomarkers of kidney disease that could be used for non-invasive, early detection and clinical trials monitoring. In particular, these mechanistic biomarkers a…

Carbon aerosol gel from continuous negative gravity reactor
Chakrabarty, Rajan ; Liu, Pai
T-017977

— A team of engineers from Washington University has developed a unique aerosol gel made from volume-spanning, semirigid networks of organic nanoparticles. Although the ultralow density and high surface area of these types of aerogels make them extremely useful for air and water purification, their pr…

CHO Gadd7 knockdown clones and control
Brookheart, Rita ; Schaffer, Jean
T-019114

— CHO Gadd7 knockdown cell lines Inventors generated two stable Chinese Hamster Ovary (CHO) cell lines with knockdown of gadd7 by transfecting cells with a custom siRNA plasmid targeting hamster gadd7 (KD1 and KD2) and a control CHO cell line by transfecting cells with a custom scrambled siRNA plasmi…

Mouse Hybridoma producing IgG2b Monoclonal Antibodies to Human FcRL4
Colonna, Marco ; Wilson, Timothy
T-007612

— Target: Fc Receptor Like 4 protein. Notes: Clone available is 413D12. Used in flow cytometry, immunoprecipitation, and functional studies.Balb/c mice were immunized three times at two week intervals with paraformaldehyde-fixed FcRL4 stable transfectants, first in CFA, then twice in IFA + CpG 1826. Three days prior to fusion with SP2/0 cells, the final immunization was performed by IP injection of irradiated cells in PBS. Hybridoma clo…

Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1)
Anastasaki, Corina ; Gutmann, David
T-015422

— Background: Neurofibromatosis type 1 (NF1) is a common neurological condition affecting roughly 1 in every 2,500 individuals. NF1 is associated with a host of clinical presentations, including malignant tumors and cognitive defects ranging from attention deficits, mental retardation, and autism. The…

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

Transgenic zebrafish line expressing gCAMP in the pancreatic beta cell
Emfinger, Christopher ; Nichols, Colin
T-019302

— Stable zebrafish line that shows calcium signaling within the pancreatic beta cells. The line was generated using the calcium sensing fluorophore gCAMP and integrated using the TOL2 transcription factor. Publication: Beta-cell excitability and excitability-driven diabetes in adult Zebrafish islets

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

IL34 tm1b and tm1c mice
Colonna, Marco ; Gilfillan, Susan ; Wang, Yaming
T-019313

— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

Therapy To Prevent Endotracheal Tube Or Catheter-Mediated Tissue Injury
Gelman, Andrew ; Puyo, Carlos
T-015918

— Technology Description Researchers at Washington University in St. Louis have developed a drug combination that can be used to prevent tissue injury resulting from placement of a variety of medical devices including, but not limited to, endotracheal tubes (ETTs) and catheters (bladder catheters). P…

MRI-based multiparametric cardiac strain analysis of myocardial viability
Cupps, Brian ; Pasque, Michael
T-006692

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Arteriovenous graft designed to prevent thrombosis and graft failure
Genin, Guy ; Williams, Dillon ; Zayed, Mohamed
T-018994

— Technology Description Prof. Mohamed Zayed and colleagues have developed an arteriovenous graft cuff with features designed to normalize the blood shear rate and decrease risk of thrombosis at the venous end anastomosis. This device could reduce the failure rate of these grafts, thereby improving …

Antibodies to Western Equine Encephalitis Virus (WEEV)
Austin, Stephen ; Diamond, Michael ; VanBlargan, Laura
T-019128

— Antibodies against Western Equine Encephalitis Virus (WEEV) Inventors demonstrated the antibodies reactivity with WEEV-infected cells or with WEEV proteins. These antibodies can be used for diagnostic and potentially therapeutic purposes.

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…

Split intein synthetic biology platform for scalable microbial production of high-performance biomimetic textiles, adhesives and other materials
Bowen, Christopher ; Dai, Bin ; Zhang, Fuzhong
T-018602

— Brief Description A team of engineers at Washington University in St. Louis have developed a synthetic biology platform for low-cost, sustainable production of high-performance composite materials. This technology uses a split intein assembly system to synthesize high molecular weight polymers (e.…

IL33 tm1b and tm1c
Colonna, Marco ; Gilfillan, Susan ; Yoshita, Satoru
T-019314

— The Colonna lab generated two IL-33 knockout mouse lines – a total and a conditional knockout models. IL-33 is a crucial mediator of inflammation. Publication: IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

Measurement of NT-ProBNP in human blood using a monoclonal antibody
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar
T-004030

— This is a monoclonal antibody specific for NT-Pro BNP and can be used singly in a competitive immunoassay to measure the amount of this analyte in blood samples for the purpose of diagnosis or monitoring of congestive heart failure. In addition, it could be used in a sandwich immunoassay with a mono…

Optical Resolution Photoacoustic Imaging Device for Port-Wine Stains
Maslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585

— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.

Rat Hybridoma producing Monoclonal Antibodies against Mouse PDCA1
Blasius, Amanda ; Cella, Marina ; Colonna, Marco
T-004377

— Target: Antibodies recognize a small leukocyte population of cells called intereron producing cells or plasmacyt-oid dendritic cells. Notes: Clone names 129c1 and 927Antibodies were produced by immunizing Wistar/CRL rats with CpG oligodeoxynucleotide 1826 or heat-killed Mycobacteria tuberculosis. The antibodies are specific for mouse IFN-producing cells (IPC). Publication: Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in …

A novel modulator of tumor angiogenesis and anti-tumor immunity
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-019294

— Technology Description Researchers in Kyunghee Choi’s lab at Washington University in St. Louis have identified a novel target, Myct1, that modulates tumor angiogenesis and anti-tumor immune response. Myct1 inhibition with siRNA blocks angiogenesis and promotes infiltration of cytotoxic T ly…

IL-33 mCherry Mice
Colonna, Marco ; Gilfillan, Susan ; Joshita, Satoru
T-019315

— Reporter mouse line that allows for identification of cells productive IL-33 through mCherry expression. IL-33 is a molecule involved in immune system responses to helminths, allergies, and asthma. Publications:

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Efficient, high velocity air purification with a soft X-ray enhanced electrostatic precipitator
Biswas, Pratim ; Chadha, Tandeep ; Fang, Jiaxi
T-015444

— Engineers in Prof. Pratim Biswas’ laboratory have developed an electrostatic precipitator device that removes ultrafine pollutants and inactivates pathogens from the air at high efficiency and low cost. This gas cleaning system has the potential to replace HEPA filters for air filtering applic…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Immunohistochemical diagnosis of human renal chromophobe carcinoma
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack
T-011164

— This novel immunohistochemical marker would be a valuable diagnostic aid to the practicing surgical pathologist who is confronted with this particular diagnostic challenge. Companies may license this antibody for clinical testing, or cases may be referred to Washington University for subspecialty c…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Xcr1 IRES mCherry-hCre Mouse Strain
Durai, Vivek ; Murphy, Kenneth ; Murphy, Theresa
T-019142

— Xcr1 IRES mCherry-hCre Mouse Strain This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…

Grueneisen-memory photoacoustic microscopy
Wang, Lidai ; Wang, Lihong ; Zhang, Chi
T-014165

— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

Combination therapy for malignant peripheral nerve sheath tumors
Amin, Neha ; Borcherding, Dana ; Hirbe, Angela
T-020000

— Technology Description Researchers in Angela Hirbe’s lab at Washington University have developed a method of treating malignant peripheral nerve sheath tumors (MPNSTs) with a combination of inhibitors. The most effective therapy is to combine an inhibitor of TYK2 with a MEK inhibitor. MPNST…

Use of ent-allopregnanolone to treat glaucoma
Covey, Douglas ; Izumi, Yukitoshi ; Zorumski, Charles
T-018940

— Technology Description Researchers from Washington University in St. Louis and colleagues have identified ent-allopregnanolone (ent-AlloP) as a potential therapeutic to treat glaucoma. Glaucoma, the leading cause of irreversible blindness, results from damage to the retinal ganglion cells (RGSs) t…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Cytokine therapy for juvenile dermatomyositis and other autoimmune diseases
Alinger, Joshua ; French, Anthony ; Throm, Allison
T-018911

— Technology Description Researchers in Prof. Anthony French’s laboratory have discovered a signaling mechanism associated with juvenile dermatomyositis (JDM) that could potentially be targeted with cytokine-based therapies to treat JDM as well as other autoimmune disorders. This therapeutic a…

E. coli plasmids and strains for biofuel synthesis
Jiang, Wen ; Xiao, Yi ; Zhang, Fuzhong
T-017688

— pA5c-tesA, pA8c-tesA-mleuABCD, pE2k-alsS-ilvCD Researchers used a standard restriction digestion cloning based on the Biobrick platform or Gibson assembly to construct the plasmids. E. coli DH10B was used for cloning. These plasmids were designed to increase branch chain fatty acid production. Pub…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Clifednamide compounds
Qi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

High Performance Direct Methanol and Direct Ethanol Fuel Cells with Microscale Bipolar Interface
Ramani, Vijay ; Sankarasubramanian, Shrihari ; Wang, Zhongyang
T-019124

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a biopolar interface membrane to prevent fuel crossover and improve the performance of direct methanol and direct ethanol fuel cells (DMFC and DEFC). This membrane separator is designed to maintain a steep pH …

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

User-friendly methods to detect artifacts in super-resolution microscopy
Lew, Matthew ; Mazidisharfabadi, Hesamaldin ; Nehorai, Arye
T-019008

— Engineers at Washington University have devised an automated system to enhance super-resolution microscopy images by detecting and quantifying image artifacts using no a priori information. This project stems from the advanced imaging research in Prof. Matthew Lew’s laboratory that includes op…

Low-cost, flexible paper substrate for sensitive trace chemical and biological detection using SERS (surface enhanced Raman scattering)
Kharasch, Evan ; Lee, Chang Hee ; Morrissey, Jeremiah ; Singamaneni, Srikanth
T-010600

— Technology Description Researchers in Prof. Srikanth Singamaneni’s laboratory have developed a patented, low-cost, flexible substrate designed to improve sample collection and enhance analyte detection with surface enhanced Raman scattering (SERS) or localized surface plasmon resonance (LSPR…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Detecting and Measuring Single Nanoparticles & Molecules with a Tapered Optical Fiber CIP
Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-011617

— The invention describes an instrument for detecting single particles, and measuring their properties (size or mass). The device contains only a tapered optical fiber. A laser diode as the light source and a photo-detector to measure the light intensity are also needed to complete the sensing system.…

Single Nanoparticle Detection by Mode Splitting in Active Microresonators using Heterodyne Technique
He, Lina ; Ozdemir, Sahin ; Yang, Lan
T-010140

— Dr. Lan Yang, Professor at Washington University in St. Louis, is a pioneer in the field of micro- and nano photonics. She recently developed a uniquely sensitive and versatile particle detector using whispering gallery mode (WGM) optical microresonators. Realtime detection and accurate sizing of la…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

Rapid, accurate RT-PCR test for enterovirus D68
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015155

— Technology Description A team of researchers at Washington University designed patented primers for a sensitive, specific, real-time reverse transcriptase PCR (RT-PCR) assay to quickly detect enterovirus D68 (EV-D68). EV-D68 is an emerging, highly contagious respiratory virus that can cause seve…

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Flame Aerosol Reactor (FLAR) Based Process for Fabricating Nanostructured Films for Solar Energy Applications with Unique Compositions
Biswas, Pratim ; McDonald, Rafael ; Thimsen, Elijah
T-006824

— The invention is a new process for fabricating nano-structured metal-oxide and other films. The films can harvest solar energy in the form of light and convert it to a more usable form (i.e: electricity or hydrogen gas). The films produced by this process have a unique morphology that grants them a …

Low cost, high performance anion exchange membranes for grid-scale energy storage and other electrochemical devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-018608

— Technology Description Engineers in Prof. Vijay Ramani’s laboratory have developed a variety of robust, versatile anion exchange membrane (AEM) materials that achieve high performance through superior ion selectivity. These mechanically and chemically stable membranes have the potential to d…

Dementia Screening test: the AD8
Galvin, James ; Morris, John ; Roe, Catherine
T-007516

— The AD8 is an 8 question interview tool which distinguishes individuals with very mild dementia from those without dementia, regardless of etiology. The AD8 is based on intraindividual decline and has been demonstrated to be a valid and reliable screening tool for dementia.

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

Photoacoustic tomography of human brain
Anastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043

— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

Deep Learning-Assisted Image Reconstruction for Tomographic Imaging
Anastasio, Mark ; Kelly, Brendan ; Matthews, Thomas
T-017311

— Background Image reconstruction for any modern imaging technique is an optimization problem. Most image reconstructions methods are iterative in nature and produce sequential intermediate images that are compared to the raw acquisition data and subsequently updated to maximize the likelihood that t…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

Anti-PDZ TIP1 Antibody Therapy for Cancer
Hallahan, Dennis ; Kapoor, Vaishali ; Yan, Heping
T-017064

— Background: Lung cancer is one of the leading causes of cancer-related deaths worldwide. In the United States, it is second most common cancer for men and women and the leader for cancer-related death. Non-small-cell lung cancer (NSCLC) accounts for 85% of all reported lung cancer cases and is relat…

Multifunctional chemical agents for metal chelation, positron emission tomography (PET) imaging, fluorescence imaging, and amyloid plaque clearance in Alzheimer’s disease
Mirica, Liviu ; Schultz, Jason ; Sharma, Anuj
T-013190

— Alzheimer’s disease (AD) is characterized by the deposition of amyloid plaques containing the amyloid beta (Aβ) peptide. Currently, no treatment is available for AD. Metal ion interactions of the Aβ peptide are believed to help formation of toxic aggregates. Developing chemical compo…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

MR-HIFU acoustic coupling device to improve performance and reduce side effects
Altman, Michael ; Chen, Hong ; Kothapalli, Veera "Satya" ; Xie, Kevin
T-017089

— Technology Description Engineers in Prof. Hong Chen’s laboratory have developed a multifunctional, MR-compatible device designed to improve the performance of Magnetic Resonance High Intensity Focused Ultrasound (MR-HIFU) by increasing the efficiency of the ultrasound transmission, cooling t…

High resolution imaging using subwavelength grating structures
Shen, Jung-Tsung ; Shen, Yuecheng ; Wang, Lihong
T-012856

— Conventional optics are generally restrained by a law of physics known as the diffraction limit, which dictates that optical systems can only resolve images down to about half the wavelength of the light used to produce the image (λ/2), or down to about 200 nanometers for most standard optics…

Peptides responsible for Type 1 diabetes
Lichti, Cheryl ; Unanue, Emil ; Wan, Xiaoxiao
T-018626

— Technology Description: Researchers in the lab of Emil Unanue at Washington University have discovered a panel of peptides responsible for autoimmune activation in Type 1 diabetes and potentially capable of diagnosing T1D at an early stage. These peptide fragments of insulin are found circulating …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

New PARP-1 Inhibitors for Imaging PARP-1 Expression in Vivo
Chu, Wenhua ; Rogers, Buck ; Xu, Jinbin ; Zhou, Dong
T-018730

— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

3D-printed patient-specific applicator for intensity modulated high-dose-rate brachytherapy
Mutic, Sasa ; Park, Chunjoo ; Zhang, Hao
T-017203

— Technology Description Inventors in Washington University’s Department of Radiation Oncology have developed a method and 3D-printed applicator for intensity modulated high-dose-rate brachytherapy that surpasses conventional brachytherapy efficiency. This device is tailored to the patient…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Isochoric Actuator
Cashin, John ; Genin, Guy ; Lee, Sanghun ; Zayed, Mohamed
T-019219

— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)
Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450

— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …

Armenian Hamster Anti-Mouse Tapasin Antibody, clone 5D3
Hansen, Ted ; Lybarger, Lonnie ; Wang, Xiaoli
T-016628

— Target: Amino acids 11-34 of mouse tapasin. Application(s): Western Blotting Armenian hamster mAb (5D3) was produced to peptide EDAGGGGLSKKPATLLLRH GPRGP, representing residues 11–34 on mouse Tapasin (TPN) (44). TPN mAb was found to be specific for mouse TPN, as determined in a Western blot analysis of cell lysates of .221 (human TPN-positive) cells, .220 (human TPN-n…

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Flexible, “Single-Shot” Image Reconstruction System for Faster EIXPCT (Edge Illumination X-ray Phase-Contrast Tomography)
Anastasio, Mark ; Chen, Yujia ; Guan, Huifeng
T-016910

— Technology Description Joint reconstruction (“JR”) is a patented image reconstruction technique for “single shot” edge illumination x-ray phase-contrast tomography (EIXPCT). This system uses standard x-ray detection hardware and enables faster image acquisition times, lower…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Stable, non-toxic lead-free perovskite materials for high efficiency solar cells and other semiconductor applications
Biswas, Pratim ; Kavadiya, Shalinee ; Mishra, Rohan ; Thind, Arashdeep Singh
T-018532

— Engineers at Washington University in St. Louis have discovered a new class of stable, benign perovskite semiconductor materials with performance properties optimized for solar cell and photocatalysis applications. Traditional lead-halide perovskites show remarkable power conversion efficiency in ph…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Low-cost, single-step vapor deposition of thin film organic perovskites for solar and memristor applications
Banerjee, Parag ; Chen, Xiao ; Myung, Yoon
T-017124

— Technology Description Engineers in the Banerjee laboratory have developed a single-step, scalable vapor deposition process for fabricating high performance thin film perovskite materials at low temperature and atmospheric pressure. These lead-free, non-toxic films could be used as solar cell abso…

VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745

— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

Tools for the Detection of High-Density Lipoprotein Transport To and From Tissues
Huang, Li-Hao ; Randolph, Gwendalyn ; Zinselmeyer, Bernd
T-015939

— Background High-density lipoproteins (HDLs) have been widely studied and linked to various diseases, especially metabolic diseases. HDL levels in the blood have traditionally been used as a benchmark for risk of cardiovascular disease. However, these blood tests may be misleading – HDL levels…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

CCR2-targeted cancer nanoimmunotherapy
Lim, Kian-Huat ; Liu, Yongjian ; Zhang, Xiaohui
T-019463

— Disease indication – Drug format – Combination containing radiolabeled copper nanocluster, small molecule, and peptide Drug class – First-in-class Target – CCR2, the receptor for CCL2 Mode of action – The ECL1i peptide is conjugated to a copper nanocluster loaded…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Deep Tissue Diagnostics with Disposable Fiber-Optic Device
Hu, Song ; Ling, Jingwei ; Yang, Shuo
T-020656

— T-020656 – Deep Tissue Diagnostics with Disposable Fiber-Optic Device Technology Description Researchers from the laboratory of Song Hu has developed a miniaturized fiber-optic device capable of minimally invasive measurements of deep-tissue biomechanical properties. The device can be rea…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Natriuretic Peptide-Mediated Imaging and/or Treatment of Atherosclerotic Plaque
Rossin, Raffaella ; Welch, Michael ; Woodard, Pamela
T-007679

— Background Atherosclerosis is a disease process in which lipid deposition causes the formation of plaques that lead to thickening of the artery walls. The cause of a majority of fatal acute myocardial infarction and sudden coronary death is due to the rupture of soft or unstable plaques; however, t…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Lrp1 and the Blood Brain Barrier
Amarasinghe, Gaya ; Ganaie, Safder ; Leung, Daisy ; Virgin, Herbert
T-019577

— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Neural interface device for complex, specific stimulation of peripheral nerves
Christiansen, Blaine ; MacEwan, Matthew ; Moran, Daniel
T-007621

— Technology Description This technology is patented bipolar sieve electrode designed to stimulate peripheral nerves in a specific direction and thereby expand the potential of using this type of neural interface device in clinical applications such as nerve regeneration and prosthetics. Sieve elec…

Methods to accurately measure diastolic function from echocardiogram
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid
T-005426

— Technology Description Researchers in Prof. Sandor Kovacs’ laboratory developed a patented, non-invasive, load-independent method to measure the intrinsic diastolic performance of the heart. This load-independent index of filling (LIIF) can be incorporated into the software of echocardiogram…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

High Throughput Acoustic Particle Separation
Berezin, Mikhail ; Binkley, Michael ; Meacham, John
T-017364

— Technology Description: Methods and devices used for acoustophoresis of biologics have been developed and allow for more than 10,000 fold throughput than existing acoustophoretic devices. Applications: 1. Isolation of cells in low abundance (immune cells, circulating tumor cells) from whole bloo…

T-018741 & T-019450 – Computational Improvements of Immunoassays
Brestoff Parker, Jonathan ; Gronowski, Ann ; Zaydman, Mark
T-018741

— T-018741 & T-019450 – Computational Improvements of Immunoassays Technology Description Researchers in Mark Zaydman’s laboratory at Washington University have optimized a new method to improve the analytical measurement range (AMR) in homogeneous turbidimetric immunoassays. The method ut…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Ultrasound “painting” for precise, targeted drug delivery to the brain
Chen, Hong ; Williamson, Jeffrey ; Yang, Yaoheng "Mack"
T-018953

— Technology Description Researchers in Prof. Hong Chen’s laboratory have developed a safe, convenient monitoring technique to precisely deliver drugs to the brain by integrating ultrasound imaging with ultrasound therapy (focused ultrasound-blood-brain-barrier delivery, “FUS-BBBD”…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Computer vision training system for robust artificial intelligence image classification
Tong, Liang ; Vorobeychik, Yevgeniy ; Wu, Tong
T-019303

— Technology Description Researchers in Prof. Yevgeniy Vorobeychik’s laboratory have developed a new adversarial model and training methods to defend deep neural networks against physical attacks that corrupt image classifications. This system outperforms previous state-of-the-art techniques a…

High-speed, low-cost, short-haul optical communications with on-chip polarization division multiplexing
Chamberlain, Roger ; Gruev, Viktor ; Ivanovich, Darko
T-018955

— Technology Description Engineers in Prof. Roger Chamberlain’s laboratory have developed a low-cost multiplexing technology for high-speed optical communications in data centers and other short-haul applications. This visible light communication (VLC) system is designed to create distinct par…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Questionnaire for Adolescents (13-18)
Jeffe, Donna ; Lieu, Judith ; Rachakonda, Tara
T-013745

— The prevalence of hearing loss (HL) in adolescents has grown over the past decade, with rates of 19.5% for HL of >15dB and 5.3% for HL >25dB. Adults with HL are 21% to 39% less likely to have attained postsecondary education than normal-hearing persons and are 1.5 to 2 times more likely to exp…

Breath-based testing for malaria
John, Audrey Odom "Audrey Odom" ; Schaber, Chad ; Trehan, Indi
T-016183

— Technology Description Researchers in Prof. Audrey Odom John’s laboratory have discovered a malaria “breathprint” that could be used for blood-free, rapid, field-stable, point-of-care testing and monitoring. In addition, certain molecules identified by the inventors could attract…

Radiotracers to detect early Parkinson’s disease
Kotzbauer, Paul ; Qiu, Lin ; Tu, Zhude "Will" ; Yu, Yanbo
T-020559

— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Tuning of photo-absorption in semiconductors, photoconductors, and other photo conversion systems using magnetic fields
Hayes, Sophia ; Mui, Stacy ; Ramaswamy, Kannan
T-008875

— Background: The idea of creating clean, sustainable power in high amounts from renewable energy sources is an interest among many across the globe. One of the many ways of creating renewable energy is applying the photovoltaic effect, the conversion of solar to electrical energy, by using semiconduc…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-016668

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

Engineered Oncolytic Zika Virus Therapy for Glioblastoma
Chheda, Milan ; Diamond, Michael ; Gorman, Matthew
T-017429

— T-017429 Engineered Oncolytic Zika Virus Therapy for Glioblastoma Technology Description Researchers in the laboratories of Michael Diamond and Milan Chheda at Washington University have developed prospective treatments for glioblastoma (GBM) through the application of an engineered Zika virus (ZI…

A Highly Efficient Brine Electrolyzer
Gayen, Pralay ; Ramani, Vijay ; Sankarasubramanian, Shrihari
T-019234

— Technology Description Researchers in the Ramani lab at Washington University have developed an electrolyzer capable of selectively splitting salty or brackish water into ultra-pure hydrogen and oxygen at high operating power densities. Originally designed to tap the perchlorate-rich water on the …

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

Effective test for active tuberculosis infection
Chandra, Pallavi ; Coullon, Heloise ; Philips, Jennifer
T-019244

— Technology Description Researchers in Jennifer Philips’ lab at Washington University in St. Louis have developed a more sensitive biomarker test for active tuberculosis infection. These biomarkers, found in the sputum and plasma, comprise of cholesterol metabolites that are cooperatively prod…

Reproducible High Yielding Cu-64 Radioisotope Manufacturing
Gaehle, Gregory ; Lawrence, Luke ; Zerkel, Patrick
T-018514

— Background: Its unique imaging characteristics and favorable half-life and decay properties make radioisotope copper-64 (Cu-64) most desirable for PET imaging. To meet the increasing demand, an efficient high yielding Cu-64 manufacturing process is essential. To address this unmet need, scientists f…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

PET Radiotracers for Imaging Free Radicals and Reactive Oxygen Species (Materials: WC-4-77)
Chu, Wenhua ; Dugan, Laura ; Mach, Robert ; Mintun, Mark
T-009254

— Many diseases can be associated with abnormal production of reactive oxygen species (ROS) due to oxidative stress. Currently there is no way to image this in situ. Dihydroethidium (DHE) naturally produces a fluorescent product when oxidized by an ROS. The signal is not strong enough for practical im…

Parity-Time Symmetric Whispering-Gallery-Mode Microcavities Sensor
Ozdemir, Sahin ; Peng, Bo ; Yang, Lan
T-014053

— A non-reciprocal transmission device based on PT symmetry was previously theorized but never before constructed and shown to work at useful optical wavelengths. The new structure allows creation of the miniaturized optical isolation function without use of the century+ known Faraday effect. Optica…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Universal Targeted Drug Delivery and Imaging Platform
Barnes, Jonathan ; Delawder, Abigail "Abby" ; Li, Ruihan ; Li, Xuesong
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

An alternative approach in antimalarial drug design
Djuranovic, Sergej ; Erath, Jessey Lee ; Pavlovic Djuranovic, Slavica
T-018688

— Technology Description Researchers in Sergei Djuranovic’s lab at Washington University have developed polybasic peptides and polymers to block Plasmodium falciparum adhesion as a treatment for malaria. These therapeutics reduce parasite infection of human cells, making this a promising alter…

Vaccines for the Pathogenic Fungus Cryptococcus Neoformans via Nasal Inoculation
Lam, Woei Chuan ; Lodge, Jennifer ; Upadhya, Rajendra
T-014064

— Cryptococcus fungi are pathogenic fungi that, unless treated, are invariably fatal to those individuals infected, particularly to those who are immunocompromised. Recent reports indicate that Cryptococcus fungi infects 1,000,000 individuals per year and causes approximately 600,000 deaths. While ant…

Graft-vs-Host Disease Prevention during Stem Cell Transplantation
Albring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478

— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1PR2-targeted PET tracers
Klein, Robyn ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-018580

— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

Plasmid to test regulation 5′ untranslated sequences in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019560

— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

Decision support process for cerebral aneurysm pattern recognition in microsurgical/endovascular decision support system
Dacey, Ralph ; Ju, Tao ; Washington, Chad
T-012982

— Cerebral Aneurysms are weak areas in the wall of a blood vessel causing it to bulge out. These aneurysms can take on many sizes, shapes, and be in different locations. Currently cerebral angiographies, spinal tap, CT or MRI are used to diagnose cerebral aneurysm. Treatment options are chosen by a do…

Oxygen-releasing hydrogel for rapid wound healing
Guan, Jianjun ; Guan, Ya ; Niu, Hong
T-019931

— Technology Description Researchers in Jianjun Guan’s lab at Washington University have developed an oxygen-releasing hydrogel that accelerates wound healing. The biodegradable hydrogel is loaded with oxygen release microspheres (ORM) that slowly release oxygen into the surrounding tissue to …

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Potent, locally-acting chemokine binding proteins to protect organ transplants and treat ischemic or inflammatory diseases
Fremont, Daved ; Lu, Yun Hsuan ; Lubman, Olga
T-017443

— Researchers in Prof. Daved Fremont’s laboratory have identified two potent, soluble proteins that could prevent damage to transplanted organs and potentially treat other autoimmune and inflammatory diseases by evading the immune response instigated by chemokines. In organ transplants, chemoki…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Plasmids to express tagged genes in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019559

— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Method of increasing chemotherapy sensitivity in leukemia using BET inhibitor
Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019486

— Technology Description Researchers in Robi Mitra’s lab at Washington University in St. Louis have developed a method to increase the sensitivity of leukemias to chemotherapy by pre-treatment with a BET inhibitor. BET inhibitors convert stem-like leukemia cells to a more differentiated state …

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Lactobacillus reuteri deltaArat
Caparon, Michael ; Cervantes-Barragan, Luisa ; Colonna, Marco ; Di Luccia, Blanda
T-018589

— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α…

Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes
Asadi Jomnani, Farzad ; Dolle, Roland "Ron" ; Piston, David
T-020153

— T-020153 – Small Molecule Agonists of EphA Receptors to Ameliorate Diabetes Technology Description Blood glucose levels (left), post-treatment plasma glucagon (center) in WCDD301 treated NOD (non-obese diabetic) mice with moderate hyperglycemia. Blood glucose levels (right) in Streptozotocin-ind…

Quantify multi-tensor for improved CNS injury diagnosis using diffusion basis spectrum imaging (DBSI)
Song, Sheng-Kwei "Victor" ; Wang, Qing ; Wang, Yong
T-009943

— Background: Diffusion tensor imaging (DTI) has demonstrated sensitivity to detect pathologies in CNS white matter disorders. However, the capability of DTI to detect CNS white matter pathologies is confounded by the coexisting structural (crossing fibers) and pathological (inflammation associated ce…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Triblock Copolymer Based Anion Exchange Membranes (Aems) As Separators in Electrochemical Devices
Parrondo, Javier ; Ramani, Vijay ; Wang, Zhongyang
T-017637

— Background: Anion exchange membranes (AEMs) are used as separators in redox flow batteries, water electrolyzers, water desalination systems, fuel cells, and other electrochemical devices. Current AEMs suffer from issues with cost, poor stability and low perm selectivity. For example, current redox flow batteries are not economical or suffer from capacity loss upon cycling due to cross species contamination while using less expensive decoupled chemistries.An advanced, tunable AEM has been developed with dramatically reduced cost and improved performance relative to industry leading AEMs. High ionic conductivity, chemical stability and enhanced mechanical performance have been shown. The technology includes tunable membrane compositions, mechanical re…

Red-Shifted Chromophore Substitution for Optogenetic Applications
Corbo, Joseph ; Enright, Jennifer ; Toomey, Matthew
T-014377

— Optogenetics is one of the most important technological breakthroughs in neuroscience during the past decade, and holds tremendous promise for dissecting the mechanisms of neurologic disease and for treating a range of disorders. Optogenetic actuators are ion channels or pumps that can be regulated …

High-performance, nanoengineered two-phase cooling system for high powered electronics
Agonafer, Damena ; Ma, Binjian ; Shan, Li
T-018032

— Technology Description Engineers in Prof. Damena Agonafer’s laboratory have developed a highly-efficient, compact, modular evaporative cooling platform with materials and nanostructured geometries designed to greatly enhance thermal management of 3D integrated circuits, power converters and …

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

Hearing Environments and Reflection on Quality of Life (HEAR-QL) Assessment for Children
Jeffe, Donna ; Lieu, Judith ; Umansky, Amy
T-010222

— Approximately 5,000 infants are born with moderate, severe, or profound bilateral sensorineural hearing loss (HL) each year in the U.S. and many more have mild, unilateral, or progressive HL that will be identified in childhood. However, the degree of HL alone cannot predict a child’s language…

Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser Systems
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…

Dual Light-Emitting Systems and Biological Applications Thereof
Achilefu, Samuel ; Berezin, Mikhail ; Zhang, Zongren
T-007596

— Background: Near Infrared (NIR) fluorescence can be highly useful in biological systems as it is highly sensitive and allows for detection and imaging of physiological and molecular processes in cells and living organisms. However, radiometric imaging is difficult in the NIR region of the light spec…

Plasmids for Cryptosporidium parvum
Funkhouser-Jones, Lisa ; Shen, Bang ; Sibley, Laurence
T-018967

— These plasmids are for performing CRISPR/Cas9 gene editing in Cryptosporidium parvum To generate a CRISPR/Cas9 plasmid for use in C. parvum, researchers used restriction cloning with SacI to insert the C. parvum U6 gene into a pUC19 vector to create pUC19-CpU6. We then inserted the C. parvum actin …

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Cytokines-induced-memory-like NK cells with reduced NKG2A checkpoint signaling
Berrien-Elliott, Melissa ; Fehniger, Todd ; Romee, Rizwan
T-017001

— Background: Natural Killer (NK) and T cells are the primary immune cells being explored for cancer immuntherapy. NK cells are relatively short-lived, making the therapy less susceptible to some of the side effects currently associated with using T cells for immunotherapy. Unlike T cells, NK cells ar…

Subtyping of schizophrenia based on genome and pathology
Cloninger, C. Robert ; Svrakic, Dragan ; Zwir, Jorge "Igor"
T-015118

— Technology Description Researchers in Igor Zwir’s lab at Washington University have developed a diagnostic system to categorize patients with schizophrenia into 8 sub-groups. The system recommends a sub-group based on both genetic and psychopathology data and provides clinicians with a knowl…

Liquid biopsy assay for personalized prostate cancer treatment
Chaudhuri, Aadel ; Maher, Christopher ; Pachynski, Russell
T-019287

— Technology Description A team of researchers at Washington University has developed “EnhanceAR-Seq”, a circulating tumor DNA (ctDNA) assay that predicts which patients are at high risk for developing resistance to androgen receptor (AR)-directed treatment for metastatic prostate cancer…

PET/SPECT Agents for Applications in Biomedical Imaging
Piwnica-Worms, David ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-010438

— Background Coronary heart disease is the primary cause of death in the Unites States. Though myocardial perfusion imaging in hospitals has mostly involved the use of 99mTc-Sestamibi and similar agents for diagnosing heart disease, there is an increased desire for PET perfusion agents. The global in…

Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response
Lomonosova, Elena ; Mullen, Mary ; Verma, Priyanka ; Zhao, Peinan
T-020659

— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response Technology Description Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…

Inflammatory bowel disease biomarkers and therapeutic target
Kaiko, Gerard ; Liu, Ta-Chiang ; Stappenbeck, Thaddeus
T-017071

— Plasminogen activator inhibitor-1 (PAI-1) has been identified as a specific biomarker that is significantly elevated in patients with inflammatory bowel disease (IBD) and is correlated with disease severity. It could be used to both diagnose the disease (including ulcerative colitis and colonic Croh…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Sigma-1 targeted PET tracers
Mach, Robert ; Tu, Zhude "Will" ; Wang, Wei
T-010394

— Technology Description Researchers at Washington University in St. Louis and their colleagues have developed positron emission tomography (PET) tracers with high affinity for sigma-1 receptors. Sigma receptors have two subtypes, sigma-1 and sigma-2. Sigma-1 has high expression in the limbic and mo…

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Autosegmentation tool
Grigsby, Perry ; Ma, Daniel ; Rao, Yuan
T-010736

— The technology encompasses a software method for automatically and interactively segmenting previously acquired medical images, including MRI and CT studies, based on edge and interior characteristics of regions. The method allows for arbitrary levels of sensitivity in differentiating areas of inte…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Zbtb46, a novel target for cancer therapy
Choi, Kyunghee ; Kabir, Ashraf Ul ; Krchma, Karen
T-020458

— T-020458 — Zbtb46, a novel target for cancer therapy Technology Description Solid neoplasms are difficult to treat using immune checkpoint inhibitors in part because of the immunosuppressive nature of the tumor microenvironment. Researchers at Washington University School of Medicine, led b…

System and Method for Multi-modality Quantification of Neuroinflammation in Alzheimer ’s Disease
Benzinger, Tammie ; Wang, Qing ; Wang, Yong
T-016125

— Background: One in three seniors will die of Alzheimer’s disease (AD) or other neurodegenerative diseases. As the prevalence of AD increases rapidly, there is a strong need for early diagnoses and the ability to evaluate efficacy of drug treatments. Typically, a combination of neurological tes…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Development of CD163 targeting agent for imaging and therapy
Heo, Gyu Seong ; Liu, Yongjian ; Zhang, Xiuli
T-020196

— T-020196 CD163 Targeting Agent for Imaging and Therapy Technology Description Researchers in Yongjian Liu’s laboratory at Washington University have synthesized a new peptide-based CD163 radiotracer. CD163 is a well-known biomarker specific to macrophages implicated in multiple diseases, but…

Versatile airway management system to reduce exposure to aerosolized SARS-CoV-2 and other pathogens
Iqbal, Zahid ; Lee, Jin Vivian ; Zayed, Mohamed
T-019443

— Technology Description Researchers in Dr. Mohamed Zayed’s laboratory have developed a versatile, sealable valve system for airway management devices that can protect healthcare workers by reducing their risk of exposure to aerosolized SARS-CoV-2 and other pathogens during risky pulmonary pro…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Pro-drug Nanoparticle Technology (Used to be: Rational Design and Synthesis of Photo chemically stable Fumagillin Conjugates)
Lanza, Gregory ; Pan, Dipanjan ; Wickline, Samuel
T-007663

— Background: Targeted nanoparticles have been shown to have high potential in the detection and characterization of various pathologies based on unique profiles of cell surface markers, as well as the delivery of therapeutic compounds. Liposomes, micelles, emulsions and other lipid-based particles ha…

PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species
Satham, Lakshminarayana ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-020300

— T-020300 PET Radiotracers Capable of Crossing the Blood Brain Barrier and Detecting Reactive Oxygen Species Technology Description Reactive Oxygen Species (ROS) is known to contribute to the pathogenesis of neuropathological conditions such as Alzheimer’s disease and cancer. However, there…

Modular Pressurized Coal Combustion (MPCC) for Highly Efficient Clean Coal Energy and Gas Production
Axelbaum, Richard ; Gopan, Akshay ; Yang, Zhiwei
T-018640

— Technology Description Engineers in Prof. Richard Axelbaum’s laboratory have developed Modular Pressurized Coal Combustion (MPCC), an economical, flexible, coal-fired boiler/burner system that could produce electricity at 1.3% higher efficiency than a state-of-the-art coal-fired plant with t…

Multiparametric Cardiac Strain Analysis of Myocardial Viability
Cupps, Brian ; Kar, Julia ; Pasque, Michael
T-014564

— Background: Assessing left ventricle (LV) cardiac contractile function is a good indicator of overall heart health and is used to determine which patients are good candidates for revascularization surgery. With over 3 million new coronary artery disease patients annually and over 1 million annual re…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Blood-based biomarkers of Alzheimer’s disease for diagnostics and clinical trials
Cruchaga, Carlos ; Dube, Umber ; Ibanez, Laura
T-019198

— Technology Description: Researchers in Prof. Carlos Cruchaga’s laboratory have identified a sensitive and specific panel of circular RNAs (circRNA) that could be used for diagnosing, screening or monitoring patients with Alzheimer’s disease. The expression of these circRNAs tracks with …

Plasmids for calling cards and single cell calling cards
Chen, Xuhua ; Lalli, Matthew ; Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019487

— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…

Synthetic Dendritic Cells for Expanding Antigen-Specific T Cells used in Cancer Immunotherapy
Klechevsky, Eynav ; Pathak, Amit ; Sarker, Bapi
T-017391

— Technology Description: A team led by Drs. Amit Pathak and Eynav Klechevsky have developed a soft alginate-gelatin matrix-based synthetic dendritic cell to rapidly expand and deliver CD8+ T cells for cancer immunotherapy. CD8+ T cells kill tumors, but current methods to expand them also activate r…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Personalized Virtual Reality Training
Engsberg, Jack ; Foreman, Matthew ; Janes, William
T-014603

— Many patients require physical therapy each year as a result of their suffering from a variety of neurological and musculoskeletal disorders including stroke, cerebral palsy, trauma and many others. Repetitive movements can increase muscle tone, range of motion and stamina to aid in their daily act…

Hydrogels for localized radiotherapy
Azab, Abdel Kareem ; Azab, Feda ; de la Puente Garcia, Maria del Pilar
T-013626

— Background External Beam Radiotherapy (EBR) is commonly used after surgical removal of a tumor (in e.g. a breast-conserving surgery) to control or kill malignant cells. The lack of selectivity due to irradiation of whole or partial organs from outside the body, however, is potentially damaging to t…

A long non-coding RNA in early and late-stage breast cancer as a prognostic marker, diagnostic marker, and therapeutic target.
Eteleeb, Abdallah ; Maher, Christopher ; Silva-Fisher, Jessica
T-020366

— Technology Description Researchers in Dr. Jessica Silva-Fisher’s laboratory have developed antisense oligonucleotide targeting a long non-coding RNA (lncRNA), LINC00355, as a treatment for late-stage relapse (LSR) breast cancer. LINC00355 is highly expressed in LSR breast cancer patients and…

New nerve cap arrests axon growth in neuroma management
Bichanich, Miles ; Hong, Thomas ; Mackinnon, Susan ; Moore, Amy ; Wood, Matthew
T-017285

— Background Neuromas (a.k.a. pinched nerve, or nerve tumor) form on peripheral nerves following trauma and possess exposed sensory axons mixed with fibrotic scar tissue. Symptomatic or painful neuromas have a profound impact on a patient’s quality of life and productivity. Pain medication offe…

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

PET tracers for detection of early stage Alzheimer’s disease
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-013525

— Technology Description Researchers at Washington University in St. Louis have developed PET radiotracers to image amyloid beta (A-beta) at early stages of Alzheimer’s Disease (AD). For AD treatment to be effective, it may have to be administered during the preclinical stage. As such, there i…

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

Multi-energy window approaches for quantitative SPECT
Jha, Abhinav Kumar ; Li, Zekun ; Thorek, Daniel
T-019824

— T-019824 Multi-energy window approaches for quantitative SPECT Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised a method to reliably obtain and significantly improve quantification of alpha-particle based SPECT tracer uptake, particularly …

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

CemOrange2 gene fusions for subcellular imaging in C. elegans
Luke, Clifford ; Pak, Stephen ; Silverman, Gary ; Thomas, Brian
T-018982

— Plasmids were generated with the NHX-2 promoter, to restrict gene expression to the C. elegans intestinal cells, driving C. elegans genes or targeting peptides, known to target different subcellular organelles, fused to a C. elegans optimized mOrange2 fluorescent protein (CemOrange2). These expressi…

Design and Development of Organomedicinals for Imaging and Treatment of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (FTD)
Guruswami, Sundaram ; Sharma, Vijay ; Sivapackiam, Jothilingam
T-016665

— Background Frontotemporal Dementia (FTD) is the second most common form of non-Alzheimer’s dementia in the population under 65 years old. FTD represents approximately 20% of all dementias and onset normally appears in the mid to late 50s. Clinically FTD is characterized by a progressive neur…

Tissue engineering scaffold for cell differentiation and delivery to intervertebral disc for treating lower back pain
Barcellona, Marcos ; Setton, Lori ; Speer, Julie
T-019297

— Background: Severe low back pain and disability can result from intervertebral disc (IVD) degeneration caused by cell phenotype changes in the nucleus pulposus (NP) region. While autologous stem cells have be used to treat lower back pain, currently there are no tools to control differentiation of…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

Urinary Biomarker of Uropathogen Colonization
Henderson, Jeffrey P. ; Hung, Chia ; Parker, Kaveri
T-011741

— Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is one of the most common infectious diseases in women. The morbidity and economic impact are enormous, with over $2.5 billion spent annually on treatment. The high rates of recurrence, and the large numbers of women that …

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Adhesive coated sutures for stronger musculoskeletal repairs
Genin, Guy ; Linderman, Stephen ; Thomopoulos, Stavros
T-014989

— Technology Description An interdisciplinary team at Washington University in St. Louis has developed patented adhesive-coated sutures with the potential to reduce ruptures following surgical repair of tendons and ligaments. These modified sutures are designed to minimize stress by shifting the mec…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

ME1 Deficiency Primes for Ferroptosis
Kremer, Jeff ; Lange, Sara ; Van Tine, Brian
T-016416

— Background: Synovial sarcoma is a rare soft tissue sarcoma that most commonly affects young adults. Like many other cancers, there are currently no targeted chemotherapies for synovial sarcoma. Current treatment often consists of a combination of surgery, radiation therapy, and chemotherapy. The met…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo (Justin) ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

Ultra High Quality Tunable Add-Drop Filter Based on Active Whispering Gallery Mode resonators
Monifi, Faraz ; Ozdemir, Sahin ; Yang, Lan
T-013642

— Whispering Gallery Mode (WGM) Resonators have been shown to have unique properties holding great promise for use in optical communication systems. Recent innovations from Dr. Lan Yang’s Nano-Photonics lab at Washington University in St Louis bring the promise much closer to reality. In particu…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Parallel single step prediction algorithm for conductivity-tensor estimation
Gilboa, Elad ; La Rosa Araya, Patricio ; Nehorai, Arye
T-011907

— A novel method for solving the inverse problem of inferring the conductivity tensor field structure (e.g. biological tissue) from a set spatiotemporal measurement. The new method is computationally more efficient than existing methods. We achieved the computational efficiency by using the optimizati…

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical Applications
Chen, Qinghao ; Tan, Yuewen ; Zhang, Tiezhi ; Zhou, Shuang
T-019620

— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…

Gaussian Process Audiogram
Barbour, Dennis ; Gardner, Jacob ; Ledbetter, Noah ; Song, Xinyu ; Weinberger, Kilian
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

Rechargeable anode-free sodium metal battery
Bai, Peng ; Lee, Youngju ; Ma, Bingyuan
T-019512

— Technology Description Researchers in Peng Bai’s lab at Washington University have developed an inexpensive rechargeable sodium metal battery with a 99.93% sodium retention rate. This battery uses glyme-based electrolytes with a low moisture content and a bare copper current collector to ach…

ViroCap: enhanced, efficient virome sequencing with metagenomic capture probes
Storch, Gregory ; Wylie, Kristine ; Wylie, Todd
T-015124

— Technology Description A team of researchers at Washington University developed “ViroCap”, a patented capture probe technique for senistive, comprehensive, in-depth metagenomics analysis vertebrate viruses. This invention could enhance traditional metagenomics shotgun sequencing (MSS) w…

Ceramide profiling for blood-based predictive screening for cardiovascular disease, heart failure and death
Ory, Daniel ; Peterson, Linda ; Schaffer, Jean
T-014627

— Technology Description A team of researchers has developed a high throughput, FDA-compliant assay to predict coronary heart disease and mortality in the general population 6-10 years before the onset of disease. This fully validated two-dimensional liquid chromatography-tandem mass spectrometry (L…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Quit Helpers
Colditz, Graham ; McQueen, Amy ; Sumner, Walton
T-014916

— Quit Helpers is an interactive web-based tool to recommend pharmacotherapy to smokers based on medical and personal factors. Although general information about cessation aids is abundant, Quit Helpers automates the process of identifying a specific cessation aid or combination of aids for individua…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

MRI neural network segmentation in atherosclerosis
Jha, Abhinav Kumar ; Li, Ran ; Woodard, Pamela ; Zheng, Jie
T-020254

— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Low cost, versatile enzymatic synthesis of beta-lactone peptides for antibiotic or serine hydrolase inhibitor drug discovery
Reck, Margaret ; Schaffer, Jason ; Wencewicz, Timothy
T-016508

— Chemists from Washington University have discovered and characterized an enzyme pathway that could be harnessed as an efficient platform to produce peptide beta-lactone libraries for drug discovery. Beta-lactones are a family of molecules with a structure similar to penicillin and therefore could po…

TR3: a stabilized TRAIL timer for use as an anticancer therapeutic
Hawkins, William ; Hotchkiss, Richard ; Spitzer, Dirk
T-007646

— WUSTL Technology 007646 Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed a novel TRAIL (TNF-related apoptosis inducing ligand)-based anticancer drug platform, designated TR3. TRAIL has potent and specific apoptotic activity against tumor cells. Thus,…

Epigenetic drug targets to treat or prevent osteoarthritis and cartilage degradation
McAlinden, Audrey ; O'Keefe, Regis ; Shen, Jie
T-015627

— A team of researchers at Washington University in St. Louis has identified an epigenetic pathway and two therapeutic targets that could be used to prevent cartilage loss and counteract the mechanism underlying osteoarthritis. The inventors have seen promising results in a mouse model of arthritis us…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Compressed-sensing Ultrafast Photography (CUP)
Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733

— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Molecular imaging of COVID binding receptor
Abou, Diane ; Thorek, Daniel ; Zhang, Hanwen
T-019485

— Technology Description A team of researchers led by Professor Daniel Thorek at Washington University have developed a peptide specific to human ACE2, the receptor for SARS-CoV-2, that can be used for imaging or therapeutic delivery. The peptide can be easily chelated for PET imaging, allowing for …

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila
T-009276

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein (Ellebedy)
Diamond, Michael ; Ellebedy, Ali ; Fremont, Daved
T-019438

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Description: Four murine monoclonal antibodies that recognize SARS-CoV-2 spike protein. Data below includes avaiable antibodies (mCoV.1.1C02; mCoV.1.2C08; mCoV.1.2D09; mCoV.1.2F05). Related Web Links: Ellebedy Profile; Ellebedy Lab …

Control of Dietary and Microbial Exposure in Early Life as a Novel Approach to Target Allergy Development in Infants
Knoop, Kathryn ; McDonald, Keely ; Newberry, Rodney
T-016480

— Background: The frequency of allergic disorders has been rapidly increasing in children in Western societies. Previous studies have shown reduced allergic outcomes in at-risk children upon breast feeding with complementary introduction of food allergens combined with limited oral antibiotic exposure…

Metabolic biomarkers for accurate, real-time diagnostics and monitoring of C. difficile infection
Crowley, Jan ; Henderson, Jeffrey P. ; Robinson, John
T-019079

— Technology Description Researchers in Prof. Jeffrey Henderson’s laboratory have developed a method of analyzing metabolic biomarkers from fecal samples to more accurately identify C. difficile infection (CDI) and distinguish between symptomatic and asymptomatic colonization. CDI is currently …

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

Gadd7 haploinsufficient mutant CHO cell line
Listenberger, Laura ; Ory, Daniel ; Schaffer, Jean
T-019113

— Gadd7 haploinsufficient mutant CHO cell line Inventors generated a mutant Chinese Hamster Ovary (CHO) cell line with disruption of one allele encoding Gadd7, a non-coding RNA. CHO cells were transduced with retrovirus at a low multiplicity of infection and mutants were isolated. Number of retrovira…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Urine-based metabolomics signature to predict severe COVID-19
Henderson, Jeffrey P. ; Marks, Laura ; Robinson, John
T-019592

— Technology Description A team of researchers has discovered a urinary metabolite pattern occurring early in COVID-19 disease progression that can predict which patients infected with SARS-CoV-2 are at high risk for respiratory failure or death. This metabolite signature could potentially provide a…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

Treatments for Wolfram syndrome
Clark, Amy ; Mahadevan, Jana ; Urano, Fumihiko
T-015862

— Technology Description Dr. Fumihiko Urano at Washington University in St. Louis (WUSTL) and colleagues have developed therapeutic strategies to treat Wolfram syndrome. Wolfram syndrome is a rare, life-threating, genetic disorder characterized by insulin-dependent diabetes mellitus, diabetes insipi…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probe
Li, Lei ; Wang, Lihong ; Yao, Junjie
T-015670

— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

Normothermic Extracorporal Liver Perfusion (NELP)
Banan, Babak ; Chapman Sr., William ; Lin, Yiing
T-015492

— Background: In the U.S., ~15,000 adults and children are medically approved for a liver transplant and ~6,000 liver transplants are performed each year. Unfortunately, 30% of donor livers are unsuitable for transplantation while 1,500 patients per year die waiting for liver a transplant. The high de…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Deterministic two-photon controlled-phase logic gate
Chen, Zihao ; Shen, Jung-Tsung ; Zhou, Yao
T-018542

— Technology Description Researchers in the lab of Professor JT Shen at Washington University have developed a two-photon controlled-phase quantum logic gate capable of up to 97% fidelity at room temperature. The design uses chiral optical waveguides with photonic molecules to create a deterministic…

IL34 tm1b and tm1c mice
Colonna, Marco ; Gilfillan, Susan ; Wang, Yaming
T-019313

— Mouse line knockouts of IL-34. IL-34 is a growth factor for macrophages, microglia, and Langerhans cells, among others. Publication: IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

MR Method for Quantification of Anisotropic Diffusion
Conradi, Mark ; Sukstansky, Alexander ; Yablonskiy, Dmitriy
T-003068

— Magnetic Resonance (MR) is known to allow quantitative measurements of molecular diffusion in different materials. Such materials are frequently composed of structural units. Boundaries of these units serve as restrictive barriers for diffusing molecules. In case of structurally anisotropic units,…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)
Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458

— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Chimpanzee adenovirus-based vaccine for COVID-19
Curiel, David ; Diamond, Michael ; Dmitriev, Igor ; Hassan, Ahmed
T-019478

— Technology Description Researchers at Washington University in St. Louis have developed a chimpanzee adenovirus-based vaccine for COVID-19. COVID-19, the clinical syndrome caused by SARS-CoV-2 infection, has had extensive morbidity and mortality impacts and destabilized society. There is an urg…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Nano-CaCO3
Achilefu, Samuel ; Biswas, Pratim ; Raliya, Ramesh ; Som, Avik
T-015910

— Background: Physiological pH changes consistently affect millions of people worldwide. A slight variation in physiological pH exposes the body to various health risks, ranging from common heartburn to the formation of malignant tumors. Conventional methods for buffering pH are accomplished through a…

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Sulfur-containing compounds targeting on vesicular acetylcholine transporter for cognitive function
Jin, Hongjun ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-016517

— Background: Dementia caused by Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases manifests as a progressive decline in memory and other cognitive abilities. Deposits of beta-amyloid plaques and tangles of the tau protein are thought to cause the destruction o…

SARS-CoV-2 neutralizing antibody effective against all variants
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura
T-019791

— Disease indication – SARS-CoV-2 infection (COVID-19) Drug format – Chimeric monoclonal antibody Drug class – Best-in-class Research stage and Preliminary data – The inventors have developed and characterized this antibody, creating a chimeric version with a human IgG backbone. T…

Clifednamide compounds
Qi, Yunci ; Van Dyke-Blodgett, Joshua ; Wencewicz, Timothy ; Yang, Jinping
T-019321

— Clifednamide A and C are congeners of long known ikarugamycin. Ikarugamycin has anti-inflammatory, anti-ciliate, plant modulatory and other desirable bioactivities. These clifednamide compounds may also have therapeutic, industrial or agricultural value. Publication: Qi, Y., Ding, E., & Blodget…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

Low-cost, flexible paper substrate for sensitive trace chemical and biological detection using SERS (surface enhanced Raman scattering)
Kharasch, Evan ; Lee, Chang Hee ; Morrissey, Jeremiah ; Singamaneni, Srikanth
T-010600

— Technology Description Researchers in Prof. Srikanth Singamaneni’s laboratory have developed a patented, low-cost, flexible substrate designed to improve sample collection and enhance analyte detection with surface enhanced Raman scattering (SERS) or localized surface plasmon resonance (LSPR…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

Rapid PEG-based drug delivery implant for local treatment of cervical cancer
Azab, Abdel Kareem ; Federico, Cinzia ; Schwarz, Julie ; Sun, Jennifer
T-019396

— Technology Description Researchers in Prof. Kareem Azab’s laboratory have developed a fast, localized drug delivery system designed to maximize anti-tumor efficacy and reduce side effects by delivering chemotherapy directly to cervical tumors. The current standard-of-care treatment regimen …

Photoacoustic tomography of human brain
Anastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043

— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

MR-HIFU acoustic coupling device to improve performance and reduce side effects
Altman, Michael ; Chen, Hong ; Kothapalli, Veera "Satya" ; Xie, Kevin
T-017089

— Technology Description Engineers in Prof. Hong Chen’s laboratory have developed a multifunctional, MR-compatible device designed to improve the performance of Magnetic Resonance High Intensity Focused Ultrasound (MR-HIFU) by increasing the efficiency of the ultrasound transmission, cooling t…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

New PARP-1 Inhibitors for Imaging PARP-1 Expression in Vivo
Chu, Wenhua ; Rogers, Buck ; Xu, Jinbin ; Zhou, Dong
T-018730

— [18F]WC-DZ-F is a derivative of [18F]FluorThanatrace and a radiotherapeutic agent. [18F]WC-DZ-F has suitable biodistribution profile, favourable logP and super metabolic stability in vivo. We have demonstrated that [18F]WC-DZ-F is capable of imaging PARP-1 expression in PC-3 prostate cancer xenograf…

Microfluidic device for high-throughput, multiplexed electrochemical analysis with live-cell imaging and spectrometry
Binkley, Michael ; Bose, Arpita ; Meacham, John ; Rengasamy, Karthikeyan
T-018839

— Technology Description An interdisciplinary team of Washington University researchers has developed a high-throughput microfluidic bioelectrochemical cell (μBEC) that collects electrochemical data and is compatible with live-cell microscopy and spectrometry. This device transcends the capabilit…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Isochoric Actuator
Cashin, John ; Genin, Guy ; Lee, Sanghun ; Zayed, Mohamed
T-019219

— Device used to maintain a constant volume within an isolated treatment zone while exchanging its internal volume. Current aspiration and lytic delivery thrombectomy devices do not have isolated treatment zone. Suction could result in collapse or the lysis could result in the distension of the vein wall. Device allows for tandem infusion and suction of fluids from this treatment zone while ensuring that the volume within this treatment zone remains constant.

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017417

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)
Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450

— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …

Long non-coding RNA as cancer biomarker and drug target
Cabanski, Christopher ; Fields, Ryan ; Maher, Christopher ; Silva-Fisher, Jessica
T-018788

— Technology Description Researchers in Prof. Christopher Maher’s research program (in conjunction with collaborator Ryan Fields) discovered that RAMS11 (RNA Associated with Metastasis 11), a novel long non-coding RNA, (i) promotes metastatic disease, (ii) confers resistance to topoisomerase i…

Predictive biomarker for CAR T-associated neurotoxicity
Ances, Beau ; Butt, Omar ; DiPersio, John ; Ghobadi, Armin
T-019528

— Technology Description: Researchers at Washington University in St. Louis have developed a biomarker screening assay to predict which patients receiving CAR T cell therapy will experience neurotoxicity. Patients can be screened well in advance of receiving the T cell therapy with a simple serum as…

Stable, non-toxic lead-free perovskite materials for high efficiency solar cells and other semiconductor applications
Biswas, Pratim ; Kavadiya, Shalinee ; Mishra, Rohan ; Thind, Arashdeep Singh
T-018532

— Engineers at Washington University in St. Louis have discovered a new class of stable, benign perovskite semiconductor materials with performance properties optimized for solar cell and photocatalysis applications. Traditional lead-halide perovskites show remarkable power conversion efficiency in ph…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

VLDLR-based Decoy Receptors to Prevent Alphavirus Infections
Adams, Lucas ; Diamond, Michael ; Fremont, Daved ; Raju, Saravanan
T-020745

— VLDLR-based Decoy Receptors to Prevent Alphavirus Infections Technology Description Researchers at Washington University in St. Louis have developed very low-density lipoprotein receptor (VLDLR) soluble decoy receptors with potent inhibitory activity in vitro and in vivo. Eastern equine encephali…

Single cell calling cards (scCC): Transposon system to simultaneously map transcription factors and quantify gene expression
Mitra, Robi ; Moudgil, Arnav ; Qi, Zongtai ; Wilkinson, Michael Nathaniel
T-018609

— Technology Description Researchers in Prof. Rob Mitra’s laboratory have developed single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution. This technology simulta…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

Spray Pyrolysis for the Production of Li+ Ion Battery Cathodes
Atlas, Gal ; Axelbaum, Richard ; Elhassid, Dror ; Lengyel, Miklos
T-013647

— Background Material morphology and composition are critical for production of Li+ ion battery cathodes, and there is a need for improved synthesis methods that yield high quality materials through cost effective, green, scalable processes. Further, there is often a need to dope materials during syn…

PET tracer to diagnose kidney disease
Baldelomar, Edwin ; Beeman, Scott ; Bennett, Kevin ; Reichert, David
T-018902

— Technology Description Researchers at Washington University in St. Louis have developed a PET tracer that may be used to quantify kidney nephron endowment and diagnose kidney disease. Nephrons are the functional units of the kidney responsible for filtering the blood to remove waste. They are form…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Multi-Parametric Imaging of Tumor Heterogeneity Using Noninvasive, Non-radiative Water Diffusion
Benzinger, Tammie ; Guzman, Gloria ; Wang, Qing ; Wang, Yong
T-016652

— Background Currently, biopsies are the only definitive method to diagnose a brain tumor. While PET-CT is used for initial imaging and monitoring of the tumor, after completion of treatments, a 6-8-week delay is usually implemented to avoid false-positive results. Yet, the delay could also result in…

Lrp1 and the Blood Brain Barrier
Amarasinghe, Gaya ; Ganaie, Safder ; Leung, Daisy ; Virgin, Herbert
T-019577

— T-019577 – Lrp1 and the blood brain barrier Technology Description Researchers in Gaya Amarasinghe’s laboratory at Washington University have engineered new protein fragments (RVFV Gn) to target LRP1, which was recently identified as an essential entry factor for Rift Valley Fever Virus (RVF…

Fast, simple, low-cost point-of-care diagnostics for COVID-19 and other infectious diseases
Buchser, William ; Lalli, Matthew ; Milbrandt, Jeffrey ; Mitra, Robi
T-019442

— Technology Description A team of Washington University researchers has developed a low-cost molecular diagnostics kit and reader that could provide rapid, widespread screening and surveillance for SARS-CoV-2 and other infections. This technology utilizes a reverse-transcription loop-mediated isot…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Modulation of the DLK/JNK Pathway as a Method for Inhibiting Axonal Degeneration
DiAntonio, Aaron ; Milbrandt, Jeffrey ; Miller, Bradley ; Press, Craig
T-008422

— Background: Axonal degeneration is a feature commonly associated with many neuropathological conditions including response to injury, exposure to neurotoxins, hereditary neuropathies, glaucoma, and neurodegenerative diseases. The degenerative process is active when neuronal insults trigger a self-de…

Non-invasive Technology Enables Brain Tumor Biopsy Without Surgery
Chen, Hong ; Dunn, Gavin ; Leuthardt, Eric ; Petti, Allegra
T-017113

— Background: The American Brain Tumor Association reports that about 80,000 of the estimated 700,000 Americans that live with a brain tumor have been diagnosed in 2017. The surgery required for a traditional brain tumor biopsy entails making a hole in the skin and skull, placing a needle probe, and r…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Radiotracers to detect early Parkinson’s disease
Kotzbauer, Paul ; Qiu, Lin ; Tu, Zhude "Will" ; Yu, Yanbo
T-020559

— Radiotracers to detect early Parkinson’s disease Technology Description Researchers at Washington University in St. Louis, led by Dr. Zhude Tu, have developed two imaging agents for α-synuclein (α-syn) aggregation for use to diagnose early Parkinson’s disease, track dise…

ELISpot assay to immune phenotype patients
Hotchkiss, Richard ; Mazer, Monty ; Remy, Kenneth ; Turnbull, Isaiah
T-019522

— Technology Description A team of researchers, led by Richard Hotchkiss at Washington University in St. Louis, have developed a version of the ELISpot assay to determine if COVID-19 patients are in a hyper-inflammatory or immunosuppressed state. The results of this assay, which can be performed wit…

A companion diagnostic to SARM1 inhibitors for neurodegenerative diseases
Bloom, Adam ; DiAntonio, Aaron ; Mao, Xianrong ; Milbrandt, Jeffrey
T-019378

— Technology Description Researchers at Washington University, led by Jeffrey Milbrandt, have developed a companion diagnostic for SARM1 inhibitors that detects pathogenic variants of the SARM1 gene. Patients with one of several identified variants of SARM1 would respond well to SARM1 inhibitor thera…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-016668

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

Vaccine to prevent catheter-associated urinary tract infection
Caparon, Michael ; Flores-Mireles, Ana ; Hultgren, Scott ; Pinkner, Jerome
T-013965

— Technology Description Researchers at Washington University in St. Louis have developed a vaccine strategy to prevent catheter-associated urinary tract infections (CAUTIs). CAUTIs are the most common cause of hospital-acquired infections. Many of these are caused by Enterococcus bacteria. CAUTIs a…

Alpha-synuclein ligands as specific PET imaging probes for Parkinson’s Disease and other disorders
Dhavale, Dhruva ; Kotzbauer, Paul ; Tu, Zhude "Will" ; Yue, Xuyi
T-018038

— Technology Description A team of researchers at Washington University have developed and optimized highly potent PET imaging probes which are specific for the misfolded protein that is the hallmark of Parkinson’s disease and related disorders. This family of molecules was designed based on s…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

PET Radiotracers for Imaging Free Radicals and Reactive Oxygen Species (Materials: WC-4-77)
Chu, Wenhua ; Dugan, Laura ; Mach, Robert ; Mintun, Mark
T-009254

— Many diseases can be associated with abnormal production of reactive oxygen species (ROS) due to oxidative stress. Currently there is no way to image this in situ. Dihydroethidium (DHE) naturally produces a fluorescent product when oxidized by an ROS. The signal is not strong enough for practical im…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Universal Targeted Drug Delivery and Imaging Platform
Barnes, Jonathan ; Delawder, Abigail "Abby" ; Li, Ruihan ; Li, Xuesong
T-018548

— Background Targeted delivery of cytotoxic therapeutics is crucial to prevent adverse side effects of chemotherapy and to increase drug concentrations at the tumor site. These prerequisites also apply to the treatment of infections caused by multiple drug resistant bacteria. To address this unmet n…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

S1PR2-targeted PET tracers
Klein, Robyn ; Liu, Hui ; Luo, Zonghua ; Tu, Zhude "Will"
T-018580

— Technology Description Researchers at Washington University in St. Louis and colleagues have developed S1PR2-targeted PET tracers. Sphingosine-1-phosphate (S1P) is an important bioactive lipid that regulates critical biological functions by acting through five specific G protein-coupled S1P recept…

Plasmid to test regulation 5′ untranslated sequences in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019560

— This plasmid was created to test the regulatory impact of 5’ untranslated regions in yeast. It consists of EGFP under the control of the S. cerevisiae TEF2 promoter with cloning sites to modify the 5’UTR. Publication: Roy, B., Granas, D., Bragg, F., Cher, J. A., White, M. A., & Stor…

Development of Colloidal Iron Oxide Contrast Agent for MRI and MPI
Lanza, Gregory ; Pan, Dipanjan ; Senpan, Angana ; Wickline, Samuel
T-007545

— Background: Biodegradable magnetic carriers have been increasingly utilized in biomedical and clinical research, but the larger size of ferromagnetic agents previously used leads to long circulation times and restriction to the vasculature, making these particles ideally suited for detection of spa…

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Plasmids to express tagged genes in yeast
Granas, David ; Roy, Basab ; Stormo, Gary ; White, Michael A
T-019559

— Three yeast plasmids that express yeast genes tagged with the fluorescent mCherry protein under the control of the GAL promoter. The genes were modified to be cre-less to so the plasmids could be used to study autoregulation in yeast. pMBJ1 pMBJ1-RPL1B-cl pMBJ1-RPS22-cl Publication: Roy, B., Gr…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Lysosomal Enzyme GlcNAc-1-phosphotransferase with Enhanced Ability to Phosphorylate Lysosomal Enzymes
Doray, Balraj ; Kornfeld, Stuart ; Lee, Wang ; Liu, Lin
T-016569

— Lysosomal storage disorders result in severe, multi-system dysfunction and frequently, early death. Currently, a number of lysosomal storage disorders are treated with enzyme replacement therapy (ERT), which requires periodic infusions of the deficient enzyme. However, in a number of instances the…

Lactobacillus reuteri deltaArat
Caparon, Michael ; Cervantes-Barragan, Luisa ; Colonna, Marco ; Di Luccia, Blanda
T-018589

— Bacteria modified from the parental strain Lactobacillus reuteri 100-23 that doesn’t express the enzyme aryl aminotransferase. Culture supernatants from this bacterial strain failed to stimulate AhR reporter cells. Publication: Lactobacillus reuteri induces gut intraepithelial CD4+CD8α…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Water filtration platform technologies using crumpled graphene oxide nanocomposites
Biswas, Pratim ; Fortner, John ; Jiang, Yi ; Wang, WeiNing
T-014428

— Technology Description A team of researchers at Washington University, led by Pratim Biswas and John Fortner, has constructed crumpled graphene oxide nanoparticles encapsulating TiO2 and Ag to create reactive, easily cleaned water filtration membranes. The TiO2 and Ag, which can be periodically re…

Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser Systems
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

EMMI- non-invasive imaging method for safe, accurate, robust monitoring of uterine contractions
Cahill, Alison ; Cuculich, Phillip ; Schwartz, Alan ; Wang, Yong
T-015805

— Technology Description Researchers at Washington University in St. Louis have developed an electromyometrial imaging (EMMI) method to non-invasively monitor uterine contractions. During pregnancy, many women experience preterm contractions. Sometimes these contractions progress to pre-term labor a…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response
Lomonosova, Elena ; Mullen, Mary ; Verma, Priyanka ; Zhao, Peinan
T-020659

— T-020659 — Functional Biomarkers of Platinum Chemotherapy and PARP Inhibitor Response Technology Description Most patients diagnosed with high-grade serous ovarian cancer (HGSOC) undergo first-line platinum therapy and PARP inhibitor maintenance therapy. However, the degree to which HGSOC p…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Real-time interference compensation in MRI guided radiotherapy
Curcuru, Austen ; Gach, H. Michael ; Kim, Taeho ; Villa, Umberto
T-019745

— Technology Description Researchers at Washington University in St. Louis have developed a method to improve image quality during MR imaging guided radiation therapy (MR-IGRT) by correcting for B0 fluctuation in real-time. The corrections reduce electromagnetic interference (EMI) between the MRI sc…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Biomarkers for Alzheimer’s Disease and Brain Injury
Ladenson, Jack ; Landt, Yvonne ; Laterza, Omar ; Modur, Vijay
T-004414

— Technology Description Researchers in Prof. Jack Ladenson’s laboratory have discovered biomarkers and associated antibodies for Alzheimer’s disease (AD) that could be used for early/presymptomatic diagnosis or in clinical trials for AD drugs. This patented technology is based on the i…

Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
Maslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922

— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Plasmids for calling cards and single cell calling cards
Chen, Xuhua ; Lalli, Matthew ; Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019487

— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

New nerve cap arrests axon growth in neuroma management
Bichanich, Miles ; Hong, Thomas ; Mackinnon, Susan ; Moore, Amy ; Wood, Matthew
T-017285

— Background Neuromas (a.k.a. pinched nerve, or nerve tumor) form on peripheral nerves following trauma and possess exposed sensory axons mixed with fibrotic scar tissue. Symptomatic or painful neuromas have a profound impact on a patient’s quality of life and productivity. Pain medication offe…

Therapeutic targeting of LDL in ALS
Kreple, Collin ; Miller, Timothy ; Nielsen, Susan ; Racette, Brad
T-020021

— Technology Description Researchers in Brad Racette and Tim Miller’s labs at Washington University have developed a therapeutic strategy for treating ALS by using statins to lower LDL. Statins were successful at prolonging both survival and time with a normal gait. The researchers identif…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

Accurate, efficient 2D strain mapping with robust detection of strain localization
Boyle, John ; Genin, Guy ; Pless, Robert ; Thomopoulos, Stavros
T-014090

— Summary DDE (Direct Deformation Estimation) and SIMPLE (Strain Interference with Measures of Probable Local Elevation) are two simple Digital Image Correlation algorithms that combine image analysis techniques with mechanical engineering principles to provide accurate, efficient, quantitative strai…

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

CemOrange2 gene fusions for subcellular imaging in C. elegans
Luke, Clifford ; Pak, Stephen ; Silverman, Gary ; Thomas, Brian
T-018982

— Plasmids were generated with the NHX-2 promoter, to restrict gene expression to the C. elegans intestinal cells, driving C. elegans genes or targeting peptides, known to target different subcellular organelles, fused to a C. elegans optimized mOrange2 fluorescent protein (CemOrange2). These expressi…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

NMDA receptor modulator for neuroprotection after a stroke
Mennerick, Steven ; Sun, Min-Yu ; Taylor, Amanda ; Zorumski, Charles
T-016328

— Disease indication – neuroprotection in stroke/ischemia with potential for treating other neurodegenerative diseases Drug format – neurosteroid Drug class – drug repurposing (25-hydroxycholesterol) Research stage and Preliminary data: In vitro – The inventors demonstrated…

Nanomaterials for Imaging and Treatment of Amyloidosis
Bieschke, Jan ; Guruswami, Sundaram ; Liu, Yongjian ; Sharma, Vijay
T-017876

— Background 8 million people per year are diagnosed with light-chain (AL) amyloidosis, a progressive disease than can quickly affect the kidney, heart, and nervous system if left untreated. The current method of diagnosis involves histological confirmation via biopsies of bone marrow, fat, and organ…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Selective RANK ligand to treat osteoporosis
Fremont, Daved ; Nelson, Christopher ; Teitelbaum, Steven ; Warren, Julia
T-014404

— Disease indication – Osteoporosis, skeletal metastasis, and potentially rheumatoid arthritis, psoriasis, acute myeloid leukemia, and breast cancer Drug format – Engineered Protein Research stage and Preliminary data – Proof of concept in vitro and in vivo Target – Receptor A…

Machine learning methods for real-time MRI image processing: MRI-only radiation treatment planning and improving MR image resolution
Green, Olga ; Mutic, Sasa ; Park, Chunjoo (Justin) ; Zhang, Hao
T-018522

— Technology Description A team of researchers at Washington University School of Medicine developed deep learning image processing techniques to improve MRI diagnostics and potentially enable faster, more precise MRI-guided radiation therapy without exposing patients to radiation from CT imaging. S…

PI3K inhibitors to treat Cytokine Release Syndrome
Amatya, Parmeshwar ; Carter, Alun ; Cooper, Matthew ; DiPersio, John
T-019429

— Technology Description A team of researchers, led by John DiPersio and Matthew Cooper at Washington University in St. Louis, have identified a small molecule kinase inhibitor capable of mitigating cytokine release syndrome following CAR-T cell therapy. PI3K inhibitors can suppress production of IL-…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Mobile PET imaging system
Li, Ke ; Mathews, Aswin ; Tai, Yuan-Chuan ; Wen, Jie
T-014964

— Background PET scanners are valued for their ability to provide whole-body functional and anatomic information, important in the diagnoses and management of metabolic conditions. However, there is currently a need in the market for a smaller imaging system that can be used for point-of-care applica…

Super-Resolution Dental Tetrahedron Beam Computed Tomography (TBCT) System Improves Image Quality Without Sacrificing Speed for Expanded Clinical Applications
Chen, Qinghao ; Tan, Yuewen ; Zhang, Tiezhi ; Zhou, Shuang
T-019620

— Current cone beam computed tomography (CBCT) systems lack concurrent high-resolution imaging and speed With current digital CBCT imaging technology, x-ray tube power limitations mean high-resolution images can only be achieved by reducing imaging speeds. In dental applications, CBCT suffers from im…

Gaussian Process Audiogram
Barbour, Dennis ; Gardner, Jacob ; Ledbetter, Noah ; Song, Xinyu ; Weinberger, Kilian
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

Recombinant Chikungunya Virus Soluble E2 Protein
Barrow, Melissa ; Diamond, Michael ; Fremont, Daved ; Pal, Pankaj
T-014734 microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Self-capacitance Power Transfer for Efficient Wireless Charging of Small Wearables
Alazzawi, Yarub ; Aono, Kenji ; Chakrabartty, Shantanu ; Scheller, Erica
T-018759

— Technology Description Engineers in Prof. Shantanu Chakrabartty’s laboratory have developed a convenient, wireless power transfer system that exploits the body’s self-capacitance to charge small, low power, wearable and minimally-invasive devices. Wearable devices traditionally rely o…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

MRI neural network segmentation in atherosclerosis
Jha, Abhinav Kumar ; Li, Ran ; Woodard, Pamela ; Zheng, Jie
T-020254

— Technology Description Researchers at Washington University in St. Louis have developed a two-stage neural network model, with CNN and BNN architecture, to segment carotid atherosclerotic plaque components based on multi-weighted MR images and measure the uncertainty of the segmentation output. Th…

Lightweight, wearable cap for bedside functional optical neuroimaging
Bergonzi, Karla ; Culver, Joseph ; Eggebrecht, Adam ; Ferradal, Silvina
T-013611

— Technology Description Researchers in Prof. Joseph Culver’s laboratory have developed a patented, compact, lightweight functional neuroimaging device for long-term bedside monitoring. This technology, based on high-density diffuse optical tomography (HD-DOT), could be used as a surrogate for …

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Low-Power, Fast Sensors for Infrastructure‐to‐Vehicle Communications in Autonomous Driving
Aono, Kenji ; Chakrabartty, Shantanu ; Kondapalli, Sri Harsha ; Pochettino, Owen
T-019014

— Engineers in Prof. Shantanu Chakrabarty’s laboratory have developed an RFID embedded sensor system for infrastructure-to-vehicle (I2V) communications that uses near-zero standby energy and offers the robust performance of actively powered communications. This technology is designed to provide …

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Capture-based sequencing for comprehensive, cost-effective multiple myeloma prognostics and monitoring
Fulton, Robert ; Lanc, Irena ; Tomasson, Michael ; White, Brian
T-016907

— Technology Description Researchers at Washington University developed a prognostic assay for multiple myeloma that detects the full range of common multiple myeloma mutations using a single capture-based sequencing platform. This technology utilizes probes designed to analyze 465 genes associated …

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila
T-009276

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

S1P1-targeted PET tracers
Liu, Hui ; Rosenberg, Adam ; Tu, Zhude "Will" ; Yue, Xuyi
T-016151

— Technology Description Researchers at Washington University in St. Louis have developed sphingosine 1-phosphate receptor 1 (S1P1)-specific PET tracers. Sphingosine 1-phosphate receptors are G-protein coupled receptors, with five subtypes denoted S1P1-5, that have key functions in immune, inflammat…

New Method to Produce a DNA Mutation Library
Alvarado, David ; Dobbs, Matthew ; Gurnett, Christina ; Haller, Gabriel
T-015343

— Background: A DNA point mutation is a single nucleotide base substitution, insertion, or deletion in a gene sequence. Point mutations are responsible for several diseases including cystic fibrosis, sickle-cell disease, polycystic kidney disease, microcephaly, and Crohn’s disease. The study on …

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Targeting hepatic arginine metabolism for treatment of metabolic diseases
DeBosch, Brian ; Higgins, Cassandra ; Mayer, Allyson ; Zhang, Yiming
T-017490

— Background Over 30% of adults in the world are overweight or obese. Lifestyle management has proven to be impractical and ineffective in real-life settings and there are no current treatments available for metabolic disease. Technology Summary Pharmacological or genetic activation of the Arginine…

Pressure recovery ratio (PRR) index for real-time assessment of heart failure
Chung, Charles ; Kovacs, Sandor ; Shmuylovich, Leonid ; Zhang, Weixiong
T-007562

— Technology Description Researchers in the Cardiovascular Biophysics Laboratory at Washington University developed a patented, real-time, automated index to reliably detect delayed relaxation during cardiac catheterization diagnostics. This technique, called pressure recovery ratio (PRR), serves as…

Styryl Heteroaromatic Ring Containing Analogues for Alpha-Synuclein
Kotzbauer, Paul ; Li, Junfeng ; Tu, Zhude "Will" ; Yue, Xuyi
T-014558

— Compounds with high affinity for aggregated alpha-synuclein, after radiolabeling with C-11 or F-18, 1- 125, 1-123 and Br-76, could be used as PET tracers to measure the level and distribution of aggregated alpha-synuclein in patients with Parkinson’s disease and related diseases such as DLB…

Nanomaterial to eliminate cold chain by preserving biological reagents and patient samples
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Wang, Congzhou
T-017288

— Technology Description An interdisciplinary team at Washington University has developed low-cost, easy-to-use, nanoparticles that can preserve antibodies, proteins and other biological molecules without refrigeration. This technology employs metal organic frameworks (MOF) that can be used in two w…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 Tri-heterocyclic ring compounds as alpha-synuclein ligands
Kotzbauer, Paul ; Mach, Robert ; Tu, Zhude "Will" ; Yu, Lihai
T-011942

— A novel series of phenothiazine-derived molecules are useful for detecting Parkinson’s disease using positron emission tomography (PET) imaging. The molecules bind with high affinity to the alpha- synuclein protein, which forms aggregates in the brain and is associated with the neurodegenerati…

An Intradermal Method for the Treatment of Hair Loss and Alopecia
Feng, Jing ; Hu, Hongzhen ; Luo, Jialie ; Yang, Pu
T-017716

— Technology Description: A team of researchers, led by Hongzhen Hu, at Washington University in St. Louis has developed a method of treating hair loss and alopecia by intradermal injection targeting TRPV4 activation. Using a small molecule TRPV4 agonist, a single intradermal injection is sufficient…

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Conformationally-flexible benzamide analogs as sigma-2 selective ligands
Mach, Robert ; Rowland, Douglas ; Tu, Zhude "Will" ; Welch, Michael
T-004063

— The sigma-2 (σ2) receptor is an important target for the development of molecular probes in oncology because of its 10-fold higher density in proliferating tumor cells than in quiescent tumor cells, and the observation that σ2 receptor agonists are able to kill tumor cells via apoptotic …

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Novel Monoclonal Antibodies against Dengue Viruses (1,2,3, & 4) E Proteins
Brien, James ; Diamond, Michael ; Shrestha, Bimmi ; Sukupolvi, Soila

— Description: Monoclonal antibodies against Dengue virus E proteins. These mAbs are generated in mouse against different Dengue viruses and have been shown, by functional assays, to neutralize infection of the individual Dengue serotypes. Target: Dengue Virus Notes: Contact for more info. Publicat…

Simple, stable plasmonic biosensors for point-of-care diagnosis of cardiac arrest and other conditions
Kharasch, Evan ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva
T-014923

— Technology Description An interdisciplinary team of researchers at Washington University have developed a sensitive, shelf-stable, label-free system for quickly quantifying biomarkers in point-of-care settings (e.g., office, ambulance or battlefield). Localized surface plasmon resonance (LSPR) off…

Low-cost, high-performance materials for solar-driven membrane distillation in water treatment and desalination
Jiang, Qisheng ; Jun, Young-Shin ; Singamaneni, Srikanth ; Wu, Xuanhao
T-019047

— Technology Description Engineers in Prof. Young-Shin Jun’s laboratory and Prof. Singamaneni’s laboratory have developed high performance, stable membrane materials that can be used for photothermal membrane distillation (PMD) to purify or desalinate water with minimal input of electric…

Modulation of Lymphocyte Activity
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061

— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…

Mouse monoclonal antibodies against SARS-CoV-2 spike protein
Diamond, Michael ; Fremont, Daved ; VanBlargan, Laura ; Zhao, Haiyan
T-019470

— Species: Mouse Target: SARS-CoV-2 spike protein Applications: Data: See table below for library of antibodies, inventor can recommend specific clones based on intended application. Related Web Links: Diamond Profile Available Antibodies Ab: Well # Final Boost flow cytometer…

Myocardial perfusion SPECT optimization
Jha, Abhinav Kumar ; Rahman, Md Ashequr ; Siegel, Barry ; Yu, Zitong
T-020357

— T-020357, T-020358, T-020744 Myocardial perfusion SPECT optimization Technology Description Researchers from the laboratory of Abhinav Jha at Washington University have devised methods to reliably improve and personalize myocardial perfusion SPECT imaging. The inventions include the following capa…

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

Novel human astrovirus sequences for diagnostics and vaccine development for encephalitis and gastroenteritis
Finkbeiner, Stacy ; Virgin, Herbert ; Wang, David ; Zhao, Guoyan
T-009294

— Technology Description A team of researchers at Washington University and the Centers for Disease Control discovered, sequenced and patented a novel human astrovirus that can cause encephalitis and gastroenteritis (non-etiologic diarrhea), offering a path to detection and diagnostics. The virus (…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Dynamic seal valve to prevent aerosol infection
Cashin, John ; Hartquist, Chase ; Lowe, Halle ; Zayed, Mohamed
T-019628

— Technology Description Researchers in Mohamed Zayed’s lab at Washington University have developed a dynamic seal valve that creates a seal around devices with varying cross sections. This valve could be deployed in masks to protect health care workers from aerosol infection while using airwa…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Compositions for targeting pathologic cells and tissues
Achilefu, Samuel ; Liang, Kexian ; Shen, Duanwen ; Tang, Rui ; Xu, Baogang
T-015230

— Background: Almost 1.7 million new cancer cases are diagnosed in the US each year. Pancreatic cancer is particularly lethal, with an estimated 38,000 deaths in 2013 alone and a 5-year survival rate of 5%. Despite advances in noninvasive imaging modalities, the current gold standard consisting of …

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

Washington University Profile System (WUPS)
Hunstad, David ; Kenney, Kenneth ; Komeshak, Rachel ; Lackey, Ian ; Rich, Eliot
T-017287

— Background: Faculty members from institutions all over the world are publishing scientific articles, presenting data to conferences, and writing proposals for government-funded grants all simultaneously at one time. Of course, the outcomes happen to be known at different times for each specific task…

Targeting B Cells for Antibody-Mediated Graft Rejection
Edelson, Brian ; Fremont, Daved ; Liu, Chang ; Nelson, Christopher ; Wang, Xiaoli
T-018682

— Disease Indications Drug type: Biologic – engineered protein Drug class: First in class Technology: A recombinant fusion protein that depletes B cells in the recipient that are specific to the donor HLA. The fusion protein offers a targeted therapy for antibody-mediated rejection in the …

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Interferon-gamma treatment to improve efficacy of hematopoietic stem cell transplantation for AML and other cancer
Christopher, Matthew ; DiPersio, John ; Ley, Timothy ; Petti, Allegra ; Rettig, Michael
T-018954

— Technology Description Researchers at Washington University in St. Louis have discovered that interferon-gamma treatment could potentially prevent relapse after hematopoietic stem cell transplantation (HCT) treatment by making the cancer cells more visible to the donor immune cells. This technolog…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

Machine learning paired with photoacoustic microscopy and ultrasound for improved rectal cancer imaging
Chapman Jr., William "Will Jr" ; Leng, Xiandong ; Mutch, Matthew ; Uddin, Shihab ; Zhu, Quing
T-019449

— Technology Description: Researchers led by Quing Zhu at Washington University have developed a method for imaging rectal tumors using photoacoustic microscopy and ultrasound with a machine learning component. This method is better able to differentiate residual cancer from healthy tissue following…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

Photoacoustic tomography of human brain
Anastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043

— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…

Software to predict low back pain from brain imaging
Hawasli, Ammar ; Jayasekera, Dinal ; Lamichhane, Bidhan ; Leuthardt, Eric ; Ray, Wilson
T-019322

— Technology Description: Researchers at Washington University, led by Eric Leuthardt, have developed software that can identify specific brain regions involved in chronic low back pain from neuroimaging data. This software, powered by machine learning, relies on differences in cortical thickness an…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

NRF2 inhibitors as cancer therapeutics
Bowman, Brittany ; Dolle, Roland "Ron" ; Lapak, Kyle ; Major, Michael "Ben" ; Medcalf, Matthew
T-019534

— Disease indication – Diseases related to oxidative stress, including cancer, autoimmune disease, and Toxoplasma infection Drug format – Small molecule Drug class – Best-in-class Research stage and preliminary data – The researchers have synthesized a series of pyrimethamin…

Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)
Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450

— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Antibiotic-sparing small molecule therapy for urinary tract infection and other Gram-negative pathogens
Dodson, Karen ; Hultgren, Scott ; Omattage, Natalie ; Pinkner, Jerome ; Yuan, Peng
T-018046

— Technology Description Researchers in Prof. Scott Hultgren’s laboratory have discovered an antibiotic-sparing method for treating infections from E. coli and other Gram-negative bacteria. This approach is designed to block pathogens from colonizing their host by using small molecule inhibito…

Kinase toolkit for the production of phosphorylated proteins
Gale, Emily ; Naegle, Kristen ; Schaberg, Katherine ; Sloutsky, Roman ; Stoka, Kellie
T-014736

— Background: Abnormal phosphorylation of proteins is associated with a number of human diseases including cancer, neurodegenerative disorders, and diabetes. Due to their role as phosphorlyators, kinases are popular drug targets. However, the difficulty of selectively phosphorylating a desired substra…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Treatment for chronic migraines
Cao, Yu-Qing ; Cloud, Megan ; Hu, Rong ; Zhang, Jintao ; Zhang, Zhiyu
T-018942

— Technology Description Researchers at Washington University in St. Louis (WUSTL) have developed two methods for treating chronic migraine and post-traumatic headache. Chronic migraine and post-traumatic headache are highly prevalent and debilitating with limited treatment options. Further, for m…

Fuel-Staged Oxy-Combustion Process and Apparatus
Axelbaum, Richard ; Dhungel, Bhupesh ; Gopan, Akshay ; Kumfer, Benjamin ; Xia, Fei
T-013736

— Technology Description: Washington University in St. Louis researchers have developed new technology for clean coal combustion. The Staged Pressurized Oxy-Combustion (SPOC) system, pioneered by researchers at Dr Axelbaum’s Laboratory for Advanced Combustion & Energy Research, provides a pa…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Tumor Detection Using Digitally Enhanced and Stimulated Thermal Imaging
Achilefu, Samuel ; Meng, Hongyu ; Mondal, Suman ; O'Brien, Christine ; Shmuylovich, Leonid
T-018541

— Background Temperature differences between tumor and healthy tissue due to increased blood flow and metabolic activity are exploited for thermal imaging (TI) as an adjunct imaging modality for cancer diagnosis. Despite many technological advances and recent improvements, TI has a limited tumor dept…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

VarScan
Ding, Li ; Koboldt, Daniel ; Larson, David ; McLellan, Michael ; Wylie, Todd
T-009883

— arScan is a Java-based, platform-independent, software tool that can detect variants in next-generation sequencing (NGS) data. It employs a robust statistical approach to call variants and is able to handle germline variants, multi-sample variants, somatic mutations and somatic copy number alterati…

Therapeutic food supplements that promote healthy gut microbiome to treat malnutrition
Barratt, Michael ; Chang, Hao-Wei ; Gehrig, Jeanette ; Gordon, Jeffrey ; Venkatesh, Siddarth
T-018889

— Technology Description Prof. Jeffrey Gordon and his colleagues have developed an inexpensive food formulation that could treat malnutrition and a range of associated health problems by repairing the gut microbiome. Children who are malnourished are currently treated with supplemental nutrition tha…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Bacterial and Mammalian Expression Vectors for Production of SARS-CoV Proteins
Dai, Yanan ; Fremont, Daved ; Harvey, Ian ; Nelson, Christopher ; Zhao, Haiyan
T-019413

— A number of bacterial and mammalian expression vectors for production of SARS-CoV proteins that can be used for immunization, B-cell sorting, and human serum evaluation are available. Expression constructs produce: spike, ACE2, CD147, Surface display, SARS-1 and SARS-2 ORF7a, ORF8, and nucleocapsid…

Robust Suite of Technologies Offers Significant Enhancements for Whispering Gallery Mode (WGM) Microresonator Sensors and Laser Systems
Chen, Da-Ren ; He, Lina ; Ozdemir, Sahin ; Yang, Lan ; Zhu, Jiangang
T-009642

— WGM microresonators are an immature technology with room for improvement Microresonators are optical devices that are an important component of microlasers used in optoelectronics, data communications, and sensing. Most microresonators are WGM type, which confine light to a very small volume for si…

PARTNER program
Dodd, Sherry ; Garbutt, Jane ; Highstein, Gabrielle ; Rook, Shannon ; Strunk, Robert
T-014455

— Background: Many children with asthma live with frequent symptoms and activity limitations, and visits for urgent care are common. Pediatricians do not typically meet with families regularly in order to monitor asthma, identify possible problems with the management of the child’s asthma, or pr…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Automated image processing tools for quantitative SPECT and PET scans
Jha, Abhinav Kumar ; Liu, Ziping ; Moon, Hae Sol ; Rahman, Md Ashequr ; Yu, Zitong
T-019331

— Engineers in Washington University’s Computational Medical Imaging Lab have developed automated, machine-learning techniques to improve nuclear medicine imaging (SPECT and PET). These tools include estimation-based segmentation methods to define boundaries and ASC (attenuation and scatter comp…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Plasmids for calling cards and single cell calling cards
Chen, Xuhua ; Lalli, Matthew ; Mitra, Robi ; Moudgil, Arnav ; Wilkinson, Michael Nathaniel
T-019487

— These plasmids can be used for single cell calling cards (“scCCs”), a robust and versatile self-reporting transposon system for high throughput analysis of protein-DNA binding with single cell resolution (WUSTL Technology T-018069). scCC simultaneously maps the precise location of tran…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

New nerve cap arrests axon growth in neuroma management
Bichanich, Miles ; Hong, Thomas ; Mackinnon, Susan ; Moore, Amy ; Wood, Matthew
T-017285

— Background Neuromas (a.k.a. pinched nerve, or nerve tumor) form on peripheral nerves following trauma and possess exposed sensory axons mixed with fibrotic scar tissue. Symptomatic or painful neuromas have a profound impact on a patient’s quality of life and productivity. Pain medication offe…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Radiation Oncology Dashboards (LATTICE)
Danieley, Jonathan ; LaBrash, Jason ; Mutic, Sasa ; Santanam, Lakshmi ; Scholle, Glen
T-014089

— Software management tool for clinic business manager & coordination tool. Collects information on patient flow, treatment plans, machine availability and personnel to optimize clinic operations.

VISIT-TS Version 2
Black, Kevin ; Gordon, Mollie ; Schroeder, Miriam ; Striley, Catherine ; Vachon, Matthew
T-016526

— This is a brief (5 minutes exposition plus just under 5 minutes of questions) video that was designed for epidemiological research in tic disorders (including Tourette syndrome). The video shows lay people the broad definition of tics, so they can more accurately answer questions about whether they…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Knockout Mouse lacking Expression of the Batf3 Gene
Diamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136

— Notes: Batf3-/- knockout mouse with a 129SvEv background.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Pediatric Hematology-Oncology Roadmap Builder
Brown, Robert ; Drozda, Mandy ; Jones, Sally ; Lackey, Ian ; Rich, Eliot
T-010823

— Background: The process is an innovative process that uses the paper Oncology protocols to create customized electronic Oncology treatment Roadmaps on demand. The new process completely changes the existing paradigm to create a fully electronic process that can be integrated into existing inpatient …

Gaussian Process Audiogram
Barbour, Dennis ; Gardner, Jacob ; Ledbetter, Noah ; Song, Xinyu ; Weinberger, Kilian
T-015053

— Technology Description: The current audiogram takes 20 minutes per employee per test. The Gaussian Process Audiogram is an improved system for conducting audiograms that would cut the test time in half while avoiding ‘false fails’. This is a machine learning approach to improve speed and…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

microRNA biomarker and drug target for ALS and other motor neuron diseases
Dougherty, Joseph ; Hoye, Mariah ; Hyman, Theodore ; Koval, Erica ; Miller, Timothy
T-015167

— Prof. Timothy Miller and colleagues have identified a motor neuron-specific, drug responsive microRNA (miR-218) that reflects the pathology of amyotrophic lateral sclerosis (ALS). This biomarker could be a target for therapeutic intervention or a proxy for motor neuron health and survival, including…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Human monoclonal antibodies against SARS-CoV-2 spike protein
Ellebedy, Ali ; McIntire, Katherine ; Mudd, Philip ; Schmitz, Aaron ; Turner, Jackson
T-019454

— Species: Human Target: SARS-CoV-2 spike protein Applications: Description: Ten recombinant fully human monoclonal antibodies that recognize SARS-CoV-2 spike protein (data below). Related Web Links: Ellebedy Profile; Ellebedy Lab Available Antibodies mAb name Ag 30.0000 10.0…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 “Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

Rotoscope – A Self-Cleaning Endoscope
Genin, Guy ; Leuthardt, Eric ; Margolis, Daniel ; Somers, Thane ; Yarbrough, Chester
T-016245

— Technology Description: Drs. Eric Leuthardt and Guy Genin have devised a medical device designed for faster and safer endoscopic surgeries. During these surgeries, the camera lens of the endoscope can become obscured with blood, fog and debris. This slows down the procedure, as the surgeon has to r…

Hands-free, Wireless Goggles for Near-infrared fluorescence and Real-time Image-guided Surgery
Achilefu, Samuel ; Akers, Walter ; Bauer, Adam ; Culver, Joseph ; Liu, Yang
T-010825

— Background: Current cancer management faces several challenges, including high occurrence of residual tumor after resection, adverse effects from sentinel lymph node (SLN) biopsy, and use of bulky systems in surgical suites for image guidance. Technology Description: To overcome these limitations, …

Generating pancreatic beta cells from pluripotent stem cells for diabetes cell therapy or drug development
Hogrebe, Nathaniel ; Millman, Jeffrey ; Velazco-Cruz, Leonardo ; Veronese Paniagua, Daniel ; Wernes, Kristina
T-019409

— Technology Description: Researchers in Prof. Jeffrey Millman’s laboratory have developed multiple techniques for enhancing the differentiation, maturation and function of glucose-responsive, insulin-producing SC-beta cells (pancreatic beta cells made from human pluripotent stem cells). Downst…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Obligate Heterotetrameric Pairs of Cre Recombinase Mutants for Efficient Recombination at Asymmetric Sites
Corbo, Joseph ; Havranek, James ; Mitra, Robi ; Myers, Connie ; Qi, Zongtai ; Zhang, Chi
T-015523

— Background: The function of enzymes involved in homologous recombination can be exploited in the field of genetic engineering in order to generate mutations of interest. However, this machinery is not functionally efficient in post mitotic or terminally differentiated cells. Viral gene therapy techn…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Reformulated model [1] based prediction, monitoring and control of rechargeable electrochemical batteries
De, Sumitava ; Lawder, Matthew ; Northrop, Paul ; Ramadesigan, Venkatasailanathan ; Subramanian, Venkat ; Suthar, Bharatkumar
T-013089

— Advanced technology for Li ion batteries that allows 20% greater energy storage and 50% reduction in charging time without compromising the safety or lifetime of the battery system. Rechargeable batteries (e.g. Li ion) are managed as part of a subsystem that includes control of the charge and disch…

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Encapsulation to protect detection antibodies in implantable and wearable biosensors
Chakrabartty, Shantanu ; Gupta, Rohit ; Luan, Jingyi ; Morrissey, Jeremiah ; Scheller, Erica ; Singamaneni, Srikanth
T-019364

— Technology Description An interdisciplinary team of researchers at Washington University have developed a universal system designed to extend the lifetime of implantable and wearable biosensors by protecting detection antibodies from harsh conditions and enabling a refreshing process to release bo…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

ACALADE: surgical device designed for faster, safer lumbar discectomy
Johnson, Tim ; Leuthardt, Eric ; Moran, Daniel ; Reynolds, Benton ; Stoev, Ivan ; Wright, Neill
T-016236

— Technology Description A team of researchers at Washington University have developed ACALADE (Advanced Capability Lumbar Discectomy), a device designed to help surgeons safely access and quickly remove the back portions of herniated discs for faster, lower risk lumbar discectomy. Currently, about…

Artificial antibody platform to eliminate cold-chain in label-free plasmonic biosensor detection for diagnostics and research
Abbas, Abdennour ; Kharasch, Evan ; Liu, Keng-Ku ; Morrissey, Jeremiah ; Singamaneni, Srikanth ; Tian, Limei
T-013772

— Technology Description An interdisciplinary team of researchers at Washington University have developed a patented plasmonic nanotransducer system with built-in, highly stable artificial antibodies that can quickly detect and quantify biological molecules. These artificial antibodies can be rapidl…

Novel kinase inhibitor drugs to treat respiratory disease or breast cancer
Alevy, Yael ; Brett, Thomas ; Holtzman, Michael ; Patel, Anand ; Patel, Dhara ; Romero, Arthur
T-011991

— Disease indications: Drug format: small molecule Drug class: first in class Research stage and Preliminary data: Preclinical development of the lead compound for respiratory disease includes in vitro and in vivo efficacy, selectivity and initial toxicity testing. Preclinical development of the…

Biomimetic device for stronger repair of rotator cuff and other soft tissue-to-bone tears
Galatz, Leesa ; Genin, Guy ; Hoppe, Ethan ; Smith, Lester ; Thomopoulos, Stavros ; Yoon, Dong Hwan
T-019211

— Technology Description A team of engineers led by Professor Guy Genin has developed a device to strengthen the reattachment of soft tissue to bone for use in orthopedic procedures such as rotator cuff repairs. Although tendon and ligament tears are common, the techniques used to reattach these tis…

Monoclonal Antibodies Against Zika Virus and Purified Zika E Protein
Diamond, Michael ; Fernandez, Estefania ; Fremont, Daved ; Nelson, Christopher ; Platt, Derek ; Zhao, Haiyan
T-016168

— To generate a panel of antibodies against ZIKV, we serially infected Irf3/ mice 30 days apart with ZIKV MR-766 (Uganda, 1947) and ZIKV H/PF/2013 (French Polynesia, 2013). Irf3/ mice were used instead of wild-type (WT) mice, because ZIKV strains are deficient in evading type I interferon-mediated imm…

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

PANIR: Photoacoustic near-infrared spectroscopy for monitoring preterm birth
Hu, Peng ; Macones, George ; Qu, Yuan "Ed" ; Stout, Molly ; Tuuli, Methodius ; Zhao, Peinan
T-018998

— Technology Description An interdisciplinary team of researchers has developed a photoacoustic near-infrared (PANIR) probe to predict preterm birth by quantifying water content in cervical tissue (an early and objective indicator of cervical remodeling). This compact photoacoustic endoscopy probe u…

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Machine learning method for fast, reliable quality assurance of patient imaging in radiation therapy or computer-aided detection
Altman, Michael ; Green, Olga ; Kavanaugh, James ; Li, Hua ; Mutic, Sasa ; Wooten, Hasani
T-013577

— Technology Description A team of researchers at Washington University has created a machine learning method to quickly and reliably validate patient contours in digital medical images for radiation therapy and computer aided image analysis. Currently, automated contouring tools for delineating tu…

Anti-MIOX antibodies for sensitive, specific early detection of acute kidney injury
Crimmins, Dan ; Gaut, Joseph ; Ladenson, Jack ; Laterza, Omar ; Lockwood, Christina ; Modur, Vijay
T-013292

— Technology Description A team of researchers at Washington University in St. Louis have developed patented antibodies designed to identify MIOX (myo-inositol oxygenase), a renal-specific biomarker that can be detected immediately following acute kidney injury (AKI). AKI can be caused by surgery, s…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Patient Access Scheduling System
Dodt, Jeremy ; Hughes, Scott ; Mantia, Jill ; Melnek, Christine ; Reynolds, Steven ; Whipple, Toni
T-015846

— Background: Current EHR systems require that scheduling changes are performed by the scheduling team acting as a “hub”. The provider is unable to see availability of rooms and resources, especially of those that open up due to pending cancellations. This results in inefficiencies that co…

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 “Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Mouse and Human Anti-MR1 Hybridoma
Cella, Marina ; Colonna, Marco ; Fremont, Daved ; Gilfillan, Susan ; Hansen, Ted ; Myers, Nancy
T-013681

— Target: Major Histocompatibility Complex, Class 1-Related Protein Notes: Clone available is 26.5Hybridoma clone 26.5 secreting mAb 26.5 to human and mouse MR1, an MHC-like molecule that restricts the activation of anti-microbial MIAT cells. Publication: Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

Novel Murine Astroviruses
Loh, Joy ; Stappenbeck, Thaddeus ; Thackray, Larissa ; Virgin, Herbert ; Wang, David ; Yokoyama, Christine ; Zhao, Guoyan
T-012077

— Background: Mice are critical animal models for scientists investigating both basic and applied research principles. Several novel murine astroviruses have been identified in mouse facility at Washington University School of Medicine. Astroviruses are RNA viruses often associated with gastrointestin…

Target and method to treat alphavirus infections
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kim, Arthur ; Nelson, Christopher ; Thackray, Larissa ; Zhang, Rong
T-017583

— Technology Description Researchers at Washington University in St. Louis have identified a target for therapeutic development and created methods to potentially treat arthritogenic alphavirus infection. Arthritogenic alphaviruses, including chikungunya (CHIKV), Ross River, Mayaro and O’nyong…

Nanofiber scaffolds for delivery of heparin binding growth factors.
Gelberman, Richard ; Sakiyama-Elbert, Shelly ; Schwartz, Andrea "Annie" ; Silva, Matthew ; Thomopoulos, Stavros ; Xia, Younan ; Xie, Jingwei
T-010125

— Background: Despite advanced surgical techniques and improved rehabilitation therapies, outcomes of tendon repairs are still highly variable. Current surgical interventions are perhaps unsuccessful due to the relatively few numbers of cells present at the repair site. An engineered delivery of stem …

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

Small molecule inhibitors to prevent tetracycline resistance
Dantas, Gautam ; Forsberg, Kevin ; Gasparrini, Andrew ; Park, Jooyoung ; Tolia, Niraj ; Vogel, Joseph ; Wencewicz, Timothy
T-016593

— Disease indication – Tetracycline resistant infections Drug format – Small molecule (anhydrotetracycline (aTC) or analogs) Drug class – Combination therapy Research stage and Preliminary data Target – Tetracycline destructases (Tet(X), Tet(50), etc) Background &ndas…

Fusion protein for treating multiple strains of Venezuelan equine encephalitis virus
Basore, Katherine ; Diamond, Michael ; Fremont, Daved ; Kafai, Natasha ; Kim, Arthur ; Ma, Hongming ; Thackray, Larissa
T-019414

— Disease indication – Venezuelan equine encephalitis virus (VEEV) infection, either naturally-arising and as a result of bioterrorism Drug format – Biologic (soluble receptor fusion protein) Drug class – First-in-class Mode of action – This soluble fusion protein contains domain …

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Uropathogen Vaccines
Dodson, Karen ; Ellebedy, Ali ; Feldman, Mario ; Hultgren, Scott ; Pinkner, Jerome ; Tamadonfar, Kevin ; Timm, Morgan
T-020120

— Technology Description Researchers in Scott Hultgren’s laboratory at Washington University have created two prospective vaccine treatments designed to prevent the colonization of prominent uropathogens. These vaccines have potential for treating urinary tract infections (UTIs) with specific m…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Disulfide trapped antigenic peptide in an MHC molecule.
Connolly, Janet ; Fremont, Daved ; Hansen, Ted ; Lybarger, Lonnie ; Miley, Michael ; Mitaksov, Vesselin ; Truscott, Steven
T-004551 “Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

ID CUBE: Interactive Discovery Cube
Berezin, Mikhail ; Du, Tommy ; Garnett, Roman ; Huang, Yunshen ; Kim, David ; Mishra, Deependra ; Wu, Qian ; Zhang, Hairong
T-016317

— Background: With the advancement in the area of hyperspectral imaging technology, there is an influx of data being collected from disparate sources of highly sophisticated technology. Processing these data using current software is either non-interactive, in capable of leveraging the wealth of infor…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

String Theory: Neurovascular Catheter System with 2-in-1 Variable Rigidity
Chandrasekaran, Vinay ; Genin, Guy ; Hafez, Daniel ; Hartquist, Chase ; Leuthardt, Eric ; Lowe, Halle ; Osbun, Joshua ; Zayed, Mohamed
T-019184

— An interdisciplinary team at Washington University has developed an easy-to-use neurovascular catheter system designed to reduce surgery time and prevent herniation during transradial interventions for stroke, aneurysms and other conditions. This device, called “String Theory”, can be sw…

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

Comprehensive Test Suite for Radiotherapy Machines Fully Automates Acceptance, Commissioning, and Daily Quality Assurance for Increased Profitability
Hao, Yao ; Knutson, Nels ; Mahon, Rebecca "Nicky" ; Raman, Caleb ; Reynoso, Francisco ; Schmidt, Matthew ; Sun, Baozhou ; Wu, Yu
T-019746

— Quality assurance is critical in the setup and operation of linear accelerators (LINACs) and requires significant time and expense Before they can be put into use, new LINAC radiotherapy machines and their integrated treatment planning systems (TPSs) must go through a labor-intensive acceptance and…

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…

Trackable pedicle screws
Brunner, Peter ; Genin, Guy ; Hacker, Carl ; Leuthardt, Eric ; Lowe, Halle ; Molina, Camilo ; Moran, Daniel ; Repka, Alicia ; Sandler, Jacob
T-019941

— Technology Description Researchers at Washington University in St. Louis have developed a system that uses lenticular arrays to better track pedicle screw placement during spinal fusion surgery. By enabling an accurate assessment of the screws’ locations, this system allows for computer-auto…

SIMPEL: electrode device to safely and precisely stimulate sympathetic nerves to treat asthma, hypertension and other conditions
Cloonan, Paige ; Kamath, Ashwin ; Leuthardt, Eric ; MacEwan, Matthew ; Moore, Amy ; Moran, Daniel ; Qin, Yidan (Ida) ; Ray, Wilson ; Zhang, Christopher
T-017895

— Technology Description A team of researchers at Washington University have developed “SIMPEL”, a small, implanted electrode device designed to manage a variety of conditions (such as asthma, hypertension or neuropathy) by delivering current from a defined, fixed position near specific …

Bio-robotic “artificial nose” system for detecting explosives and other chemicals
Altan, Ege ; Chakrabartty, Shantanu ; Chandak, Rishabh ; Mehta, Darshit ; Raman, Baranidharan ; Saha, Debajit ; Singamaneni, Srikanth ; Tadepalli, Sirimuvva ; Traner, Michael
T-019136

— Technology Description Prof. Barani Raman and colleagues have developed a robust, insect-based, non-invasive sensing system to detect explosives or other chemicals. This “artificial nose” technology includes methods to decode neural signals from the insect’s olfactory system and …

SPARTA – A Stent for Fusiform Aneurysms that Prevents Endoleaks
Bayly, Philip ; Derdeyn, Colin ; Elbert, Donald ; Genin, Guy ; Leuthardt, Eric ; McCoy, Kathleen ; Suh, JunWoo ; Teh, Yuni ; Vemuri, Chandu ; Zhao, Alan ; Zipfel, Gregory
T-015969

— Background: Popliteal artery aneurysms are the most prevalent type of peripheral aneurysms and are treated surgically to prevent rupture. Currently, surgical options include open surgery or endovascular aneurysm repair (EVAR). EVAR is less invasive than open surgery, resulting in shorter hospital st…

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

Cell permaeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (PNAs) with unr mRNA targeting sequences for early diagnosis and therapy of cancers
Becker, Matthew ; Fang, Huafeng ; Pan, Dipanjan ; Rossin, Raffaella ; Sun, Xiankai ; Taylor, John-Stephen ; Turner, Jeffrey ; Welch, Michael ; Wooley, Karen
T-004487

— This invention features cell permeable nano conjugates of shell-cross-linked knedel (SCK) and peptide nucleic acids (PNA) with mRNA targeting sequences for early diagnosis and therapy of cancers.

“Gemini” connector device to prevent peripheral venous catheters from dislodging and leaking
Arias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841

— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…